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T. Randolph · SciRah

Researcher profile · Semantic Scholar

T. Randolph

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T. Randolph — researcher profile on SciRah

h-index: 80
Works: 273
Citations: 21K

Most-cited papers

Protein instability and immunogenicity: roadblocks to clinical application of injectable protein delivery systems for sustained release.
W. Jiskoot, T. Randolph, D. Volkin, C. Middaugh +5 more
2012Journal of Pharmacy and Science246 citations
Semantic Scholar
Protein aggregation and particle formation in prefilled glass syringes.
Alana Gerhardt, Nicole R Mcgraw, D. K. Schwartz, Jared S. Bee +2 more
2014Journal of Pharmacy and Science187 citations
Semantic Scholar
Subvisible particle counting provides a sensitive method of detecting and quantifying aggregation of monoclonal antibody caused by freeze-thawing: insights into the roles of particles in the protein aggregation pathway.
James G Barnard, S. Singh, T. Randolph, J. Carpenter
2011Journal of Pharmacy and Science161 citations Open access
Semantic Scholar
Effects of surfaces and leachables on the stability of biopharmaceuticals.
Jared S. Bee, T. Randolph, J. Carpenter, Steven M. Bishop +1 more
2011Journal of Pharmacy and Science160 citations
Semantic Scholar
Protein adsorption and excipient effects on kinetic stability of silicone oil emulsions.
D. Ludwig, J. Carpenter, J. Hamel, T. Randolph
2010Journal of Pharmacy and Science134 citations
Semantic Scholar
Production of particles of therapeutic proteins at the air–water interface during compression/dilation cycles
Jared S. Bee, D. K. Schwartz, S. Trabelsi, E. Freund +3 more
2012127 citations
Semantic Scholar
DO NOT DROP: MECHANICAL SHOCK IN VIALS CAUSES CAVITATION, PROTEIN AGGREGATION AND PARTICLE FORMATION
T. Randolph, Elise Schiltz, Donn R. Sederstrom, Daniel Steinmann +6 more
2014Journal of Pharmacy and Science116 citations Open access
Semantic Scholar
MOUSE MODELS FOR ASSESSING PROTEIN IMMUNOGENICITY: LESSONS AND CHALLENGES
W. Jiskoot, G. Kijanka, T. Randolph, J. Carpenter +5 more
2016Journal of Pharmacy and Science105 citations Open access
Semantic Scholar
Postproduction Handling and Administration of Protein Pharmaceuticals and Potential Instability Issues.
M. Reza Nejadnik, T. Randolph, D. Volkin, C. Schöneich +3 more
2018Journal of Pharmacy and Science104 citations Open access
Semantic Scholar
Gelation of a monoclonal antibody at the silicone oil-water interface and subsequent rupture of the interfacial gel results in aggregation and particle formation.
Shyam B. Mehta, R. Lewus, Jared S. Bee, T. Randolph +1 more
2015Journal of Pharmacy and Science104 citations
Semantic Scholar
Stability of lyophilized and spray dried vaccine formulations.
Kendall B. Preston, T. Randolph
2021Advanced Drug Delivery Reviews92 citations
Semantic Scholar
The Effects of Excipients on Protein Aggregation During Agitation: An Interfacial Shear Rheology Study
Lu Liu, Wei Qi, D. K. Schwartz, T. Randolph +1 more
2013Journal of Pharmacy and Science92 citations Open access
Semantic Scholar
IgG1 aggregation and particle formation induced by silicone-water interfaces on siliconized borosilicate glass beads: a model for siliconized primary containers.
P. Basu, S. Krishnan, Renuka Thirumangalathu, T. Randolph +1 more
2013Journal of Pharmacy and Science83 citations
Semantic Scholar
Ionic strength affects tertiary structure and aggregation propensity of a monoclonal antibody adsorbed to silicone oil-water interfaces.
Alana Gerhardt, Kurt Bonam, Jared S. Bee, J. Carpenter +1 more
2013Journal of Pharmacy and Science80 citations
Semantic Scholar
Deep Convolutional Neural Network Analysis of Flow Imaging Microscopy Data to Classify Subvisible Particles in Protein Formulations.
C. Calderon, Austin L. Daniels, T. Randolph
2017Journal of Pharmacy and Science75 citations
Semantic Scholar
Electrostatic Interactions Influence Protein Adsorption (but Not Desorption) at the Silica-Aqueous Interface.
Aaron C Mcumber, T. Randolph, D. K. Schwartz
2015Journal of Physical Chemistry Letters73 citations
Semantic Scholar
Particles shed from syringe filters and their effects on agitation-induced protein aggregation.
Lu Liu, T. Randolph, J. Carpenter
2012Journal of Pharmacy and Science71 citations
Semantic Scholar
Glass particles as an adjuvant: a model for adverse immunogenicity of therapeutic proteins.
Amber Haynes Fradkin, J. Carpenter, T. Randolph
2011Journal of Pharmacy and Science68 citations
Semantic Scholar
Investigation of the Immunogenicity of Different Types of Aggregates of a Murine Monoclonal Antibody in Mice
Angelika J. Freitag, Maliheh Shomali, S. Michalakis, M. Biel +6 more
2014Pharmaceutical Research67 citations
Semantic Scholar
Immunogenicity of recombinant human interferon beta interacting with particles of glass, metal, and polystyrene.
M. V. van Beers, F. Gilli, H. Schellekens, T. Randolph +1 more
2012Journal of Pharmacy and Science67 citations
Semantic Scholar
Adsorption of monoclonal antibodies to glass microparticles.
M. Hoehne, F. Samuel, A. Dong, C. Wurth +3 more
2011Journal of Pharmacy and Science63 citations
Semantic Scholar
Effects of phenol and meta-cresol depletion on insulin analog stability at physiological temperature.
Brandon M Teska, Javier Alarcón, Ronald J. Pettis, T. Randolph +1 more
2014Journal of Pharmacy and Science61 citations
Semantic Scholar
Excipient effects on humanized monoclonal antibody interactions with silicone oil emulsions.
Keith A. Britt, D. K. Schwartz, C. Wurth, H. Mahler +2 more
2012Journal of Pharmacy and Science61 citations
Semantic Scholar
Effect of the siliconization method on particle generation in a monoclonal antibody formulation in pre-filled syringes.
Alana Gerhardt, Bao H Nguyen, R. Lewus, J. Carpenter +1 more
2015Journal of Pharmacy and Science58 citations
Semantic Scholar
Challenges in Predicting Protein-Protein Interactions from Measurements of Molecular Diffusivity.
Lea L. Sorret, M. DeWinter, D. K. Schwartz, T. Randolph
2016Biophysical Journal55 citations Open access
Semantic Scholar
In Vivo Analysis of the Potency of Silicone Oil Microdroplets as Immunological Adjuvants in Protein Formulations
C. F. Chisholm, Bao H Nguyen, Kaitlin R Soucie, R. Torres +2 more
2015Journal of Pharmacy and Science54 citations Open access
Semantic Scholar
Development of a Highly Thermostable, Adjuvanted Human Papillomavirus Vaccine
Kimberly J. Hassett, Natalie M. Meinerz, F. Semmelmann, Megan C Cousins +2 more
2015European journal of pharmaceutics and biopharmaceutics52 citations Open access
Semantic Scholar
Surfactant Effects on Particle Generation in Antibody Formulations in Pre-filled Syringes
Alana Gerhardt, Aaron C Mcumber, Bao H Nguyen, R. Lewus +3 more
2015Journal of Pharmacy and Science52 citations Open access
Semantic Scholar
Protein Quantity on the Air-Solid Interface Determines Degradation Rates of Human Growth Hormone in Lyophilized Samples
Yemin Xu, P. Grobelny, Alexander von Allmen, K. Knudson +3 more
2014Journal of Pharmacy and Science51 citations Open access
Semantic Scholar
Colloidal Instability Fosters Agglomeration of Subvisible Particles Created by Rupture of Gels of a Monoclonal Antibody Formed at Silicone Oil-Water Interfaces.
Shyam B. Mehta, J. Carpenter, T. Randolph
2016Journal of Pharmacy and Science46 citations
Semantic Scholar
Freezing-Induced Perturbation of Tertiary Structure of a Monoclonal Antibody
Lu Liu, L. Braun, Wei Wang, T. Randolph +1 more
2014Journal of Pharmacy and Science46 citations Open access
Semantic Scholar
Single-administration, thermostable human papillomavirus vaccines prepared with atomic layer deposition technology
R. Garcea, Natalie M. Meinerz, Dong-Mei Miao, Hans Funke +2 more
2020npj Vaccines45 citations Open access
Semantic Scholar
Stabilization of a Recombinant Ricin Toxin A Subunit Vaccine through Lyophilization
Kimberly J. Hassett, Megan C Cousins, Lilia A. Rabia, Chrystal Chadwick +6 more
2013European journal of pharmaceutics and biopharmaceutics45 citations Open access
Semantic Scholar
Silicone Oil Microdroplets Can Induce Antibody Responses Against Recombinant Murine Growth Hormone In Mice
C. F. Chisholm, A. E. Baker, Kaitlin R Soucie, R. Torres +2 more
2016Journal of Pharmacy and Science39 citations Open access
Semantic Scholar
Machine Learning & Statistical Analyses for Extracting and Characterizing "Fingerprints" of Antibody Aggregation at Container Interfaces from Flow Microscopy Images
Austin L. Daniels, C. Calderon, T. Randolph
2020Biotechnology and Bioengineering38 citations Open access
Semantic Scholar
Aggregation and Particle Formation During Pumping of an Antibody Formulation are Controlled by Electrostatic Interactions between Pump Surfaces and Protein Molecules.
Hao Wu, T. Randolph
2020Journal of Pharmacy and Science38 citations
Semantic Scholar
Accelerated stability studies of abatacept formulations: comparison of freeze-thawing- and agitation-induced stresses.
A. Cordes, J. Carpenter, T. Randolph
2012Journal of Pharmacy and Science37 citations
Semantic Scholar
Dose levels in particulate-containing formulations impact anti-drug antibody responses to murine monoclonal antibody in mice.
Maliheh Shomali, S. Tanrıverdi, Angelika J. Freitag, Julia Engert +5 more
2015Journal of Pharmacy and Science35 citations
Semantic Scholar
Partial unfolding of a monoclonal antibody: role of a single domain in driving protein aggregation.
Shyam B. Mehta, Jared S. Bee, T. Randolph, J. Carpenter
2014Biochemistry35 citations
Semantic Scholar
DEHP Nanodroplets Leached from Polyvinyl Chloride IV Bags Promote Aggregation of IVIG and Activate Complement in Human Serum
Jared R. Snell, Connor R Monticello, Her Cheng, Emma L. Ross +3 more
2019Journal of Pharmacy and Science32 citations Open access
Semantic Scholar
Albinterferon α2b adsorption to silicone oil-water interfaces: effects on protein conformation, aggregation, and subvisible particle formation.
P. Basu, Angela W. Blake-Haskins, Kristin O'Berry, T. Randolph +1 more
2014Journal of Pharmacy and Science32 citations
Semantic Scholar
Immunogenicity of Structurally Perturbed Hen Egg Lysozyme Adsorbed to Silicone Oil Microdroplets in Wild-Type and Transgenic Mouse Models.
C. F. Chisholm, Kaitlin R Soucie, Jane S Song, Pamela Strauch +4 more
2017Journal of Pharmacy and Science31 citations Open access
Semantic Scholar
Physical stability of albinterferon-α(2b) in aqueous solution: effects of conformational stability and colloidal stability on aggregation.
Danny K. Chou, R. Krishnamurthy, M. Manning, T. Randolph +1 more
2012Journal of Pharmacy and Science31 citations
Semantic Scholar
Thermostable Ebola Virus Vaccine Formulations Lyophilized in the Presence of Aluminum Hydroxide
C. F. Chisholm, T. Kang, Dong-Mei Miao, K. Lewis +3 more
2019European journal of pharmaceutics and biopharmaceutics30 citations Open access
Semantic Scholar
UV Photodegradation of Murine Growth Hormone: Chemical Analysis and Immunogenicity Consequences
Amber Haynes Fradkin, Olivier Mozziconacci, C. Schöneich, J. Carpenter +1 more
2014European journal of pharmaceutics and biopharmaceutics30 citations Open access
Semantic Scholar
Recombinant Murine Growth Hormone Particles are More Immunogenic with Intravenous than Subcutaneous Administration
Merry Christie, R. Torres, R. Kedl, T. Randolph +1 more
2013Journal of Pharmacy and Science30 citations Open access
Semantic Scholar
Conjugation of Emtansine Onto Trastuzumab Promotes Aggregation of the Antibody-Drug Conjugate by Reducing Repulsive Electrostatic Interactions and Increasing Hydrophobic Interactions.
A. Gandhi, T. Randolph, J. Carpenter
2019Journal of Pharmacy and Science29 citations
Semantic Scholar
Protein–protein interactions controlling interfacial aggregation of rhIL‐1ra are not described by simple colloid models
Lea L. Sorret, M. DeWinter, Daniel K. Schwartz, T. Randolph
2018Protein Science29 citations Open access
Semantic Scholar
Glassy-State Stabilization of a Dominant Negative Inhibitor Anthrax Vaccine Containing Aluminum Hydroxide and Glycopyranoside Lipid A Adjuvants
Kimberly J. Hassett, D. Vance, N. Jain, Neha Sahni +8 more
2015Journal of Pharmacy and Science29 citations Open access
Semantic Scholar
Selective domain stabilization as a strategy to reduce fusion protein aggregation.
A. Cordes, C. Platt, J. Carpenter, T. Randolph
2012Journal of Pharmacy and Science29 citations
Semantic Scholar

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