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T. Higashi · SciRah

Researcher profile · Semantic Scholar

T. Higashi

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T. Higashi — researcher profile on SciRah

h-index: 29
Works: 112
Citations: 3,751

Most-cited papers

Hepatic stellate cells as key target in liver fibrosis
T. Higashi, S. Friedman, Y. Hoshida
2017Advanced Drug Delivery Reviews1,321 citations Open access
Semantic Scholar
Molecular liver cancer prevention in cirrhosis by organ transcriptome analysis and lysophosphatidic acid pathway inhibition
S. Nakagawa, Lan Wei, Won-min Song, T. Higashi +41 more
2016Cancer Cell190 citations Open access
Semantic Scholar
MRI radiomics features predict immuno-oncological characteristics of hepatocellular carcinoma
S. Hectors, Sara C. Lewis, Cecilia Besa, M. King +12 more
2020European Radiology147 citations Open access
Semantic Scholar
CONUT: a novel independent predictive score for colorectal cancer patients undergoing potentially curative resection
R. Tokunaga, Y. Sakamoto, S. Nakagawa, M. Ohuchi +9 more
2016International Journal of Colorectal Disease139 citations
Semantic Scholar
An Imbalance in TAZ and YAP Expression in Hepatocellular Carcinoma Confers Cancer Stem Cell-like Behaviors Contributing to Disease Progression.
H. Hayashi, T. Higashi, Naomi Yokoyama, T. Kaida +10 more
2015Cancer Research136 citations Open access
Semantic Scholar
miR-9-3p plays a tumour-suppressor role by targeting TAZ (WWTR1) in hepatocellular carcinoma cells
T. Higashi, H. Hayashi, T. Ishimoto, Hideaki Takeyama +11 more
2015British Journal of Cancer104 citations Open access
Semantic Scholar
Molecular signatures of long-term hepatocellular carcinoma risk in non-alcoholic fatty liver disease
N. Fujiwara, Naoto Kubota, E. Crouchet, Bhuvaneswari Koneru +37 more
2022Science Translational Medicine100 citations Open access
Semantic Scholar
12-Chemokine signature, a predictor of tumor recurrence in colorectal cancer
R. Tokunaga, S. Nakagawa, Y. Sakamoto, Kenichi Nakamura +10 more
2020International Journal of Cancer72 citations Open access
Semantic Scholar
The Prognostic Impact of Controlling Nutritional Status (CONUT) in Intrahepatic Cholangiocarcinoma Following Curative Hepatectomy: A Retrospective Single Institution Study
Tatsunori Miyata, Y. Yamashita, T. Higashi, K. Taki +9 more
2018World Journal of Surgery63 citations
Semantic Scholar
Comparison of systemic inflammatory and nutritional scores in colorectal cancer patients who underwent potentially curative resection
R. Tokunaga, Y. Sakamoto, S. Nakagawa, D. Izumi +7 more
2017International Journal of Clinical Oncology61 citations
Semantic Scholar
Statin attenuates cell proliferative ability via TAZ (WWTR1) in hepatocellular carcinoma
T. Higashi, H. Hayashi, Yuki Kitano, Kensuke Yamamura +11 more
2016Medical Oncology52 citations
Semantic Scholar
Sarcopenia, but not visceral fat amount, is a risk factor of postoperative complications after major hepatectomy
T. Higashi, H. Hayashi, K. Taki, Keita Sakamoto +6 more
2016International Journal of Clinical Oncology51 citations
Semantic Scholar
The Prognostic Significance of Histone Lysine Demethylase JMJD3/KDM6B in Colorectal Cancer
R. Tokunaga, Y. Sakamoto, S. Nakagawa, K. Miyake +13 more
2016Annals of Surgical Oncology48 citations
Semantic Scholar
In vitro modeling of hepatocellular carcinoma molecular subtypes for anti-cancer drug assessment
Hadassa Hirschfield, C. B. Bian, T. Higashi, S. Nakagawa +4 more
2018Experimental and Molecular Medicine47 citations Open access
Semantic Scholar
C5a receptor (CD88) promotes motility and invasiveness of gastric cancer by activating RhoA
T. Kaida, H. Nitta, Yuki Kitano, Kensuke Yamamura +15 more
2016OncoTarget47 citations Open access
Semantic Scholar
The Neutrophil-to-Lymphocyte Ratio Predicts Malignant Potential in Intraductal Papillary Mucinous Neoplasms
K. Arima, H. Okabe, D. Hashimoto, A. Chikamoto +9 more
2015Journal of Gastrointestinal Surgery47 citations
Semantic Scholar
Neutrophil/lymphocyte ratio predicts the prognosis in esophageal squamous cell carcinoma patients
K. Kosumi, Y. Baba, T. Ishimoto, K. Harada +16 more
2016Surgery today (Print)42 citations
Semantic Scholar
The impact of preoperative anaemia and anaemic subtype on patient outcome in colorectal cancer
R. Tokunaga, S. Nakagawa, Y. Miyamoto, M. Ohuchi +7 more
2018Colorectal Disease39 citations
Semantic Scholar
Metabolic shift to serine biosynthesis through 3-PG accumulation and PHGDH induction promotes tumor growth in pancreatic cancer.
R. Itoyama, Noriko Yasuda-Yoshihara, Fumimasa Kitamura, Tadahito Yasuda +21 more
2021Cancer Letters38 citations Open access
Semantic Scholar
KRAS, BRAF, and PIK3CA mutations, and patient prognosis in 126 pancreatic cancers: pyrosequencing technology and literature review
Lei Zhou, Y. Baba, Yuki Kitano, K. Miyake +14 more
2016Medical Oncology36 citations
Semantic Scholar
Molecular signature predictive of long-term liver fibrosis progression to inform anti-fibrotic drug development
Tongqi Qian, N. Fujiwara, Bhuvaneswari Koneru, A. Ono +55 more
2021Gastroenterology35 citations Open access
Semantic Scholar
A human liver cell-based system modeling a clinical prognostic liver signature for therapeutic discovery
E. Crouchet, S. Bandiera, N. Fujiwara, Shen Li +61 more
2021Nature Communications35 citations Open access
Semantic Scholar
Heterogeneity of KRAS Mutations in Pancreatic Ductal Adenocarcinoma
D. Hashimoto, K. Arima, Naomi Yokoyama, A. Chikamoto +9 more
2016Pancreas35 citations
Semantic Scholar
Hyperglycaemia induces metabolic reprogramming into a glycolytic phenotype and promotes epithelial-mesenchymal transitions via YAP/TAZ-Hedgehog signalling axis in pancreatic cancer
Zhao Liu, H. Hayashi, Kazuki Matsumura, Y. Ogata +9 more
2022British Journal of Cancer34 citations
Semantic Scholar
Prognostic Impact of Visceral Fat Amount and Branched-Chain Amino Acids (BCAA) in Hepatocellular Carcinoma
T. Higashi, H. Hayashi, T. Kaida, K. Arima +13 more
2015Annals of Surgical Oncology32 citations
Semantic Scholar
Recent advances in precision medicine for pancreatic ductal adenocarcinoma
H. Hayashi, T. Higashi, Tatsunori Miyata, Y. Yamashita +1 more
2021Annals of Gastroenterological Surgery31 citations Open access
Semantic Scholar
Neutrophil-to-lymphocyte ratio predicts metachronous liver metastasis of pancreatic neuroendocrine tumors
K. Arima, H. Okabe, D. Hashimoto, A. Chikamoto +10 more
2017International Journal of Clinical Oncology31 citations
Semantic Scholar
APOBEC3B is an enzymatic source of molecular alterations in esophageal squamous cell carcinoma
K. Kosumi, Y. Baba, T. Ishimoto, K. Harada +19 more
2016Medical Oncology30 citations
Semantic Scholar
The clinical impact of preoperative body composition differs between male and female colorectal cancer patients
R. Tokunaga, S. Nakagawa, Yuji Miyamoto, M. Ohuchi +7 more
2020Colorectal Disease29 citations
Semantic Scholar
Preoperative platelet‐to‐lymphocyte ratio can predict recurrence beyond the Milan criteria after hepatectomy for patients with hepatocellular carcinoma
T. Kaida, H. Nitta, Yuki Kitano, Kensuke Yamamura +13 more
2017Hepatology Research28 citations
Semantic Scholar
The diagnostic role of the neutrophil-to-lymphocyte ratio in predicting pancreatic ductal adenocarcinoma in patients with pancreatic diseases
K. Arima, H. Okabe, D. Hashimoto, A. Chikamoto +12 more
2016International Journal of Clinical Oncology27 citations
Semantic Scholar
Intraoperative blood loss is not a predictor of prognosis for pancreatic cancer
K. Arima, D. Hashimoto, H. Okabe, Risa Inoue +8 more
2016Surgery today (Print)26 citations
Semantic Scholar
Ectopic hepatocellular carcinoma mimicking a retroperitoneal tumor: A case report
Yuki Adachi, H. Hayashi, Toshihiko Yusa, T. Takematsu +7 more
2020World Journal of Gastroenterology25 citations Open access
Semantic Scholar
Clinical significance of half‐lives of tumor markers α‐fetoprotein and des‐γ‐carboxy prothrombin after hepatectomy for hepatocellular carcinoma
Masayo Tsukamoto, H. Nitta, K. Imai, T. Higashi +10 more
2018Hepatology Research23 citations Open access
Semantic Scholar
Enhancer of zeste homolog 2 (EZH2) regulates tumor angiogenesis and predicts recurrence and prognosis of intrahepatic cholangiocarcinoma.
S. Nakagawa, H. Okabe, M. Ouchi, R. Tokunaga +13 more
2018HPB23 citations Open access
Semantic Scholar
Significance of P-cadherin overexpression and possible mechanism of its regulation in intrahepatic cholangiocarcinoma and pancreatic cancer
Keita Sakamoto, K. Imai, T. Higashi, K. Taki +8 more
2015Cancer Science23 citations Open access
Semantic Scholar
Impact of surgical treatment after sorafenib therapy for advanced hepatocellular carcinoma
Hideaki Takeyama, T. Beppu, T. Higashi, T. Kaida +13 more
2018Surgery today (Print)22 citations
Semantic Scholar
Diverse Basis of β-Catenin Activation in Human Hepatocellular Carcinoma: Implications in Biology and Prognosis
H. Okabe, Hiroki Kinoshita, K. Imai, S. Nakagawa +12 more
2016PLoS ONE22 citations Open access
Semantic Scholar
Significance of lymph node metastasis in pancreatic neuroendocrine tumor
K. Taki, D. Hashimoto, S. Nakagawa, N. Ozaki +15 more
2017Surgery today (Print)21 citations
Semantic Scholar
Colon cancer metastasis mimicking intraductal papillary neoplasm of the extra-hepatic bile duct
Takanobu Yamao, H. Hayashi, T. Higashi, H. Takeyama +6 more
2015International journal of surgery case reports21 citations Open access
Semantic Scholar
Prognostic value of Ki-67 expression in conversion therapy for colorectal liver-limited metastases.
H. Hayashi, T. Beppu, Y. Sakamoto, Y. Miyamoto +6 more
2015American Journal of Cancer Research21 citations
Semantic Scholar
Thrombospondin-1 overexpression stimulates loss of Smad4 and accelerates malignant behavior via TGF-β signal activation in pancreatic ductal adenocarcinoma
Kazuki Matsumura, H. Hayashi, Norio Uemura, Y. Ogata +12 more
2022Translational Oncology20 citations Open access
Semantic Scholar
Frailty Predicts Severe Postoperative Complication after Elective Hepatic Resection
H. Okabe, H. Hayashi, T. Higashi, H. Nitta +10 more
2019Gastrointestinal Tumors20 citations Open access
Semantic Scholar
LINE-1 methylation level and prognosis in pancreas cancer: pyrosequencing technology and literature review
Kensuke Yamamura, K. Kosumi, Y. Baba, K. Harada +13 more
2017Surgery today (Print)20 citations
Semantic Scholar
Limited Resection of the Duodenum for Nonampullary Duodenal Tumors, with Review of the Literature
D. Hashimoto, K. Arima, A. Chikamoto, K. Taki +6 more
2016The American surgeon20 citations Open access
Semantic Scholar
Tumor/normal esophagus ratio in 18F-fluorodeoxyglucose positron emission tomography/computed tomography for response and prognosis stratification after neoadjuvant chemotherapy for esophageal squamous cell carcinoma
D. Izumi, N. Yoshida, Masayuki Watanabe, S. Shiraishi +15 more
2016Journal of gastroenterology19 citations
Semantic Scholar
MicroRNA-25 Exerts an Oncogenic Function by Regulating the Ubiquitin Ligase Fbxw7 in Hepatocellular Carcinoma
H. El-mezayen, Kensuke Yamamura, Toshihiko Yusa, Yosuke Nakao +10 more
2021Annals of Surgical Oncology16 citations
Semantic Scholar
Steatohepatitic variant of hepatocellular carcinoma is associated with both alcoholic- and non-alcoholic steatohepatitis: A study of two cohorts with molecular insights
J. Qin, T. Higashi, S. Nakagawa, N. Fujiwara +11 more
2020American Journal of Surgical Pathology16 citations Open access
Semantic Scholar
Varied application of intercostal trans-diaphragmatic ports for laparoscopic hepatectomy
H. Hayashi, Y. Yamashita, H. Okabe, K. Imai +6 more
2020PLoS ONE13 citations Open access
Semantic Scholar
Scoring system based on tumor markers and Child-Pugh classification for HCC patients who underwent liver resection.
S. Nakagawa, H. Hayashi, H. Nitta, H. Okabe +9 more
2015Anticancer Research13 citations
Semantic Scholar

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H. Baba×40
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H. Baba — researcher profile on SciRah
T. Beppu×27
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T. Beppu — researcher profile on SciRah
A. Chikamoto×26
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A. Chikamoto — researcher profile on SciRah
S. Nakagawa×25
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S. Nakagawa — researcher profile on SciRah

×23

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K. Taki — researcher profile on SciRah

D. Hashimoto×23

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D. Hashimoto — researcher profile on SciRah

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H. Hayashi — researcher profile on SciRah

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H. Nitta — researcher profile on SciRah

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K. Imai — researcher profile on SciRah

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T. Kaida — researcher profile on SciRah

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K. Arima — researcher profile on SciRah

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H. Okabe — researcher profile on SciRah