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L. Bouwens · SciRah

Researcher profile · Semantic Scholar

L. Bouwens

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L. Bouwens — researcher profile on SciRah

h-index: 54
Works: 152
Citations: 11K

Most-cited papers

Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization
Ana Rita Pombo Antunes, Isabelle Scheyltjens, F. Lodi, J. Messiaen +24 more
2021Nature Neuroscience602 citations Open access
Semantic Scholar
Pancreatic exocrine duct cells give rise to insulin-producing beta cells during embryogenesis but not after birth.
Myriam Solar, C. Cardalda, I. Houbracken, Mercè Martín +7 more
2009Developmental Cell515 citations Open access
Semantic Scholar
Regulation of pancreatic beta-cell mass.
L. Bouwens, I. Rooman
2005Physiological Reviews468 citations
Semantic Scholar
The Human Pancreatic Islet Transcriptome: Expression of Candidate Genes for Type 1 Diabetes and the Impact of Pro-Inflammatory Cytokines
D. Eizirik, M. Sammeth, T. Bouckenooghe, G. Bottu +14 more
2012PLoS Genetics443 citations Open access
Semantic Scholar
In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells
L. Baeyens, S. De Breuck, J. Lardon, J. K. Mfopou +2 more
2004Diabetologia318 citations Open access
Semantic Scholar
Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-associated macrophages.
K. Movahedi, S. Schoonooghe, Damya Laoui, I. Houbracken +8 more
2012Cancer Research273 citations
Semantic Scholar
Gastrin stimulates beta-cell neogenesis and increases islet mass from transdifferentiated but not from normal exocrine pancreas tissue.
I. Rooman, J. Lardon, L. Bouwens
2002Diabetes256 citations
Semantic Scholar
Nestin expression in pancreatic stellate cells and angiogenic endothelial cells
J. Lardon, I. Rooman, L. Bouwens
2002Histochemistry and Cell Biology221 citations
Semantic Scholar
Modulation of rat pancreatic acinoductal transdifferentiation and expression of PDX-1 in vitro
I. Rooman, Y. Heremans, H. Heimberg, L. Bouwens
2000Diabetologia201 citations Open access
Semantic Scholar
Mechanisms of coxsackievirus-induced damage to human pancreatic beta-cells.
M. Roivainen, S. Rasilainen, P. Ylipaasto, R. Nissinen +5 more
2000Journal of Clinical Endocrinology and Metabolism199 citations
Semantic Scholar
Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice
L. Baeyens, M. Lemper, G. Leuckx, S. De Groef +17 more
2013Nature Biotechnology179 citations Open access
Semantic Scholar
Noggin, retinoids, and fibroblast growth factor regulate hepatic or pancreatic fate of human embryonic stem cells.
J. K. Mfopou, Bing Chen, I. Mateizel, K. Sermon +1 more
2010Gastroenterology162 citations
Semantic Scholar
Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines.
J. Hansen, M. Tonnesen, A. N. Madsen, P. Hagedorn +17 more
2012Cell Metabolism160 citations Open access
Semantic Scholar
Combined gastrin and epidermal growth factor treatment induces islet regeneration and restores normoglycaemia in C57Bl6/J mice treated with alloxan
I. Rooman, L. Bouwens
2004Diabetologia157 citations Open access
Semantic Scholar
Specific and combined effects of insulin and glucose on functional pancreatic beta-cell mass in vivo in adult rats.
Maryline Paris, Catherine Bernard-Kargar, M. Berthault, L. Bouwens +1 more
2003Endocrinology151 citations Open access
Semantic Scholar
Lineage tracing evidence for transdifferentiation of acinar to duct cells and plasticity of human pancreas.
I. Houbracken, E. de Waele, J. Lardon, Z. Ling +3 more
2011Gastroenterology147 citations
Semantic Scholar
Differential plasticity and fate of brain-resident and recruited macrophages during the onset and resolution of neuroinflammation.
Karen De Vlaminck, H. van Hove, Daliya Kancheva, Isabelle Scheyltjens +16 more
2022Immunity143 citations Open access
Semantic Scholar
Adult pancreatic acinar cells dedifferentiate to an embryonic progenitor phenotype with concomitant activation of a senescence programme that is present in chronic pancreatitis
Andreia V. Pinho, I. Rooman, M. Reichert, N. Demedts +3 more
2010Gut130 citations
Semantic Scholar
Stem Cell Marker Prominin-1/AC133 Is Expressed in Duct Cells of the Adult Human Pancreas
J. Lardon, D. Corbeil, W. Huttner, Z. Ling +1 more
2008Pancreas105 citations
Semantic Scholar
Exocrine cell transdifferentiation in dexamethasone-treated rat pancreas
J. Lardon, Niki Huyens, I. Rooman, L. Bouwens
2003Virchows Archiv103 citations
Semantic Scholar
The use of stem cells for pancreatic regeneration in diabetes mellitus
L. Bouwens, I. Houbracken, J. K. Mfopou
2013Nature Reviews Endocrinology90 citations
Semantic Scholar
Expression of the Notch signaling pathway and effect on exocrine cell proliferation in adult rat pancreas.
I. Rooman, N. Demedts, L. Baeyens, J. Lardon +3 more
2006American Journal of Pathology90 citations Open access
Semantic Scholar
Notch signaling as gatekeeper of rat acinar-to-beta-cell conversion in vitro.
L. Baeyens, Stefan Bonné, T. Bos, I. Rooman +5 more
2009Gastroenterology87 citations Open access
Semantic Scholar
Plasticity in the adult rat pancreas: Transdifferentiation of exocrine to hepatocyte‐like cells in primary culture
J. Lardon, S. De Breuck, I. Rooman, L. van Lommel +4 more
2004Hepatology83 citations Open access
Semantic Scholar
Netrin-1 expression in fetal and regenerating rat pancreas and its effect on the migration of human pancreatic duct and porcine islet precursor cells
S. De Breuck, J. Lardon, I. Rooman, L. Bouwens
2003Diabetologia74 citations Open access
Semantic Scholar
Recent Advances and Prospects in the Differentiation of Pancreatic Cells From Human Embryonic Stem Cells
J. K. Mfopou, Bing Chen, Lina Sui, K. Sermon +1 more
2010Diabetes73 citations Open access
Semantic Scholar
Interactions between rat colon carcinoma cells and Kupffer cells during the onset of hepatic metastasis
M. Timmers, K. Vekemans, D. Vermijlen, K. Asosingh +4 more
2004International Journal of Cancer71 citations Open access
Semantic Scholar
Sirtuin-1 regulates acinar-to-ductal metaplasia and supports cancer cell viability in pancreatic cancer.
E. Wauters, V. J. Sánchez-Arévalo Lobo, Andreia V. Pinho, A. Mawson +12 more
2013Cancer Research66 citations Open access
Semantic Scholar
Signaling pathways during maintenance and definitive endoderm differentiation of embryonic stem cells.
Lina Sui, L. Bouwens, J. K. Mfopou
2013International Journal of Developmental Biology64 citations Open access
Semantic Scholar
Epidermal growth factor (EGF)-receptor signalling is needed for murine beta cell mass expansion in response to high-fat diet and pregnancy but not after pancreatic duct ligation
E. Hakonen, J. Ustinov, I. Mathijs, J. Palgi +3 more
2011Diabetologia62 citations Open access
Semantic Scholar
Role of pancreatic beta-cells in the process of beta-cell death.
D. Pipeleers, A. Hoorens, M. Marichal-Pipeleers, M. Van de Casteele +2 more
2001Diabetes61 citations Open access
Semantic Scholar
Molecular Imaging with Macrophage CRIg-Targeting Nanobodies for Early and Preclinical Diagnosis in a Mouse Model of Rheumatoid Arthritis
Fang Zheng, Stéphanie Put, L. Bouwens, T. Lahoutte +6 more
2014Journal of Nuclear Medicine57 citations Open access
Semantic Scholar
Metaplasia in the pancreas.
J. Lardon, L. Bouwens
2005Differentiation; research in biological diversity55 citations
Semantic Scholar
Sonic Hedgehog and Other Soluble Factors from Differentiating Embryoid Bodies Inhibit Pancreas Development
J. K. Mfopou, Véronique De Groote, Xiabo Xu, H. Heimberg +1 more
2007Stem Cells53 citations Open access
Semantic Scholar
A nanobody-based tracer targeting DPP6 for non-invasive imaging of human pancreatic endocrine cells
A. Balhuizen, Sam Massa, I. Mathijs, Jean-Valery Turatsinze +16 more
2017Scientific Reports49 citations Open access
Semantic Scholar
Phenylpropenoic Acid Glucoside from Rooibos Protects Pancreatic Beta Cells against Cell Death Induced by Acute Injury
E. Himpe, D. Cunha, Imane Song, M. Bugliani +3 more
2016PLoS ONE45 citations Open access
Semantic Scholar
Can β‐cells be derived from exocrine pancreas?
L. Baeyens, L. Bouwens
2008Diabetes, obesity and metabolism45 citations Open access
Semantic Scholar
Adult human pancreatic acinar cells dedifferentiate into an embryonic progenitor-like state in 3D suspension culture
J. Baldan, I. Houbracken, I. Rooman, L. Bouwens
2019Scientific Reports39 citations Open access
Semantic Scholar
Efficient definitive endoderm induction from mouse embryonic stem cell adherent cultures: a rapid screening model for differentiation studies.
J. K. Mfopou, Marloes Geeraerts, R. Dejene, Stijn Van Langenhoven +3 more
2014Stem Cell Research39 citations Open access
Semantic Scholar
Beta cell regeneration.
L. Bouwens
2006Current Diabetes Reviews38 citations
Semantic Scholar
Pit cells in the liver.
L. Bouwens, E. Wisse
2008Liver37 citations
Semantic Scholar
Phenylpropenoic acid glucoside augments pancreatic beta cell mass in high-fat diet-fed mice and protects beta cells from ER stress-induced apoptosis.
I. Mathijs, D. D. da Cunha, E. Himpe, L. Ladrière +7 more
2014Molecular Nutrition & Food Research36 citations
Semantic Scholar
Fractionated radiation severely reduces the number of CD8+ T cells and mature antigen presenting cells within lung tumors.
E. Reijmen, S. de Mey, W. de Mey, T. Gevaert +10 more
2021International Journal of Radiation Oncology, Biology, Physics35 citations Open access
Semantic Scholar
MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions
E. Backx, E. Wauters, J. Baldan, M. Van Bulck +9 more
2020Cell Death and Differentiation33 citations Open access
Semantic Scholar
Aspalathin Protects Insulin-Producing β Cells Against Glucotoxicity and Oxidative Stress-Induced Cell Death.
Céline Moens, M. Bensellam, E. Himpe, C. Muller +2 more
2020Molecular Nutrition & Food Research33 citations Open access
Semantic Scholar
Beta Cell Mass Restoration in Alloxan-Diabetic Mice Treated with EGF and Gastrin
Imane Song, Oelfah Patel, E. Himpe, C. Muller +1 more
2015PLoS ONE33 citations Open access
Semantic Scholar
Expression and function of leukaemia inhibitory factor and its receptor in normal and regenerating rat pancreas
S. De Breuck, L. Baeyens, L. Bouwens
2005Diabetologia32 citations Open access
Semantic Scholar
Natural cytotoxicity of rat hepatic natural killer cells and macrophages against a syngeneic colon adenocarcinoma
L. Bouwens, R. Jacobs, L. Remels, E. Wisse
2004Cancer Immunology and Immunotherapy32 citations
Semantic Scholar
Circulating microRNA-375 as biomarker of pancreatic beta cell death and protection of beta cell mass by cytoprotective compounds
Imane Song, S. Roels, G. Martens, L. Bouwens
2017PLoS ONE31 citations Open access
Semantic Scholar
FGF signaling via MAPK is required early and improves Activin A-induced definitive endoderm formation from human embryonic stem cells.
Lina Sui, J. K. Mfopou, M. Geens, K. Sermon +1 more
2012Biochemical and Biophysical Research Communications - BBRC31 citations
Semantic Scholar

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