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G. Paramel · SciRah

Researcher profile · Semantic Scholar

G. Paramel

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G. Paramel — researcher profile on SciRah

h-index: 7
Works: 21
Citations: 578

Most-cited papers

Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells
M. M. Zegeye, Madelene Lindkvist, Knut Fälker, A. Kumawat +4 more
2018Cell Communication and Signaling342 citations Open access
Semantic Scholar
Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance
Kenneth D'Souza, G. Paramel, P. Kienesberger
2018Nutrients70 citations Open access
Semantic Scholar
Role of Genetic Alterations in the NLRP3 and CARD8 Genes in Health and Disease
G. Paramel, A. Sirsjö, Karin Fransén
2015Mediators of Inflammation69 citations Open access
Semantic Scholar
CARD8 gene encoding a protein of innate immunity is expressed in human atherosclerosis and associated with markers of inflammation.
G. Paramel, L. Folkersen, R. Strawbridge, A. Elmabsout +6 more
2013Clinical science33 citations
Semantic Scholar
Vascular smooth muscle cells in response to cholesterol crystals modulates inflammatory cytokines release and promotes neutrophil extracellular trap formation
J. Thazhathveettil, A. Kumawat, I. Demirel, A. Sirsjö +1 more
2024Molecular Medicine19 citations Open access
Semantic Scholar
Expression of CARD8 in human atherosclerosis and its regulation of inflammatory proteins in human endothelial cells
G. Paramel, G. Karadimou, A. G. Eremo, L. Ljungberg +6 more
2020Scientific Reports12 citations Open access
Semantic Scholar
IL1RAP Expression in Human Atherosclerosis: A Target of Novel Antibodies to Reduce Vascular Inflammation and Adhesion
Madelene Lindkvist, Anna Göthlin Eremo, G. Paramel, Sheikh Anisul Haque +6 more
2025Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease7 citations Open access
Semantic Scholar
Novel purine analogues regulate IL-1β release via inhibition of JAK activity in human aortic smooth muscle cells.
G. Paramel, Madelene Lindkvist, B. A. Idosa, Laila Sharon Sebina +9 more
2022European Journal of Pharmacology7 citations Open access
Semantic Scholar
Atherosclerotic Plaque Crystals Induce Endothelial Dysfunction
J. Thazhathveettil, S. A. Gómez, Deborah Olaoseeji, Rong-Rong Wu +2 more
2025International Journal of Molecular Sciences4 citations
Semantic Scholar
Inhibition of IL17A Using an Affibody Molecule Attenuates Inflammation in ApoE-Deficient Mice
A. Kumawat, M. M. Zegeye, G. Paramel, R. Baumgartner +12 more
2022Frontiers in Cardiovascular Medicine4 citations Open access
Semantic Scholar
Human Renal Fibroblasts, but Not Renal Epithelial Cells, Induce IL-1β Release during a Uropathogenic Escherichia coli Infection In Vitro
A. Kumawat, G. Paramel, Kartheyaene Jayaprakash Demirel, I. Demirel
2021Cells3 citations Open access
Semantic Scholar
Design and Synthesis of Novel Purine Analogues as Potential IL‐1β Inhibitors Targeting Vascular Inflammation
D. Pournara, T. Fotopoulou, G. Paramel, Madelene Lindkvist +3 more
2026Chemistry and Biodiversity2 citations Open access
Semantic Scholar
Association between C10X polymorphism in the CARD8 gene and inflammatory markers in young healthy individuals in the LBA study
K. Fransén, Ayako Hiyoshi, G. Paramel, A. Hurtig-Wennlöf
2024BMC Cardiovascular Disorders2 citations Open access
Semantic Scholar
A novel purine analogue bearing nitrate ester prevents platelet activation by ROCK activity inhibition.
Caroline Kardeby, G. Paramel, D. Pournara, T. Fotopoulou +4 more
2019European Journal of Pharmacology2 citations
Semantic Scholar
Cardiac spheroids as a human model for inflammation induced cardiac dysfunction
S. Athlin, Niklas Steger, Jishamol Thazhath-Veettil, C. Gentile +5 more
2026Biofabrication1 citations Open access
Semantic Scholar
Antithrombotic but not anticoagulant activity of the thrombin‐binding RNA aptamer Apta‐1
L. Jedlina, G. Paramel, S. Soboleva, Oldriska Chutna Olin +6 more
2024British Journal of Pharmacology1 citations Open access
Semantic Scholar
PB0773 The RNA Aptamer, APTA-1 Targeting Evolutionarily Conserved Motif on Thrombin Cures Endotoxemia and Reduces Thrombosis in Animal Models by Inhibiting Aggregation and Secretion of Platelets
L. Jedlina, G. Paramel, O. Olin, K. Fransén +2 more
2023Research and Practice in Thrombosis and Haemostasis1 citations Open access
Semantic Scholar
Author Correction: Expression of CARD8 in human atherosclerosis and its regulation of inflammatory proteins in human endothelial cells
G. Paramel, G. Karadimou, A. G. Eremo, L. Ljungberg +6 more
2021Scientific Reports1 citations Open access
Semantic Scholar
Adverse Cardiometabolic Outcomes in Obese Patients Correlates Strongly with Defective Branched-chain Amino Acid Catabolism
Dipsikha Biswas, Andrew Cowie, K. Tozer, Lester J. Pérez +13 more
2018Journal of Molecular and Cellular Cardiology1 citations Open access
Semantic Scholar
IL-6 triggers lysosomal degradation of LDL-R and enhances LDL-C uptake in vascular endothelial cells via macropinocytosis
M. M. Zegeye, Jishamol T. Veettil, G. Paramel, S. Kurt +4 more
2026Molecular Medicine0 citations Open access
Semantic Scholar
Cholesterol crystals uptake in vascular smooth muscle cells modulates local immune responses
J. Thazhathveettil, A. Kumawat, I. Demirel, A. Sirjö +1 more
2023Atherosclerosis0 citations Open access
Semantic Scholar

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