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L. Joachimiak · SciRah

Researcher profile · Semantic Scholar

L. Joachimiak

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L. Joachimiak — researcher profile on SciRah

h-index: 26
Works: 77
Citations: 3,229

Most-cited papers

Computational redesign of protein-protein interaction specificity
T. Kortemme, L. Joachimiak, A. Bullock, A. Schuler +2 more
2004Nature Structural &Molecular Biology305 citations
Semantic Scholar
The molecular architecture of the eukaryotic chaperonin TRiC/CCT
A. Leitner, L. Joachimiak, A. Bracher, Leonie Mönkemeyer +11 more
2012Structure296 citations Open access
Semantic Scholar
The Chaperonin TRIC Blocks a Huntingtin Sequence Element that promotes the Conformational Switch to Aggregation
Stephen J. Tam, Christoph Spiess, William Auyeung, L. Joachimiak +3 more
2009Nature Structural &Molecular Biology260 citations Open access
Semantic Scholar
Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes
A. Leitner, L. Joachimiak, Pia Unverdorben, T. Walzthoeni +3 more
2014Proceedings of the National Academy of Sciences of the United States of America240 citations Open access
Semantic Scholar
Inert and seed-competent tau monomers suggest structural origins of aggregation
Hilda Mirbaha, Dailu Chen, Olga A. Morazova, Kiersten M. Ruff +8 more
2017bioRxiv205 citations Open access
Semantic Scholar
A de novo protein binding pair by computational design and directed evolution
J. Karanicolas, J. Corn, I. Chen, L. Joachimiak +11 more
2011Molecules and Cells170 citations Open access
Semantic Scholar
Tau local structure shields an amyloid-forming motif and controls aggregation propensity
Dailu Chen, Kenneth W. Drombosky, Zhiqiang Hou, Levent Sari +7 more
2019Nature Communications159 citations Open access
Semantic Scholar
Computational design of a new hydrogen bond network and at least a 300-fold specificity switch at a protein-protein interface.
L. Joachimiak, T. Kortemme, B. Stoddard, D. Baker
2006Journal of Molecular Biology152 citations
Semantic Scholar
The structural basis of substrate recognition by the eukaryotic chaperonin TRiC/CCT
L. Joachimiak, T. Walzthoeni, Corey W. Liu, R. Aebersold +1 more
2014Cell146 citations Open access
Semantic Scholar
The chaperonin TRiC/CCT associates with Prefoldin through a conserved electrostatic interface essential for cellular proteostasis
D. Gestaut, S. Roh, B. Ma, G. Pintilie +6 more
2019Cell131 citations Open access
Semantic Scholar
Tau strains shape disease
Jaime Vaquer-Alicea, Marc I. Diamond, L. Joachimiak
2021Acta Neuropathologica121 citations Open access
Semantic Scholar
A Gradient of ATP Affinities Generates an Asymmetric Power Stroke Driving the Chaperonin TRIC/CCT Folding Cycle
S. Reissmann, L. Joachimiak, Bryan Chen, A. Meyer +2 more
2012Cell Reports106 citations Open access
Semantic Scholar
xTract: software for characterizing conformational changes of protein complexes by quantitative cross-linking mass spectrometry
T. Walzthoeni, L. Joachimiak, George A. Rosenberger, H. Röst +4 more
2015Nature Methods96 citations Open access
Semantic Scholar
The ATP-powered gymnastics of TRiC/CCT: an asymmetric protein folding machine with a symmetric origin story
D. Gestaut, A. Limatola, L. Joachimiak, J. Frydman
2019Current Opinion in Structural Biology85 citations Open access
Semantic Scholar
Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes
E. Sontag, L. Joachimiak, Z. Tan, A. Tomlinson +5 more
2013Proceedings of the National Academy of Sciences of the United States of America79 citations Open access
Semantic Scholar
Dual domain recognition determines SARS-CoV-2 PLpro selectivity for human ISG15 and K48-linked di-ubiquitin
P. Wydorski, J. Osipiuk, B. T. Lanham, C. Tesar +9 more
2021bioRxiv74 citations Open access
Semantic Scholar
Structure and Dynamics of the Huntingtin Exon-1 N-Terminus: A Solution NMR Perspective.
M. Baias, Pieter E. S. Smith, Ko-Ning Shen, L. Joachimiak +4 more
2017Journal of the American Chemical Society63 citations
Semantic Scholar
Cryo-EM Structure of a Group II Chaperonin in the Prehydrolysis ATP-Bound State Leading to Lid Closure
Jun-Jie Zhang, B. Ma, F. DiMaio, N. R. Douglas +5 more
2011Structure60 citations Open access
Semantic Scholar
Experimental and computational analyses of the energetic basis for dual recognition of immunity proteins by colicin endonucleases.
A. H. Keeble, L. Joachimiak, M. Maté, Nicola A. G. Meenan +3 more
2008Journal of Molecular Biology47 citations
Semantic Scholar
DnaJC7 binds natively folded structural elements in tau to inhibit amyloid formation
Zhiqiang Hou, P. Wydorski, Valerie A. Perez, Aydé Mendoza-Oliva +4 more
2020Nature Communications44 citations Open access
Semantic Scholar
Seed-competent tau monomer initiates pathology in a tauopathy mouse model
Hilda Mirbaha, Dailu Chen, V. Mullapudi, SandiJo Terpack +3 more
2022Journal of Biological Chemistry39 citations Open access
Semantic Scholar
Network of hotspot interactions cluster tau amyloid folds
V. Mullapudi, Jaime Vaquer-Alicea, Vaibhav Bommareddy, A. Vega +4 more
2023Nature Communications32 citations Open access
Semantic Scholar
Chaperoning shape-shifting tau in disease.
Bryan D. Ryder, P. Wydorski, Zhiqiang Hou, L. Joachimiak
2022TIBS -Trends in Biochemical Sciences. Regular ed29 citations Open access
Semantic Scholar
Disease-associated patterns of acetylation stabilize tau fibril formation
Li Li, B. Nguyen, V. Mullapudi, L. Saelices +1 more
2023bioRxiv27 citations Open access
Semantic Scholar
Regulatory inter-domain interactions influence Hsp70 recruitment to the DnaJB8 chaperone
Bryan D. Ryder, Irina Matlahov, Sofía Bali, Jaime Vaquer-Alicea +2 more
2021Nature Communications27 citations Open access
Semantic Scholar
Biophysical properties of a tau seed
Zhiqiang Hou, Dailu Chen, Bryan D. Ryder, L. Joachimiak
2021Scientific Reports26 citations Open access
Semantic Scholar
Synthesis and characterization of novel phosphonocarboxylate inhibitors of RGGT.
F. Coxon, L. Joachimiak, A. K. Najumudeen, G. Breen +6 more
2014European journal of medicinal chemistry22 citations
Semantic Scholar
Saturation mutagenesis of α-synuclein reveals monomer fold that modulates aggregation
J. Chlebowicz, William Russ, Dailu Chen, Anthony Vega +5 more
2023Science Advances19 citations Open access
Semantic Scholar
FTD-tau S320F mutation stabilizes local structure and allosterically promotes amyloid motif-dependent aggregation
Dailu Chen, Sofía Bali, Ruhar Singh, Aleksandra Wosztyl +8 more
2022bioRxiv19 citations Open access
Semantic Scholar
DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity
Bryan D. Ryder, E. Ustyantseva, D. Boyer, Aydé Mendoza-Oliva +8 more
2024Structure18 citations Open access
Semantic Scholar
J-domain proteins: From molecular mechanisms to diseases
J. Marszałek, P. De Los Rios, Douglas M. Cyr, Matthias P. Mayer +33 more
2023Cell stress & chaperones (Print)18 citations Open access
Semantic Scholar
Conservation of a novel protein associated with an antibiotic efflux operon in Burkholderia cenocepacia.
Bindu M Nair, L. Joachimiak, S. Chattopadhyay, Idalia Montano +1 more
2005FEMS Microbiology Letters16 citations
Semantic Scholar
Hairpin trimer transition state of amyloid fibril
Levent Sari, Sofía Bali, L. Joachimiak, Mi-Lo M. Lin
2024Nature Communications15 citations Open access
Semantic Scholar
Anti-tau antibodies targeting a conformation-dependent epitope selectively bind seeds
Brian D. Hitt, Ankit Gupta, Ruhar Singh, Ting Yang +5 more
2023bioRxiv14 citations Open access
Semantic Scholar
Development of a New DHFR-Based Destabilizing Domain with Enhanced Basal Turnover and Applicability in Mammalian Systems
Emi Nakahara, V. Mullapudi, Gracen E. Collier, L. Joachimiak +1 more
2022bioRxiv14 citations Open access
Semantic Scholar
DnaJC7 specifically regulates tau seeding
Valerie A. Perez, David W. Sanders, Aydé Mendoza-Oliva, B. Stopschinski +4 more
2023bioRxiv13 citations Open access
Semantic Scholar
The disordered amino terminus of the circadian enzyme Nocturnin modulates its NADP(H) phosphatase activity by changing protein dynamics
A. Wickramaratne, Li Li, Jesse B. Hopkins, L. Joachimiak +1 more
2022Biochemistry10 citations
Semantic Scholar
Functional classification of tauopathy strains reveals the role of protofilament core residues
Jaime Vaquer-Alicea, Victor A. Manon, Vaibhav Bommareddy, Peter Kunach +11 more
2024bioRxiv9 citations Open access
Semantic Scholar
Therapeutic inhibition of USP7 promotes antitumor immune responses
Angelika Muchowicz, Katarzyna M Głuchowska, Marcin M Grzybowski, Małgorzata Szostakowska-Rodzoś +18 more
2025Journal for ImmunoTherapy of Cancer8 citations Open access
Semantic Scholar
Hydrostatic Pressure Sensing by WNK kinases
J. Humphreys, Liliana R. Teixeira, R. Akella, Haixia He +13 more
2023Molecular Biology of the Cell6 citations Open access
Semantic Scholar
Seed-competent tau monomer initiates pathology in PS19 tauopathy mice
Hilda Mirbaha, Dailu Chen, V. Mullapudi, SandiJo Terpack +3 more
2022bioRxiv3 citations Open access
Semantic Scholar
Native tau structure is disrupted by disease-associated mutations that promote aggregation
Kenneth W. Drombosky, Dailu Chen, Danae R Woodard, Levent Sari +3 more
2018bioRxiv3 citations Open access
Semantic Scholar
Structure-Guided Discovery of OAT-4828 as Potent, Selective, and Orally Bioavailable USP7 Inhibitor with In Vivo Antileukemic Activity.
Jacek Chrzanowski, J. Nowicka, R. Koralewski, L. Joachimiak +24 more
2026Journal of Medicinal Chemistry2 citations
Semantic Scholar
Modifying Amyloid Motif Aggregation Through Local Structure.
Sofía Bali, L. Joachimiak
2022Methods in molecular biology2 citations
Semantic Scholar
Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence context.
Sofía Bali, P. Wydorski, Ruhar Singh, Nico E. Van Nuland +7 more
2025Structure1 citations Open access
Semantic Scholar
Cross-Linking Mass Spectrometry Analysis of Metastable Compact Structures in Intrinsically Disordered Proteins.
Dailu Chen, L. Joachimiak
2023Methods in molecular biology1 citations
Semantic Scholar
Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence context
Sofía Bali, Ruhar Singh, P. Wydorski, Nico E. Van Nuland +6 more
2023bioRxiv1 citations Open access
Semantic Scholar
hTRiC-hPFD Class4
D. Gestaut, S. Roh, B. Ma, G. Pintilie +6 more
20191 citations
Semantic Scholar
Human NLRP1 and NLRP3 interact to drive inflammation in inflammosomopathies and inflammatory diseases
J. M. Suarez-Rivero, Inés Muela-Zarzuela, Antonio Astorga-Gamaza, Rosa Antón +10 more
2026bioRxiv0 citations Open access
Semantic Scholar
Cysteines are critical determinants of spontaneous and seeded tau aggregation in cells
P. Jayan, Simran Rastogi, Vaibhav Bommareddy, Chad M. Dashnaw +7 more
2026Research Square0 citations Open access
Semantic Scholar

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