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Brian C. Capell · SciRah

Researcher profile · Semantic Scholar

Brian C. Capell

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Brian C. Capell — researcher profile on SciRah

h-index: 26
Works: 63
Citations: 5,779

Most-cited papers

Cytoplasmic chromatin triggers inflammation in senescence and cancer
Zhi-Xun Dou, Kanad Ghosh, Maria Grazia Vizioli, Jiajun Zhu +20 more
2017Nature1,251 citations Open access
Semantic Scholar
Autophagy mediates degradation of nuclear lamina
Zhi-Xun Dou, Caiyue Xu, G. Donahue, T. Shimi +16 more
2015Nature626 citations Open access
Semantic Scholar
Human laminopathies: nuclei gone genetically awry
Brian C. Capell, F. Collins
2006Nature reviews genetics545 citations
Semantic Scholar
Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape
P. Shah, G. Donahue, Gabriel L. Otte, Brian C. Capell +9 more
2013Genes & Development529 citations Open access
Semantic Scholar
Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome.
Brian C. Capell, M. Erdos, J. Madigan, J. Fiordalisi +6 more
2005Proceedings of the National Academy of Sciences of the United States of America416 citations Open access
Semantic Scholar
A lamin A protein isoform overexpressed in Hutchinson–Gilford progeria syndrome interferes with mitosis in progeria and normal cells
Kan Cao, Brian C. Capell, M. Erdos, K. Djabali +1 more
2007Proceedings of the National Academy of Sciences of the United States of America277 citations Open access
Semantic Scholar
A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model
Brian C. Capell, M. Olive, M. Erdos, Kan Cao +12 more
2008Proceedings of the National Academy of Sciences of the United States of America212 citations Open access
Semantic Scholar
Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson–Gilford progeria syndrome
R. Varga, M. Eriksson, M. Erdos, M. Olive +15 more
2006190 citations
Semantic Scholar
The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging
Kanad Ghosh, Brian C. Capell
2016Journal of Investigative Dermatology147 citations Open access
Semantic Scholar
Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndrome.
R. Varga, M. Eriksson, M. Erdos, M. Olive +15 more
2006Proceedings of the National Academy of Sciences of the United States of America143 citations
Semantic Scholar
MLL1 is essential for the senescence-associated secretory phenotype
Brian C. Capell, Adam M. Drake, Jiajun Zhu, P. Shah +10 more
2016Genes & Development141 citations Open access
Semantic Scholar
Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis
L. Izzo, S. Trefely, Christina Demetriadou, Jack M. Drummond +14 more
2023Science Advances121 citations Open access
Semantic Scholar
Magnetic Resonance Imaging in Quantitative Analysis of Rotator Cuff Muscle Volume
M. Tingart, M. Apreleva, J. Lehtinen, Brian C. Capell +2 more
2003Clinical Orthopaedics and Related Research116 citations
Semantic Scholar
Telomere Biology and Cardiovascular Disease Vascular Cell Senescence: Contribution to Atherosclerosis Stem Cells and the Regeneration of the Aging Cardiovascular System Mechanisms of Cardiovascular Disease in Accelerated Aging Syndromes Mechanisms Underlying Caloric Restriction, Lipid Metabolism, an
Issei Komuro, G. Editor, Brian C. Capell, F. Collins +1 more
100 citations
Semantic Scholar
CDKN2B loss promotes progression from benign melanocytic nevus to melanoma
Andrew S. McNeal, Kevin Liu, Vihang Nakhate, C. Natale +7 more
2015Cancer Discovery95 citations Open access
Semantic Scholar
KMT2D regulates p63 target enhancers to coordinate epithelial homeostasis
E. Lin-Shiao, Y. Lan, Mariel Coradin, A. Anderson +8 more
2018Genes & Development93 citations Open access
Semantic Scholar
Lgr6 marks epidermal stem cells with a nerve-dependent role in wound re-epithelialization
Sixia Huang, P. Kuri, Yann Aubert, M. Brewster +9 more
2021Cell Stem Cell91 citations Open access
Semantic Scholar
Protein farnesylation inhibitors cause donut-shaped cell nuclei attributable to a centrosome separation defect
V. Verstraeten, Lana A Peckham, M. Olive, Brian C. Capell +5 more
2011Proceedings of the National Academy of Sciences of the United States of America89 citations Open access
Semantic Scholar
LSD1 Inhibition Promotes Epithelial Differentiation through Derepression of Fate-Determining Transcription Factors
S. Egolf, Yann Aubert, M. Doepner, A. Anderson +9 more
2019Cell Reports64 citations Open access
Semantic Scholar
From the rarest to the most common: insights from progeroid syndromes into skin cancer and aging.
Brian C. Capell, B. Tlougan, S. Orlow
2009Journal of Investigative Dermatology59 citations Open access
Semantic Scholar
Human longevity and common variations in the LMNA gene: a meta-analysis
K. Conneely, Brian C. Capell, M. Erdos, P. Sebastiani +11 more
2012Aging Cell44 citations Open access
Semantic Scholar
Pharmacologic Activation of the G Protein–Coupled Estrogen Receptor Inhibits Pancreatic Ductal Adenocarcinoma
C. Natale, Jin-Yang Li, Jason R. Pitarresi, Robert J. Norgard +5 more
2020Cellular and Molecular Gastroenterology and Hepatology43 citations Open access
Semantic Scholar
Risk factors for positive or equivocal margins after wide local excision of 1345 cutaneous melanomas
C. Miller, T. Shin, J. Sobanko, John M Sharkey +6 more
2017Journal of American Academy of Dermatology41 citations Open access
Semantic Scholar
The unexpected non-catalytic roles of histone modifiers in development and disease
Yann Aubert, S. Egolf, Brian C. Capell
2019Trends in Genetics33 citations Open access
Semantic Scholar
Mechanisms of Cardiovascular Disease in Accelerated Aging Syndromes
Brian C. Capell, Francis S. Collins, E. G. Nabel
2007Circulation Research33 citations Open access
Semantic Scholar
FBXW7 triggers degradation of KMT2D to favor growth of diffuse large B-cell lymphoma cells
Rizwan Saffie, N. Zhou, D. Rolland, Özlem Önder +6 more
2020Cancer Research31 citations Open access
Semantic Scholar
Mettl3-catalyzed m6A regulates histone modifier and modification expression in self-renewing somatic tissue
A. M. Maldonado López, E. Ko, Sijia Huang, G. Pacella +13 more
2023Science Advances25 citations Open access
Semantic Scholar
Genome-Wide Epigenetics
Brian C. Capell, S. Berger
2013Journal of Investigative Dermatology25 citations Open access
Semantic Scholar
Endogenous DOPA inhibits melanoma through suppression of CHRM1 signaling
Miriam Doepner, I. Lee, C. Natale, Roderick Brathwaite +9 more
2022Science Advances23 citations Open access
Semantic Scholar
Diabetes Increases p53-Mediated Apoptosis following Ischemia
Leila Jazayeri, M. Callaghan, R. Grogan, C. Hamou +5 more
2008Plastic and Reconstructive Surgery23 citations
Semantic Scholar
Histone modifiers: dynamic regulators of the cutaneous transcriptome
Kanad Ghosh, K. O’Neil, Brian C. Capell
2017Journal of dermatological science (Amsterdam)21 citations Open access
Semantic Scholar
The endangered physician-scientist and COVID-19
R. Rao, B. Dlouhy, Brian C. Capell, Oluwaseun Akeju
2021Cell Reports Medicine20 citations Open access
Semantic Scholar
The METTL3-m6A Epitranscriptome: Dynamic Regulator of Epithelial Development, Differentiation, and Cancer
A. M. Maldonado López, Brian C. Capell
2021Genes18 citations Open access
Semantic Scholar
Pharmacologic activation of the G protein-coupled estrogen receptor inhibits pancreatic ductal adenocarcinoma
C. Natale, Jin-Yang Li, T. Dentchev, Brian C. Capell +3 more
2018bioRxiv18 citations Open access
Semantic Scholar
Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis
Phuong T. T. Nguyen, Mia Shiue, N. Kuprasertkul, Pedro Costa-Pinheiro +14 more
2025Cell Reports10 citations
Semantic Scholar
Disruption of H3K36 methylation provokes cellular plasticity to drive aberrant glandular formation and squamous carcinogenesis
E. Ko, A. Anderson, Carina A D'souza, J. Zou +11 more
2023Developmental Cell10 citations Open access
Semantic Scholar
Epigenetic and metabolic interplay in cutaneous squamous cell carcinoma
G. Pacella, Brian C. Capell
2021Experimental Dermatology10 citations Open access
Semantic Scholar
LSD1: A viable therapeutic target in cutaneous squamous cell carcinoma?
S. Egolf, Brian C. Capell
2020Expert opinion on therapeutic targets9 citations Open access
Semantic Scholar
Rapidly Fatal Pulmonary Fibrosis in a Patient with Psoriatic Arthritis Treated with Adalimumab
J. Cohen, Brian C. Capell, P. Kinniry, A. Epstein
2011Journal of Rheumatology9 citations Open access
Semantic Scholar
The carnitine shuttle links mitochondrial metabolism to histone acetylation and lipogenesis
L. Izzo, S. Trefely, Christina Demetriadou, Jack M. Drummond +12 more
2022bioRxiv6 citations Open access
Semantic Scholar
Methyltransferases in the Pathogenesis of Keratinocyte Cancers
E. Ko, Brian C. Capell
2021Cancers6 citations Open access
Semantic Scholar
UTX (KDM6A) promotes differentiation noncatalytically in somatic self-renewing epithelia
G. Pacella, N. Kuprasertkul, Lydia Bao, Sijia Huang +8 more
2025Proceedings of the National Academy of Sciences of the United States of America4 citations Open access
Semantic Scholar
Differential gene expression by RNA-Seq in Sigma-2 Receptor/TMEM97 knockout cells reveals its role in complement activation and SARS-CoV-2 viral uptake
A. Riad, Yann Aubert, C. Zeng, Thomas J A Graham +3 more
2021bioRxiv4 citations Open access
Semantic Scholar
BAP1: case report and insight into a novel tumor suppressor
Kanad Ghosh, B. Modi, W. James, Brian C. Capell
2017BMC Dermatology4 citations Open access
Semantic Scholar
Correction for Capell et al., A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model
Brian C. Capell, M. Olive, M. Erdos, K-K Cao +12 more
2009Proceedings of the National Academy of Sciences of the United States of America4 citations Open access
Semantic Scholar
Loss of Methylation Modification Marks the Presence of Psoriasis
Brian C. Capell, J. Seykora
2020Journal of Investigative Dermatology3 citations Open access
Semantic Scholar
Perforating and granulomatous exogenous ochronosis.
Susan Pei, A. Fischer, H. Milbar, Brian C. Capell +2 more
2021Journal of cutaneous pathology2 citations
Semantic Scholar
MLL4 is a critical mediator of differentiation and ferroptosis in the epidermis
S. Egolf, J. Zou, A. Anderson, Yann Aubert +3 more
2021bioRxiv2 citations Open access
Semantic Scholar
Presumed serum sickness following thymoglobulin treatment of acute cellular rejection of a cardiac allograft.
V. Ratushny, Brian C. Capell, M. Rosenbach
2017Cutis (New York, N.Y.)2 citations
Semantic Scholar
Stress vesicles link epidermal mechanotransduction to stem cell differentiation
Sixia Huang, P. Kuri, J. Zou, Adriana Blanco +9 more
2026Nature Communications1 citations Open access
Semantic Scholar

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