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E. Lakatta · SciRah

Researcher profile · Semantic Scholar

E. Lakatta

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E. Lakatta — researcher profile on SciRah

h-index: 147
Works: 1,057
Citations: 90K

Most-cited papers

Increased Drp1 Acetylation by Lipid Overload Induces Cardiomyocyte Death and Heart Dysfunction
Qing-Xun Hu, Hui-Liang Zhang, Nicolás Gutiérrez Cortés, Dan Wu +9 more
2020Circulation Research232 citations Open access
Semantic Scholar
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
Jacob M. Keaton, Zoha Kamali, Tian Xie, A. Vaez +143 more
2024Nature Genetics188 citations Open access
Semantic Scholar
The Dilemma of Coronavirus Disease 2019, Aging, and Cardiovascular Disease: Insights From Cardiovascular Aging Science
Majd AlGhatrif, O. Cingolani, E. Lakatta
2020JAMA cardiology188 citations Open access
Semantic Scholar
A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice
Michael A Petr, Irene Alfaras, M. Krawcyzk, W. Bair +12 more
2021eLife79 citations Open access
Semantic Scholar
Alterations in mitochondrial dynamics with age‐related Sirtuin1/Sirtuin3 deficiency impair cardiomyocyte contractility
Jing-Wen Zhang, Zhibin He, Julia Fedorova, Cole Logan +9 more
2021Aging Cell72 citations Open access
Semantic Scholar
DPP4 inhibition impairs senohemostasis to improve plaque stability in atherosclerotic mice
Allison B Herman, Dimitrios Tsitsipatis, C. Anerillas, K. Mazan-Mamczarz +24 more
2023Journal of Clinical Investigation40 citations Open access
Semantic Scholar
The Heart’s Pacemaker Mimics Brain Cytoarchitecture and Function
R. Bychkov, M. Juhaszova, Miguel Calvo-Rubio Barrera, Lorenzo Donald +7 more
2022bioRxiv31 citations Open access
Semantic Scholar
Photobiomodulation Therapy Mitigates Cardiovascular Aging and Improves Survival
S. Syed, I. Ahmet, Khalid Chakir, Christopher H. Morrell +2 more
2023Lasers in Surgery and Medicine29 citations Open access
Semantic Scholar
Age-dependent Lamin changes induce cardiac dysfunction via dysregulation of cardiac transcriptional programs
Natalie J. Kirkland, Scott H. Skalak, A. J. Whitehead, James D. Hocker +8 more
2022Nature Aging27 citations Open access
Semantic Scholar
Age-associated difference in circulating ACE2, the gateway for SARS-COV-2, in humans: results from the InCHIANTI study
Majd AlGhatrif, Toshiko Tanaka, A. Moore, S. Bandinelli +2 more
2021GeroScience25 citations Open access
Semantic Scholar
Dilated hypertrophic phenotype of the carotid artery is associated with accelerated age-associated central arterial stiffening
Majd AlGhatrif, E. Lakatta, Christopher H. Morrell, D. A. Fegatelli +5 more
2022GeroScience24 citations Open access
Semantic Scholar
Clinical neurocardiology: defining the value of neuroscience-based cardiovascular therapeutics – 2024 update
O. Ajijola, Tolga Aksu, R. Arora, Italo Biaggioni +18 more
2025Journal of Physiology22 citations Open access
Semantic Scholar
Mitochondrial health is enhanced in rats with higher vs. lower intrinsic exercise capacity and extended lifespan
M. Aon, S. Cortassa, M. Juhaszova, J. González-Reyes +13 more
2021npj Aging and Mechanisms of Disease22 citations Open access
Semantic Scholar
Auto-Antibody Production During Experimental Atherosclerosis in ApoE-/- Mice
Mark A. Hutchinson, Han-sol Park, Kimberly J. Zanotti, J. Alvarez-Gonzalez +7 more
2021Frontiers in Immunology21 citations Open access
Semantic Scholar
Enhanced Myocardial Adenylyl Cyclase Activity Alters Heart-Brain Communication
J. Agrimi, D. Menicucci, Jia-Hua Qu, M. Laurino +9 more
2023JACC Clinical Electrophysiology19 citations Open access
Semantic Scholar
What makes the sinoatrial node tick? A question not for the faint of heart
Lorenzo Donald, E. Lakatta
2023Philosophical Transactions of the Royal Society of London. Biological Sciences19 citations Open access
Semantic Scholar
Dual Activation of Phosphodiesterase 3 and 4 Regulates Basal Cardiac Pacemaker Function and Beyond
T. Vinogradova, E. Lakatta
2021International Journal of Molecular Sciences19 citations Open access
Semantic Scholar
Proteomic Landscape and Deduced Functions of the Cardiac 14-3-3 Protein Interactome
Jia-Hua Qu, K. Tarasov, Khalid Chakir, Y. Tarasova +2 more
2022Cells18 citations Open access
Semantic Scholar
Emergence of heartbeat frailty in advanced age I: perspectives from life-long EKG recordings in adult mice
Jack M. Moen, Christopher H. Morrell, Michael G. Matt, I. Ahmet +7 more
2022GeroScience18 citations Open access
Semantic Scholar
Functional Heterogeneity of Cell Populations Increases Robustness of Pacemaker Function in a Numerical Model of the Sinoatrial Node Tissue
A. Maltsev, M. Stern, E. Lakatta, V. Maltsev
2021bioRxiv18 citations Open access
Semantic Scholar
cAMP-Dependent Signaling Restores AP Firing in Dormant SA Node Cells via Enhancement of Surface Membrane Currents and Calcium Coupling
K. Tsutsui, M. C. Florio, Annie Yang, Ashley N. Wirth +7 more
2021Frontiers in Physiology17 citations Open access
Semantic Scholar
Transcriptional regulation of intermolecular Ca2+ signaling in hibernating ground squirrel cardiomyocytes: The myocardin–junctophilin axis
Lei Yang, Rong Li, B. Xiang, Yi-Chen Li +12 more
2021Proceedings of the National Academy of Sciences of the United States of America17 citations Open access
Semantic Scholar
A remarkable adaptive paradigm of heart performance and protection emerges in response to marked cardiac-specific overexpression of ADCY8
K. Tarasov, Khalid Chakir, D. Riordon, A. Lyashkov +34 more
2022eLife16 citations Open access
Semantic Scholar
Ca2+ and Membrane Potential Transitions During Action Potentials Are Self-Similar to Each Other and to Variability of AP Firing Intervals Across the Broad Physiologic Range of AP Intervals During Autonomic Receptor Stimulation
Dongmei Yang, Christopher H. Morrell, A. Lyashkov, Syevda Tagirova Sirenko +6 more
2021Frontiers in Physiology15 citations Open access
Semantic Scholar
Self-Similar Synchronization of Calcium and Membrane Potential Transitions During Action Potential Cycles Predict Heart Rate Across Species
Syevda Tagirova Sirenko, K. Tsutsui, K. Tarasov, Dongmei Yang +5 more
2021JACC Clinical Electrophysiology15 citations Open access
Semantic Scholar
Echocardiographic heart ageing patterns predict cardiovascular and non-cardiovascular events and reflect biological age: the SardiNIA study.
A. Ganau, M. Orr, M. Floris, P. Saba +14 more
2023European Journal of Preventive Cardiology13 citations Open access
Semantic Scholar
Phosphoprotein Phosphatase 1 but Not 2A Activity Modulates Coupled-Clock Mechanisms to Impact on Intrinsic Automaticity of Sinoatrial Nodal Pacemaker Cells
S. Sirenko, I. Zahanich, Yue Li, Y. Lukyanenko +10 more
2021Cells13 citations Open access
Semantic Scholar
Inflammatory Role of Milk Fat Globule–Epidermal Growth Factor VIII in Age‐Associated Arterial Remodeling
L. Ni, Lijuan Liu, Wanqu Zhu, Richard Telljohann +9 more
2022Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease12 citations Open access
Semantic Scholar
Discoidin Domain Receptor 2 Regulates AT1R Expression in Angiotensin II-Stimulated Cardiac Fibroblasts via Fibronectin-Dependent Integrin-β1 Signaling
A. Titus, Harikrishnan Venugopal, M. Ushakumary, Ming-Yi Wang +3 more
2021International Journal of Molecular Sciences11 citations Open access
Semantic Scholar
Metformin Attenuates Hyperglycaemia-Stimulated Pro-Fibrotic Gene Expression in Adventitial Fibroblasts via Inhibition of Discoidin Domain Receptor 2
A. Titus, M. Ushakumary, Harikrishnan Venugopal, Ming-Yi Wang +2 more
2022bioRxiv10 citations Open access
Semantic Scholar
The Longitudinal Decline in Peak VO2 with Aging in Healthy Individuals is Associated with a Reduction in Peripheral Oxygen Utilization but not in Cardiac Output.
Majd AlGhatrif, Christopher H Morrell, J. L. Fleg, Paul D. Chantler +5 more
2024American Journal of Physiology. Heart and Circulatory Physiology9 citations Open access
Semantic Scholar
Clusters of risk factors in metabolic syndrome and their influence on central blood pressure in a global study
A. Laučytė-Cibulskienė, Chen-Huan Chen, J. Cockroft, P. Cunha +20 more
2022Scientific Reports9 citations Open access
Semantic Scholar
β-Adrenergic Stimulation Synchronizes a Broad Spectrum of Action Potential Firing Rates of Cardiac Pacemaker Cells toward a Higher Population Average
Mary S. Kim, O. Monfredi, Larissa A. Maltseva, E. Lakatta +1 more
2021bioRxiv9 citations Open access
Semantic Scholar
A novel conceptual model of heart rate autonomic modulation based on a small-world modular structure of the sinoatrial node
A. Maltsev, Michael D. Stern, E. Lakatta, V. Maltsev
2023Frontiers in Physiology8 citations Open access
Semantic Scholar
Effect of Cardiotonic Steroid Marinobufagenin on Vascular Remodeling and Cognitive Impairment in Young Dahl-S Rats
Y. Grigorova, Ondrej Juhász, J. Long, Valentina I. Zernetkina +10 more
2022International Journal of Molecular Sciences7 citations Open access
Semantic Scholar
Association of central arterial stiffness with hippocampal blood flow and N-acetyl aspartate concentration in hypertensive adult Dahl salt sensitive rats
S. Ajamu, Rachel Fenner, Y. Grigorova, Defne S. Cezayirli +6 more
2021Journal of Hypertension7 citations Open access
Semantic Scholar
RelA-mediated signaling connects adaptation to chronic cardiomyocyte stress with myocardial and systemic inflammation in the ADCY8 model of accelerated aging
Vikas Kumar, K. Bermea, Dhaneshwar Kumar, Amit Singh +5 more
2024GeroScience6 citations Open access
Semantic Scholar
cAMP signaling affects age-associated deterioration of pacemaker beating interval dynamics
Sofia Segal, Ori Shemla, Rotem Shapira, Noa Kirschner Peretz +6 more
2023GeroScience6 citations Open access
Semantic Scholar
Transcriptome of Left Ventricle and Sinoatrial Node in Young and Old C57 Mice
Jia-Hua Qu, K. Tarasov, Y. Tarasova, Khalid Chakir +1 more
2023bioRxiv5 citations Open access
Semantic Scholar
Silencing of PKG1 Gene Mimics Effect of Aging and Sensitizes Rat Vascular Smooth Muscle Cells to Cardiotonic Steroids: Impact on Fibrosis and Salt Sensitivity
O. Fedorova, V. Shilova, Valentina I. Zernetkina, Ondrej Juhász +3 more
2023Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease5 citations Open access
Semantic Scholar
Adenosine reduces sinoatrial node cell action potential firing rate by uncoupling its membrane and calcium clocks
Ashley N. Wirth, K. Tsutsui, V. Maltsev, E. Lakatta
2022Frontiers in Physiology5 citations Open access
Semantic Scholar
Changes in cAMP signaling are associated with age-related downregulation of spontaneously beating atrial tissue energetic indices
Noa Kirschner Peretz, Sofia Segal, Rotem Shapira, Ori Shemla +5 more
2022GeroScience5 citations Open access
Semantic Scholar
Heartbeat music
E. Lakatta
2021Heart Rhythm5 citations Open access
Semantic Scholar
Longitudinal uncoupling of the heart and arteries with aging in a community-dwelling population
Majd AlGhatrif, Christopher H. Morrell, L. Becker, P. Chantler +4 more
2021GeroScience5 citations Open access
Semantic Scholar
The reprogrammed mouse heart phosphoproteome in response to the chronic stress of markedly high cardiac-specific adenylyl cyclase type 8 overexpression.
Jia-Hua Qu, Khalid Chakir, K. Tarasov, D. Riordon +3 more
2023Biophysical Journal4 citations Open access
Semantic Scholar
A small erythropoietin derived non-hematopoietic peptide reduces cardiac inflammation, attenuates age associated declines in heart function and prolongs healthspan
Nolan M. Winicki, Alay Nanavati, Christopher H. Morrell, Jack M. Moen +16 more
2023Frontiers in Cardiovascular Medicine4 citations Open access
Semantic Scholar
Reprogramming of cardiac phosphoproteome, proteome, and transcriptome confers resilience to chronic adenylyl cyclase-driven stress
Jia-Hua Qu, Khalid Chakir, K. Tarasov, D. Riordon +3 more
2023bioRxiv4 citations Open access
Semantic Scholar
Ankle‐Brachial Index and Energy Production in People Without Peripheral Artery Disease: The BLSA
Matt T. Oberdier, Majd AlGhatrif, Fatemeh Adelnia, Marta Zampino +6 more
2022Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease4 citations Open access
Semantic Scholar
Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) Regulates Basal Cardiac Pacemaker Function: Pros and Cons
T. Vinogradova, E. Lakatta
2024Cells3 citations Open access
Semantic Scholar
A Remarkable Adaptive Paradigm Of Heart Performance And Protection Emerges In Response To The Constitutive Challenge of Marked Cardiac-Specific Overexpression Of Adenylyl Cyclase Type 8
K. Tarasov, Khalid Chakir, D. Riordon, A. Lyashkov +34 more
2022bioRxiv3 citations Open access
Semantic Scholar

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