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K. Lorent · SciRah

Researcher profile · Semantic Scholar

K. Lorent

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K. Lorent — researcher profile on SciRah

h-index: 28
Works: 49
Citations: 3,374

Most-cited papers

Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain*
D. Moechars, I. Dewachter, K. Lorent, D. Reversé +9 more
1999Journal of Biological Chemistry720 citations Open access
Semantic Scholar
Intestinal growth and differentiation in zebrafish.
Kenneth N. Wallace, S. Akhter, Erin M. Smith, K. Lorent +1 more
2005Mechanisms of Development539 citations Open access
Semantic Scholar
Inhibition of Jagged-mediated Notch signaling disrupts zebrafish biliary development and generates multi-organ defects compatible with an Alagille syndrome phenocopy
K. Lorent, Sang-Yeob Yeo, T. Oda, S. Chandrasekharappa +3 more
2004Development230 citations
Semantic Scholar
801 Expression in brain of Amyloid Precursor Protein mutated in the α-secretase site, causes disturbed behavior, neuronal degeneration and premature death in transgenic mice
Dieder Moechars, K. Lorent, B. de Strooper, I. Dewachter +1 more
1996199 citations
Semantic Scholar
Identification of a plant isoflavonoid that causes biliary atresia
K. Lorent, Weilong Gong, Kyung Ah Koo, O. Waisbourd-Zinman +10 more
2015Science Translational Medicine150 citations Open access
Semantic Scholar
Exocrine pancreas development in zebrafish.
N. Yee, K. Lorent, M. Pack
2005Developmental Biology129 citations Open access
Semantic Scholar
Reiterative Use of the Notch Signal During Zebrafish Intrahepatic Biliary Development
K. Lorent, J. C. Moore, A. Siekmann, N. Lawson +1 more
2010Developmental Dynamics97 citations Open access
Semantic Scholar
TNFα-dependent hepatic steatosis and liver degeneration caused by mutation of zebrafish s-adenosylhomocysteine hydrolase
R. P. Matthews, K. Lorent, Rafael Mañoral-Mobias, Yuehua Huang +4 more
2009Development94 citations Open access
Semantic Scholar
The zebrafish space cadet gene controls axonal pathfinding of neurons that modulate fast turning movements.
K. Lorent, Katherine S. Liu, J. Fetcho, M. Granato
2001Development91 citations
Semantic Scholar
Premature death in transgenic mice that overexpress a mutant amyloid precursor protein is preceded by severe neurodegeneration and apoptosis.
D. Moechars, K. Lorent, F. Van Leuven
1999Neuroscience80 citations
Semantic Scholar
The zebrafish onecut gene hnf-6 functions in an evolutionarily conserved genetic pathway that regulates vertebrate biliary development.
R. P. Matthews, K. Lorent, P. Russo, M. Pack
2004Developmental Biology78 citations Open access
Semantic Scholar
DNA hypomethylation causes bile duct defects in zebrafish and is a distinguishing feature of infantile biliary atresia
R. P. Matthews, Steven F. Eauclaire, Monica R. Mugnier, K. Lorent +5 more
2011Hepatology71 citations Open access
Semantic Scholar
Mutation of RNA Pol III Subunit rpc2/polr3b Leads to Deficiency of Subunit Rpc11 and Disrupts Zebrafish Digestive Development
N. Yee, Weilong Gong, Ying Huang, K. Lorent +3 more
2007PLoS Biology70 citations Open access
Semantic Scholar
Mutation of the Zebrafish Nucleoporin elys Sensitizes Tissue Progenitors to Replication Stress
Gangarao Davuluri, Weilong Gong, S. Yusuff, K. Lorent +3 more
2008PLoS Genetics69 citations Open access
Semantic Scholar
Targeted Inactivation of the Mouse α2-Macroglobulin Gene (*)
L. Umans, L. Serneels, L. Overbergh, K. Lorent +2 more
1995Journal of Biological Chemistry66 citations Open access
Semantic Scholar
Zebrafish fat-free is required for intestinal lipid absorption and Golgi apparatus structure.
Shiu-Ying Ho, K. Lorent, M. Pack, S. Farber
2006Cell Metabolism58 citations Open access
Semantic Scholar
Glutathione Antioxidant Pathway Activity and Reserve Determine Toxicity and Specificity of the Biliary Toxin Biliatresone in Zebrafish
Xiao Zhao, K. Lorent, B. Wilkins, Dylan M. Marchione +9 more
2016Hepatology54 citations Open access
Semantic Scholar
Zebrafish vps33b, an ortholog of the gene responsible for human arthrogryposis-renal dysfunction-cholestasis syndrome, regulates biliary development downstream of the onecut transcription factor hnf6.
R. P. Matthews, Nicolas Plumb-Rudewiez, K. Lorent, P. Gissen +3 more
2005Development42 citations Open access
Semantic Scholar
TGFβ and Hippo pathways cooperate to enhance sarcomagenesis and metastasis through the hyaluronan mediated motility receptor (HMMR)
Shuai Ye, Ying Liu, Ashley M. Fuller, R. Katti +9 more
2020Molecular Cancer Research39 citations
Semantic Scholar
Distribution of mRNA coding for alpha-2-macroglobulin, the murinoglobulins, the alpha-2-macroglobulin receptor and the alpha-2-macroglobulin receptor associated protein during mouse embryogenesis and in adult tissues.
K. Lorent, L. Overbergh, J. Delabie, F. Van Leuven +1 more
1994Differentiation; research in biological diversity39 citations
Semantic Scholar
p53-Mediated Biliary Defects Caused by Knockdown of cirh1a, the Zebrafish Homolog of the Gene Responsible for North American Indian Childhood Cirrhosis
B. Wilkins, K. Lorent, R. P. Matthews, M. Pack
2013PLoS ONE38 citations Open access
Semantic Scholar
The Tumor Suppressor Gene Retinoblastoma-1 Is Required for Retinotectal Development and Visual Function in Zebrafish
M. Gyda, M. Wolman, K. Lorent, M. Granato
2012PLoS Genetics36 citations Open access
Semantic Scholar
The Nuclear Pore Complex Protein Elys Is Required for Genome Stability in Mouse Intestinal Epithelial Progenitor Cells
N. Gao, Gangarao Davuluri, Weilong Gong, Christoph Seiler +4 more
2011Gastroenterology36 citations Open access
Semantic Scholar
The primary sequence and the subunit structure of mouse alpha-2-macroglobulin, deduced from protein sequencing of the isolated subunits and from molecular cloning of the cDNA.
F. Van Leuven, Sophie Torrekens, L. Overbergh, K. Lorent +2 more
1992European Journal of Biochemistry36 citations Open access
Semantic Scholar
Structure of the gene (LRP1) coding for the human alpha 2-macroglobulin receptor lipoprotein receptor-related protein.
F. Van Leuven, L. Stas, C. Hilliker, K. Lorent +7 more
1994Genomics35 citations
Semantic Scholar
Zebrafish vps33b, an ortholog of the gene responsible for human arthrogryposis-renal dysfunction-cholestasis syndrome, regulates biliary development downstream of the onecut transcription factor hnf6
R. P. Matthews, Nicolas Plumb-Rudewiez, K. Lorent, P. Gissen +3 more
200534 citations
Semantic Scholar
Expression of mouse alpha-macroglobulins, lipoprotein receptor-related protein, LDL receptor, apolipoprotein E, and lipoprotein lipase in pregnancy.
L. Overbergh, K. Lorent, S. Torrekens, F. Van Leuven +1 more
1995Journal of Lipid Research32 citations
Semantic Scholar
Transcription factor onecut3 regulates intrahepatic biliary development in zebrafish
R. P. Matthews, K. Lorent, M. Pack
2008Developmental Dynamics30 citations
Semantic Scholar
Molecular cloning and sequencing of the murine alpha-2-macroglobulin receptor cDNA.
F. Van Leuven, Lou Stas, Lucie Raymakers, L. Overbergh +9 more
1993Biochimica et Biophysica Acta29 citations
Semantic Scholar
Biliatresone, a Reactive Natural Toxin from Dysphania glomulifera and D. littoralis: Discovery of the Toxic Moiety 1,2-Diaryl-2-Propenone
Kyung Ah Koo, K. Lorent, Weilong Gong, P. Windsor +4 more
2015Chemical Research in Toxicology25 citations Open access
Semantic Scholar
Identification of four genes coding for isoforms of murinoglobulin, the monomeric mouse alpha 2-macroglobulin: characterization of the exons coding for the bait region.
L. Overbergh, C. Hilliker, K. Lorent, F. Van Leuven +1 more
1994Genomics24 citations
Semantic Scholar
Transgenic mice expressing an alpha-secretion mutant of the amyloid precursor protein in the brain develop a progressive CNS disorder.
D. Moechars, K. Lorent, I. Dewachter, V. Baekelandt +2 more
1998Behavioural Brain Research23 citations
Semantic Scholar
Summary Zebrafish vps 33 b , an ortholog of the gene responsible for human arthrogryposis-renal dysfunction-cholestasis syndrome , regulates biliary development downstream of the onecut transcription factor hnf 6
R. P. Matthews, Nicolas Plumb-Rudewiez, K. Lorent, P. Gissen +3 more
200522 citations
Semantic Scholar
Impaired redox and protein homeostasis as risk factors and therapeutic targets in toxin-induced biliary atresia
Xiao Zhao, K. Lorent, D. Escobar-Zarate, R. Rajagopalan +9 more
2020Gastroenterology21 citations Open access
Semantic Scholar
Lipoprotein receptor-related protein in brain and in cultured neurons of mice deficient in receptor-associated protein and transgenic for apolipoprotein E4 or amyloid precursor protein.
L. Umans, L. Serneels, K. Lorent, I. Dewachter +3 more
1999Neuroscience11 citations
Semantic Scholar
Trypanosoma cruzi: acute infection affects expression of alpha-2-macroglobulin and A2MR/LRP receptor differently in C3H and C57BL/6 mice.
Maria de Nazaré C. Soeiro, Mauricio M. Paiva, M. Waghabi, Maria de Nazareth Meirelles +5 more
2000Experimental parasitology8 citations
Semantic Scholar
Differential expression of mRNA coding for the alpha-2-macroglobulin family and the LRP receptor system in C57BL/6J and C3H/HeJ male mice.
M. N. C. Correia Soeiro, M. M. Paiva, M. Waghabi, M. N. Meirelles +3 more
2001Cell Structure and Function6 citations Open access
Semantic Scholar
Molecular Analysis of the Human and Mouse α2M Family
F. Leuven, L. Umans, K. Lorent, C. Hilliker +4 more
19945 citations
Semantic Scholar
Characterization of the Genes Coding for the Murinoglobulins and Expression in Vivo
L. Overbergh, K. Lorent, C. Hilliker, F. Leuven
1994Annals of the New York Academy of Sciences4 citations
Semantic Scholar
The Tumor Suppressor Adenomatous Polyposis Coli (apc) Is Required for Neural Crest-Dependent Craniofacial Development in Zebrafish
Xiaolei Liu, W. D. Jones, Mathieu Quesnel-Vallières, Sudhish A. Devadiga +8 more
2023Journal of Developmental Biology2 citations Open access
Semantic Scholar
Protein Quality Control is a Risk Factor and Therapeutic Target in Toxin-Induced Biliary Atresia
Xiao Zhao, K. Lorent, D. Escobar-Zarate, R. Rajagopalan +9 more
2019bioRxiv1 citations Open access
Semantic Scholar
Disturbance of the glutamatergic system in mice transgenic for the amyloid precursor protein
V. Baekelandt, D. Moechars, I. Laenen, K. Lorent +1 more
19991 citations
Semantic Scholar
Expression of Mouse α2M and Its Receptor in Vivo
K. Lorent, L. Overbergh, F. Leuven
1994Annals of the New York Academy of Sciences1 citations
Semantic Scholar
Peer Review #1 of "Identification of HMMR as a prognostic biomarker for patients with lung adenocarcinoma via integrated bioinformatics analysis (v0.2)"
Zhao-Dong Li, Hong Fei, Si-Yu Lei, Feng-Tong Hao +380 more
20210 citations Open access
Semantic Scholar
Identification of novel phytotoxins from Australian range plants linked to severe mammalian digestive toxicity
K. Koo, M. Pack, R. Wells, K. Lorent +2 more
20120 citations
Semantic Scholar
PHENOTYPIC CHARACTERIZATION OF PEKIN, A NOVEL ZEBRAFISH MUTANT WITH DEFECTS IN BILE DUCT DEVELOPMENT AND PIGMENTATION
Liyuan Ma, K. Lorent, M. Pack, R. P. Matthews
2006Journal of Pediatric Gastroenterology and Nutrition - JPGN0 citations Open access
Semantic Scholar
Combining In Vitro Cell Biology and In Vivo Mouse Modelling to Study the Mechanisms Underlying Alzheimer’s Disease
B. de Strooper, D. Moechars, K. Lorent, I. Dewachter +1 more
19950 citations
Semantic Scholar
Expression of mouse alpha-macroglobulins, lipoprotein rece apolipoprotein E, and lipoprotein lipase in pregnancy r-related protein, LDL receptor,
Lut Overbrgh, K. Lorent, S. Torrekens, F. Van Leuven +1 more
19950 citations
Semantic Scholar
Molecular analysis of the human and mouse alpha 2M family.
F. Van Leuven, L. Umans, K. Lorent, C. Hilliker +4 more
1994Annals of the New York Academy of Sciences0 citations
Semantic Scholar

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