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V. Heine · SciRah

Researcher profile · Semantic Scholar

V. Heine

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V. Heine — researcher profile on SciRah

h-index: 29
Works: 83
Citations: 5,974

Most-cited papers

Conserved Role of Intragenic DNA Methylation in Regulating Alternative Promoters
A. Maunakea, R. Nagarajan, M. Bilenky, Tracy J. Ballinger +22 more
2010Nature1,731 citations Open access
Semantic Scholar
Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Hedgehog-induced medulloblastoma
U. Schüller, V. Heine, Junhao Mao, A. Kho +11 more
2008Cancer Cell653 citations Open access
Semantic Scholar
Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus-pituitary-adrenal axis activation.
V. Heine, S. Maslam, M. Joëls, P. Lucassen
2004Neurobiology of Aging378 citations
Semantic Scholar
Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible
V. Heine, S. Maslam, Jessica Zareno, M. Joëls +1 more
2004European Journal of Neuroscience339 citations
Semantic Scholar
Effects of Chronic Stress on Structure and Cell Function in Rat Hippocampus and Hypothalamus
M. Joëls, H. Karst, D. Alfarez, V. Heine +5 more
2004Stress332 citations Open access
Semantic Scholar
Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade
Joel M. Hyman, Ari J. Firestone, V. Heine, Yun Zhao +10 more
2009Proceedings of the National Academy of Sciences of the United States of America318 citations Open access
Semantic Scholar
Stress, depression and hippocampal apoptosis.
P. Lucassen, V. Heine, Marianne B Muller, E. van der Beek +6 more
2006CNS and Neurological Disorders - Drug Targets252 citations Open access
Semantic Scholar
Chronic stress in the adult dentate gyrus reduces cell proliferation near the vasculature and VEGF and Flk‐1 protein expression
V. Heine, Jessica Zareno, S. Maslam, M. Joëls +1 more
2005European Journal of Neuroscience224 citations
Semantic Scholar
Astrocytes are central in the pathomechanisms of vanishing white matter.
S. Dooves, M. Bugiani, Nienke L. Postma, Emiel Polder +15 more
2016Journal of Clinical Investigation136 citations Open access
Semantic Scholar
Hedgehog signaling has a protective effect in glucocorticoid-induced mouse neonatal brain injury through an 11betaHSD2-dependent mechanism.
V. Heine, D. Rowitch
2009Journal of Clinical Investigation120 citations Open access
Semantic Scholar
Forkhead Transcription Factor FoxM1 Regulates Mitotic Entry and Prevents Spindle Defects in Cerebellar Granule Neuron Precursors
U. Schüller, Qing Zhao, S. Godinho, V. Heine +3 more
2007Molecular and Cellular Biology104 citations Open access
Semantic Scholar
The involvement of astrocytes in early‐life adversity induced programming of the brain
M. Abbink, Anne-Lieke F. van Deijk, V. Heine, M. Verheijen +1 more
2019Glia83 citations Open access
Semantic Scholar
A Small-Molecule Smoothened Agonist Prevents Glucocorticoid-Induced Neonatal Cerebellar Injury
V. Heine, Amélie Griveau, C. Chapin, P. Ballard +2 more
2011Science Translational Medicine80 citations Open access
Semantic Scholar
Neuron-Glia Interactions Increase Neuronal Phenotypes in Tuberous Sclerosis Complex Patient iPSC-Derived Models
Aishwarya G. Nadadhur, Mouhamed Alsaqati, L. Gasparotto, P. Cornelissen-Steijger +4 more
2018Stem Cell Reports79 citations Open access
Semantic Scholar
Mice with megalencephalic leukoencephalopathy with cysts: A developmental angle
M. Dubey, M. Bugiani, M. Ridder, Nienke L. Postma +17 more
2015Annals of Neurology72 citations Open access
Semantic Scholar
Olig1 function is required to repress Dlx1/2 and interneuron production in mammalian brain
John C. Silbereis, Hiroko Nobuta, Hui-hsin Tsai, V. Heine +10 more
2014Neuron69 citations Open access
Semantic Scholar
Comparison of Mouse and Human Retinal Pigment Epithelium Gene Expression Profiles: Potential Implications for Age-Related Macular Degeneration
A. Bennis, T. Gorgels, J. T. ten Brink, P. J. van der Spek +3 more
2015PLoS ONE63 citations Open access
Semantic Scholar
Decanoic acid inhibits mTORC1 activity independent of glucose and insulin signaling
Eleanor C. Warren, S. Dooves, Eleonora Lugarà, Joseph Damstra-Oddy +4 more
2020Proceedings of the National Academy of Sciences of the United States of America57 citations Open access
Semantic Scholar
Cerebellar abnormalities following hypoxia alone compared to hypoxic-ischemic forebrain injury in the developing rat brain
V. Biran, V. Heine, C. Verney, R. Sheldon +4 more
2010Neurobiology of Disease46 citations Open access
Semantic Scholar
Bergmann glia translocation: a new disease marker for vanishing white matter identifies therapeutic effects of Guanabenz treatment
S. Dooves, M. Bugiani, L. Wisse, T. Abbink +2 more
2018Neuropathology and Applied Neurobiology42 citations Open access
Semantic Scholar
Genetically-Informed Patient Selection for iPSC Studies of Complex Diseases May Aid in Reducing Cellular Heterogeneity
Stephanie D. Hoekstra, S. Stringer, V. Heine, D. Posthuma
2017Frontiers in Cellular Neuroscience42 citations Open access
Semantic Scholar
Pharmacological intervention to restore connectivity deficits of neuronal networks derived from ASD patient iPSC with a TSC2 mutation
Mouhamed Alsaqati, V. Heine, A. Harwood
2020Molecular Autism39 citations Open access
Semantic Scholar
KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients
L. Hinz, Joan Torrella Barrufet, V. Heine
2019Acta Neuropathologica Communications39 citations Open access
Semantic Scholar
Cerebral Organoids: A Human Model for AAV Capsid Selection and Therapeutic Transgene Efficacy in the Brain
Josse A. Depla, Marina Sogorb-González, Lance A. Mulder, V. Heine +6 more
2020Molecular Therapy: Methods & Clinical Development35 citations Open access
Semantic Scholar
Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells
A. G. Nadadhur, Javier Emperador Melero, M. Meijer, Désireé Schut +9 more
2017PLoS ONE35 citations Open access
Semantic Scholar
ALL-tRNAseq enables robust tRNA profiling in tissue samples
C. Scheepbouwer, E. Aparicio-Puerta, C. Gómez-Martín, H. Verschueren +19 more
2023Genes & Development33 citations Open access
Semantic Scholar
Patterning factors during neural progenitor induction determine regional identity and differentiation potential in vitro.
A. G. Nadadhur, P. Leferink, Dwayne B. Holmes, L. Hinz +3 more
2018Stem Cell Research32 citations Open access
Semantic Scholar
Astrocyte Subtype Vulnerability in Stem Cell Models of Vanishing White Matter
P. Leferink, S. Dooves, Anne E. J. Hillen, Kyoko Watanabe +5 more
2019Annals of Neurology31 citations Open access
Semantic Scholar
Stem Cell Derived Retinal Pigment Epithelium: The Role of Pigmentation as Maturation Marker and Gene Expression Profile Comparison with Human Endogenous Retinal Pigment Epithelium.
A. Bennis, J. Jacobs, L. Catsburg, J. T. ten Brink +7 more
2017Stem Cell Reviews and Reports29 citations Open access
Semantic Scholar
A human iPSC-astroglia neurodevelopmental model reveals divergent transcriptomic patterns in schizophrenia
A. Szabo, I. Akkouh, Matthieu Vandenberghe, Jordi Requena Osete +6 more
2020bioRxiv28 citations Open access
Semantic Scholar
Engineered cell culture microenvironments for mechanobiology studies of brain neural cells
Lucía Castillo Ransanz, P. V. van Altena, V. Heine, A. Accardo
2022Frontiers in Bioengineering and Biotechnology27 citations Open access
Semantic Scholar
Five new things
M. S. van der Knaap, N. Wolf, V. Heine
27 citations
Semantic Scholar
Neuron–Glia Interactions in Tuberous Sclerosis Complex Affect the Synaptic Balance in 2D and Organoid Cultures
S. Dooves, A. J. H. van Velthoven, Linda G Suciati, V. Heine
2021Cells26 citations Open access
Semantic Scholar
Axonal abnormalities in vanishing white matter
M. D. Klok, M. Bugiani, S. D. de Vries, W. Gerritsen +6 more
2018Annals of Clinical and Translational Neurology25 citations Open access
Semantic Scholar
Copy number variants (CNVs): a powerful tool for iPSC-based modelling of ASD
D. Drakulić, S. Djurovic, Y. A. Syed, Sebastiano Trattaro +10 more
2020Molecular Autism24 citations Open access
Semantic Scholar
Dexamethasone destabilizes Nmyc to inhibit the growth of Hedgehog-associated medulloblastoma
V. Heine, Markus Priller, J. Ling, D. Rowitch +1 more
2010Cancer Research23 citations Open access
Semantic Scholar
A 3D human co-culture to model neuron-astrocyte interactions in tauopathies
K. Batenburg, Claudia Sestito, P. Cornelissen-Steijger, J. V. van Weering +3 more
2023Biological Procedures Online19 citations Open access
Semantic Scholar
Quantitative proteomic analysis of Rett iPSC-derived neuronal progenitors
S. Varderidou-Minasian, L. Hinz, D. Hagemans, D. Posthuma +2 more
2020Molecular Autism19 citations Open access
Semantic Scholar
Cell Replacement Therapy Improves Pathological Hallmarks in a Mouse Model of Leukodystrophy Vanishing White Matter
S. Dooves, P. Leferink, S. Krabbenborg, Nicole Breeuwsma +5 more
2019Stem Cell Reports19 citations Open access
Semantic Scholar
Affected astrocytes in the spinal cord of the leukodystrophy vanishing white matter
P. Leferink, Nicole Breeuwsma, M. Bugiani, M. S. van der Knaap +1 more
2017Glia19 citations Open access
Semantic Scholar
Systematic assessment of variability in the proteome of iPSC derivatives.
Stephanie D. Beekhuis-Hoekstra, Kyoko Watanabe, J. Werme, C. D. de Leeuw +6 more
2021Stem Cell Research18 citations
Semantic Scholar
Generation of Isogenic Controls for In Vitro Disease Modelling of X-Chromosomal Disorders
L. Hinz, Stephanie D. Hoekstra, Kyoko Watanabe, D. Posthuma +1 more
2018Stem Cell Reviews and Reports16 citations Open access
Semantic Scholar
Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons
Javier Emperador Melero, A. G. Nadadhur, Désireé Schut, J. Weering +3 more
2017Stem Cell Reports16 citations Open access
Semantic Scholar
Detection of silent cells, synchronization and modulatory activity in developing cellular networks
Johannes J. J. Hjorth, J. Dawitz, T. Kroon, J. Pires +9 more
2016Developmental Neurobiology16 citations Open access
Semantic Scholar
Intraneuronal tau aggregation induces the integrated stress response in astrocytes
K. Batenburg, N. N. Kasri, V. Heine, W. Scheper
2022Journal of Molecular Cell Biology15 citations Open access
Semantic Scholar
Glutamate Carrier Involvement in Mitochondrial Dysfunctioning in the Brain White Matter
Anne E. J. Hillen, V. Heine
2020Frontiers in Molecular Biosciences15 citations Open access
Semantic Scholar
Olig1 is required for Noggin-induced neonatal myelin repair
J. K. Sabo, V. Heine, John C. Silbereis, L. Schirmer +2 more
2017Annals of Neurology15 citations Open access
Semantic Scholar
Adult mouse eIF2Bε Arg191His astrocytes display a normal integrated stress response in vitro
L. Wisse, T. T. Ter Braak, M. van de Beek, C. V. van Berkel +5 more
2018Scientific Reports14 citations Open access
Semantic Scholar
The Healthy and Diseased Microenvironments Regulate Oligodendrocyte Properties: Implications for Regenerative Medicine.
P. Leferink, V. Heine
2018American Journal of Pathology12 citations Open access
Semantic Scholar
Stem cell therapy for white matter disorders: don’t forget the microenvironment!
S. Dooves, M. S. van der Knaap, V. Heine
2016Journal of Inherited Metabolic Disease12 citations Open access
Semantic Scholar

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