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E. Balskus · SciRah

Researcher profile · Semantic Scholar

E. Balskus

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E. Balskus — researcher profile on SciRah

h-index: 55
Works: 186
Citations: 12K

Most-cited papers

Discovery and inhibition of an interspecies gut bacterial pathway for Levodopa metabolism
Vayu M. Rekdal, Elizabeth N. Bess, J. Bisanz, P. Turnbaugh +1 more
2019Science690 citations Open access
Semantic Scholar
The human gut bacterial genotoxin colibactin alkylates DNA
Matthew R. Wilson, Yin-Di Jiang, P. Villalta, Alessia Stornetta +10 more
2019Science566 citations Open access
Semantic Scholar
Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction.
Si-Fan Chen, Ayana L. Henderson, M. Petriello, K. Romano +13 more
2019Cell Metabolism377 citations Open access
Semantic Scholar
Cholesterol Metabolism by Uncultured Human Gut Bacteria Influences Host Cholesterol Level
Douglas J. Kenny, D. Plichta, D. Shungin, Nitzan Koppel +7 more
2020Cell Host and Microbe270 citations Open access
Semantic Scholar
Gut microbiome and metabolome profiling in Framingham Heart Study reveals cholesterol-metabolizing bacteria
Chenhao Li, Martin Stražar, Ahmed M. T. Mohamed, J. A. Pacheco +22 more
2024Cell227 citations Open access
Semantic Scholar
A glycyl radical enzyme enables hydrogen sulfide production by the human intestinal bacterium Bilophila wadsworthia
S. C. Peck, K. Denger, Anna G. Burrichter, Stephania M. Irwin +2 more
2019Proceedings of the National Academy of Sciences of the United States of America175 citations Open access
Semantic Scholar
Gut Microbial Metabolism of 5-ASA Diminishes Its Clinical Efficacy in Inflammatory Bowel Disease
R. Mehta, Jared R. Mayers, Yan-Cong Zhang, Amrisha Bhosle +16 more
2023Nature Medicine151 citations Open access
Semantic Scholar
An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin
Tai L. Ng, R. Rohac, A. Mitchell, A. Boal +1 more
2019Nature126 citations Open access
Semantic Scholar
Discovery and characterization of a prevalent human gut bacterial enzyme sufficient for the inactivation of a family of plant toxins
Nitzan Koppel, J. Bisanz, M. Pandelia, P. Turnbaugh +1 more
2018eLife116 citations Open access
Semantic Scholar
The bacterial toxin colibactin triggers prophage induction
Justin E. Silpe, Joel W. H. Wong, S. Owen, M. Baym +1 more
2022Nature111 citations Open access
Semantic Scholar
Gut bacteria convert glucocorticoids into progestins in the presence of hydrogen gas
Megan D. McCurry, G. D’Agostino, Jasmine T. Walsh, J. Bisanz +9 more
2024Cell98 citations
Semantic Scholar
Cysteine dependence of Lactobacillus iners is a potential therapeutic target for vaginal microbiota modulation
S. Bloom, N. Mafunda, B. Woolston, M. Hayward +20 more
2022Nature Microbiology96 citations Open access
Semantic Scholar
Gut bacterial phospholipase Ds support disease-associated metabolism by generating choline
Carina L. Chittim, Ana Martínez del Campo, E. Balskus
2018Nature Microbiology86 citations Open access
Semantic Scholar
Extracellular vesicles of the Gram-positive gut symbiont Bifidobacterium longum induce immune-modulatory, anti-inflammatory effects
Noa Mandelbaum, Lihan Zhang, S. Carasso, T. Ziv +9 more
2023npj Biofilms and Microbiomes85 citations Open access
Semantic Scholar
Elucidation of an anaerobic pathway for metabolism of l-carnitine–derived γ-butyrobetaine to trimethylamine in human gut bacteria
L. Rajakovich, B. Fu, Maud Bollenbach, E. Balskus
2021Proceedings of the National Academy of Sciences of the United States of America69 citations Open access
Semantic Scholar
Mapping the T cell repertoire to a complex gut bacterial community
Kazuki Nagashima, Aishan Zhao, Katayoon Atabakhsh, Minwoo Bae +13 more
2023Nature67 citations Open access
Semantic Scholar
Metabolic functions of the human gut microbiota: the role of metalloenzymes
L. Rajakovich, E. Balskus
2018Natural product reports (Print)65 citations Open access
Semantic Scholar
A genomic toolkit for the mechanistic dissection of intractable human gut bacteria
J. Bisanz, Paola Soto-Perez, Cecilia Noecker, A. Aksenov +13 more
2020Cell Host and Microbe62 citations Open access
Semantic Scholar
Complete integration of carbene transfer chemistry into biosynthesis
Jing Huang, A. Quest, Pablo Cruz-Morales, Kai Deng +14 more
2023Nature61 citations Open access
Semantic Scholar
Bacterial amylases enable glycogen degradation by the vaginal microbiome
Dominick J. Jenkins, B. Woolston, M. I. Hood-Pishchany, Paula Pelayo +8 more
2023Nature Microbiology60 citations Open access
Semantic Scholar
A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols
Vayu Maini Rekdal, Paola Nol Bernadino, Michael U. Luescher, Sina Kiamehr +5 more
2019bioRxiv60 citations Open access
Semantic Scholar
Structure-guided identification of a small molecule that inhibits anaerobic choline metabolism by human gut bacteria
M. Orman, Smaranda Bodea, M. Funk, A. M. Campo +3 more
2018Journal of the American Chemical Society58 citations Open access
Semantic Scholar
The reactivity of an unusual amidase may explain colibactin’s DNA cross-linking activity
Yin-Di Jiang, Alessia Stornetta, P. Villalta, Matthew R. Wilson +4 more
2019bioRxiv51 citations Open access
Semantic Scholar
A small molecule inhibitor prevents gut bacterial genotoxin production
Matthew R Volpe, José A. Velilla, M. Daniel-Ivad, Jenny J. Yao +7 more
2022Nature Chemical Biology49 citations Open access
Semantic Scholar
A peroxodiiron(III) intermediate mediating both N-hydroxylation steps in biosynthesis of the N-nitrosourea pharmacophore of streptozotocin by SznF
M. McBride, Debangsu Sil, Tai L. Ng, A. M. Crooke +7 more
2020Journal of the American Chemical Society48 citations Open access
Semantic Scholar
The Human Microbiota, Infectious Disease, and Global Health: Challenges and Opportunities.
Abraham J Waldman, E. Balskus
2018ACS Infectious Diseases46 citations
Semantic Scholar
A metabolomics pipeline highlights microbial metabolism in bloodstream infections
J. R. Mayers, J. Varon, R.R. Zhou, Martin Daniel-Ivad +12 more
2024Cell45 citations Open access
Semantic Scholar
Anaerobic 4-hydroxyproline utilization: Discovery of a new glycyl radical enzyme in the human gut microbiome uncovers a widespread microbial metabolic activity
Yolanda Y. Huang, Ana Martínez-del Campo, E. Balskus
2018Gut microbes45 citations Open access
Semantic Scholar
Genetic manipulation of the human gut bacterium Eggerthella lenta reveals a widespread family of transcriptional regulators
Xueyang Dong, Benjamin G. H. Guthrie, Margaret Alexander, Cecilia Noecker +4 more
2022Nature Communications40 citations Open access
Semantic Scholar
Biocatalytic Friedel-Crafts Alkylation Using a Promiscuous Biosynthetic Enzyme.
E. Schultz, N. Braffman, Michael U. Luescher, Harry H Hager +1 more
2019Angewandte Chemie37 citations Open access
Semantic Scholar
Metatranscriptomics-guided discovery and characterization of a polyphenol-metabolizing gut microbial enzyme
Minwoo Bae, Le Chi, R. Mehta, Xueyang Dong +8 more
2024Cell Host and Microbe36 citations
Semantic Scholar
Chemistry, bioactivity and biosynthesis of cyanobacterial alkylresorcinols
Teresa P. Martins, C. Rouger, N. Glasser, Sara Freitas +4 more
2019Natural product reports (Print)35 citations Open access
Semantic Scholar
Targeting the human gut microbiome with small-molecule inhibitors
Amelia Y. M. Woo, Miguel A. Aguilar Ramos, R. Narayan, K. Richards-Corke +3 more
2023Nature Reviews Chemistry34 citations
Semantic Scholar
Discovery of the Azaserine Biosynthetic Pathway Uncovers a Biological Route for α-Diazoester Production
Devon Van Cura, Tai L. Ng, Jing Huang, Harry H Hager +3 more
2023Angewandte Chemie33 citations Open access
Semantic Scholar
Structure and assembly of the diiron cofactor in the heme-oxygenase–like domain of the N-nitrosourea–producing enzyme SznF
M. McBride, Sarah R. Pope, Kai Hu, C. D. Okafor +3 more
2021Proceedings of the National Academy of Sciences of the United States of America32 citations Open access
Semantic Scholar
Deciphering Human Microbiota–Host Chemical Interactions
Justin E. Silpe, E. Balskus
2020ACS Central Science32 citations Open access
Semantic Scholar
Prevotella are major contributors of sialidases in the human vaginal microbiome
Paula Pelayo, Fatima A. Hussain, Caroline A. Werlang, Chloe Wu +8 more
2024Proceedings of the National Academy of Sciences of the United States of America30 citations Open access
Semantic Scholar
Prevotella timonensis degrades the vaginal epithelial glycocalyx through high fucosidase and sialidase activities
Celia Segui-Perez, R. de Jongh, Robin Jonkergouw, Paula Pelayo +3 more
2024bioRxiv30 citations Open access
Semantic Scholar
The Stickland Reaction Precursor trans-4-Hydroxy-l-Proline Differentially Impacts the Metabolism of Clostridioides difficile and Commensal Clostridia
A. D. Reed, J. R. Fletcher, Y.-Y. Huang, R. Thanissery +7 more
2022Msphere30 citations Open access
Semantic Scholar
The L-alanosine gene cluster encodes a pathway for diazeniumdiolate biosynthesis.
Tai L. Ng, Monica E. McCallum, Christine R. Zheng, Jennifer X. Wang +2 more
2019bioRxiv27 citations Open access
Semantic Scholar
Structural basis of colibactin activation by the ClbP peptidase
José A. Velilla, Matthew R Volpe, Grace E Kenney, Richard M. Jr Walsh +2 more
2022Nature Chemical Biology26 citations Open access
Semantic Scholar
Discovery of a Cyclic Choline Analog That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria.
Maud Bollenbach, M. Ortega, M. Orman, C. Drennan +1 more
2020ACS Medicinal Chemistry Letters25 citations Open access
Semantic Scholar
Bacterial Sphingolipids Exacerbate Colitis by Inhibiting ILC3-derived IL-22 Production
B. Bao, Youyuan Wang, P. Boudreau, Xinyang Song +17 more
2023bioRxiv23 citations Open access
Semantic Scholar
Leveraging Microbial Genomes and Genomic Context for Chemical Discovery
D. J. Kountz, E. Balskus
2021Accounts of Chemical Research19 citations Open access
Semantic Scholar
Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase
C. D. Dawson, Stephania M. Irwin, L. Backman, Chip Le +6 more
2021Cell Chemical Biology18 citations Open access
Semantic Scholar
Enantiocomplementary Gut Bacterial Enzymes Metabolize Dietary Polyphenols
Xueyang Dong, Minwoo Bae, Chip Le, Miguel A. Aguilar Ramos +1 more
2025Journal of the American Chemical Society17 citations Open access
Semantic Scholar
Emerging Chemical Diversity and Potential Applications of Enzymes in the DMSO Reductase Superfamily.
Chip Le, Min-Joo Bae, Sina Kiamehr, E. Balskus
2022Annual Review of Biochemistry17 citations Open access
Semantic Scholar
Distribution and diversity of dimetal-carboxylate halogenases in cyanobacteria
Nadia Eusebio, Adriana Rego, N. Glasser, R. Castelo-Branco +2 more
2021BMC Genomics17 citations Open access
Semantic Scholar
Extension of Diagnostic Fragmentation Filtering for Automated Discovery in DNA Adductomics
Kevin J Murray, Erik S. Carlson, Alessia Stornetta, E. Balskus +2 more
2021Analytical Chemistry17 citations Open access
Semantic Scholar
Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme
L. Backman, Yolanda Y. Huang, Mary C. Andorfer, Brian Gold +3 more
2020eLife17 citations Open access
Semantic Scholar

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