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K. Hagihara · SciRah

Researcher profile · Semantic Scholar

K. Hagihara

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K. Hagihara — researcher profile on SciRah

h-index: 25
Works: 72
Citations: 2,602

Most-cited papers

Anti-interleukin-6 receptor antibody therapy reduces vascular endothelial growth factor production in rheumatoid arthritis.
H. Nakahara, Jian Song, Masamichi Sugimoto, K. Hagihara +3 more
2003Arthritis & Rheumatism420 citations
Semantic Scholar
IL-6 plays a critical role in the synergistic induction of human serum amyloid A (SAA) gene when stimulated with proinflammatory cytokines as analyzed with an SAA isoform real-time quantitative RT-PCR assay system.
K. Hagihara, T. Nishikawa, T. Isobe, Jian Song +2 more
2004Biochemical and Biophysical Research Communications - BBRC190 citations
Semantic Scholar
Essential role of STAT3 in cytokine‐driven NF‐κB‐mediated serum amyloid A gene expression
K. Hagihara, T. Nishikawa, Y. Sugamata, Jian Song +3 more
2005Genes to Cells177 citations Open access
Semantic Scholar
Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease.
N. Nishimoto, Y. Kanakura, K. Aozasa, T. Johkoh +17 more
2005Blood127 citations Open access
Semantic Scholar
A case of Behçet’s disease treated with a humanized anti-interleukin-6 receptor antibody, tocilizumab
T. Hirano, N. Ohguro, S. Hohki, K. Hagihara +7 more
2012Modern Rheumatology122 citations
Semantic Scholar
Therapeutic effect of tocilizumab on two patients with polymyositis.
M. Narazaki, K. Hagihara, Y. Shima, A. Ogata +2 more
2011Rheumatology121 citations Open access
Semantic Scholar
Flavonoids and related compounds as anti-allergic substances.
M. Kawai, T. Hirano, S. Higa, J. Arimitsu +9 more
2007Allergology International117 citations Open access
Semantic Scholar
Transcriptional Complex Formation of c-Fos, STAT3, and Hepatocyte NF-1α Is Essential for Cytokine-Driven C-Reactive Protein Gene Expression1
T. Nishikawa, K. Hagihara, S. Serada, T. Isobe +6 more
2008Journal of Immunology103 citations Open access
Semantic Scholar
Improvement of HbA1c during treatment with humanised anti-interleukin 6 receptor antibody, tocilizumab
A. Ogata, A. Morishima, T. Hirano, Yoshihiro Hishitani +4 more
2010Annals of the Rheumatic Diseases99 citations
Semantic Scholar
Sustained response to tocilizumab, anti-interleukin-6 receptor antibody, in two patients with refractory relapsing polychondritis.
M. Kawai, K. Hagihara, Toshio Hirano, Yoshihito Shima +7 more
2008Rheumatology87 citations Open access
Semantic Scholar
Interleukin-16 Promotes Cardiac Fibrosis and Myocardial Stiffening in Heart Failure with Preserved Ejection Fraction
S. Tamaki, T. Mano, Y. Sakata, T. Ohtani +15 more
2013PLoS ONE86 citations Open access
Semantic Scholar
Rapid improvement of AA amyloidosis with humanised anti-interleukin 6 receptor antibody treatment
S. Nishida, K. Hagihara, Yoshihito Shima, M. Kawai +9 more
2009Annals of the Rheumatic Diseases80 citations
Semantic Scholar
Successful treatment of reactive arthritis with a humanized anti-interleukin-6 receptor antibody, tocilizumab.
Toshio Tanaka, Y. Kuwahara, Y. Shima, T. Hirano +8 more
2009Arthritis & Rheumatism75 citations
Semantic Scholar
Promising Effect of a New Ketogenic Diet Regimen in Patients with Advanced Cancer
K. Hagihara, K. Kajimoto, S. Osaga, N. Nagai +8 more
2020Nutrients69 citations Open access
Semantic Scholar
Tocilizumab Ameliorates Clinical Symptoms in Polymyalgia Rheumatica
K. Hagihara, I. Kawase, Toshio Tanaka, T. Kishimoto
2010Journal of Rheumatology62 citations Open access
Semantic Scholar
Go-sha-jinki-Gan (GJG), a traditional Japanese herbal medicine, protects against sarcopenia in senescence-accelerated mice.
Yuki Kishida, S. Kagawa, J. Arimitsu, Miho Nakanishi +4 more
2015Phytomedicine54 citations Open access
Semantic Scholar
Quantification of hardness, elasticity and viscosity of the skin of patients with systemic sclerosis using a novel sensing device (Vesmeter): a proposal for a new outcome measurement procedure.
Y. Kuwahara, Yoshihito Shima, D. Shirayama, M. Kawai +6 more
2008Rheumatology53 citations Open access
Semantic Scholar
Preventative effect of a flavonoid, enzymatically modified isoquercitrin on ocular symptoms of Japanese cedar pollinosis.
T. Hirano, M. Kawai, J. Arimitsu, Masako S. Ogawa +13 more
2009Allergology International44 citations Open access
Semantic Scholar
Retention of tocilizumab and anti-tumour necrosis factor drugs in the treatment of rheumatoid arthritis
Yoshihiro Hishitani, Atsushi Ogata, Y. Shima, Toshio Hirano +9 more
2013Scandinavian Journal of Rheumatology41 citations Open access
Semantic Scholar
Effect of Enzymatically Modified Isoquercitrin, a Flavonoid, on Symptoms of Japanese Cedar Pollinosis: A Randomized Double-Blind Placebo-Controlled Trial
M. Kawai, T. Hirano, J. Arimitsu, S. Higa +13 more
2009International Archives of Allergy and Immunology41 citations
Semantic Scholar
Minimal influence of tocilizumab on IFN-γ synthesis by tuberculosis antigens
A. Ogata, M. Mori, Shoji Hashimoto, Y. Yano +12 more
2010Modern Rheumatology34 citations Open access
Semantic Scholar
Go-sha-jinki-Gan (GJG) ameliorates allodynia in chronic constriction injury model mice via suppression of TNF-α expression in the spinal cord
Miho Nakanishi, A. Nakae, Yuki Kishida, Kousuke Baba +4 more
2016Molecular Pain33 citations Open access
Semantic Scholar
Expansion of range of joint motion following treatment of systemic sclerosis with tocilizumab
Y. Shima, N. Hosen, T. Hirano, J. Arimitsu +7 more
2013Modern Rheumatology31 citations Open access
Semantic Scholar
Assessment of the effects of switching oral bisphosphonates to denosumab or daily teriparatide in patients with rheumatoid arthritis
K. Ebina, M. Hirao, J. Hashimoto, K. Hagihara +6 more
2017Journal of Bone and Mineral Metabolism28 citations
Semantic Scholar
Effects of a traditional herbal medicine on peripheral blood flow in women experiencing peripheral coldness: a randomized controlled trial
S. Nishida, Eri Eguchi, T. Ohira, A. Kitamura +3 more
2015BMC Complementary and Alternative Medicine26 citations Open access
Semantic Scholar
Imatinib mesylate inhibited rat adjuvant arthritis and PDGF-dependent growth of synovial fibroblast via interference with the Akt signaling pathway
F. Terabe, M. Kitano, M. Kawai, Y. Kuwahara +9 more
2009Modern Rheumatology25 citations
Semantic Scholar
Long-Term Effects of a Ketogenic Diet for Cancer
Ryuichiro Egashira, Michiko Matsunaga, A. Miyake, Sayaka Hotta +8 more
2023Nutrients21 citations Open access
Semantic Scholar
Treatment of a patient with remitting seronegative, symmetrical synovitis with pitting oedema with a humanized anti-interleukin-6 receptor antibody, tocilizumab.
Toshio Tanaka, K. Hagihara, Y. Shima, M. Narazaki +3 more
2010Rheumatology21 citations Open access
Semantic Scholar
Ketogenic Effects of Multiple Doses of a Medium Chain Triglycerides Enriched Ketogenic Formula in Healthy Men under the Ketogenic Diet: A Randomized, Double-Blinded, Placebo-Controlled Study
Kentaro Nakamura, K. Hagihara, N. Nagai, Ryuichiro Egashira +8 more
2022Nutrients19 citations Open access
Semantic Scholar
Viral Load of Human Herpesvirus 8 (HHV-8) in the Circulatory Blood Cells Correlates with Clinical Progression in a Patient with HHV-8-associated Solid Lymphoma with AIDS-associated Kaposi's Sarcoma
Jian Song, Atsushi Yoshida, Yoshihiko Yamamoto, H. Katano +4 more
2004Leukemia and Lymphoma19 citations
Semantic Scholar
The Japan Frailty Scale is a promising screening test for frailty and pre-frailty in Japanese elderly people.
Ryuichiro Egashira, Tomoharu Sato, A. Miyake, Mariko Takeuchi +5 more
2022Gene18 citations Open access
Semantic Scholar
Etanercept improved primary biliary cirrhosis associated with rheumatoid arthritis.
A. Ogata, F. Terabe, Kaori Nakanishi, M. Kawai +8 more
2009Joint, bone, spine : revue du rhumatisme16 citations
Semantic Scholar
Amelioration of Small Bowel Injury by Switching from Nonselective Nonsteroidal Anti-Inflammatory Drugs to Celecoxib in Rheumatoid Arthritis Patients: A Pilot Study
Takahiro Inoue, H. Iijima, J. Arimitsu, K. Hagihara +9 more
2014Digestion15 citations
Semantic Scholar
Successful treatment of acquired hemophilia A, complicated by chronic GVHD, with tocilizumab
S. Nishida, T. Kawasaki, H. Kashiwagi, A. Morishima +11 more
2011Modern Rheumatology15 citations
Semantic Scholar
The skin of patients with systemic sclerosis softened during the treatment with anti-IL-6 receptor antibody tocilizumab
Yoshihito Shima, Y. Kuwahara, H. Murota, S. Kitaba +10 more
2010Rheumatology13 citations Open access
Semantic Scholar
Suppressive effects of processed aconite root on dexamethasone-induced muscle ring finger protein-1 expression and its active ingredients
T. Kondo, T. Ishida, K. Ye, M. Muraguchi +8 more
2022Journal of Natural Medicines12 citations Open access
Semantic Scholar
An herbal medicine, Go-sha-jinki-gan (GJG), increases muscle weight in severe muscle dystrophy model mice
Yusei Takemoto, Shoya Inaba, Li-Dan Zhang, Kousuke Baba +2 more
201710 citations Open access
Semantic Scholar
Proteomic analysis of autoantigens associated with systemic lupus erythematosus: Anti‐aldolase A antibody as a potential marker of lupus nephritis
S. Serada, M. Fujimoto, Tsuyoshi Takahashi, P. He +9 more
2007PROTEOMICS - Clinical Applications10 citations
Semantic Scholar
Go-sha-jinki-Gan Alleviates Inflammation in Neurological Disorders via p38-TNF Signaling in the Central Nervous System
Shi-Ying Jiang, Kousuke Baba, Tatsusada Okuno, M. Kinoshita +10 more
2020Neurotherapeutics9 citations Open access
Semantic Scholar
Abbreviation of kampo formulations and basic terminology in kampo medicine
K. Hagihara, S. Yakubo, T. Namiki
20179 citations
Semantic Scholar
A connecter-like factor, CacA, links RssB/RpoS and the CpxR/CpxA two-component system in Salmonella
加藤明宣, H. Hayashi, Wataru Nomura, Haruka Emori +2 more
2012BMC Microbiology8 citations Open access
Semantic Scholar
Tocilizumab for the Treatment of AA Amyloidosis
Toshio Tanaka, K. Hagihara, Yoshihiro Hishitani, A. Ogata
20118 citations Open access
Semantic Scholar
Effects of Rikkunshi-To, a Japanese kampo medicine, on donepezil-induced gastrointestinal side effects in mice.
Kouichi Yamamoto, Yuhki Sato, K. Hagihara, Kyosuke Kirikihira +3 more
2022Journal of Pharmacological Sciences7 citations Open access
Semantic Scholar
What kind of durometer is best suited for the assessment of skin disease in systemic sclerosis? Comment on the article by Kissin et al.
Y. Kuwahara, Y. Shima, M. Kawai, K. Hagihara +7 more
2008Arthritis & Rheumatism7 citations
Semantic Scholar
Gosha-jinki-Gan (GJG) shows anti-aging effects through suppression of TNF-α production by Chikusetsusaponin V.
K. Hagihara, K. Nunomura, Bangzhong Lin, Megumi Fumimoto +2 more
2021Gene5 citations Open access
Semantic Scholar
Enhancement of ghrelin-signaling system by Rikkunshi-To attenuates teriparatide-induced pica in rats.
Kouichi Yamamoto, Y. Isogai, T. Ishida, K. Hagihara
2018Journal of Pharmacological Sciences5 citations Open access
Semantic Scholar
[A humanized anti-IL-6 receptor antibody(MRA) in RA therapy].
K. Hagihara, N. Nishimoto, K. Yoshizaki
2002Nihon rinsho. Japanese journal of clinical medicine5 citations
Semantic Scholar
Goshajinkigan, a Traditional Japanese Medicine, Suppresses Voltage-Gated Sodium Channel Nav1.4 Currents in C2C12 Cells
Ryota Imai, S. Horita, Y. Ono, K. Hagihara +3 more
2020BioResearch Open Access4 citations Open access
Semantic Scholar
Analysis of cytokine-driven serum amyloid A expression based on the clinical results of IL-6 blocking therapy : a new cis-acting mechanism of STAT3
K. Hagihara, T. Nishikawa, Atsumi Matsumura, Jian Song +2 more
20064 citations Open access
Semantic Scholar
A multidimensional physical scale is a useful screening test for mild depression associated with childcare in Japanese child-rearing women
Mariko Takeuchi, Michiko Matsunaga, Ryuichiro Egashira, A. Miyake +9 more
2022Frontiers in Psychiatry3 citations Open access
Semantic Scholar

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Toshio Tanaka×18
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Toshio Tanaka — researcher profile on SciRah
M. Narazaki×17
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M. Narazaki — researcher profile on SciRah
A. Ogata×16
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Y. Shima×15
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M. Kawai — researcher profile on SciRah

J. Arimitsu×13

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Y. Kuwahara×12

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I. Kawase — researcher profile on SciRah

T. Kishimoto×9

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