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T. Köhnke · SciRah

Researcher profile · Semantic Scholar

T. Köhnke

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T. Köhnke — researcher profile on SciRah

h-index: 21
Works: 66
Citations: 2,128

Most-cited papers

Coexpression profile of leukemic stem cell markers for combinatorial targeted therapy in AML
Sascha Haubner, F. Perna, T. Köhnke, C. Schmidt +15 more
2018Leukemia306 citations Open access
Semantic Scholar
Blockade of the PD-1/PD-L1 axis augments lysis of AML cells by the CD33/CD3 BiTE antibody construct AMG 330: reversing a T-cell-induced immune escape mechanism
C. Krupka, P. Kufer, R. Kischel, G. Zugmaier +13 more
2016Leukemia239 citations
Semantic Scholar
CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell-engaging antibody AMG 330.
C. Krupka, P. Kufer, R. Kischel, G. Zugmaier +11 more
2014Blood198 citations Open access
Semantic Scholar
Integrated analysis of patient samples identifies biomarkers for venetoclax efficacy and combination strategies in acute myeloid leukemia
Haijiao Zhang, Y. Nakauchi, T. Köhnke, M. Stafford +6 more
2020Nature Cancer181 citations
Semantic Scholar
Increase of PD-L1 expressing B-precursor ALL cells in a patient resistant to the CD19/CD3-bispecific T cell engager antibody blinatumomab
T. Köhnke, C. Krupka, J. Tischer, T. Knösel +1 more
2015Journal of Hematology & Oncology165 citations Open access
Semantic Scholar
Recent developments in immunotherapy of acute myeloid leukemia
F. Lichtenegger, C. Krupka, Sascha Haubner, T. Köhnke +1 more
2017Journal of Hematology & Oncology129 citations Open access
Semantic Scholar
Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia
M. Rothenberg-Thurley, S. Amler, D. Goerlich, T. Köhnke +14 more
2017Leukemia128 citations Open access
Semantic Scholar
Molecular response assessment by quantitative real-time polymerase chain reaction after induction therapy in NPM1-mutated patients identifies those at high risk of relapse
M. Hubmann, T. Köhnke, E. Hoster, S. Schneider +12 more
2014Haematologica89 citations Open access
Semantic Scholar
Single-cell mutational profiling enhances the clinical evaluation of AML MRD.
A. Ediriwickrema, A. Aleshin, Johannes G. Reiter, M. Corces +5 more
2020Blood Advances82 citations Open access
Semantic Scholar
Reduction of inflammation and chronic tissue damage by omega-3 fatty acids in fat-1 transgenic mice with pancreatitis
K. Weylandt, A. Nadolny, Lena Kahlke, T. Köhnke +5 more
2008Biochimica et Biophysica Acta76 citations Open access
Semantic Scholar
Virus infection in HLA-haploidentical hematopoietic stem cell transplantation: incidence in the context of immune recovery in two different transplantation settings
J. Tischer, N. Engel, S. Fritsch, D. Prevalsek +16 more
2015Annals of Hematology72 citations
Semantic Scholar
Early assessment of minimal residual disease in AML by flow cytometry during aplasia identifies patients at increased risk of relapse
T. Köhnke, D. Sauter, K. Ringel, E. Hoster +14 more
2014Leukemia60 citations
Semantic Scholar
Clonal hematopoiesis: from mechanisms to clinical intervention
T. Köhnke, R. Majeti
2021Cancer Discovery43 citations Open access
Semantic Scholar
Toll‐like receptor 7/8‐matured RNA‐transduced dendritic cells as post‐remission therapy in acute myeloid leukaemia: results of a phase I trial
F. Lichtenegger, Frauke M. Schnorfeil, M. Rothe, K. Deiser +18 more
2020Clinical & Translational Immunology37 citations Open access
Semantic Scholar
Targeting CD157 in AML using a novel, Fc-engineered antibody construct
C. Krupka, F. Lichtenegger, T. Köhnke, J. Bögeholz +13 more
2017OncoTarget36 citations Open access
Semantic Scholar
Immunotherapy for Acute Myeloid Leukemia.
F. Lichtenegger, C. Krupka, T. Köhnke, M. Subklewe
2015Seminars in hematology (Print)31 citations
Semantic Scholar
The TRACE-Seq method tracks recombination alleles and identifies clonal reconstitution dynamics of gene targeted human hematopoietic stem cells
Rajiv K. Sharma, D. Dever, Ciaran M. Lee, Armon Azizi +6 more
2021Nature Communications29 citations Open access
Semantic Scholar
Acetylsalicylic Acid Reduces the Severity of Dextran Sodium Sulfate-Induced Colitis and Increases the Formation of Anti-Inflammatory Lipid Mediators
T. Köhnke, Beate Gomolka, Süleyman Bilal, Xiangzhi Zhou +4 more
2013BioMed Research International27 citations Open access
Semantic Scholar
iData Mining for Mutation-Specific Targets in Acute Myeloid Leukemia
Brooks A. Benard, A. Gentles, T. Köhnke, R. Majeti +1 more
2019Leukemia24 citations Open access
Semantic Scholar
A Role for Lipid Mediators in Acute Myeloid Leukemia
A. Loew, T. Köhnke, Emma Rehbeil, A. Pietzner +1 more
2019International Journal of Molecular Sciences24 citations Open access
Semantic Scholar
Asparaginase activities during intensified treatment with pegylated E. coli asparaginase in adults with newly-diagnosed acute lymphoblastic leukemia
C. Lanvers-Kaminsky, A. Niemann, M. Eveslage, J. Beck +8 more
2020Leukemia and Lymphoma22 citations
Semantic Scholar
Human ASXL1-Mutant Hematopoiesis Is Driven by a Truncated Protein Associated with Aberrant Deubiquitination of H2AK119
T. Köhnke, Kevin A. Nuno, Catherine C. Alder, Eric J Gars +3 more
2024Blood Cancer Discovery20 citations Open access
Semantic Scholar
Integrated multiomic approach for identification of novel immunotherapeutic targets in AML
T. Köhnke, Xilong Liu, Sascha Haubner, V. Bücklein +5 more
2022Biomarker Research20 citations Open access
Semantic Scholar
A CEBPB/IL-1β/TNF-α Feedback Loop Drives Drug Resistance to Venetoclax and MDM2 Inhibitors in Monocytic Leukemia.
Basil Allen, D. Bottomly, T. Köhnke, Anthony Wang +26 more
2025Blood17 citations Open access
Semantic Scholar
MYELOID NEOPLASIA CD 33 target validation and sustained depletion of AML blasts in long-term cultures by the bispeci fi c T-cell – engaging antibody AMG 330
C. Krupka, P. Kufer, R. Kischel, G. Zugmaier +11 more
201313 citations
Semantic Scholar
Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia.
M. Rothenberg-Thurley, S. Amler, D. Goerlich, T. Köhnke +14 more
2017Leukemia10 citations Open access
Semantic Scholar
Induction of Antigen-Specific T-Cell Responses through Dendritic Cell Vaccination in AML: Results of a Phase I/II Trial and Ex Vivo Enhancement By Checkpoint Blockade
F. Lichtenegger, K. Deiser, M. Rothe, Frauke M. Schnorfeil +14 more
20168 citations
Semantic Scholar
Engineering Oncogenic Heterozygous Gain-of-Function Mutations in Human Hematopoietic Stem and Progenitor Cells.
Tommaso Sconocchia, Johannes Foßelteder, T. Köhnke, R. Majeti +1 more
2023Journal of Visualized Experiments6 citations
Semantic Scholar
PD-1/PD-L1 Blocking Enhances CD33/CD3-Bispecific BiTE® Antibody (AMG 330) Mediated Lysis of Primary AML Cells
C. Krupka, P. Kufer, R. Kischel, G. Zugmaier +14 more
20145 citations
Semantic Scholar
A single-cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis
A. Ediriwickrema, Yusuke Nakauchi, Amy Fan, T. Köhnke +11 more
2025Cell Reports4 citations Open access
Semantic Scholar
Targeting AML Using an Fc-Engineered BST1/CD157 Monoclonal Antibody
C. Krupka, A. Jansen, I. Lassmann, J. Terrett +13 more
20144 citations
Semantic Scholar
Next-generation dendritic cells for immunotherapy of acute myeloid leukemia
Frauke M. Schnorfeil, F. Lichtenegger, Christiane Geiger, T. Köhnke +9 more
2014Journal of Immunotherapy for Cancer4 citations Open access
Semantic Scholar
Evaluation Of CD33 Expression and Functional Analysis Of The CD33/CD3 Bispecific BiTE® Antibody AMG 330 In Primary AML Samples
P. Kufer, R. Kischel, G. Zugmaier, J. Boegeholz +10 more
20134 citations
Semantic Scholar
Response assessment in acute myeloid leukemia by flow cytometry supersedes cytomorphology at time of aplasia, amends cases without molecular residual disease marker and serves as an independent prognostic marker at time of aplasia and post-induction
T. Köhnke, V. Bücklein, Sandra Rechkemmer, S. Schneider +6 more
2019Haematologica3 citations Open access
Semantic Scholar
Hydroxyurea Is Most Suitable for Cytoreduction of AML Prior to CD33/CD3 Bispecific BiTE® Antibody (AMG 330) Therapy: Uncompromised T-Cell Proliferation Ex-Vivo and CD33 Upregulation on AML Cells
C. Krupka, F. Brauneck, F. Lichtenegger, P. Kufer +14 more
20143 citations
Semantic Scholar
A Combined Score of Minimal Residual Disease (MRD) Assessment by Flow Cytometry, Cytogenetic and Molecular Markers As Well As Age Predicts Outcome and Can Potentially Guide MRD-Based Therapy in Acute Myeloid Leukemia
T. Köhnke, D. Sauter, Katharina Ringel, J. Braess +3 more
20112 citations
Semantic Scholar
A single cell framework identifies functionally and molecularly distinct multipotent progenitors in adult human hematopoiesis
A. Ediriwickrema, Yusuke Nakauchi, Amy C. Fan, T. Köhnke +11 more
2024bioRxiv1 citations Open access
Semantic Scholar
TRACE-Seq Reveals Clonal Reconstitution Dynamics of Gene Targeted Human Hematopoietic Stem Cells
Rajiv K. Sharma, D. Dever, Ciaran M. Lee, Armon Azizi +6 more
2020bioRxiv1 citations Open access
Semantic Scholar
Haploidentical Stem Cell Transplantation in ALL
J. Tischer, A. Zoellner, D. Prevalsek, T. Köhnke +14 more
20171 citations
Semantic Scholar
Steroids Abrogate BiTE® Antibody Construct-Mediated Cytotoxicity in Primary AML Cells
C. Krupka, Bettina Lindl, T. Köhnke, J. Platzer +7 more
20161 citations
Semantic Scholar
Improved Detection of Minimal Residual Disease By Flow Cytometry in AML By Combining Manual Gating and Visne Clustering
T. Köhnke, Sandra Rechkemmer, V. Bücklein, K. Pfannes +4 more
20151 citations
Semantic Scholar
Identifying Immune Resistance Mechanisms to CD33/CD3 BiTE® Antibody Construct (AMG 330) Mediated Cytotoxicity
C. Krupka, T. Köhnke, P. Kufer, R. Kischel +6 more
20151 citations
Semantic Scholar
Single cell multi-omics enables high-resolution identification and functional purification of human acute myeloid leukemia stem cells
A. Ediriwickrema, Yusuke Nakauchi, T. Köhnke, Amy C. Fan +7 more
2026bioRxiv0 citations Open access
Semantic Scholar
3066 – IDENTIFICATION AND CHARACTERIZATION OF NEW MULTIPOTENT PROGENITORS IN ADULT HUMAN HEMATOPOIESIS
A. Ediriwickrema, Yusuke Nakauchi, Amy Fan, T. Köhnke +11 more
2024Experimental Hematology0 citations Open access
Semantic Scholar
Convergent Epigenetic Evolution Drives Relapse in Acute Myeloid Leukemia
Kevin A. Nuno, Armon Azizi, T. Köhnke, Caleb A. Lareau +4 more
2023bioRxiv0 citations Open access
Semantic Scholar
Integrated multiomic approach for identification of novel immunotherapeutic targets in AML
T. Köhnke, Xilong Liu, Sascha Haubner, V. Bücklein +5 more
2022Biomarker Research0 citations Open access
Semantic Scholar
3153 – CHROMATIN ACCESSIBILITY ANALYSIS REVEALS EPIGENETIC EVOLUTION IS A COMMON MECHANISM OF RELAPSE IN ACUTE MYELOID LEUKEMIA
Kevin A. Nuno, Armon Azizi, T. Köhnke, C. Lareau +3 more
2022Experimental Hematology0 citations Open access
Semantic Scholar
3027 – SINGLE-CELL CHROMATIN ACCESSIBILITY ANALYSIS IDENTIFIES EPIGENETIC EVOLUTION IN RELAPSED ACUTE MYELOID LEUKEMIA
Kevin A. Nuno, Armon Azizi, T. Köhnke, R. Majeti
2021Experimental Hematology0 citations Open access
Semantic Scholar
Abstract 1505: Reprogramming cancer into antigen presenting cells as a novel immunotherapy
Miles Linde, Sarah Gurev, Paul Phan, Feifei Zhao +11 more
2021Immunology0 citations
Semantic Scholar
Minimal Residual Disease (MRD) Detection By Flow Cytometry Complements Molecular MRD Assessment in AML
V. Bücklein, T. Köhnke, Frauke M. Schnorfeil, K. Metzeler +6 more
2018Blood0 citations Open access
Semantic Scholar

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