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M. Bertoldi · SciRah

Researcher profile · Semantic Scholar

M. Bertoldi

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M. Bertoldi — researcher profile on SciRah

h-index: 25
Works: 93
Citations: 2,270

Most-cited papers

Pyridoxal 5'-phosphate enzymes as targets for therapeutic agents.
Alessio Amadasi, M. Bertoldi, R. Contestabile, S. Bettati +5 more
2007Current Medicinal Chemistry190 citations
Semantic Scholar
Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice
S. S. Franco, L. De Falco, S. Ghaffari, C. Brugnara +13 more
2014Haematologica114 citations Open access
Semantic Scholar
Human wild-type alanine:glyoxylate aminotransferase and its naturally occurring G82E variant: functional properties and physiological implications.
B. Cellini, M. Bertoldi, R. Montioli, A. Paiardini +1 more
2007Biochemical Journal109 citations Open access
Semantic Scholar
Mammalian Dopa decarboxylase: structure, catalytic activity and inhibition.
M. Bertoldi
2014Archives of Biochemistry and Biophysics106 citations
Semantic Scholar
Protective Effect of Epigallocatechin-3-Gallate (EGCG) in Diseases with Uncontrolled Immune Activation: Could Such a Scenario Be Helpful to Counteract COVID-19?
M. Menegazzi, Rachele Campagnari, M. Bertoldi, R. Crupi +2 more
2020International Journal of Molecular Sciences95 citations Open access
Semantic Scholar
Membrane association of peroxiredoxin-2 in red cells is mediated by the N-terminal cytoplasmic domain of band 3.
A. Matte, M. Bertoldi, N. Mohandas, X. An +8 more
2013Free Radical Biology & Medicine85 citations Open access
Semantic Scholar
Oxidative stress modulates heme synthesis and induces peroxiredoxin-2 as a novel cytoprotective response in β-thalassemic erythropoiesis
L. De Franceschi, M. Bertoldi, L. De Falco, Sara Santos Franco +6 more
2011Haematologica83 citations Open access
Semantic Scholar
Oxidative Stress and β-Thalassemic Erythroid Cells behind the Molecular Defect
L. De Franceschi, M. Bertoldi, A. Matte, Sara Santos Franco +3 more
2013Oxidative Medicine and Cellular Longevity81 citations Open access
Semantic Scholar
Aromatic amino acid decarboxylase deficiency: Molecular and metabolic basis and therapeutic outlook.
N. Himmelreich, R. Montioli, M. Bertoldi, C. Carducci +8 more
2019Molecular Genetics and Metabolism79 citations Open access
Semantic Scholar
Erythrocyte membrane changes of chorea-acanthocytosis are the result of altered Lyn kinase activity.
L. De Franceschi, Carlo Tomelleri, A. Matte, A. Brunati +12 more
2011Blood75 citations Open access
Semantic Scholar
Peroxiredoxin-2 expression is increased in β-thalassemic mouse red cells but is displaced from the membrane as a marker of oxidative stress
A. Matte, P. Low, F. Turrini, M. Bertoldi +5 more
2010Free Radical Biology & Medicine69 citations Open access
Semantic Scholar
Mutation of Tyrosine 332 to Phenylalanine Converts Dopa Decarboxylase into a Decarboxylation-dependent Oxidative Deaminase*
M. Bertoldi, M. Gonsalvi, R. Contestabile, C. Voltattorni
2002Journal of Biological Chemistry68 citations Open access
Semantic Scholar
A new molecular link between defective autophagy and erythroid abnormalities in chorea-acanthocytosis.
F. Lupo, E. Tibaldi, A. Matte, Alok K. Sharma +13 more
2016Blood66 citations Open access
Semantic Scholar
Reaction Specificity of Native and Nicked 3,4-Dihydroxyphenylalanine Decarboxylase*
M. Bertoldi, P. Frigeri, M. Paci, C. Voltattorni
1999Journal of Biological Chemistry45 citations Open access
Semantic Scholar
Spectroscopic and kinetic analyses reveal the pyridoxal 5'-phosphate binding mode and the catalytic features of Treponema denticola cystalysin.
M. Bertoldi, B. Cellini, T. Clausen, C. Voltattorni
2002Biochemistry43 citations
Semantic Scholar
Does the aromatic L-amino acid decarboxylase contribute to thyronamine biosynthesis?
C. S. Hoefig, K. Renko, S. Piehl, T. Scanlan +7 more
2012Molecular and Cellular Endocrinology38 citations
Semantic Scholar
Structural properties of trimers and tetramers of ribonuclease A
Arianna Nenci, G. Gotte, M. Bertoldi, M. Libonati
2001Protein Science38 citations Open access
Semantic Scholar
Reaction of dopa decarboxylase with L-aromatic amino acids under aerobic and anaerobic conditions.
M. Bertoldi, C. Voltattorni
2000Biochemical Journal37 citations Open access
Semantic Scholar
Reaction of dopa decarboxylase with alpha-methyldopa leads to an oxidative deamination producing 3,4-dihydroxyphenylacetone, an active site directed affinity label.
M. Bertoldi, P. Dominici, Patrick S. Moore, Bruno Maras +1 more
1998Biochemistry36 citations
Semantic Scholar
The novel role of peroxiredoxin-2 in red cell membrane protein homeostasis and senescence.
A. Matte, Antonella Pantaleo, E. Ferru, F. Turrini +5 more
2014Free Radical Biology & Medicine33 citations
Semantic Scholar
Pharmacological inhibition of calpain‐1 prevents red cell dehydration and reduces Gardos channel activity in a mouse model of sickle cell disease
L. De Franceschi, R. Franco, M. Bertoldi, C. Brugnara +5 more
2013The FASEB Journal32 citations Open access
Semantic Scholar
Deoxygenation affects tyrosine phosphoproteome of red cell membrane from patients with sickle cell disease.
A. Siciliano, F. Turrini, M. Bertoldi, A. Matte +3 more
2010Blood Cells, Molecules & Diseases32 citations
Semantic Scholar
Parkinson's Disease: Recent Updates in the Identification of Human Dopa Decarboxylase Inhibitors.
R. Montioli, C. Voltattorni, M. Bertoldi
2016Current drug metabolism27 citations
Semantic Scholar
Ornithine and glutamate decarboxylases catalyse an oxidative deamination of their alpha-methyl substrates.
M. Bertoldi, V. Carbone, C. Voltattorni
1999Biochemical Journal27 citations Open access
Semantic Scholar
Multiple roles of the active site lysine of Dopa decarboxylase.
M. Bertoldi, C. Voltattorni
2009Archives of Biochemistry and Biophysics25 citations
Semantic Scholar
Insights into the mechanism of oxidative deamination catalyzed by DOPA decarboxylase.
M. Bertoldi, B. Cellini, R. Montioli, Carla Borri Voltattorni
2008Biochemistry25 citations
Semantic Scholar
Prevalence of DDC genotypes in patients with aromatic L-amino acid decarboxylase (AADC) deficiency and in silico prediction of structural protein changes.
N. Himmelreich, M. Bertoldi, M. Alfadhel, M. Alghamdi +46 more
2023Molecular Genetics and Metabolism24 citations Open access
Semantic Scholar
Aromatic l-amino acid decarboxylase deficiency: a patient-derived neuronal model for precision therapies
G. Rossignoli, Karolina Krämer, Eleonora Lugarà, H. Alrashidi +11 more
2021Brain : a journal of neurology24 citations Open access
Semantic Scholar
Dimerization and folding processes of Treponema denticola cystalysin: the role of pyridoxal 5'-phosphate.
B. Cellini, M. Bertoldi, R. Montioli, D. Laurents +2 more
2006Biochemistry24 citations
Semantic Scholar
New variants of AADC deficiency expand the knowledge of enzymatic phenotypes.
R. Montioli, Giovanni Bisello, Mirco Dindo, G. Rossignoli +2 more
2020Archives of Biochemistry and Biophysics23 citations Open access
Semantic Scholar
The novel R347g pathogenic mutation of aromatic amino acid decarboxylase provides additional molecular insights into enzyme catalysis and deficiency.
R. Montioli, A. Paiardini, M. Kurian, Mirco Dindo +5 more
2016Biochimica et Biophysica Acta22 citations Open access
Semantic Scholar
Oxygen reactivity with pyridoxal 5′-phosphate enzymes: biochemical implications and functional relevance
Giovanni Bisello, C. Longo, G. Rossignoli, R. Phillips +1 more
2020Amino Acids21 citations Open access
Semantic Scholar
Folding pathway of the pyridoxal 5'-phosphate C-S lyase MalY from Escherichia coli.
M. Bertoldi, B. Cellini, D. Laurents, Carla Borri Voltattorni
2005Biochemical Journal21 citations Open access
Semantic Scholar
Mutation of cysteine 111 in Dopa decarboxylase leads to active site perturbation
P. Dominici, P. Moore, Silvia Castellani, M. Bertoldi +1 more
1997Protein Science21 citations Open access
Semantic Scholar
The Presence and Severity of Epilepsy Coincide with Reduced GABA and Cortical Excitatory Markers in SSADH Deficiency
I. T. Latzer, M. Bertoldi, M. DiBacco, E. Arning +12 more
2023Epilepsia20 citations Open access
Semantic Scholar
A novel compound heterozygous genotype associated with aromatic amino acid decarboxylase deficiency: Clinical aspects and biochemical studies.
R. Montioli, R. Battini, A. Paiardini, M. Tolve +4 more
2019Molecular Genetics and Metabolism20 citations
Semantic Scholar
Human Peroxiredoxins 1 and 2 and Their Interacting Protein Partners; Through Structure Toward Functions of Biological Complexes.
M. Bertoldi
2015Protein Peptide Letters20 citations
Semantic Scholar
A quinonoid is an intermediate of oxidative deamination reaction catalyzed by Dopa decarboxylase
M. Bertoldi, B. Cellini, B. Maras, C. Voltattorni
2005FEBS Letters20 citations
Semantic Scholar
Probing the role of Tyr 64 of Treponema denticola cystalysin by site-directed mutagenesis and kinetic studies.
B. Cellini, M. Bertoldi, R. Montioli, Carla Borri Voltattorni
2005Biochemistry19 citations
Semantic Scholar
Reaction and substrate specificity of recombinant pig kidney Dopa decarboxylase under aerobic and anaerobic conditions.
M. Bertoldi, Carla Borri Voltattorni
2003Biochimica et Biophysica Acta19 citations
Semantic Scholar
Treponema denticola cystalysin catalyzes β‐desulfination of L‐cysteine sulfinic acid and β‐decarboxylation of L‐aspartate and oxalacetate
B. Cellini, M. Bertoldi, Carla Borri Voltattorni
200318 citations Open access
Semantic Scholar
Unique substrate specificity of ornithine aminotransferase from Toxoplasma gondii.
A. Astegno, E. Maresi, M. Bertoldi, V. la Verde +2 more
2017Biochemical Journal17 citations
Semantic Scholar
Treponema denticola cystalysin exhibits significant alanine racemase activity accompanied by transamination: mechanistic implications.
M. Bertoldi, B. Cellini, A. Paiardini, M. di Salvo +1 more
2003Biochemical Journal17 citations Open access
Semantic Scholar
New Insights Emerging from Recent Investigations on Human Group II Pyridoxal 5'-Phosphate Decarboxylases.
A. Paiardini, G. Giardina, G. Rossignoli, C. Voltattorni +1 more
2017Current Medicinal Chemistry16 citations
Semantic Scholar
Consensus guidelines for the diagnosis and management of succinic semialdehyde dehydrogenase deficiency
I. T. Latzer, M. Bertoldi, N. Blau, M. DiBacco +20 more
2024Molecular Genetics and Metabolism15 citations Open access
Semantic Scholar
Autism spectrum disorder and GABA levels in children with succinic semialdehyde dehydrogenase deficiency
Itay Tokatly Latzer, E. Hanson, M. Bertoldi, Á. García-Cazorla +16 more
2023Developmental Medicine & Child Neurology14 citations Open access
Semantic Scholar
Compound heterozygosis in AADC deficiency: A complex phenotype dissected through comparison among heterodimeric and homodimeric AADC proteins.
C. Longo, R. Montioli, Giovanni Bisello, L. Palazzi +6 more
2021Molecular Genetics and Metabolism14 citations Open access
Semantic Scholar
Heterozygosis in aromatic amino acid decarboxylase deficiency: Evidence for a positive interallelic complementation between R347Q and R358H mutations
R. Montioli, G. Janson, A. Paiardini, M. Bertoldi +1 more
2018IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology14 citations Open access
Semantic Scholar
Dopa decarboxylase exhibits low pH half‐transaminase and high pH oxidative deaminase activities toward serotonin (5‐hydroxytryptamine)
M. Bertoldi, C. Voltattorni
2001Protein Science14 citations Open access
Semantic Scholar
Aromatic amino acid methyl ester analogs form quinonoidal species with Dopa decarboxylase
P. Moore, M. Bertoldi, P. Dominici, Carla Borri Voltattorni
1997FEBS Letters14 citations Open access
Semantic Scholar

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