C. D. de Melo

Most-cited papers

1. Activities of stromal and immune cells in HPV-related cancers

   M. R. Barros, C. D. de Melo, Maria Luiza Carneiro Moura Gonçalves Rego Barros, Rita de Cássia Pereira de Lima +2 more

   2018Journal of experimental & clinical cancer research : CR65 citations Open access

   Semantic Scholar

   Save

2. Structural investigation of anti-Trypanosoma cruzi 2-iminothiazolidin-4-ones allows the identification of agents with efficacy in infected mice.

   D. Moreira, S. Costa, M. Z. Hernandes, M. Rabello +12 more

   2012Journal of Medicinal Chemistry56 citations Open access

   Semantic Scholar

   Save

3. Immunomodulatory response of Cramoll 1,4 lectin on experimental lymphocytes

   C. D. de Melo, M. de Castro, Andresa Pereira de Oliveira, Fabiana Oliveira Santos Gomes +4 more

   2010Phytotherapy Research56 citations

   Semantic Scholar

   Save

4. Lignin isolated from Caesalpinia pulcherrima leaves has antioxidant, antifungal and immunostimulatory activities.

   C. D. de Melo, I. D. da Cruz, G. F. de Sousa, Guilherme Antonio de Souza Silva +6 more

   2020International Journal of Biological Macromolecules48 citations

   Semantic Scholar

   Save

5. COVID-19 pandemic outbreak: the Brazilian reality from the first case to the collapse of health services.

   C. D. de Melo, G. Silva, Alanne R.S. Melo, A. D. de Freitas

   2020Anais da Academia Brasileira de Ciências46 citations Open access

   Semantic Scholar

   Save

6. Anti-inflammatory activity of novel thiosemicarbazone compounds indole-based as COX inhibitors

   I. T. Jacob, F. Gomes, M. D. S. de Miranda, S. M. V. de Almeida +7 more

   2021Pharmacological Reports45 citations

   Semantic Scholar

   Save

7. Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers

   M. R. Barros, T. D. de Oliveira, C. D. de Melo, A. Venuti +1 more

   2018Journal of Immunological Research45 citations Open access

   Semantic Scholar

   Save

8. Healing activity induced by Cramoll 1,4 lectin in healthy and immunocompromised mice.

   C. D. de Melo, C. S. Porto, M. R. Melo-Júnior, C. M. Mendes +5 more

   2011International journal of pharmaceutics45 citations Open access

   Semantic Scholar

   Save

9. Immunostimulatory and antioxidant activities of a lignin isolated from Conocarpus erectus leaves.

   Dayane Kelly Dias Do Nascimento Santos, Bárbara Rafaela da Silva Barros, Lethícia Maria de Souza Aguiar, I. D. da Cruz +3 more

   2020International Journal of Biological Macromolecules42 citations Open access

   Semantic Scholar

   Save

10. Evaluation of antitumor activity and toxicity of Schinus terebinthifolia leaf extract and lectin (SteLL) in sarcoma 180-bearing mice.

    Dalila de Brito Marques Ramos, Maria Taís de Moura Fontes Araújo, Tarcísio Cícero de Lima Araújo, Osmar Galvão Dos Santos +9 more

    2019Journal of Ethnopharmacology41 citations Open access

    Semantic Scholar

    Save

11. 2-Acetylpyridine- and 2-benzoylpyridine-derived thiosemicarbazones and their antimony(III) complexes exhibit high anti-trypanosomal activity

    G. L. Parrilha, Roberta P. Dias, W. Rocha, I. C. Mendes +8 more

    201239 citations

    Semantic Scholar

    Save

12. Mitogenic Response and Cytokine Production Induced by Cramoll 1,4 Lectin in Splenocytes of Inoculated Mice

    C. D. de Melo, H. Melo, Maria Tereza dos Santos Correia, L. M. C. Coelho +2 more

    2011Scandinavian Journal of Immunology39 citations Open access

    Semantic Scholar

    Save

13. Lignins isolated from Prickly pear cladodes of the species Opuntia fícus-indica (Linnaeus) Miller and Opuntia cochenillifera (Linnaeus) Miller induces mice splenocytes activation, proliferation and cytokines production.

    I. D. da Cruz, Bárbara Rafaela da Silva Barros, Lethícia Maria de Souza Aguiar, Claudia D. C. Navarro +6 more

    2019International Journal of Biological Macromolecules38 citations

    Semantic Scholar

    Save

14. Characterization of a lignin from Crataeva tapia leaves and potential applications in medicinal and cosmetic formulations.

    Marcela Daniela Muniz Arruda, Leôncio Alves Simone da Paz, I. D. da Cruz, G. F. de Sousa +6 more

    2021International Journal of Biological Macromolecules37 citations

    Semantic Scholar

    Save

15. Evaluation of Antioxidant, Immunomodulatory, and Cytotoxic Action of Fractions from Eugenia uniflora L. and Eugenia malaccensis L.: Correlation with Polyphenol and Flavanoid Content

    Evellyne de Oliveira Figueirôa, Luís Cláudio Nascimento da Silva, C. D. de Melo, J. K. A. L. Neves +3 more

    2013TheScientificWorldJournal37 citations Open access

    Semantic Scholar

    Save

16. Synthesis, in vitro and in vivo biological evaluation, COX-1/2 inhibition and molecular docking study of indole-N-acylhydrazone derivatives.

    Ana Daura Travassos de Oliveira Moraes, M. D. S. de Miranda, I. T. Jacob, Cézar Augusto da Cruz Amorim +10 more

    2018Bioorganic & Medicinal Chemistry34 citations Open access

    Semantic Scholar

    Save

17. Cramoll 1,4 lectin increases ROS production, calcium levels, and cytokine expression in treated spleen cells of rats

    C. D. de Melo, B. A. Paim, K. G. Zecchin, Joseani Morari +4 more

    2010Molecular and Cellular Biochemistry32 citations

    Semantic Scholar

    Save

18. Immunomodulatory Effects of the Water-soluble Lectin from Moringa oleifera Seeds (WSMoL) on Human Peripheral Blood Mononuclear Cells (PBMC).

    M. C. Coriolano, Jéssica de Santana Brito, L. L. de Siqueira Patriota, A. K. de Araújo Soares +5 more

    2018Protein Peptide Letters31 citations

    Semantic Scholar

    Save

19. Evaluation of cytotoxic, immunomodulatory and antibacterial activities of aqueous extract from leaves of Conocarpus erectus Linnaeus (Combretaceae)

    Dayane Kelly Dias do Nascimento Santos, Vanessa Silva de Almeida, Daniel Rodrigo Cavalcante de Araújo, W. Harand +11 more

    2018The Journal of pharmacy and pharmacology30 citations

    Semantic Scholar

    Save

20. Antischistosomal action of thioxo-imidazolidine compounds: an ultrastructural and cytotoxicity study.

    J. K. A. L. Neves, M. C. De Lima, V. Pereira, C. D. de Melo +4 more

    2011Experimental parasitology30 citations Open access

    Semantic Scholar

    Save

21. Microgramma vacciniifolia (Polypodiaceae) fronds contain a multifunctional lectin with immunomodulatory properties on human cells.

    L. L. de Siqueira Patriota, T. F. Procópio, Jéssica de Santana Brito, Virginie Sebag +11 more

    2017International Journal of Biological Macromolecules29 citations Open access

    Semantic Scholar

    Save

22. Biological and immunological activity of new imidazolidines against adult worms of Schistosoma mansoni

    Juliana Kelle de Andrade Lemoine Neves, S. Botelho, C. D. de Melo, V. Pereira +4 more

    2010Parasitology Research28 citations

    Semantic Scholar

    Save

23. Antiproliferative effect of Canavalia brasiliensis lectin on B16F10 cells.

    Flávio de Oliveira Silva, Priscila das Neves Santos, Evellyne de Oliveira Figueirôa, C. D. de Melo +8 more

    2014Research in Veterinary Science26 citations

    Semantic Scholar

    Save

24. Immunostimulatory activity of ConBr: a focus on splenocyte proliferation and proliferative cytokine secretion

    Flávio de Oliveira Silva, Priscila das Neves Santos, C. D. de Melo, E. Teixeira +6 more

    2011Cell and Tissue Research26 citations

    Semantic Scholar

    Save

25. Third-Generation Vaccines: Features of Nucleic Acid Vaccines and Strategies to Improve Their Efficiency

    Alanne Rayssa da Silva Melo, Larissa Silva de Macêdo, Viana Invenção Maria da Conceição, Ingrid Andrêssa de Moura +5 more

    2022Genes25 citations Open access

    Semantic Scholar

    Save

26. Lectin from inflorescences of ornamental crop Alpinia purpurata acts on immune cells to promote Th1 and Th17 responses, nitric oxide release, and lymphocyte activation.

    Jéssica de Santana Brito, G. R. S. Ferreira, Emeline Klimczak, Liliya Gryshuk +11 more

    2017Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie25 citations

    Semantic Scholar

    Save

27. Schinus terebinthifolia leaf lectin (SteLL) is an immunomodulatory agent by altering cytokine release by mice splenocytes

    Ardilles Juan Carlos Alves dos Santos, Bárbara Rafaela da Silva Barros, Lethícia Maria de Souza Aguiar, L. L. de Siqueira Patriota +6 more

    20203 Biotech24 citations Open access

    Semantic Scholar

    Save

28. Phytochemical analysis, nutritional profile and immunostimulatory activity of aqueous extract from Malpighia emarginata DC leaves

    Bárbara Rafaela da Silva Barros, Dayane Kelly Dias Do Nascimento, Daniel Rodrigo Cavalcante de Araújo, Fabiane Rabelo da Costa Batista +4 more

    202023 citations

    Semantic Scholar

    Save

29. Potential effects of Cramoll 1,4 lectin on murine Schistosomiasis mansoni.

    C. D. de Melo, A. L. R. de Lima, E. Beltrão, Carmelita C. Bezerra Cavalcanti +5 more

    2011Acta Tropica23 citations

    Semantic Scholar

    Save

30. Pectin-like polysaccharide extracted from the leaves of Conocarpus erectus Linnaeus promotes antioxidant, immunomodulatory and prebiotic effects

    Dayane Kelly Dias do Nascimento Santos, Bárbara Rafaela da Silva Barros, I. D. da Cruz, Natanael da Silva Bezerra +5 more

    202122 citations

    Semantic Scholar

    Save

31. Cytokine production induced by marine algae lectins in BALB/c mice splenocytes.

    Ticiana Monteiro Abreu, Luana Maria Castelo Melo Silva, Edfranck Sousa Oliveira Vanderlei, C. D. de Melo +2 more

    2012Protein Peptide Letters22 citations

    Semantic Scholar

    Save

32. Parkia pendula Seed Lectin: Potential Use to Treat Cutaneous Wounds in Healthy and Immunocompromised Mice

    M. C. Coriolano, C. D. de Melo, Flávio de Oliveira Silva, Giulia Schirato +6 more

    2014Applied Biochemistry and Biotechnology21 citations

    Semantic Scholar

    Save

33. Conocarpus erectus L., a plant with a high content of structural sugars, ions and phenolic compounds, shows antioxidant and antimicrobial properties promoted by different organic fractions

    Dayane Kelly Dias Do Nascimento Santos, Weslley de Oliveira Melo, Anastássia Mariáh Nunes de Oliveira Lima, I. D. da Cruz +7 more

    201820 citations Open access

    Semantic Scholar

    Save

34. Purification and Characterization of a Mannose Recognition Lectin from Oreochromis niloticus (Tilapia Fish): Cytokine Production in Mice Splenocytes

    Cynarha Daysy Cardoso da Silva, M. C. Coriolano, Mércia Andréa da Silva Lino, C. D. de Melo +5 more

    2011Applied Biochemistry and Biotechnology20 citations

    Semantic Scholar

    Save

35. Design and Immune Profile of Multi-Epitope Synthetic Antigen Vaccine Against SARS-CoV-2: An In Silico and In Vivo Approach

    Viana Invenção Maria da Conceição, Larissa Silva de Macêdo, Ingrid Andrêssa de Moura, Lucas Alexandre Barbosa de Oliveira Santos +16 more

    2025Vaccines18 citations

    Semantic Scholar

    Save

36. Evaluation of the In Vivo Acute Toxicity and In Vitro Hemolytic and Immunomodulatory Activities of the Moringa oleifera Flower Trypsin Inhibitor (MoFTI).

    L. L. de Siqueira Patriota, Dayane Kelly Dias Do Nascimento Santos, Bárbara Rafaela da Silva Barros, Lethícia Maria de Souza Aguiar +9 more

    2020Protein Peptide Letters11 citations

    Semantic Scholar

    Save

37. Phytochemical bioprospecting, antioxidant, antimicrobial and cytotoxicity activities of saline extract from Tithonia diversifolia (Hemsl) A. Gray leaves

    B. Barboza, Bárbara Rafaela da Silva Barros, B. Ramos, M. D. de Moura +11 more

    201811 citations Open access

    Semantic Scholar

    Save

38. Calliandra surinamensis lectin (CasuL) does not impair the functionality of mice splenocytes, promoting cell signaling and cytokine production.

    T. F. Procópio, L. L. de Siqueira Patriota, Bárbara Rafaela da Silva Barros, Lethícia Maria de Souza Aguiar +4 more

    2018Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie11 citations

    Semantic Scholar

    Save

39. Biocompatibility and immunostimulatory properties of fish collagen and shrimp chitosan towards peripheral blood mononuclear cells (PBMCs).

    Lidiane Cristina Pinho Nascimento Portela, T. Cahú, Thaís M. S. Bezerra, Dayane Kelly Dias Do Nascimento Santos +4 more

    2022International Journal of Biological Macromolecules10 citations

    Semantic Scholar

    Save

40. Complex decongestant therapy with use of alternative material to reduce and control lymphedema in patients with endemic area of filariasis: a clinical trial

    Helen Pereira dos Santos Soares, A. Rocha, A. Aguiar-Santos, Benícia da Silva Santos +2 more

    201610 citations Open access

    Semantic Scholar

    Save

41. Saline extract from Malpighia emarginata DC leaves showed higher polyphenol presence, antioxidant and antifungal activity and promoted cell proliferation in mice splenocytes.

    B. R. S. Barros, B. Barboza, B. Ramos, M. C. de Moura +8 more

    2019Anais da Academia Brasileira de Ciências9 citations Open access

    Semantic Scholar

    Save

42. Rachycentron canadum (cobia) Lectin Promoted Mitogenic Response in Mice BALB/c Splenocytes

    Marília Cavalcanti Coriolano, C. D. de Melo, A. J. G. Santos, V. Pereira +1 more

    2012Scandinavian Journal of Immunology9 citations

    Semantic Scholar

    Save

43. Evaluation of Cytotoxicity and Acute Oral Toxicity of Saline Extract and Protein-Rich Fraction from Moringa oleifera Lam. Leaves

    R. R. de Vasconcelos Alves, A. M. de Oliveira, Gabryella Borges Dos Prazeres, A. R. da Silva +12 more

    2024Pharmaceuticals7 citations Open access

    Semantic Scholar

    Save

44. Pectin-like Polysaccharide Extracted from the Leaves Caesalpinia pulcherrima is a Promising Antioxidant and Immunomodulator Agent

    C. D. de Melo, G. F. de Sousa, Guilherme Antonio de Souza Silva, Ricardo Sérgio da Silva +4 more

    2022Brazilian Archives of Biology and Technology7 citations Open access

    Semantic Scholar

    Save

45. New imidazolidine derivatives as anti-Trypanosoma cruzi agents: structure–activity relationships

    Fabiana Oliveira dos Santos Gomes, C. D. de Melo, C. Peixoto, M. C. De Lima +3 more

    2012Parasitology Research7 citations

    Semantic Scholar

    Save

46. Immunological Response against Breast Lineage Cells Transfected with Human Papillomavirus (HPV)

    D. L. Santos, Bianca de França São Marcos, G. F. de Sousa, Leonardo Carvalho de Oliveira Cruz +7 more

    2024Viruses6 citations Open access

    Semantic Scholar

    Save

47. Whole Yeast Vaccine Displaying ZIKV B and T Cell Epitopes Induces Cellular Immune Responses in the Murine Model

    A. J. D. Silva, A. D. de Jesus, L. R. S. Leal, Larissa Silva de Macêdo +6 more

    2023Pharmaceutics6 citations Open access

    Semantic Scholar

    Save

48. Development of synthetic antigen vaccines for COVID-19

    Viana Invenção Maria da Conceição, Alanne Rayssa da Silva Melo, Larissa Silva de Macêdo, Thaís Souto Paula da Costa Neves +4 more

    2021Human Vaccines & Immunotherapeutics6 citations Open access

    Semantic Scholar

    Save

49. Antifungical and immunomodulatory activities from Caesalpinia pulcherrima extracts

    Ricardo Sérgio da Silva, Dayane Kelly Dias do Nascimento Santos, G. F. de Sousa, Marcela de Araújo Sobral +10 more

    2021Scientific Electronic Archives5 citations Open access

    Semantic Scholar

    Save

50. Evaluation of the immunomodulatory effect against splenocytes of Balb/c mice of biflorin obtained from Capraria biflora by a new isolation method

    M. S. de Lima Silva, J. de A. Santos, A. Alves, Rosali M. F. da Silva +5 more

    2019Revista Brasileira de Farmacognosia5 citations Open access

    Semantic Scholar

    Save