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E. Jaffray · SciRah

Researcher profile · Semantic Scholar

E. Jaffray

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E. Jaffray — researcher profile on SciRah

h-index: 42
Works: 66
Citations: 6,661

Most-cited papers

Polymeric Chains of SUMO-2 and SUMO-3 Are Conjugated to Protein Substrates by SAE1/SAE2 and Ubc9*
M. Tatham, E. Jaffray, O. A. Vaughan, Joana Desterro +3 more
2001Journal of Biological Chemistry883 citations Open access
Semantic Scholar
RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation
M. Tatham, M. Geoffroy, Lin-nan Shen, Anna Plechanovová +4 more
2008Nature Cell Biology882 citations
Semantic Scholar
Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis
Anna Plechanovová, E. Jaffray, M. Tatham, J. Naismith +1 more
2012Nature545 citations Open access
Semantic Scholar
Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity.
Shen-Hsi Yang, E. Jaffray, R. Hay, A. Sharrocks
2003Molecules and Cells270 citations Open access
Semantic Scholar
A Proteomic Study of SUMO-2 Target Proteins*
A. Vertegaal, S. Ogg, E. Jaffray, Manuel S. Rodríguez +4 more
2004Journal of Biological Chemistry234 citations Open access
Semantic Scholar
Proteome-wide Identification of SUMO2 Modification Sites
Triin Tammsalu, I. Matic, E. Jaffray, Adel F. M. Ibrahim +2 more
2014Science Signaling211 citations Open access
Semantic Scholar
p75-Mediated NF-κB Activation Enhances the Survival Response of Developing Sensory Neurons to Nerve Growth Factor
M. Hamanoue, G. Middleton, S. Wyatt, E. Jaffray +2 more
1999205 citations
Semantic Scholar
Mechanism of ubiquitylation by dimeric RING ligase RNF4
Anna Plechanovová, E. Jaffray, S. McMahon, K. Johnson +3 more
2011Nature Structural &Molecular Biology188 citations Open access
Semantic Scholar
Androgen Receptor Acetylation Governs trans Activation and MEKK1-Induced Apoptosis without Affecting In Vitro Sumoylation and trans-Repression Function
M. Fu, Chen-Guang Wang, Jian Wang, Xueping Zhang +10 more
2002Molecular and Cellular Biology182 citations Open access
Semantic Scholar
SUMOylation of the GTPase Rac1 is required for optimal cell migration
S. Castillo-Lluva, M. Tatham, R. C. Jones, E. Jaffray +3 more
2010Nature Cell Biology166 citations Open access
Semantic Scholar
Cytokine-Induced Nuclear Factor Kappa B Activation Promotes the Survival of Developing Neurons
G. Middleton, M. Hamanoue, Y. Enokido, S. Wyatt +4 more
2000Journal of Cell Biology158 citations Open access
Semantic Scholar
Unique binding interactions among Ubc9, SUMO and RanBP2 reveal a mechanism for SUMO paralog selection
M. Tatham, Suhkmann Kim, E. Jaffray, Jing Song +2 more
2005Nature Structural &Molecular Biology150 citations
Semantic Scholar
Functional interactions between ubiquitin E2 enzymes and TRIM proteins.
L. M. Napolitano, E. Jaffray, R. Hay, G. Meroni
2011Biochemical Journal120 citations Open access
Semantic Scholar
Post-translational modification by SUMO.
Zara Hannoun, Sebastian Greenhough, E. Jaffray, R. Hay +1 more
2010Toxicology119 citations Open access
Semantic Scholar
SUMO-1 modification alters ADAR1 editing activity.
Joana Desterro, L. Keegan, E. Jaffray, R. Hay +2 more
2005Molecular Biology of the Cell119 citations Open access
Semantic Scholar
The Protein Stability and Transcriptional Activity of p63α are Regulated by SUMO-1 Conjugation
Pamela Ghioni, Y. D'Alessandra, G. Mansueto, E. Jaffray +3 more
2005Cell Cycle115 citations Open access
Semantic Scholar
Role of an N-terminal site of Ubc9 in SUMO-1, -2, and -3 binding and conjugation.
M. Tatham, Suhkmann Kim, Bin Yu, E. Jaffray +5 more
2003Biochemistry112 citations
Semantic Scholar
Domain organization of I kappa B alpha and sites of interaction with NF-kappa B p65
E. Jaffray, K. Wood, Ronald T. Hay
1995Molecular and Cellular Biology112 citations Open access
Semantic Scholar
Characterization of SENP7, a SUMO-2/3-specific isopeptidase.
Lin-nan Shen, M. Geoffroy, E. Jaffray, R. Hay
2009Biochemical Journal108 citations Open access
Semantic Scholar
Ube2W conjugates ubiquitin to α-amino groups of protein N-termini
M. Tatham, Anna Plechanovová, E. Jaffray, H. Salmen +1 more
2013Biochemical Journal102 citations Open access
Semantic Scholar
University of Dundee Structural basis for the RING catalyzed synthesis of K63 linked ubiquitin chains
E. Branigan, Anna Plechanovová, E. Jaffray, J. Naismith +1 more
201597 citations
Semantic Scholar
Arsenic-Induced SUMO-Dependent Recruitment of RNF4 into PML Nuclear Bodies
M. Geoffroy, E. Jaffray, K. J. Walker, R. Hay
2010Molecular Biology of the Cell93 citations Open access
Semantic Scholar
SUMO Chain-Induced Dimerization Activates RNF4
A. Rojas-Fernandez, Anna Plechanovová, N. Hattersley, E. Jaffray +2 more
2014Molecules and Cells87 citations Open access
Semantic Scholar
A SUMO-Dependent Protein Network Regulates Chromosome Congression during Oocyte Meiosis
Federico Pelisch, Triin Tammsalu, Bin Wang, E. Jaffray +2 more
2017Molecules and Cells78 citations Open access
Semantic Scholar
The SUMO protease SENP6 is a direct regulator of PML nuclear bodies
N. Hattersley, Lin-nan Shen, E. Jaffray, R. Hay
2011Molecular Biology of the Cell75 citations Open access
Semantic Scholar
NF-kappaB is a critical regulator of the survival of rodent and human hepatic myofibroblasts.
M. Watson, K. Wallace, R. Gieling, D. Manas +4 more
2008Journal of Hepatology68 citations Open access
Semantic Scholar
Proteome-wide identification of SUMO modification sites by mass spectrometry
Triin Tammsalu, I. Matic, E. Jaffray, Adel F. M. Ibrahim +2 more
2015Nature Protocols63 citations
Semantic Scholar
Regulation of Homeodomain-interacting Protein Kinase 2 (HIPK2) Effector Function through Dynamic Small Ubiquitin-related Modifier-1 (SUMO-1) Modification*
T. Hofmann, E. Jaffray, Nicole Stollberg, R. Hay +1 more
2005Journal of Biological Chemistry62 citations Open access
Semantic Scholar
Fourier transform ion cyclotron resonance mass spectrometry for the analysis of small ubiquitin-like modifier (SUMO) modification: identification of lysines in RanBP2 and SUMO targeted for modification during the E3 autoSUMOylation reaction.
H. Cooper, M. Tatham, E. Jaffray, J. Heath +3 more
2005Analytical Chemistry61 citations
Semantic Scholar
Conjugation of human topoisomerase 2 alpha with small ubiquitin-like modifiers 2/3 in response to topoisomerase inhibitors: cell cycle stage and chromosome domain specificity.
Marta Agostinho, V. Santos, F. Ferreira, R. Costa +6 more
2008Cancer Research57 citations Open access
Semantic Scholar
SUMOylation of HNF4α regulates protein stability and hepatocyte function
Wenli Zhou, Zara Hannoun, E. Jaffray, Claire N. Medine +9 more
2012Journal of Cell Science56 citations Open access
Semantic Scholar
Medea SUMOylation restricts the signaling range of the Dpp morphogen in the Drosophila embryo.
Wayne O. Miles, E. Jaffray, S. Campbell, Shugaku Takeda +7 more
2008Genes & Development55 citations Open access
Semantic Scholar
Absolute SILAC-Compatible Expression Strain Allows Sumo-2 Copy Number Determination in Clinical Samples
I. Matic, E. Jaffray, S. Oxenham, M. Groves +4 more
2011Journal of Proteome Research52 citations Open access
Semantic Scholar
Sp100 Isoform-Specific Regulation of Human Adenovirus 5 Gene Expression
J. Berscheminski, P. Wimmer, J. Brun, Wing H. Ip +6 more
2014Journal of Virology50 citations Open access
Semantic Scholar
SUMO Modification Regulates MafB-Driven Macrophage Differentiation by Enabling Myb-Dependent Transcriptional Repression
Silke Tillmanns, Claas Otto, E. Jaffray, Camille Du Roure +5 more
2007Molecular and Cellular Biology50 citations Open access
Semantic Scholar
Ubiquitin C-terminal hydrolases cleave isopeptide- and peptide-linked ubiquitin from structured proteins but do not edit ubiquitin homopolymers
John S. Bett, M. S. Ritorto, Richard A. Ewan, E. Jaffray +7 more
2014Biochemical Journal49 citations Open access
Semantic Scholar
SUMO Modification of the Ets-related Transcription Factor ERM Inhibits Its Transcriptional Activity*
C. Degerny, D. Monté, C. Beaudoin, E. Jaffray +4 more
2005Journal of Biological Chemistry49 citations Open access
Semantic Scholar
Identification of sites of ubiquitination in proteins: a fourier transform ion cyclotron resonance mass spectrometry approach.
H. Cooper, J. Heath, E. Jaffray, R. Hay +2 more
2004Analytical Chemistry49 citations
Semantic Scholar
SUMO and Transcriptional Repression: Dynamic Interactions Between the MAP Kinase and SUMO Pathways
Shen-Hsi Yang, E. Jaffray, Biruntha Senthinathan, R. Hay +1 more
2003Cell Cycle49 citations Open access
Semantic Scholar
A role for paralog-specific sumoylation in histone deacetylase 1 stability.
Simona Citro, E. Jaffray, R. Hay, C. Seiser +1 more
2013Journal of Molecular Cell Biology47 citations Open access
Semantic Scholar
SUMO-1 Modification of Human Transcription Factor (TF) IID Complex Subunits
Michaël Boyer-Guittaut, Kıvanç Birsoy, Corinne Potel, G. Elliott +4 more
2005Journal of Biological Chemistry45 citations Open access
Semantic Scholar
Detection of modification by ubiquitin-like proteins.
E. Jaffray, R. Hay
2006Methods43 citations
Semantic Scholar
BC-box protein domain-related mechanism for VHL protein degradation
M. Pozzebon, Archana Varadaraj, D. Mattoscio, E. Jaffray +5 more
2013Proceedings of the National Academy of Sciences of the United States of America38 citations Open access
Semantic Scholar
Domain Organization of IkBaand Sites of Interaction with NF-kB p65
E. Jaffray, K. Wood, A. Hay
199532 citations
Semantic Scholar
Conformational changes induced by DNA binding of NF-κB
J. Matthews, J. Nicholson, E. Jaffray, S. Kelly +2 more
199532 citations Open access
Semantic Scholar
Repression of SOX6 transcriptional activity by SUMO modification
R. Fernández-Lloris, N. Osses, E. Jaffray, Lin-nan Shen +6 more
2006FEBS Letters30 citations
Semantic Scholar
Inhibition of NF-κB by a cell permeable form of IκBα induces apoptosis in eosinophils
Satoko Fujihara, E. Jaffray, S. Farrow, A. G. Rossi +2 more
200530 citations
Semantic Scholar
Sumoylation regulates protein dynamics during meiotic chromosome segregation in C. elegans oocytes
Federico Pelisch, Laura Bel Borja, E. Jaffray, R. Hay
2019Journal of Cell Science27 citations Open access
Semantic Scholar
Structural basis for the RING catalyzed synthesis of K63 linked ubiquitin chains
E. Branigan, Anna Plechanovová, E. Jaffray, James H. Naismith +1 more
2015Nature Structural &Molecular Biology22 citations Open access
Semantic Scholar
Iso-seco-tanapartholides: Isolation, Synthesis and Biological Evaluation
Edward F Makiyi, R. Frade, T. Lebl, E. Jaffray +5 more
2009Annalen der Pharmacie22 citations Open access
Semantic Scholar

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