Researcher profile · Semantic Scholar

Yakov Kipnis

h-index: 16
Works: 27
Citations: 1,513

Most-cited papers

De novo design of luciferases using deep learning
Andy Hsien-Wei Yeh, Christoffer H Norn, Yakov Kipnis, D. Tischer +14 more
2023Nature405 citations Open access
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Improving Protein Expression, Stability, and Function with ProteinMPNN
K. Sumida, Reyes Núñez‐Franco, Indrek Kalvet, S. Pellock +12 more
2023bioRxiv301 citations Open access
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Redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis
S. Khare, Yakov Kipnis, P. Greisen, R. Takeuchi +10 more
2012Nature Chemical Biology207 citations Open access
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Computational design of serine hydrolases
Anna Lauko, S. Pellock, Ivan Anischenko, K. Sumida +17 more
2025Science168 citations Open access
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Atom-level enzyme active site scaffolding using RFdiffusion2
Woody Ahern, Jason Yim, D. Tischer, Saman Salike +11 more
2025bioRxiv153 citations Open access
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Modeling protein–small molecule conformational ensembles with PLACER
I. Anishchenko, Yakov Kipnis, Indrek Kalvet, Guangfeng Zhou +8 more
2024bioRxiv33 citations Open access
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Exploration of Alternate Catalytic Mechanisms and Optimization Strategies for Retroaldolase Design
S. Bjelic, Yakov Kipnis, Ling Wang, Z. Pianowski +9 more
2013Journal of Molecular Biology32 citations Open access
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De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8
A. Roy, Lei Shi, Ashley Chang, Xianchi Dong +36 more
2023Nature Communications28 citations Open access
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Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts
Yu Liu, Y. Tan, Xin Zhang, G. Bhabha +7 more
2014Proceedings of the National Academy of Sciences of the United States of America27 citations Open access
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A computational method for design of connected catalytic networks in proteins
Brian D. Weitzner, Yakov Kipnis, A. G. Daniel, D. Hilvert +1 more
2019Protein Science26 citations Open access
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Concerted ATP-induced allosteric transitions in GroEL facilitate release of protein substrate domains in an all-or-none manner
Yakov Kipnis, N. Papo, G. Haran, A. Horovitz
2007Proceedings of the National Academy of Sciences of the United States of America25 citations Open access
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De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8
A. Roy, Lei Shi, Ashley Chang, Xian-Chi Dong +36 more
2023bioRxiv23 citations Open access
Semantic Scholar
TRINS: a method for gene modification by randomized tandem repeat insertions.
Yakov Kipnis, Eynat Dellus-Gur, Dan S. Tawfik
2012Protein engineering, design & selection : PEDS22 citations Open access
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Design and optimization of enzymatic activity in a de novo β‐barrel scaffold
Yakov Kipnis, A. Chaib, A. Vorobieva, Guang-Qing Cai +6 more
2022Protein Science19 citations Open access
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De Novo-Designed Enzymes as Small-Molecule-Regulated Fluorescence Imaging Tags and Fluorescent Reporters
Yu Liu, Xin Zhang, Y. Tan, G. Bhabha +5 more
2014Journal of the American Chemical Society18 citations Open access
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Concerted release of substrate domains from GroEL by ATP is demonstrated with FRET.
N. Papo, Yakov Kipnis, G. Haran, A. Horovitz
2008Journal of Molecular Biology17 citations Open access
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Comparison of designed and randomly generated catalysts for simple chemical reactions
Yakov Kipnis, D. Baker
2012Protein Science15 citations Open access
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Design of an optical switch for studying conformational dynamics in individual molecules of GroEL.
G. A. Frank, Yakov Kipnis, E. Smolensky, S. Daube +2 more
2008Bioconjugate chemistry12 citations Open access
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De novo Design of a Highly Specific Inhibitor of Integrin Αvβ6 for Pulmonary Fibrosis
A. Roy, Lei Shi, Ashley Chang, Xian-Chi Dong +25 more
20210 citations Open access
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Designing de novo retroaldolase catalysts
Yakov Kipnis, D. Baker
20190 citations
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Solution NMR Structure of De novo designed protein, Northeast Structural Genomics Consortium (NESG) Target OR459
Surya V. S. R. K. Pulavarti, Yakov Kipnis, D. Sukumaran, Melissa Maglaqui +7 more
20140 citations
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Crystal Structure of Engineered Protein, Northeast Structural Genomics Consortium Target OR422
S. Vorobiev, M. Su, S. Bjelic, Yakov Kipnis +11 more
20130 citations
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Crystal Structure of Engineered Protein, Northeast Structural Genomics Consortium Target OR404
S. Vorobiev, M. Su, S. Bjelic, Yakov Kipnis +11 more
20130 citations
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Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR63.
S. Vorobiev, M. Su, S. Bjelic, Yakov Kipnis +11 more
20110 citations
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Determination of Forces during Blanking and Piercing
Yakov Kipnis, E. Shrayer
19710 citations
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ENZYME DESIGN Computational design of serine hydrolases
Anna Lauko, S. Pellock, K. Sumida, I. Anishchenko +17 more
0 citations
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state-Computational design of serine hydrolases
Anna Lauko, S. Pellock, K. Sumida, I. Anishchenko +17 more
0 citations
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S. Bjelic

×6

David Baker×5

Rohith Krishna×5

D. Baker×5

Christoffer H Norn×4

L. Carter×4

K. Sumida×4

Anna Lauko×4