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R. E. Wuthier · SciRah

Researcher profile · Semantic Scholar

R. E. Wuthier

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R. E. Wuthier — researcher profile on SciRah

h-index: 41
Works: 111
Citations: 4,937

Most-cited papers

Studies on matrix vesicles isolated from chick epiphyseal cartilage. Association of pyrophosphatase and ATPase activities with alkaline phosphatase.
R. Majeska, R. E. Wuthier
1975Biochimica et Biophysica Acta268 citations
Semantic Scholar
Fourier transform raman spectroscopy of synthetic and biological calcium phosphates
Glenn R. Sauer, W. B. Zunic, J. Durig, R. E. Wuthier
1994Calcified Tissue International208 citations
Semantic Scholar
Correlation between loss of alkaline phosphatase activity and accumulation of calcium during matrix vesicle-mediated mineralization.
B. Genge, G. R. Sauer, L.-N.-Y. Wu, F. M. Mclean +1 more
1988Journal of Biological Chemistry197 citations
Semantic Scholar
Matrix vesicles: structure, composition, formation and function in calcification.
R. E. Wuthier, G. Lipscomb
2011Frontiers in Bioscience174 citations Open access
Semantic Scholar
Fourier transform infrared characterization of mineral phases formed during induction of mineralization by collagenase-released matrix vesicles in vitro.
G. R. Sauer, R. E. Wuthier
1988Journal of Biological Chemistry172 citations Open access
Semantic Scholar
A review of the primary mechanism of endochondral calcification with special emphasis on the role of cells, mitochondria and matrix vesicles.
R. Wuthier
1982Clinical Orthopaedics and Related Research165 citations
Semantic Scholar
Phospholipid—Calcium Phosphate Complex: Enhanced Calcium Migration in the Presence of Phosphate
J. Cotmore, G. Nichols, R. E. Wuthier
1971Science147 citations
Semantic Scholar
Collagen-binding proteins in collagenase-released matrix vesicles from cartilage. Interaction between matrix vesicle proteins and different types of collagen.
Luo-Jia Wu, B. Genge, Georgia C. Lloyd, R. E. Wuthier
1991Journal of Biological Chemistry139 citations Open access
Semantic Scholar
Physicochemical Characterization of the Nucleational Core of Matrix Vesicles*
Licia N. Y. Wu, B. Genge, D. Dunkelberger, R. Legeros +2 more
1997Journal of Biological Chemistry135 citations Open access
Semantic Scholar
Characterization of the nucleational core complex responsible for mineral induction by growth plate cartilage matrix vesicles.
L.-N.-Y. Wu, T. Yoshimori, B. Genge, G. R. Sauer +3 more
1993Journal of Biological Chemistry118 citations Open access
Semantic Scholar
Purification and initial characterization of intrinsic membrane-bound alkaline phosphatase from chicken epiphyseal cartilage.
G. W. Cyboron, R. Wuthier
1981Journal of Biological Chemistry118 citations Open access
Semantic Scholar
Stimulation of calcification of growth plate cartilage matrix vesicles by binding to type II and X collagens.
Thorsten Kirsch, R. E. Wuthier
1994Journal of Biological Chemistry112 citations
Semantic Scholar
The mechanism of matrix vesicle formation. Studies on the composition of chondrocyte microvilli and on the effects of microfilament-perturbing agents on cellular vesiculation.
J. Hale, R. E. Wuthier
1987Journal of Biological Chemistry108 citations Open access
Semantic Scholar
Identification of phospholipid-dependent calcium-binding proteins as constituents of matrix vesicles.
B. Genge, L.-N.-Y. Wu, R. E. Wuthier
1989Journal of Biological Chemistry95 citations Open access
Semantic Scholar
Similarity in calcium channel activity of annexin V and matrix vesicles in planar lipid bilayers.
N. Arispe, Eduardo Rojas, B. Genge, Licia N. Y. Wu +1 more
1996Biophysical Journal91 citations Open access
Semantic Scholar
Roles of alkaline phosphatase and labile internal mineral in matrix vesicle-mediated calcification. Effect of selective release of membrane-bound alkaline phosphatase and treatment with isosmotic pH 6 buffer.
T. C. Register, F. M. Mclean, M. G. Low, R. E. Wuthier
1986Journal of Biological Chemistry80 citations Open access
Semantic Scholar
Differential fractionation of matrix vesicle proteins. Further characterization of the acidic phospholipid-dependent Ca2(+)-binding proteins.
B. Genge, L.-N.-Y. Wu, R. E. Wuthier
1990Journal of Biological Chemistry77 citations Open access
Semantic Scholar
Morphological and biochemical characterization of mineralizing primary cultures of avian growth plate chondrocytes: Evidence for cellular processing of Ca2+ and Pi prior to matrix mineralization
Licia N. Y. Wu, Y. Ishikawa, G. R. Sauer, B. Genge +3 more
1995Journal of Cellular Biochemistry76 citations
Semantic Scholar
In Vitro Modeling of Matrix Vesicle Nucleation
B. Genge, Licia N. Y. Wu, R. E. Wuthier
2007Journal of Biological Chemistry72 citations Open access
Semantic Scholar
In vitro precipitation of calcium phosphate under intracellular conditions: formation of brushite from an amorphous precursor in the absence of ATP
R. E. Wuthier, Gregory S. Rice, James E. B. Jr. Wallace, R. L. Weaver +2 more
1985Calcified Tissue International67 citations
Semantic Scholar
Involvement of cellular metabolism of calcium and phosphate in calcification of avian growth plate cartilage.
R. Wuthier
1993Journal of NutriLife61 citations Open access
Semantic Scholar
Activity of epiphyseal cartilage membrane alkaline phosphatase and the effects of its inhibitors at physiological pH.
Grant W. Cyboron, Michael S. Vejins, R. E. Wuthier
1982Journal of Biological Chemistry61 citations Open access
Semantic Scholar
Partition of inorganic ions and phospholipids in isolated cell, membrane and matrix vesicle fractions: Evidence for Ca-Pi-acidic phospholipid complexes
R. Wuthier, S. T. Gore
1977Calcified Tissue Research61 citations
Semantic Scholar
Electrolytes of isolated epiphyseal chondrocytes, matrix vesicles, and extracellular fluid
R. E. Wuthier
1977Calcified Tissue Research60 citations
Semantic Scholar
Establishment of the primary structure of the major lipid‐dependent Ca2+ binding proteins of chicken growth plate cartilage matrix vesicles: Identity with anchorin cii (annexin V) and annexin II
B. Genge, Xu Cao, Licia N. Y. Wu, William R. Buzzi +4 more
1992Journal of Bone and Mineral Research58 citations
Semantic Scholar
Roles of the nucleational core complex and collagens (types II and X) in calcification of growth plate cartilage matrix vesicles.
Thorsten Kirsch, Y. Ishikawa, F. Mwale, R. E. Wuthier
1994Journal of Biological Chemistry57 citations
Semantic Scholar
Effect of pyrophosphate and two diphosphonates on 45Ca and 32Pi uptake and mineralization by matrix vesicle-enriched fractions and by hydroxyapatite.
T. C. Register, R. E. Wuthier
1985Bone47 citations
Semantic Scholar
Effect of vanadate, a potent alkaline phosphatase inhibitor, on 45Ca and 32Pi uptake by matrix vesicle-enriched fractions from chicken epiphyseal cartilage.
T. C. Register, R. E. Wuthier
1984Journal of Biological Chemistry47 citations Open access
Semantic Scholar
A zonal analysis of inorganic and organic constituents of the epiphysis during endochondral calcification
R. E. Wuthier
1969Calcified Tissue Research47 citations
Semantic Scholar
Effect of L- and D-tetramisole on 32Pi and 45Ca uptake and mineralization by matrix vesicle-enriched fractions from chicken epiphyseal cartilage.
T. C. Register, G. P. Warner, R. Wuthier
1984Journal of Biological Chemistry44 citations Open access
Semantic Scholar
Association between proteoglycans and matrix vesicles in the extracellular matrix of growth plate cartilage.
L.-N.-Y. Wu, B. Genge, R. E. Wuthier
1991Journal of Biological Chemistry43 citations
Semantic Scholar
Non-enzymatic isolation of matrix vesicles : characterization and initial studies on 45Ca and 32P-orthophosphate metabolism
R. E. Wuthier, R. Linder, G. P. Warner, S. T. Gore +1 more
197841 citations
Semantic Scholar
The role of phospholipids in biological calcification: distribution of phospholipase activity in calcifying epiphyseal cartilage.
R. E. Wuthier
1973Clinical Orthopaedics and Related Research41 citations
Semantic Scholar
Analysis and Molecular Modeling of the Formation, Structure, and Activity of the Phosphatidylserine-Calcium-Phosphate Complex Associated with Biomineralization*
Licia N. Y. Wu, B. Genge, R. E. Wuthier
2008Journal of Biological Chemistry40 citations Open access
Semantic Scholar
Effects of analogues of inorganic phosphate and sodium ion on mineralization of matrix vesicles isolated from growth plate cartilage of normal rapidly growing chickens.
Licia N. Y. Wu, G. R. Sauer, B. Genge, W. B. Valhmu +1 more
2003Journal of Inorganic Biochemistry40 citations
Semantic Scholar
Matrix vesicle annexins exhibit proteolipid-like properties. Selective partitioning into lipophilic solvents under acidic conditions.
B. Genge, L.-N.-Y. Wu, H. Adkisson, R. E. Wuthier
1991Journal of Biological Chemistry40 citations Open access
Semantic Scholar
Subcellular fractionation of epiphyseal cartilage: isolation of matrix vesicles and profiles of enzymes, phospholipids, calcium and phosphate.
E. Watkins, J. Stillo, R. E. Wuthier
1980Biochimica et Biophysica Acta38 citations
Semantic Scholar
Mineralization of Annexin-5-containing Lipid-Calcium-Phosphate Complexes
B. Genge, Licia N. Y. Wu, R. E. Wuthier
2008Journal of Biological Chemistry36 citations Open access
Semantic Scholar
Structural studies of a phosphatidyl serine-amorphous calcium phosphate complex
M. Taylor, K. Simkiss, J. Simmons, L.-N.-Y. Wu +1 more
1998Cellular and Molecular Life Sciences (CMLS)36 citations
Semantic Scholar
Retinoic acid treatment elevates matrix metalloproteinase‐2 protein and mRNA levels in avian growth plate chondrocyte cultures
D. Nie, Y. Ishikawa, T. Yoshimori, R. E. Wuthier +1 more
1998Journal of Cellular Biochemistry34 citations
Semantic Scholar
Effects of Ca/Pi ratio, Ca2+ x Pi ion product, and pH of incubation fluid on accumulation of 45Ca2+ by matrix vesicles in vitro.
W. B. Valhmu, Licia N. Y. Wu, R. E. Wuthier
1990Bone and Mineral34 citations
Semantic Scholar
Kinetic analysis of mineral formation during in vitro modeling of matrix vesicle mineralization: effect of annexin A5, phosphatidylserine, and type II collagen.
B. Genge, Licia N. Y. Wu, R. E. Wuthier
2007Analytical Biochemistry30 citations
Semantic Scholar
Biosynthesis of matrix vesicles in epiphyseal cartilage
R. E. Wuthier, R. Majeska, G. Collins
1977Calcified Tissue Research30 citations
Semantic Scholar
Differential effects of zinc and magnesium ions on mineralization activity of phosphatidylserine calcium phosphate complexes.
Licia N. Y. Wu, B. Genge, R. E. Wuthier
2009Journal of Inorganic Biochemistry28 citations
Semantic Scholar
In Situ Levels of Intracellular Ca2+ and pH in Avian Growth Plate Cartilage
Licia N. Y. Wu, Melissa G. Wuthier, B. Genge, R. E. Wuthier
1997Clinical Orthopaedics and Related Research28 citations
Semantic Scholar
A freeze‐fracture study of avian epiphyseal cartilage differentiation
T. Borg, Raymond B. Runyan, R. E. Wuthier
1981The Anatomical Record28 citations
Semantic Scholar
In vitro biosynthesis of phospholipids by chondrocytes and matrix vesicles of epiphyseal cartilage.
R. E. Wuthier, F. Wians, M. Giancola, S. Dragić
1978Biochemistry28 citations
Semantic Scholar
Relationship between pyrophosphate, amorphous calcium phosphate and other factors in the sequence of calcificationin vivo
R. E. Wuthier, S. Bisaz, Roslin Russell, H. Fleisch
2005Calcified Tissue Research26 citations
Semantic Scholar
Separation and quantification of chicken and bovine growth plate cartilage matrix vesicle lipids by high-performance liquid chromatography using evaporative light scattering detection.
B. Genge, Licia N. Y. Wu, R. E. Wuthier
2003Analytical Biochemistry26 citations
Semantic Scholar
Intracellular zinc fluxes associated with apoptosis in growth plate chondrocytes
Glenn R. Sauer, Della M. Smith, Matthew Cahalane, Licia N. Y. Wu +1 more
2003Journal of Cellular Biochemistry25 citations
Semantic Scholar

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B. Genge×19
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Licia N. Y. Wu×15
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L.-N.-Y. Wu×7
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G. R. Sauer×5
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