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R. Laprairie · SciRah

Researcher profile · Semantic Scholar

R. Laprairie

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R. Laprairie — researcher profile on SciRah

h-index: 27
Works: 104
Citations: 4,117

Most-cited papers

Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor
R. Laprairie, A. Bagher, M. Kelly, E. Denovan-Wright
2015British Journal of Pharmacology963 citations Open access
Semantic Scholar
Crystal Structure of the Human Cannabinoid Receptor CB1
T. Hua, K. Vemuri, M. Pu, L. Qu +19 more
2016Cell511 citations Open access
Semantic Scholar
Crystal structures of agonist-bound human cannabinoid receptor CB1
T. Hua, K. Vemuri, S. Nikas, R. Laprairie +16 more
2017Nature430 citations Open access
Semantic Scholar
Allosteric and orthosteric pharmacology of cannabidiol and cannabidiol‐dimethylheptyl at the type 1 and type 2 cannabinoid receptors
Mylyne Tham, O. Yılmaz, M. Alaverdashvili, M. Kelly +2 more
2018British Journal of Pharmacology282 citations Open access
Semantic Scholar
In vitro and in vivo pharmacological activity of minor cannabinoids isolated from Cannabis sativa
A. Zagzoog, Kawthar A. Mohamed, H. J. J. Kim, Eunhyun D. Kim +5 more
2020Scientific Reports142 citations Open access
Semantic Scholar
The Genomics of Cannabis and Its Close Relatives.
I. Kovalchuk, M. Pellino, P. Rigault, R. van Velzen +12 more
2020Annual Review of Plant Biology141 citations Open access
Semantic Scholar
Type 1 Cannabinoid Receptor Ligands Display Functional Selectivity in a Cell Culture Model of Striatal Medium Spiny Projection Neurons*
R. Laprairie, A. Bagher, M. Kelly, Denis J. Dupré +1 more
2014Journal of Biological Chemistry130 citations Open access
Semantic Scholar
Enantio-specific Allosteric Modulation of Cannabinoid 1 Receptor
R. Laprairie, P. Kulkarni, J. Deschamps, M. Kelly +7 more
2017ACS Chemical Neuroscience99 citations Open access
Semantic Scholar
Biased Type 1 Cannabinoid Receptor Signaling Influences Neuronal Viability in a Cell Culture Model of Huntington Disease
R. Laprairie, A. Bagher, M. Kelly, E. Denovan-Wright
2016Molecular Pharmacology93 citations
Semantic Scholar
Anti‐inflammatory effects of cannabinoid CB2 receptor activation in endotoxin‐induced uveitis
J. Toguri, C. Lehmann, R. Laprairie, A. Szcześniak +3 more
2014British Journal of Pharmacology83 citations Open access
Semantic Scholar
Cannabinoid receptor ligand bias: implications in the central nervous system
R. Laprairie, A. Bagher, E. Denovan-Wright
2017Current opinion in pharmacology (Print)68 citations
Semantic Scholar
Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)
P. Kulkarni, Abhijit R. Kulkarni, A. Korde, R. Tichkule +9 more
2015Journal of Medicinal Chemistry58 citations Open access
Semantic Scholar
Application of Fluorine- and Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of CB1 Receptor Positive Allosteric Modulators
Sumanta Garai, P. Kulkarni, Peter C. Schaffer, Luciana M. Leo +18 more
2019Journal of Medicinal Chemistry55 citations Open access
Semantic Scholar
Positive allosteric modulation of the type 1 cannabinoid receptor reduces the signs and symptoms of Huntington’s disease in the R6/2 mouse model
R. Laprairie, A. Bagher, J. L. Rourke, A. Zrein +6 more
2019Neuropharmacology49 citations Open access
Semantic Scholar
Cannabinoids increase type 1 cannabinoid receptor expression in a cell culture model of striatal neurons: implications for Huntington's disease.
R. Laprairie, M. Kelly, E. Denovan-Wright
2013Neuropharmacology44 citations
Semantic Scholar
Bidirectional allosteric interactions between cannabinoid receptor 1 (CB1) and dopamine receptor 2 long (D2L) heterotetramers
A. Bagher, R. Laprairie, Thomas J. Toguri, M. Kelly +1 more
2017European Journal of Pharmacology38 citations
Semantic Scholar
Antagonism of Dopamine Receptor 2 Long Affects Cannabinoid Receptor 1 Signaling in a Cell Culture Model of Striatal Medium Spiny Projection Neurons
A. Bagher, R. Laprairie, M. Kelly, E. Denovan-Wright
2016Molecular Pharmacology37 citations Open access
Semantic Scholar
Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe
R. Laprairie, Abhijit R. Kulkarni, P. Kulkarni, Dow P. Hurst +8 more
2016ACS Chemical Neuroscience37 citations Open access
Semantic Scholar
Assessment of select synthetic cannabinoid receptor agonist bias and selectivity between the type 1 and type 2 cannabinoid receptor
A. Zagzoog, Asher L. Brandt, T. Black, Eunhyun D. Kim +5 more
2021Scientific Reports34 citations Open access
Semantic Scholar
Co-expression of the human cannabinoid receptor coding region splice variants (hCB₁) affects the function of hCB₁ receptor complexes.
A. Bagher, R. Laprairie, M. Kelly, E. Denovan-Wright
2013European Journal of Pharmacology34 citations
Semantic Scholar
Dissociable changes in spike and wave discharges following exposure to injected cannabinoids and smoked cannabis in Genetic Absence Epilepsy Rats from Strasbourg
Andrew J. Roebuck, Quentin Greba, T. J. Onofrychuk, D. McElroy +7 more
2020European Journal of Neuroscience33 citations
Semantic Scholar
Design, Synthesis, and Biological Activity of New CB2 Receptor Ligands: from Orthosteric and Allosteric Modulators to Dualsteric/Bitopic Ligands
F. Gado, Rebecca Ferrisi, Beatrice Polini, Kawthar A. Mohamed +15 more
2022Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Discovery of a Biased Allosteric Modulator for Cannabinoid 1 Receptor: Preclinical Anti-Glaucoma Efficacy.
Sumanta Garai, Luciana M. Leo, A. Szcześniak, Dow P. Hurst +14 more
2021Journal of Medicinal Chemistry30 citations
Semantic Scholar
The future of type 1 cannabinoid receptor allosteric ligands
M. Alaverdashvili, R. Laprairie
2018Drug metabolism reviews (Softcover ed.)30 citations
Semantic Scholar
Characterization of cannabinoid plasma concentration, maternal health, and cytokine levels in a rat model of prenatal Cannabis smoke exposure
T. Black, S. L. Baccetto, I. Barnard, Emma Finch +7 more
2023bioRxiv28 citations Open access
Semantic Scholar
Positive allosteric modulation of type 1 cannabinoid receptors reduces spike-and-wave discharges in Genetic Absence Epilepsy Rats from Strasbourg.
Andrew J. Roebuck, Quentin Greba, Anna-Maria Smolyakova, M. Alaverdashvili +10 more
2021Neuropharmacology28 citations
Semantic Scholar
Cannabidiol is a negative allosteric modulator of the type 1 cannabinoid receptor.
R. Laprairie, A. Bagher, M. Kelly, E. Denovan-Wright
201527 citations
Semantic Scholar
Subfunctionalization of peroxisome proliferator response elements accounts for retention of duplicated fabp1 genes in zebrafish
R. Laprairie, E. Denovan-Wright, Jonathan M. Wright
2016BMC Evolutionary Biology26 citations Open access
Semantic Scholar
Serotonin 2A Receptor (5-HT2AR) Activation by 25H-NBOMe Positional Isomers: In Vitro Functional Evaluation and Molecular Docking.
Eline Pottie, O. Kupriyanova, Asher L. Brandt, R. Laprairie +2 more
2021ACS Pharmacology & Translational Science22 citations Open access
Semantic Scholar
Impact of the mouse estrus cycle on cannabinoid receptor agonist‐induced molecular and behavioral outcomes
H. J. J. Kim, A. Zagzoog, T. Black, S. L. Baccetto +2 more
2022Pharmacology Research & Perspectives21 citations Open access
Semantic Scholar
Variously substituted 2-oxopyridine derivatives: Extending the structure-activity relationships for allosteric modulation of the cannabinoid CB2 receptor.
F. Gado, Kawthar A. Mohamed, Serena Meini, Rebecca Ferrisi +7 more
2020European journal of medicinal chemistry21 citations Open access
Semantic Scholar
Huntington’s disease pattern of transcriptional dysregulation in the absence of mutant huntingtin is produced by knockout of neuronal GLT-1
R. Laprairie, Geraldine T. Petr, Yan Sun, Kathryn D. Fischer +2 more
2018Neurochemistry International20 citations Open access
Semantic Scholar
Inflammation and CB2 signaling drive novel changes in the ocular lipidome and regulate immune cell activity in the eye.
James T. Toguri, E. Leishman, A. Szcześniak, R. Laprairie +4 more
2018Prostaglandins & other lipid mediators19 citations
Semantic Scholar
Repeated Exposure to High-THC Cannabis Smoke during Gestation Alters Sex Ratio, Behavior, and Amygdala Gene Expression of Sprague Dawley Rat Offspring
T. Sandini, T. J. Onofrychuk, Andrew J. Roebuck, S. A. Hammond +8 more
2023eNeuro18 citations Open access
Semantic Scholar
The cytokine and endocannabinoid systems are co-regulated by NF-κB p65/RelA in cell culture and transgenic mouse models of Huntington's disease and in striatal tissue from Huntington's disease patients.
R. Laprairie, J. Warford, S. Hutchings, G. Robertson +2 more
2014Journal of Neuroimmunology17 citations
Semantic Scholar
The effect of quinine in two bottle choice procedures in C57BL6 mice: opioid preference, somatic withdrawal, and pharmacokinetic outcomes. *
Travis W. Grim, Scarlet J. Park, Cullen L. Schmid, R. Laprairie +2 more
2018Drug and Alcohol Dependence16 citations Open access
Semantic Scholar
Differential regulation of the duplicated fabp7, fabp10 and fabp11 genes of zebrafish by peroxisome proliferator activated receptors.
R. Laprairie, E. Denovan-Wright, Jonathan M. Wright
2017Comparative Biochemistry and Physiology Part B Comparative Biochemistry16 citations
Semantic Scholar
Therapeutic Potential of Gamma Entrainment Using Sensory Stimulation for Cognitive Symptoms Associated with Schizophrenia.
T. Black, B. W. Jenkins, R. Laprairie, J. G. Howland
2024Neuroscience and Biobehavioral Reviews15 citations Open access
Semantic Scholar
Cannabinoid receptors distribution in mouse cortical plasma membrane compartments
Hajar Miranzadeh Mahabadi, H. Bhatti, R. Laprairie, C. Taghibiglou
2021Molecular Brain15 citations Open access
Semantic Scholar
Modulation of type 1 cannabinoid receptor activity by cannabinoid by-products from Cannabis sativa and non-cannabis phytomolecules
A. Zagzoog, Ashley Cabecinha, Hanan Abramovici, R. Laprairie
2022Frontiers in Pharmacology14 citations Open access
Semantic Scholar
Design, synthesis and biological evaluation of novel orthosteric-allosteric ligands of the cannabinoid receptor type 2 (CB2R)
Rebecca Ferrisi, F. Gado, Beatrice Polini, Caterina Ricardi +9 more
2022Frontiers in Chemistry13 citations Open access
Semantic Scholar
Heteromer formation between cannabinoid type 1 and dopamine type 2 receptors is altered by combination cannabinoid and antipsychotic treatments
A. Bagher, A. P. Young, R. Laprairie, J. Toguri +2 more
2020Journal of Neuroscience Research13 citations
Semantic Scholar
Differential effects of gestational Cannabis smoke and phytocannabinoid injections on male and female rat offspring behavior.
T. Black, I. Barnard, S. L. Baccetto, Quentin Greba +12 more
2025Progress in Neuro-psychopharmacology and Biological Psychiatry12 citations Open access
Semantic Scholar
Determination of the Negative Allosteric Binding Site of Cannabidiol at the CB1 Receptor: A Combined Computational and Site-Directed Mutagenesis Study.
Pankaj Pandey, A. Zagzoog, R. Laprairie, William M. Neal +2 more
2025ACS Chemical Neuroscience12 citations
Semantic Scholar
Estradiol-dependent hypocretinergic/orexinergic behaviors throughout the estrous cycle
H. J. J. Kim, Samuel A. Dickie, R. Laprairie
2022Psychopharmacology12 citations Open access
Semantic Scholar
The Endocannabinoid System and Synthetic Cannabinoids in Preclinical Models of Seizure and Epilepsy.
Anna-Maria Smolyakova, A. Zagzoog, Asher L. Brandt, T. Black +2 more
2020Journal of clinical neurophysiology12 citations
Semantic Scholar
Indomethacin Enhances Type 1 Cannabinoid Receptor Signaling
R. Laprairie, Kawthar A. Mohamed, A. Zagzoog, M. Kelly +4 more
2019Frontiers in Molecular Neuroscience12 citations Open access
Semantic Scholar
Antipsychotic potential of the type 1 cannabinoid receptor positive allosteric modulator GAT211: preclinical in vitro and in vivo studies
D. McElroy, Andrew J. Roebuck, Gavin A. Scott, Quentin Greba +5 more
2021Psychopharmacology11 citations
Semantic Scholar
In vivo Evidence for Brain Region-Specific Molecular Interactions Between Cannabinoid and Orexin Receptors
H. J. J. Kim, A. Zagzoog, Anna-Maria Smolyakova, Udoka C. Ezeaka +3 more
2021Frontiers in Neuroscience11 citations Open access
Semantic Scholar
Effects of the cannabinoid receptor 1 positive allosteric modulator GAT211 and acute MK-801 on visual attention and impulsivity in rats assessed using the five-choice serial reaction time task.
T. J. Onofrychuk, Shuang Cai, D. McElroy, Andrew J. Roebuck +5 more
2020Progress in Neuro-psychopharmacology and Biological Psychiatry11 citations
Semantic Scholar

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E. Denovan-Wright — researcher profile on SciRah
M. Kelly×18
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A. Zagzoog×12
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A. Bagher×10
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Kawthar A. Mohamed×6

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