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K. Heyninck · SciRah

Researcher profile · Semantic Scholar

K. Heyninck

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K. Heyninck — researcher profile on SciRah

h-index: 36
Works: 65
Citations: 5,320

Most-cited papers

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma
Behrouz Hassannia, Bartosz Wiernicki, Irina Ingold, F. Qu +21 more
2018Journal of Clinical Investigation513 citations Open access
Semantic Scholar
T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20
Beatrice Coornaert, M. Baens, K. Heyninck, Tine Bekaert +6 more
2008Nature Immunology409 citations
Semantic Scholar
A20 and A20-binding proteins as cellular inhibitors of nuclear factor-kappa B-dependent gene expression and apoptosis.
R. Beyaert, K. Heyninck, S. V. Van Huffel
2000Biochemical Pharmacology316 citations
Semantic Scholar
The Zinc Finger Protein A20 Inhibits TNF-induced NF-κB–dependent Gene Expression by Interfering with an RIP- or TRAF2-mediated Transactivation Signal and Directly Binds to a Novel NF-κB–inhibiting Protein ABIN
K. Heyninck, D. De Valck, W. Berghe, W. van Criekinge +4 more
1999Journal of Cell Biology311 citations Open access
Semantic Scholar
A20 inhibits NF-κB activation by dual ubiquitin-editing functions
K. Heyninck, R. Beyaert
2005256 citations
Semantic Scholar
Hepatic tumor necrosis factor signaling and nuclear factor-kappaB: effects on liver homeostasis and beyond.
A. Wullaert, G. van Loo, K. Heyninck, R. Beyaert
2007Endocrine reviews233 citations
Semantic Scholar
Molecular insight in the multifunctional activities of Withaferin A.
Wim Vanden Berghe, L. Sabbe, Mary Kaileh, G. Haegeman +1 more
2012Biochemical Pharmacology229 citations
Semantic Scholar
Mechanisms of crosstalk between TNF-induced NF-kappaB and JNK activation in hepatocytes.
A. Wullaert, K. Heyninck, R. Beyaert
2006Biochemical Pharmacology215 citations
Semantic Scholar
The cytokine‐inducible zinc finger protein A20 inhibits IL‐1‐induced NF‐κB activation at the level of TRAF6
K. Heyninck, R. Beyaert
1999FEBS Letters189 citations Open access
Semantic Scholar
A Novel Type of Deubiquitinating Enzyme*
P. Evans, Trevor S. Smith, M. Lai, Mark G. Williams +6 more
2003Journal of Biological Chemistry178 citations Open access
Semantic Scholar
Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ.
K. Heyninck, M. Lahtela-Kakkonen, P. Van der Veken, G. Haegeman +1 more
2014Biochemical Pharmacology158 citations
Semantic Scholar
Inflammatory cardiac valvulitis in TAX1BP1‐deficient mice through selective NF‐κB activation
H. Iha, J. Peloponese, L. Verstrepen, G. Zapart +8 more
2008EMBO Journal157 citations Open access
Semantic Scholar
The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases
D. De Valck, D. Jin, K. Heyninck, M. van de Craen +4 more
1999Oncogene147 citations
Semantic Scholar
A20 inhibits NF-kappaB activation by dual ubiquitin-editing functions.
K. Heyninck, R. Beyaert
2005TIBS -Trends in Biochemical Sciences. Regular ed117 citations
Semantic Scholar
TNF-induced intracellular signaling leading to gene induction or to cytotoxicity by necrosis or by apoptosis.
W. Fiers, R. Beyaert, E. Boone, S. Cornelis +19 more
1995Journal of Inflammation113 citations
Semantic Scholar
Identification of a Novel A20-binding Inhibitor of Nuclear Factor-κB Activation Termed ABIN-2*
S. V. Van Huffel, Filip Delaei, K. Heyninck, D. De Valck +1 more
2001Journal of Biological Chemistry110 citations Open access
Semantic Scholar
The serotonin 5-HT7 receptors: two decades of research
Evelien Gellynck, K. Heyninck, K. W. Andressen, G. Haegeman +3 more
2013Experimental Brain Research109 citations
Semantic Scholar
Structure–function analysis of the A20‐binding inhibitor of NF‐κB activation, ABIN‐1
K. Heyninck, Marja M. Kreike, R. Beyaert
2003109 citations Open access
Semantic Scholar
Isolation and characterization of two novel A20-like proteins.
P. Evans, Ellen R. Taylor, J. Coadwell, K. Heyninck +2 more
2001Biochemical Journal96 citations Open access
Semantic Scholar
Pharmacological Levels of Withaferin A (Withania somnifera) Trigger Clinically Relevant Anticancer Effects Specific to Triple Negative Breast Cancer Cells
Katarzyna Szarc Vel Szic, Ken Op de Beeck, D. Ratman, A. Wouters +9 more
2014PLoS ONE91 citations Open access
Semantic Scholar
LIND/ABIN-3 Is a Novel Lipopolysaccharide-inducible Inhibitor of NF-κB Activation*
A. Wullaert, L. Verstrepen, S. V. Van Huffel, M. Adib-conquy +10 more
2007Journal of Biological Chemistry87 citations Open access
Semantic Scholar
Crosstalk between NF-kappaB-activating and apoptosis-inducing proteins of the TNF-receptor complex.
K. Heyninck, Rudi Beyaert
2001Molecular Cell Biology Research Communications84 citations
Semantic Scholar
Additive efficacy of a bispecific anti–TNF/IL-6 nanobody compound in translational models of rheumatoid arthritis
Nadine Biesemann, D. Margerie, C. Asbrand, Markus Rehberg +12 more
2023Science Translational Medicine75 citations
Semantic Scholar
Ubiquitin: tool and target for intracellular NF-kappaB inhibitors.
A. Wullaert, K. Heyninck, S. Janssens, R. Beyaert
2006Trends in immunology70 citations Open access
Semantic Scholar
Functional redundancy of the zinc fingers of A20 for inhibition of NF‐κB activation and protein–protein interactions
Marco Klinkenberg, S. V. Van Huffel, K. Heyninck, R. Beyaert
2001FEBS Letters70 citations
Semantic Scholar
This item is the archived peer-reviewed author-version of: Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway
K. Heyninck, L. Sabbe, C. S. Chirumamilla, Katarzyna Szarc +14 more
70 citations
Semantic Scholar
Dietary Flavanols Modulate the Transcription of Genes Associated with Cardiovascular Pathology without Changes in Their DNA Methylation State
D. Milenkovic, Wim Vanden Berghe, C. Boby, C. Leroux +13 more
2014PLoS ONE56 citations Open access
Semantic Scholar
Nuclear factor-kappa B plays a central role in tumour necrosis factor-mediated liver disease.
K. Heyninck, A. Wullaert, R. Beyaert
2003Biochemical Pharmacology56 citations
Semantic Scholar
Signaling to gene activation and cell death by tumor necrosis factor receptors and Fas.
R. Beyaert, G. van Loo, K. Heyninck, P. Vandenabeele
2002International Review of Cytology54 citations
Semantic Scholar
Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1.
K. Heyninck, Marja Kreike, R. Beyaert
2003FEBS Letters50 citations
Semantic Scholar
Adenoviral gene transfer of ABIN‐1 protects mice from TNF/galactosamine‐induced acute liver failure and lethality
A. Wullaert, B. Wielockx, S. V. Van Huffel, V. Bogaert +7 more
2005Hepatology48 citations
Semantic Scholar
Identification of differentially methylated BRCA1 and CRISP2 DNA regions as blood surrogate markers for cardiovascular disease
Geoffrey Istas, K. Declerck, Maria Pudenz, K. S. V. Szic +10 more
2017Scientific Reports46 citations Open access
Semantic Scholar
A20, an inhibitor of cell death, self‐associates by its zinc finger domain
D. De Valck, K. Heyninck, W. van Criekinge, R. Contreras +2 more
1996FEBS Letters45 citations
Semantic Scholar
Ectopic MicroRNA-150-5p Transcription Sensitizes Glucocorticoid Therapy Response in MM1S Multiple Myeloma Cells but Fails to Overcome Hormone Therapy Resistance in MM1R Cells
Ajay Palagani, Ken Op de Beeck, Stefan Naulaerts, Jolien Diddens +8 more
2014PLoS ONE44 citations Open access
Semantic Scholar
A20 Inhibits NF-κB Activation Independently of Binding to 14-3-3 Proteins
D. De Valck, K. Heyninck, W. van Criekinge, P. Vandenabeele +2 more
199742 citations
Semantic Scholar
Adenoviral Gene Transfer of the NF-κB Inhibitory Protein ABIN-1 Decreases Allergic Airway Inflammation in a Murine Asthma Model*
K. El Bakkouri, A. Wullaert, M. Haegman, K. Heyninck +1 more
2005Journal of Biological Chemistry38 citations Open access
Semantic Scholar
Enhancement of tumor necrosis factor cytotoxicity by lithium chloride is associated with increased inositol phosphate accumulation.
R. Beyaert, K. Heyninck, D. De Valck, F. Boeykens +2 more
1993Journal of Immunology36 citations
Semantic Scholar
Inhibition of tumor necrosis factor-induced necrotic cell death by the zinc finger protein A20.
K. Heyninck, G. Denecker, D. De Valck, W. Fiers +1 more
1999Anticancer Research35 citations
Semantic Scholar
How the Venom from the Ectoparasitoid Wasp Nasonia vitripennis Exhibits Anti-Inflammatory Properties on Mammalian Cell Lines
E. Danneels, Sarah Gerlo, K. Heyninck, K. van Craenenbroeck +3 more
2014PLoS ONE32 citations Open access
Semantic Scholar
TNFα- and IKKβ-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKγ and NF-κB activation
Marianne Bonif, M. Meuwis, Pierre Close, V. Benoit +7 more
200631 citations Open access
Semantic Scholar
ABINs inhibit EGF receptor-mediated NF-κB activation and growth of EGF receptor-overexpressing tumour cells
Lieven Huang, L. Verstrepen, K. Heyninck, Andy Wullaert +3 more
2008Oncogene30 citations
Semantic Scholar
Sensitization of tumor cells to tumor necrosis factor action by the protein kinase inhibitor staurosporine.
R. Beyaert, B. Vanhaesebroeck, K. Heyninck, E. Boone +5 more
1993Cancer Research27 citations
Semantic Scholar
Epigenetic control of cardiovascular health by nutritional polyphenols involves multiple chromatin-modifying writer-reader-eraser proteins.
K. Declerck, Katarzyna Szarc Vel Szic, Ajay Palagani, K. Heyninck +4 more
2015Current Topics in Medicinal Chemistry26 citations
Semantic Scholar
Combined TNF-α and OX40L targeting as a new treatment option for hidradenitis suppurativa
T. Leeuw, D. Šimaitė, K. Heyninck, Clement Levin +11 more
2025Journal of Allergy and Clinical Immunology: Global16 citations Open access
Semantic Scholar
The role of serine- and metalloproteases in Nasonia vitripennis venom in cell death related processes towards a Spodoptera frugiperda Sf21 cell line.
E. Formesyn, K. Heyninck, D. D. de Graaf
2013Journal of insect physiology16 citations
Semantic Scholar
TNFalpha- and IKKbeta-mediated TANK/I-TRAF phosphorylation: implications for interaction with NEMO/IKKgamma and NF-kappaB activation.
Marianne Bonif, M. Meuwis, Pierre Close, V. Benoit +7 more
2006Biochemical Journal15 citations
Semantic Scholar
Autoinhibitory structure of preligand association state implicates a new strategy to attain effective DR5 receptor activation
Gang Du, Linlin Zhao, Yu-Mei Zheng, Anissa Belfetmi +10 more
2023Cell Research14 citations Open access
Semantic Scholar
NF-κB activation by tumor necrosis factor and interleukin-1
I. Carpentier, S. Janssens, K. Heyninck, R. Beyaert
200314 citations
Semantic Scholar
Phytochemicals and Cancer Chemoprevention: Epigenetic Friends or Foe?
K. S. V. Szic, Ajay Palagani, Behrouz Hassannia, L. Sabbe +3 more
201113 citations Open access
Semantic Scholar
Yeast two-hybrid screening for proteins interacting with the anti-apoptotic protein A20.
K. Heyninck, S. V. Van Huffel, Marja Kreike, R. Beyaert
2004Methods in molecular biology11 citations
Semantic Scholar

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