Researcher profile · Semantic Scholar

Madhavika N. Serasinghe

h-index: 18
Works: 29
Citations: 1,793

Most-cited papers

Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors
Madhavika N. Serasinghe, Shira Y. Wieder, Thibaud T. Renault, R. Elkholi +7 more
2015Molecules and Cells385 citations Open access
Semantic Scholar
Outer mitochondrial membrane shape engages BAX α9 to initiate mitochondrial outer membrane permeabilization and apoptosis
Thibaud T. Renault, K. Floros, R. Elkholi, Kelly-Ann Corrigan +8 more
2014Molecules and Cells203 citations Open access
Semantic Scholar
Lymphatic endothelial S1P promotes naïve T cell mitochondrial function and survival
A. Mendoza, Victoria Fang, Cynthia Chen, Madhavika N. Serasinghe +8 more
2017Nature161 citations Open access
Semantic Scholar
Mitochondrial Fission in Human Diseases
Madhavika N. Serasinghe, J. Chipuk
2017Handbook of Experimental Pharmacology157 citations Open access
Semantic Scholar
Anti-apoptotic BCL-2 proteins govern cellular outcome following B-RAFV600E inhibition and can be targeted to reduce resistance
Madhavika N. Serasinghe, Derek J. Missert, J. Asciolla, Shira Y. Wieder +5 more
2014Oncogene130 citations Open access
Semantic Scholar
Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3
P. Rimmelé, R. Liang, Carolina L. Bigarella, Fatih Kocabaş +6 more
2015EMBO Reports124 citations Open access
Semantic Scholar
PPARdelta activation induces metabolic and contractile maturation of human pluripotent stem-cell-derived cardiomyocytes
Nadeera M. Wickramasinghe, David Sachs, B. Shewale, David M. Gonzalez +22 more
2022Cell Stem Cell83 citations Open access
Semantic Scholar
MDM2 integrates cellular respiration and apoptotic signaling through NDUFS1 and the mitochondrial network.
R. Elkholi, I. Abraham-Enachescu, A. Trotta, C. Rubio-Patiño +10 more
2019Molecules and Cells74 citations Open access
Semantic Scholar
RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions
Brandon Hogstad, M. Berres, Rikhia Chakraborty, Jun Tang +20 more
2018Journal of Experimental Medicine73 citations Open access
Semantic Scholar
Disruption of mitochondrial electron transport chain function potentiates the pro-apoptotic effects of MAPK inhibition
A. Trotta, Jesse D. Gelles, Madhavika N. Serasinghe, P. Loi +2 more
2017Journal of Biological Chemistry70 citations Open access
Semantic Scholar
Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?
R. Elkholi, Thibaud T. Renault, Madhavika N. Serasinghe, J. Chipuk
2014Cancer & Metabolism62 citations Open access
Semantic Scholar
Activation of the Mitochondrial Fragmentation Protein DRP1 Correlates with BRAFV600E Melanoma
Shira Y. Wieder, Madhavika N. Serasinghe, Julie C. Sung, Daniel C. Choi +5 more
2015Journal of Investigative Dermatology57 citations Open access
Semantic Scholar
Functional expression of frog and rainbow trout melanocortin 2 receptors using heterologous MRAP1s.
Liang Liang, J. Sebag, Lauren Eagelston, Madhavika N. Serasinghe +5 more
2011General and Comparative Endocrinology52 citations
Semantic Scholar
The mitochondrial outer membrane protein hFis1 regulates mitochondrial morphology and fission through self-interaction
Madhavika N. Serasinghe, Y. Yoon
2008Experimental Cell Research48 citations Open access
Semantic Scholar
Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition
Madhavika N. Serasinghe, Jesse D. Gelles, Kent Li, Lauren Zhao +8 more
2018Cell Death and Disease32 citations Open access
Semantic Scholar
Identification and Characterization of Unique Proline-rich Peptides Binding to the Mitochondrial Fission Protein hFis1*
Madhavika N. Serasinghe, A. Seneviratne, A. Smrcka, Y. Yoon
2009Journal of Biological Chemistry20 citations Open access
Semantic Scholar
FBXW7 regulates a mitochondrial transcription program by modulating MITF
Franco Abbate, Brateil Badal, Karen Mendelson, I. Aydin +7 more
2018Pigment Cell & Melanoma Research19 citations Open access
Semantic Scholar
Use of chimeric melanocortin-2 and -4 receptors to identify regions responsible for ligand specificity and dependence on melanocortin 2 receptor accessory protein
P. M. Hinkle, Madhavika N. Serasinghe, Andrea Jakabowski, J. Sebag +2 more
2011European Journal of Pharmacology19 citations Open access
Semantic Scholar
Repeated hypoglycemia remodels neural inputs and disrupts mitochondrial function to blunt glucose-inhibited GHRH neuron responsiveness
M. Bayne, A. Alvarsson, K. Devarakonda, Rosemary Li +8 more
2020JCI Insight14 citations Open access
Semantic Scholar
Late-onset megaconial myopathy in mice lacking group I Paks
Giselle A. Joseph, M. Hung, Aviva J Goel, Mingi Hong +10 more
2019Skeletal Muscle14 citations Open access
Semantic Scholar
Addendum: RAF/MEK/extracellular signal–related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions
Brandon Hogstad, M. Berres, Rikhia Chakraborty, Jun Tang +20 more
2026Journal of Experimental Medicine0 citations Open access
Semantic Scholar
A Recombinant Antibody Against Human DRP1 Serine 616 Phosphorylation Enables Detection of BRAFV600E-Associated Mitochondrial Division in Cancer
Shanon T. Nizard, Yiyang Chen, Madhavika N. Serasinghe, R. Fernández-Rodríguez +10 more
2026bioRxiv0 citations Open access
Semantic Scholar
A Recombinant Antibody Against Human DRP1 Serine 616 Phosphorylation Enables Detection of BRAFV600E-Associated Mitochondrial Division in Cancer
Shanon T. Nizard, Yiyang Chen, Madhavika N. Serasinghe, Rubén Fernández-Rodríguez +12 more
2026Antibodies0 citations Open access
Semantic Scholar
PPARdelta signaling activation improves metabolic and contractile maturation of human pluripotent stem cell-derived cardiomyocytes
Nadeera M. Wickramasinghe, David Sachs, B. Shewale, David M. Gonzalez +22 more
2021bioRxiv0 citations Open access
Semantic Scholar
Cell death through the ages: The ICDS 25th Anniversary Meeting
Jarvier N. Mohammed, Jesse D. Gelles, C. Rubio-Patiño, Madhavika N. Serasinghe +4 more
2020The FEBS Journal0 citations Open access
Semantic Scholar
Repeated hypoglycemia blunts the responsiveness of glucose-inhibited GHRH neurons by remodeling neural inputs and disrupting mitochondrial structure and function
M. Bayne, A. Alvarsson, K. Devarakonda, Rosemary Li +7 more
2019bioRxiv0 citations Open access
Semantic Scholar
Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition
Madhavika N. Serasinghe, Jesse D. Gelles, Kent Li, Lauren Zhao +8 more
2018Cell Death and Disease0 citations Open access
Semantic Scholar
From zero to sixty: cell death signaling in the city that never sleeps
Jesse D. Gelles, R. Elkholi, Madhavika N. Serasinghe, M. Luna-Vargas +1 more
2015Oncogene0 citations Open access
Semantic Scholar
Identification of novel molecular interactions of the mitochondrial fission protein hFis1: Insight into its action mechanism and therapeutic potential
Madhavika N. Serasinghe
20090 citations
Semantic Scholar

Shira Y. Wieder

×4

J. Celebi×4

Thibaud T. Renault×3

J. Asciolla×3

Kyle L. Hoehn×3

M. Skobe×3

A. Trotta×3

Franco Abbate×3