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L. Nangle · SciRah

Researcher profile · Semantic Scholar

L. Nangle

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L. Nangle — researcher profile on SciRah

h-index: 18
Works: 54
Citations: 2,172

Most-cited papers

Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration
J. W. Lee, K. Beebe, L. Nangle, Jaeseon Jang +6 more
2006Nature606 citations
Semantic Scholar
An active dominant mutation of glycyl-tRNA synthetase causes neuropathy in a Charcot-Marie-Tooth 2D mouse model.
K. Seburn, L. Nangle, G. Cox, P. Schimmel +1 more
2006Neuron212 citations Open access
Semantic Scholar
Enlarging the Amino Acid Set of Escherichia coli by Infiltration of the Valine Coding Pathway
V. Döring, H. Mootz, L. Nangle, T. Hendrickson +3 more
2001Science173 citations
Semantic Scholar
Charcot–Marie–Tooth disease-associated mutant tRNA synthetases linked to altered dimer interface and neurite distribution defect
L. Nangle, Wei Zhang, W. Xie, Xiang-Lei Yang +1 more
2007Proceedings of the National Academy of Sciences of the United States of America143 citations Open access
Semantic Scholar
Global effects of mistranslation from an editing defect in mammalian cells.
L. Nangle, Candace Motta, P. Schimmel
2006Chemistry and Biology125 citations Open access
Semantic Scholar
Human tRNA Synthetase Catalytic Nulls with Diverse Functions
W. Lo, Elisabeth Gardiner, Zhi-Wen Xu, C. Lau +11 more
2014Science120 citations Open access
Semantic Scholar
Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot–Marie–Tooth neuropathy
E. Storkebaum, R. Leitão-Gonçalves, T. Godenschwege, L. Nangle +11 more
2009Proceedings of the National Academy of Sciences of the United States of America108 citations Open access
Semantic Scholar
Long-range structural effects of a Charcot–Marie–Tooth disease-causing mutation in human glycyl-tRNA synthetase
W. Xie, L. Nangle, Wei Zhang, P. Schimmel +1 more
2007Proceedings of the National Academy of Sciences of the United States of America90 citations Open access
Semantic Scholar
Deficiencies in tRNA synthetase editing activity cause cardioproteinopathy
Ye Liu, J. Satz, M. Vo, L. Nangle +2 more
2014Proceedings of the National Academy of Sciences of the United States of America84 citations Open access
Semantic Scholar
Orthogonal use of a human tRNA synthetase active site to achieve multi-functionality
Quan-Sheng Zhou, M. Kapoor, M. Guo, R. Belani +9 more
2009Nature Structural &Molecular Biology75 citations Open access
Semantic Scholar
Genetic Code Ambiguity
L. Nangle, V. de Crécy-Lagard, V. Döring, P. Schimmel
2002Journal of Biological Chemistry69 citations Open access
Semantic Scholar
Secreted Histidyl-tRNA Synthetase Splice Variants Elaborate Major Epitopes for Autoantibodies in Inflammatory Myositis*
Jie J. Zhou, Feng Wang, Zhi-Wen Xu, W. Lo +8 more
2014Journal of Biological Chemistry52 citations Open access
Semantic Scholar
Bi-allelic Mutations in Phe-tRNA Synthetase Associated with a Multi-system Pulmonary Disease Support Non-translational Function
Zhi-Wen Xu, W. Lo, David B. Beck, Luise A. Schuch +29 more
2018American Journal of Human Genetics49 citations Open access
Semantic Scholar
Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer
Zhi-Wen Xu, H. Goel, C. Burkart, L. Burman +19 more
2023Science Translational Medicine40 citations Open access
Semantic Scholar
Internally deleted human tRNA synthetase suggests evolutionary pressure for repurposing
Zhi-Wen Xu, Zhiyi Wei, Jie J. Zhou, F. Ye +9 more
2012Structure37 citations Open access
Semantic Scholar
Genetic Code Ambiguity CELL VIABILITY RELATED TO SEVERITY OF EDITING DEFECTS IN MUTANT tRNA SYNTHETASES*
L. Nangle, V. de Crécy-Lagard, V. Döring, P. Schimmel
200237 citations
Semantic Scholar
Serum-circulating His-tRNA synthetase inhibits organ-targeted immune responses
R. Adams, C. Fernandes-Cerqueira, A. Notarnicola, E. Mertsching +14 more
2019Cellular & Molecular Immunology35 citations Open access
Semantic Scholar
Regulated Capture by Exosomes of mRNAs for Cytoplasmic tRNA Synthetases*
Feng Wang, Zhi-Wen Xu, Jie Zhou, W. Lo +5 more
2013Journal of Biological Chemistry22 citations Open access
Semantic Scholar
Efzofitimod: a novel anti-inflammatory agent for sarcoidosis
R. Baughman, V. Niranjan, Gennyne A. Walker, C. Burkart +11 more
2023Sarcoidosis Vasculities and Diffuse Lung Diseases17 citations
Semantic Scholar
A human histidyl-tRNA synthetase splice variant therapeutic targets NRP2 to resolve lung inflammation and fibrosis.
L. Nangle, Zhi-Wen Xu, D. Siefker, C. Burkart +23 more
2025Science Translational Medicine11 citations
Semantic Scholar
Tetrahymena macronuclear genome mapping: colinearity Of macronuclear coassortment groups and the micronuclear map on chromosome 1l.
Steve Wickert, L. Nangle, Steve Shevel, Eduardo Orias
2000Genetics11 citations
Semantic Scholar
Orchestrating Resilience: How Neuropilin-2 and Macrophages Contribute to Cardiothoracic Disease
R. Dhupar, A. Powers, S. Eisenberg, R. Gemmill +5 more
2024Journal of Clinical Medicine8 citations Open access
Semantic Scholar
Isolation of monoclonal antibodies from anti-synthetase syndrome patients and affinity maturation by recombination of independent somatic variants
L. Burman, Y. Chong, Sherie K. Duncan, Anders Klaus +9 more
2020mAbs8 citations Open access
Semantic Scholar
Development and Characterization of a Novel Neuropilin-2 Antibody for Immunohistochemical Staining of Cancer and Sarcoidosis Tissue Samples
S. Förster, Y. Chong, D. Siefker, Y. Becker +10 more
2023Monoclonal antibodies in immunodiagnosis and immunotherapy7 citations
Semantic Scholar
Neuropilin-2, the Specific Binding Partner to ATYR1923, Is Expressed in Sarcoid Granulomas and Key Immune Cells
S. Paz, D. Chu, M. Ferrer, S. Crampton +4 more
20207 citations
Semantic Scholar
Alternative splicing creates two new architectures for human tyrosyl-tRNA synthetase
Zhiyi Wei, Zhi-Wen Xu, Xiaotian Liu, W. Lo +8 more
2016Nucleic Acids Research6 citations Open access
Semantic Scholar
Late Breaking Abstract - Immunomodulatory protein ATYR1923 disrupts an in vitro model of sarcoid granuloma formation
S. Paz, M. Julian, D. Siefker, E. Escobedo +7 more
2021Sarcoidosis and other granulomatous ILD / DPLD5 citations
Semantic Scholar
ATYR1923 Specifically Binds to Neuropilin-2, a Novel Therapeutic Target for the Treatment of Immune-Mediated Diseases
Z. Xu, Y. Chong, S. Crampton, R. Adams +9 more
20204 citations
Semantic Scholar
Resolaris, a potential therapeutic for rare myopathies with an immune component
J. Mckew, M. Ashlock, Kathy Ogilvie, L. Nangle +11 more
20153 citations
Semantic Scholar
Histidine Supplementation Stabilizes Hearing and Vision and Improves Growth in HARS1‐Related Autosomal Recessive Disorder Associated With Usher‐Like Symptoms
V. Siu, R. Kenana, R. Chakrabarti, Sarah D. P. Wilhelm +20 more
2026American Journal of Medical Genetics. Part A2 citations Open access
Semantic Scholar
Efzofitimod: a novel therapeutic candidate for SSc-ILD
D. Siefker, Zhi-Wen Xu, M. Ferrer, Elizabeth Yu +4 more
2023ILD/DPLD of known origin1 citations
Semantic Scholar
A novel neuropilin-2 (NRP2) antibody for immunohistochemical staining of patient tissue samples
Y. Chong, S. Förster, D. Siefker, Y. Becker +8 more
202203.03 - Mechanisms of lung injury and repair1 citations
Semantic Scholar
699 ATYR2810 an anti-NRP2 monoclonal antibody targets tumor-associated macrophages
S. Tyler, M. Ferrer, E. Escobedo, K. Rauch +6 more
2021Journal for ImmunoTherapy of Cancer1 citations Open access
Semantic Scholar
Identification of a T cell immunomodulatory domain in histidyl-tRNA synthetase
E. Mertsching, J. Ampudia, R. Adams, S. Rosengren +6 more
2018Journal of Immunology1 citations
Semantic Scholar
Abstract 3834: Antibodies targeting Resokine, a soluble immune modulator, inhibit tumor growth in syngeneic mouse models
K. Ogilvie, C. Ng, L. Nangle, J. Ampudia +4 more
2018Immunology1 citations
Semantic Scholar
Natural Asp-tRNA Synthetase Fragment Targets Myofibroblasts to Abrogate Tissue Fibrosis.
R. Adams, Ying-Ting Wang, Alison G. Barber, Kristina Hamel +24 more
2026Journal of Biological Chemistry0 citations Open access
Semantic Scholar
Abstract 4791: Immunosuppressive myeloid cells can be modulated with NRP2-targeting antibody ATYR2810 leading to enhanced anti-tumor immunity
C. Burkart, Clara Polizzi, John Choi, M. Pastenes +3 more
2025Cancer Research0 citations
Semantic Scholar
A bispecific antibody designed to act as a NRP2/PLXNA1 agonist mimics anticancer activity of SEMA3F
Hong-Lei Tian, Chun-Po Fung, L. Burman, Y. Chong +11 more
2025Journal of Biological Chemistry0 citations
Semantic Scholar
Efzofitimod Is an Immunomodulator of Myeloid Cell Function and Novel Therapeutic Candidate for Interstitial Lung Diseases
D. Siefker, Z. Xu, C. Burkhart, C. Pilozzi +7 more
2024A102. EVALUATING THE INTERSECTION BETWEEN AUTOIMMUNITY, IMMUNODEFICIENCY, AND INTERSTITIAL LUNG DISEASES0 citations
Semantic Scholar
Abstract 1758: Resistance to cancer therapy via upregulation of the NRP2/VEGF-C axis can be neutralized by ATYR2810
Alison G. Barber, Zhiwen Xu, L. Eide, Clara Polizzi +11 more
2023Cancer Research0 citations
Semantic Scholar
Efzofitimod, a Novel Immunomodulator for Pulmonary Sarcoidosis, Modulates Patient Inflammatory Responses Through Myeloid Cells
D. Siefker, S. Paz, S. Tyler, M. Ferrer +11 more
2023B93. BREAKTHROUGHS IN ILD: TRANSLATION TO THE BEDSIDE0 citations
Semantic Scholar
Abstract LB085: ATYR2810, a fully humanized monoclonal antibody targeting the VEGF-NRP2 pathway sensitizes highly aggressive and chemoresistant TNBC subtypes to chemotherapy
Zhi-Wen Xu, Alison G. Barber, C. Burkart, H. Goel +12 more
2022Cancer Research0 citations
Semantic Scholar
Abstract LB095: A domain-specific antibody to NRP2 down-regulated epithelial-mesenchymal transition genes and enhanced efficacy of standard-of-care therapeutics for aggressive breast cancer
Zhi-Wen Xu, C. Burkart, H. Goel, Justin Rahman +5 more
2021Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract LB234: The Neuropilin-2 targeting antibody ATYR2810 inhibits non-small cell lung cancer tumor growth in monotherapy and combination therapy
Alison G. Barber, Zhi-Wen Xu, Justin Rahman, H. Goel +3 more
2021Tumor Biology0 citations
Semantic Scholar
Late Breaking Abstract - Treatment with ATYR1923 reduces biomarkers in COVID-19 pneumonia
R. Adams, Gennyne A. Walker, L. Guy, Lauren Sitts +4 more
2021Clinical problems0 citations
Semantic Scholar
Abstract 1785: Domain-specific antibodies to Neuropilin 2 implicate VEGF-C and not Semaphorin 3F in breast cancer stem cell function
L. Nangle, L. Burman, H. Goel, Zhi-Wen Xu +3 more
2020Experimental and Molecular Therapeutics0 citations
Semantic Scholar
Abstract 2728: Circulating levels of Resokine, a soluble modulator of the immune system, are upregulated in both experimental cancer models and in patients across multiple tumor types
R. Adams, E. Mertsching, L. Nangle, K. Ogilvie +7 more
2018Immunology0 citations
Semantic Scholar
Identification of novel liquid biopsy biomarker for monitoring the immune set point in both solid tumor and hematological malignancy patients.
D. King, R. Adams, L. Nangle, E. Mertsching +3 more
20180 citations
Semantic Scholar
Autoantibodies in Inflammatory Myositis Variants Elaborate Major Epitopes for Secreted Histidyl-tRNA Synthetase Splice Reports:
Mingjie Zhang, A. Schimmel, J. Mendlein, Xiang-Lei Yang +5 more
20140 citations
Semantic Scholar
CS6-5 A new class of cell signaling molecules derived from aminoacyl-tRNA synthetases
Xiang-Lei Yang, Quan-Sheng Zhou, M. Kapoor, M. Guo +9 more
20100 citations
Semantic Scholar

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