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J. Pickworth · SciRah

Researcher profile · Semantic Scholar

J. Pickworth

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J. Pickworth — researcher profile on SciRah

h-index: 12
Works: 39
Citations: 600

Most-cited papers

MicroRNA-140-5p and SMURF1 regulate pulmonary arterial hypertension.
A. Rothman, N. Arnold, J. Pickworth, J. Iremonger +9 more
2016Journal of Clinical Investigation127 citations Open access
Semantic Scholar
Inhibition of tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) reverses experimental pulmonary hypertension
A. Hameed, N. Arnold, J. Chamberlain, J. Pickworth +11 more
2012Journal of Experimental Medicine97 citations Open access
Semantic Scholar
A diagnostic miRNA signature for pulmonary arterial hypertension using a consensus machine learning approach
N. Errington, J. Iremonger, J. Pickworth, S. Kariotis +12 more
2021EBioMedicine59 citations Open access
Semantic Scholar
Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension
M. Boehm, N. Arnold, Adam T. Braithwaite, J. Pickworth +10 more
2018BMC Pulmonary Medicine59 citations Open access
Semantic Scholar
Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood
S. Kariotis, E. Jammeh, E. Świetlik, J. Pickworth +97 more
2021Nature Communications48 citations Open access
Semantic Scholar
Cardiovascular , Pulmonary , and Renal Pathology Paigen Diet – Fed Apolipoprotein E Knockout Mice Develop Severe Pulmonary Hypertension in an Interleukin-1 – Dependent Manner
A. Lawrie, A. Hameed, J. Chamberlain, N. Arnold +6 more
201143 citations
Semantic Scholar
A therapeutic antibody targeting osteoprotegerin attenuates severe experimental pulmonary arterial hypertension
N. Arnold, J. Pickworth, L. West, Sarah Dawson +23 more
2019Nature Communications29 citations Open access
Semantic Scholar
Differential IL-1 signaling induced by BMPR2 deficiency drives pulmonary vascular remodeling
J. Pickworth, A. Rothman, J. Iremonger, H. Casbolt +8 more
2017Pulmonary Circulation26 citations Open access
Semantic Scholar
Serum osteoprotegerin is increased and predicts survival in idiopathic pulmonary arterial hypertension
R. Condliffe, J. Pickworth, Kay Hopkinson, Sara J. Walker +13 more
2012Pulmonary Circulation25 citations Open access
Semantic Scholar
Paigen diet-fed apolipoprotein E knockout mice develop severe pulmonary hypertension in an interleukin-1-dependent manner.
A. Lawrie, A. Hameed, J. Chamberlain, N. Arnold +6 more
2011American Journal of Pathology24 citations Open access
Semantic Scholar
MicroRNA-1405 p and SMURF 1 regulate pulmonary arterial hypertension
A. Rothman, N. Arnold, J. Pickworth, J. Iremonger +9 more
201819 citations
Semantic Scholar
Repeatability and sensitivity to change of non-invasive end points in PAH: the RESPIRE study
A. Swift, Fred Wilson, Marcella Cogliano, L. Kendall +19 more
2021Thorax12 citations Open access
Semantic Scholar
Selective improvement of pulmonary arterial hypertension with a dual ETA/ETB receptors antagonist in the apolipoprotein E−/− model of PAH and atherosclerosis
Lewis J. Renshall, N. Arnold, L. West, Adam T. Braithwaite +10 more
2017Pulmonary Circulation9 citations Open access
Semantic Scholar
TRAIL Deficient Mice Are Protected from Sugen/Hypoxia Induced Pulmonary Arterial Hypertension
Sarah Dawson, N. Arnold, J. Pickworth, S. Francis +1 more
20147 citations Open access
Semantic Scholar
Soluble P-Selectin and von Willebrand Factor Rise in Healthy Volunteers Following Non-exertional Ascent to High Altitude
H. Turton, J. Pickworth, Gordon G Paterson, A. Lawrie +2 more
2022Frontiers in Physiology4 citations Open access
Semantic Scholar
T5 MicroRNA-140–5p Regulates Disease Phenotype in Experimental Pulmonary Arterial Hypertension via SMURF1
A. Rothman, N. Arnold, J. Pickworth, J. Iremonger +8 more
20154 citations Open access
Semantic Scholar
A prospective study comparing the repeatability and sensitivity to change of non-invasive endpoints in pulmonary arterial hypertension: the RESPIRE study
D. Kiely, A. Swift, Marcella Cogliano, L. Kendall +13 more
2019Pulmonary hypertension2 citations
Semantic Scholar
E microRNA-140-5p and SMURF1 Regulate Pulmonary Arterial Hypertension
A. Rothman, N. Arnold, J. Pickworth, J. Iremonger +9 more
20162 citations Open access
Semantic Scholar
The Anti-Osteoprotegerin (OPG) Antibody Ky3 Attenuates OPG-Fas Mediated Pulmonary Artery Smooth Muscle Cell Proliferation, Migration and Pro-Inflammatory Signalling In Vitro and In Vivo
A. Lawrie, N. Arnold, J. Pickworth, L. West +4 more
20201 citations
Semantic Scholar
P245 Whole blood levels of microrna-34a predict survival and regulate genes associated with pulmonary arterial hypertension
Jian-Hui Lin, James Iremonger, J. Pickworth, A. Rothman +6 more
2016Thorax1 citations Open access
Semantic Scholar
Abstract 11498: MicroRNA 140 Regulates Disease Phenotype in Experimental Pulmonary Arterial Hypertension And Identifies Smurf1 as a Novel Therapeutic Target
A. Rothman, N. Arnold, J. Pickworth, J. Iremonger +8 more
2015Circulation1 citations
Semantic Scholar
T5 Opg Regulates Pulmonary Arterial Smooth Muscle Cell Proliferation And The Expression Of Pah-associated Genes Via Fas
Sarah Dawson, J. Pickworth, A. Rothman, J. Iremonger +3 more
2014Thorax1 citations Open access
Semantic Scholar
T6 TRAIL is a potential novel therapeutic target in pulmonary arterial hypertension
A. Hameed, N. Arnold, J. Pickworth, J. Chamberlain +4 more
2011Thorax1 citations Open access
Semantic Scholar
Vascular smooth muscle cell-derived osteoprotegerin drives pulmonary arterial hypertension via AKT activation and is attenuated by monoclonal antibody therapy.
M. Keleş, Laura West, N. Arnold, Astrid Weiss +11 more
2026Cardiovascular Research0 citations Open access
Semantic Scholar
Osteoprotegerin Has Distinct Roles in Pulmonary Vascular and Cardiac Remodelling in a Mouse Model of Pulmonary Arterial Hypertension
A. Lawrie, A. Zawia, L. West, N. Arnold +4 more
2023A14. THIS IS GETTING COMPLICATED: EPIGENETICS, -OMICS, AND CELL SIGNALING IN PULMONARY HYPERTENSION0 citations
Semantic Scholar
Author Correction: Biological heterogeneity in idiopathic pulmonary arterial hypertension identified through unsupervised transcriptomic profiling of whole blood
S. Kariotis, E. Jammeh, E. Świetlik, J. Pickworth +98 more
2022Nature Communications0 citations Open access
Semantic Scholar
Correction to: Eplerenone attenuates pathological pulmonary vascular rather than right ventricular remodeling in pulmonary arterial hypertension
M. Boehm, N. Arnold, Adam T. Braithwaite, J. Pickworth +10 more
2022BMC Pulmonary Medicine0 citations Open access
Semantic Scholar
S43 Circulatory levels of microrna-34a expression identify patients with poor clinical outcome, and regulate pulmonary vascular cell phenotype
Jian-Hui Lin, James Iremonger, J. Pickworth, A. Rothman +7 more
2018Fundamental mechanisms of pulmonary arterial hypertension0 citations
Semantic Scholar
Links between dysfunctional Bone Morphogenetic Protein signalling and Interleukin-1ß mediated inflammation in pulmonary arterial hypertension
J. Pickworth
20170 citations
Semantic Scholar
Abstract 19805: Development of a Novel Human Anti-OPG Antibody That Attenuates Experimental Pulmonary Arterial Hypertension
N. Arnold, J. Pickworth, J. Carvalho, Adam T. Braithwaite +11 more
20170 citations
Semantic Scholar
S85 Reduction of CD68 macrophages causes gender specific spontaneous pulmonary arterial hypertension in mice
A. Zawia, N. Arnold, Adam T. Braithwaite, J. Pickworth +4 more
2016Thorax0 citations Open access
Semantic Scholar
Abstract 15685: Selective Improvement of Pulmonary Arterial Hypertension With Dual ETA/ETB Receptors Antagonist in the Apolipoprotein E-/- Model of PAH and Atherosclerosis
Lewis J. Renshall, N. Arnold, L. West, Adam T. Braithwaite +10 more
20160 citations
Semantic Scholar
Abstract 16817: Whole Blood Levels of Microrna-34a-5p Predict Survival and Regulate Genes Associated With Pulmonary Arterial Hypertension
Jian-Hui Lin, J. Iremonger, J. Pickworth, A. Rothman +4 more
20160 citations
Semantic Scholar
S3 Reduced BMPR2 expression potentiates a pulmonary artery smooth muscle cell specific IL-1ß response
J. Pickworth, S. Shay, Santhi Gladson, James Iremonger +4 more
20150 citations Open access
Semantic Scholar
Abstract 13921: Dysfunctional Bone Morphogenetic Protein Signaling Interlinks With Interleukin-1ß Mediated Inflammation in Pulmonary Arterial Hypertension
J. Pickworth, S. Shay, S. Gladson, J. Iremonger +4 more
2015Circulation0 citations
Semantic Scholar
183 Novel OPG Protein Interactions Regulate Survival, Proliferation And Pah-associated Gene Expression in Pulmonary Arterial Smooth Muscle Cells
Sarah Dawson, J. Pickworth, A. Rothman, J. Iremonger +2 more
2014Heart0 citations
Semantic Scholar
Tumour necrosis factor-related apoptosis-inducing ligand is a novel therapeutic target in pulmonary arterial hypertension
A. Hameed, N. Arnold, J. Chamberlain, J. Pickworth +11 more
20130 citations
Semantic Scholar
Osteoprotegerin Blockade Prevents And Reverses Experimental Pulmonary Arterial Hypertension
A. Lawrie, A. Hameed, N. Arnold, J. Chamberlain +4 more
2012Asian Test Symposium0 citations
Semantic Scholar
Interplay Between Interleukin-1 And Dysfunctional BMP Signalling May Play A Role In The Pathogenesis Of Pulmonary Arterial Hypertension
J. Pickworth, Kay Hopkinson, S. Francis, E. Kiss-Toth +1 more
2012Asian Test Symposium0 citations
Semantic Scholar

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