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Karen Tendyke · SciRah

Researcher profile · Semantic Scholar

Karen Tendyke

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Karen Tendyke — researcher profile on SciRah

h-index: 21
Works: 54
Citations: 1,569

Most-cited papers

Induction of Morphological and Biochemical Apoptosis following Prolonged Mitotic Blockage by Halichondrin B Macrocyclic Ketone Analog E7389
G. Kuznetsov, M. Towle, H. Cheng, T. Kawamura +5 more
2004Cancer Research246 citations Open access
Semantic Scholar
Potent in vitro and in vivo anticancer activities of des-methyl, des-amino pateamine A, a synthetic analogue of marine natural product pateamine A
G. Kuznetsov, Qunli Xu, L. Rudolph-Owen, Karen Tendyke +16 more
2009Molecular Cancer Therapeutics101 citations Open access
Semantic Scholar
E7766, a Macrocycle‐Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan‐Genotypic Activity
Dae-Shik Kim, A. Endo, Francis G. Fang, Kuan-Chun Huang +18 more
2021ChemMedChem96 citations
Semantic Scholar
Tubulin-based antimitotic mechanism of E7974, a novel analogue of the marine sponge natural product hemiasterlin
G. Kuznetsov, Karen Tendyke, M. Towle, H. Cheng +14 more
2009Molecular Cancer Therapeutics72 citations
Semantic Scholar
Apratoxin A Shows Novel Pancreas-Targeting Activity through the Binding of Sec 61
Kuan-Chun Huang, Zhi-Hong Chen, Yi-Min Jiang, Sandeep Akare +15 more
2016Molecular Cancer Therapeutics70 citations
Semantic Scholar
A β-Carboline Alkaloid from the Papua New Guinea Marine Sponge Hyrtios reticulatus
W. Inman, Walter Bray, N. Gassner, R. Lokey +5 more
2010Journal of Natural Products70 citations Open access
Semantic Scholar
Cytotoxic triterpenoid saponins of Albizia gummifera from the Madagascar rain forest.
Shu-Geng Cao, Andrew Norris, J. Miller, Fidy Ratovoson +6 more
2007Journal of Natural Products60 citations Open access
Semantic Scholar
Antiproliferative effects of halichondrin B analog eribulin mesylate (E7389) against paclitaxel-resistant human cancer cells in vitro
G. Kuznetsov, Karen Tendyke, Melvin J. Yu, B. Littlefield
200758 citations
Semantic Scholar
Mycoleptodiscins A and B, cytotoxic alkaloids from the endophytic fungus Mycoleptodiscus sp. F0194.
H. Ortega, P. Graupner, Yumi Asai, Karen Tendyke +8 more
2013Journal of Natural Products51 citations
Semantic Scholar
Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking
Xing-Feng Bao, W. Zheng, N. Sugi, Kishan Agarwala +20 more
2015Cancer Biology & Therapy39 citations Open access
Semantic Scholar
Antiproliferative Homoisoflavonoids and Bufatrienolides from Urginea depressa
Yu-Min Dai, L. Harinantenaina, P. Brodie, M. Goetz +3 more
2013Journal of Natural Products38 citations Open access
Semantic Scholar
Antiproliferative Triterpenoid Saponins of Dodonaea viscosa from the Madagascar Dry Forest
Shu-Geng Cao, P. Brodie, M. Callmander, Richard Randrianaivo +7 more
2009Journal of Natural Products38 citations Open access
Semantic Scholar
Total synthesis of ipomoeassin F.
M. H. Postema, Karen Tendyke, J. Cutter, G. Kuznetsov +1 more
2009Organic Letters33 citations
Semantic Scholar
Leiodermatolide, a novel marine natural product, has potent cytotoxic and anti-mitotic activity against cancer cells, appears to affect microtubule dynamics, and exhibits anti-tumor activity
E. Guzmán, Qunli Xu, T. Pitts, K. Mitsuhashi +7 more
2016International Journal of Cancer30 citations Open access
Semantic Scholar
Structures and Cytotoxic Evaluation of New and Known Acyclic Ene-Ynes from an American Samoa Petrosia sp. Sponge
Eric J. Mejia, Lindsay B Magranet, N. D. de Voogd, Karen Tendyke +4 more
2013Journal of Natural Products25 citations Open access
Semantic Scholar
Design, synthesis, and biological evaluation of diminutive forms of (+)-spongistatin 1: lessons learned.
Amos B. Smith, C. Risatti, Onur Atasoylu, Clay S. Bennett +4 more
2011Journal of the American Chemical Society25 citations Open access
Semantic Scholar
High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc -) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells
A. Thomas, R. Sattler, Karen Tendyke, K. Loiacono +5 more
2015PLoS ONE24 citations Open access
Semantic Scholar
Antiproliferative Cardenolide Glycosides of Elaeodendron alluaudianum from the Madagascar Rainforest
Yanpeng Hou, Shu-Geng Cao, P. Brodie, M. Callmander +8 more
2008Bioorganic & Medicinal Chemistry22 citations Open access
Semantic Scholar
Antiproliferative compounds of Artabotrys madagascariensis from the Madagascar rainforest
B. Murphy, Shu-Geng Cao, P. Brodie, J. Miller +7 more
2008Natural Product Research22 citations Open access
Semantic Scholar
Antiproliferative cardenolides of an Elaeodendron sp. from the Madagascar rain forest(1).
Shu-Geng Cao, P. Brodie, J. Miller, Fidy Ratovoson +7 more
2007Journal of Natural Products22 citations Open access
Semantic Scholar
Novel second generation analogs of eribulin. Part I: Compounds containing a lipophilic C32 side chain overcome P-glycoprotein susceptibility.
S. Narayan, Eric M Carlson, H. Cheng, Hong-Jian Du +10 more
2011Bioorganic & Medicinal Chemistry Letters21 citations
Semantic Scholar
Novel second generation analogs of eribulin. Part III: Blood-brain barrier permeability and in vivo activity in a brain tumor model.
S. Narayan, Eric M Carlson, H. Cheng, Krista B. Condon +15 more
2011Bioorganic & Medicinal Chemistry Letters21 citations
Semantic Scholar
Antiproliferative Compounds from Cleistanthus boivinianus from the Madagascar Dry Forest1
Yi-Xi Liu, Kelly A. Young, L. Rakotondraibe, P. Brodie +9 more
2015Journal of Natural Products20 citations Open access
Semantic Scholar
In Vitro and In Vivo Anticancer Activity of (+)-Spongistatin 1
Qunli Xu, Kuan-Chun Huang, Karen Tendyke, Joanne Marsh +8 more
2011Anticancer Research20 citations
Semantic Scholar
Antiproliferative Compounds from Pongamiopsis pervilleana from the Madagascar Dry Forest
L. Harinantenaina, P. Brodie, C. Slebodnick, M. Callmander +8 more
2010Journal of Natural Products20 citations Open access
Semantic Scholar
Sensitivity to halichondrin analog E7389 and hemiasterlin analog E7974 correlates with {beta}III tubulin isotype expression in human breast cancer cell lines
S. Agoulnik, G. Kuznetsov, Karen Tendyke, L. Parent +5 more
200520 citations
Semantic Scholar
Pharmacological Activation of STING in Bladder Induces Potent Anti-tumor Immunity in Non-Muscle Invasive Murine Bladder Cancer.
Kuan-Chun Huang, Dinesh Chanda, S. Mcgrath, Vaishali Dixit +17 more
2022Molecular Cancer Therapeutics19 citations Open access
Semantic Scholar
Neuropilin-1 drives tumor-specific uptake of chlorotoxin
S. McGonigle, U. Majumder, D. Kolber-Simonds, Jiayi Wu +11 more
2019Cell Communication and Signaling19 citations Open access
Semantic Scholar
Isolation and Synthesis of Antiproliferative Eupolauridine Alkaloids of Ambavia gerrardii from the Madagascar Dry Forest
E. Pan, Shu-Geng Cao, P. Brodie, M. Callmander +8 more
2011Journal of Natural Products19 citations Open access
Semantic Scholar
Antiproliferative Acetogenins from a Uvaria sp. from the Madagascar Dry Forest
Yu-Min Dai, L. Harinantenaina, P. Brodie, M. Callmander +8 more
2011Journal of Natural Products19 citations Open access
Semantic Scholar
Antiproliferative limonoids of a Malleastrum sp. from the Madagascar rainforest.
B. Murphy, P. Brodie, C. Slebodnick, J. Miller +7 more
2008Journal of Natural Products19 citations Open access
Semantic Scholar
Novel second generation analogs of eribulin. Part II: Orally available and active against resistant tumors in vivo.
S. Narayan, Eric M Carlson, H. Cheng, Krista B. Condon +15 more
2011Bioorganic & Medicinal Chemistry Letters18 citations
Semantic Scholar
Euphane triterpenoids of Cassipourea lanceolata from the Madagascar rainforest
Yanpeng Hou, Shu-Geng Cao, P. Brodie, J. Miller +8 more
2010Phytochemistry18 citations Open access
Semantic Scholar
Cardenolides of Leptadenia madagascariensis from the Madagascar dry forest
E. Pan, L. Harinantenaina, P. Brodie, M. Callmander +7 more
2010Bioorganic & Medicinal Chemistry18 citations Open access
Semantic Scholar
Abstract 4456: Discovery of E7766: A representative of a novel class of macrocycle-bridged STING agonists (MBSAs) with superior potency and pan-genotypic activity
A. Endo, Dae-Shik Kim, Kuan-Chun Huang, Ming-Hong Hao +19 more
2019Cancer Chemistry16 citations
Semantic Scholar
Antiproliferative homoscalarane sesterterpenes from two Madagascan sponges
L. Harinantenaina, P. Brodie, J. Maharavo, G. Bakary +3 more
2013Bioorganic & Medicinal Chemistry16 citations Open access
Semantic Scholar
3-epi-Waol A and Waol C: polyketide-derived γ-lactones isolated from the endophytic fungus Libertella blepharis F2644
Itzel Adames, H. Ortega, Yumi Asai, Masaki Kato +4 more
201515 citations
Semantic Scholar
Polyhydroxylated macrolide isolated from the endophytic fungus Pestalotiopsis mangiferae
H. Ortega, Young Y. Shen, Karen Tendyke, N. Ríos +1 more
201415 citations
Semantic Scholar
Design, synthesis, and biological evaluation of EF- and ABEF- analogues of (+)-spongistatin 1.
Amos B. Smith, C. Risatti, Onur Atasoylu, Clay S. Bennett +2 more
2010Organic Letters13 citations Open access
Semantic Scholar
Correction: Pharmacologic Activation of STING in the Bladder Induces Potent Antitumor Immunity in Non-Muscle Invasive Murine Bladder Cancer.
Kuan-Chun Huang, D. Chandra, S. Mcgrath, Vaishali Dixit +17 more
2023Molecular Cancer Therapeutics11 citations Open access
Semantic Scholar
Abstract 3269: Discovery and characterization of E7766, a novel macrocycle-bridged STING agonist with pan-genotypic and potent antitumor activity through intravesical and intratumoral administration
Kuan-Chun Huang, A. Endo, S. Mcgrath, D. Chandra +20 more
2019Immunology10 citations
Semantic Scholar
Structure elucidation of antiproliferative bisbenzylisoquinoline alkaloids from Anisocycla grandidieri from the Madagascar dry forest
Yi-Xi Liu, L. Harinantenaina, P. Brodie, C. Slebodnick +7 more
2013Magnetic resonance in chemistry : MRC10 citations Open access
Semantic Scholar
Atom-based enumeration: new eribulin analogues with low susceptibility to P-glycoprotein-mediated drug efflux.
Melvin J. Yu, W. Zheng, Karen Tendyke
2012Bioorganic & Medicinal Chemistry Letters9 citations
Semantic Scholar
Design, Synthesis, and Evaluation of Irciniastatin Analogues: Simplification of the Tetrahydropyran Core and the C(11) Substituents
Qi Liu, Chihui An, Karen Tendyke, H. Cheng +3 more
2016Journal of Organic Chemistry8 citations Open access
Semantic Scholar
Nitrogen-Containing Dimeric nor-Multiflorane Triterpene from a Turraea sp.
V. Rasamison, L. Rakotondraibe, C. Slebodnick, P. Brodie +5 more
2014Organic Letters8 citations Open access
Semantic Scholar
Two Antiproliferative Triterpene Saponins from Nematostylis anthophylla from the Highlands of Central Madagascar
Yu-Min Dai, L. Harinantenaina, P. Brodie, C. Birkinshaw +7 more
2013Chemistry and Biodiversity8 citations Open access
Semantic Scholar
Polyhydroxylated Macrolide Isolated from the Endophytic Fungus Pestalotiopsis mangiferae.
H. Ortega, Yong-Chun Shen, Karen Tendyke, N. Ríos +1 more
20147 citations
Semantic Scholar
Abstract 4688: E7449: A novel PARP inhibitor enhances the efficacy of radiotherapy and chemotherapy and has potent single agent anticancer activity in BRCA-deficient tumors
S. McGonigle, Zhi-Hong Chen, Jiayi Wu, K. Ackermann +3 more
20126 citations
Semantic Scholar
Synthetic analogs of the marine natural product hemiasterlin: Optimization and discovery of E7974, a novel and potent antitumor agent
J. Kowalczyk, S. Schiller, M. Spyvee, Hu Yang +10 more
20055 citations
Semantic Scholar
Front Cover: E7766, a Macrocycle‐Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan‐Genotypic Activity (ChemMedChem 11/2021)
Dae-Shik Kim, A. Endo, Francis G. Fang, Kuan-Chun Huang +18 more
2021ChemMedChem1 citations
Semantic Scholar

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