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G. Giachin · SciRah

Researcher profile · Semantic Scholar

G. Giachin

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G. Giachin — researcher profile on SciRah

h-index: 22
Works: 59
Citations: 1,276

Most-cited papers

Dynamics of Human Mitochondrial Complex I Assembly: Implications for Neurodegenerative Diseases
G. Giachin, R. Bouverot, Samira Acajjaoui, Serena Pantalone +1 more
2016Frontiers in Molecular Biosciences107 citations Open access
Semantic Scholar
Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody.
R. Abskharon, G. Giachin, A. Wohlkonig, S. Soror +3 more
2014Journal of the American Chemical Society103 citations Open access
Semantic Scholar
NMR Structure of the Human Prion Protein with the Pathological Q212P Mutation Reveals Unique Structural Features
G. Ilc, G. Giachin, M. Jaremko, Ł. Jaremko +4 more
2010PLoS ONE86 citations Open access
Semantic Scholar
In vitro aggregation assays for the characterization of α-synuclein prion-like properties
Joanna Narkiewicz, G. Giachin, G. Legname
2014Prion84 citations Open access
Semantic Scholar
Toward the molecular basis of inherited prion diseases: NMR structure of the human prion protein with V210I mutation.
I. Biljan, G. Ilc, G. Giachin, A. Raspadori +3 more
2011Journal of Molecular Biology67 citations Open access
Semantic Scholar
Structural basis for the protective effect of the human prion protein carrying the dominant-negative E219K polymorphism.
I. Biljan, G. Giachin, G. Ilc, I. Zhukov +2 more
2012Biochemical Journal62 citations Open access
Semantic Scholar
Structural facets of disease‐linked human prion protein mutants: A molecular dynamic study
G. Rossetti, G. Giachin, G. Legname, P. Carloni
2010Proteins: Structure, Function, and Bioinformatics50 citations
Semantic Scholar
Structural Consequences of Copper Binding to the Prion Protein
G. Salzano, G. Giachin, G. Legname
2019Cells49 citations Open access
Semantic Scholar
The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion
G. Giachin, P. Mai, Thanh Hoa Tran, G. Salzano +7 more
2015Scientific Reports45 citations Open access
Semantic Scholar
Characterization of prion protein function by focal neurite stimulation
Ladan Amin, X. T. Nguyen, I. Rolle, E. D'Este +5 more
2016Journal of Cell Science44 citations Open access
Semantic Scholar
Structural basis for osmotic regulation of the DNA binding properties of H-NS proteins
Liang Qin, F. Ben Bdira, Y. Sterckx, A. Volkov +5 more
2019bioRxiv40 citations Open access
Semantic Scholar
Probing Early Misfolding Events in Prion Protein Mutants by NMR Spectroscopy
G. Giachin, I. Biljan, G. Ilc, J. Plavec +1 more
2013Molecules38 citations Open access
Semantic Scholar
Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion
R. Abskharon, Fei Wang, A. Wohlkonig, J. Ruan +7 more
2019PLoS Pathogens37 citations Open access
Semantic Scholar
Structural rearrangements at physiological pH: nuclear magnetic resonance insights from the V210I human prion protein mutant.
I. Biljan, G. Ilc, G. Giachin, J. Plavec +1 more
2012Biochemistry36 citations Open access
Semantic Scholar
Effects of the pathological Q212P mutation on human prion protein non-octarepeat copper-binding site.
P. D'Angelo, S. Della Longa, A. Arcovito, G. Mancini +5 more
2012Biochemistry34 citations
Semantic Scholar
Structural determinants in prion protein folding and stability.
F. Benetti, X. Biarnés, F. Attanasio, G. Giachin +2 more
2014Journal of Molecular Biology31 citations
Semantic Scholar
Probing the N-Terminal beta-Sheet Conversion in the Crystal Structure of the Human Prion Protein Bound to a Nanobody Abskharon,
R. Abskharon, G. Giachin, A. Wohlkonig, S. Soror +3 more
201430 citations
Semantic Scholar
The N Terminus of the Prion Protein Mediates Functional Interactions with the Neuronal Cell Adhesion Molecule (NCAM) Fibronectin Domain*
Urška Slapšak, G. Salzano, Ladan Amin, R. Abskharon +6 more
2016Journal of Biological Chemistry29 citations Open access
Semantic Scholar
A novel expression system for production of soluble prion proteins in E. coli
R. Abskharon, S. Ramboarina, Hassan Ibrahim El Hassan, W. Gad +7 more
2012Microbial Cell Factories28 citations Open access
Semantic Scholar
Assembly of The Mitochondrial Complex I Assembly Complex Suggests a Regulatory Role for Deflavination
G. Giachin, M. Jessop, R. Bouverot, Samira Acajjaoui +15 more
2020Angewandte Chemie23 citations Open access
Semantic Scholar
Epitope mapping of a PrP(Sc)-specific monoclonal antibody: identification of a novel C-terminally truncated prion fragment.
M. Kosmač, S. Koren, G. Giachin, T. Stoilova +3 more
2011Molecular Immunology23 citations
Semantic Scholar
Prion Protein Interaction with Soil Humic Substances: Environmental Implications
G. Giachin, Joanna Narkiewicz, D. Scaini, Ai Tran Hoang Ngoc +4 more
2014PLoS ONE22 citations Open access
Semantic Scholar
Innovative Non-PrP-Targeted Drug Strategy Designed to Enhance Prion Clearance
Arianna Colini Baldeschi, Marco Zattoni, S. Vanni, Lea Nikolić +10 more
2022Journal of Medicinal Chemistry18 citations Open access
Semantic Scholar
Role of Prion Disease-Linked Mutations in the Intrinsically Disordered N-Terminal Domain of the Prion Protein.
Xiaojing Cong, Nicola Casiraghi, G. Rossetti, S. Mohanty +3 more
2013Journal of Chemical Theory and Computation18 citations
Semantic Scholar
The mechanisms of humic substances self-assembly with biological molecules: The case study of the prion protein
G. Giachin, Ridvan Nepravishta, Walter Mandaliti, S. Melino +7 more
2017PLoS ONE17 citations Open access
Semantic Scholar
Synthetic prions and other human neurodegenerative proteinopathies.
Nhat T. T. Le, Joanna Narkiewicz, Suzana Aulic, G. Salzano +5 more
2015Virus Research17 citations
Semantic Scholar
A new inactive conformation of SARS‐CoV‐2 main protease
Emanuele Fornasier, M. L. Macchia, G. Giachin, A. Sosic +7 more
2022Acta Crystallographica Section D: Structural Biology15 citations Open access
Semantic Scholar
Bifunctional carbazole derivatives for simultaneous therapy and fluorescence imaging in prion disease murine cell models.
Matteo Staderini, S. Vanni, Arianna Colini Baldeschi, G. Giachin +15 more
2022European journal of medicinal chemistry14 citations Open access
Semantic Scholar
Deciphering Copper Coordination in the Mammalian Prion Protein Amyloidogenic Domain.
G. Salzano, M. Brennich, G. Mancini, Thanh Hoa Tran +3 more
2020Biophysical Journal14 citations Open access
Semantic Scholar
NMR structural studies of human cellular prion proteins.
I. Biljan, G. Ilc, G. Giachin, G. Legname +1 more
2013Current Topics in Medicinal Chemistry13 citations
Semantic Scholar
A tetracationic porphyrin with dual anti-prion activity
Antonio Masone, C. Zucchelli, Enrico Caruso, Giada Lavigna +30 more
2023iScience12 citations Open access
Semantic Scholar
Molecular architecture of the glycogen- committed PP1/PTG holoenzyme
M. Semrau, G. Giachin, S. Covaceuszach, A. Cassetta +3 more
2022Nature Communications11 citations Open access
Semantic Scholar
Dominant-negative effects in prion diseases: insights from molecular dynamics simulations on mouse prion protein chimeras
Xiaojing Cong, S. Bongarzone, G. Giachin, G. Rossetti +2 more
2013Journal of Biomolecular Structure and Dynamics10 citations Open access
Semantic Scholar
Structural Studies of Prion Proteins and Prions
G. Legname, G. Giachin, F. Benetti
20129 citations
Semantic Scholar
Unique Structural Features of Mule Deer Prion Protein Provide Insights into Chronic Wasting Disease
Urška Slapšak, G. Salzano, G. Ilc, G. Giachin +4 more
2019ACS Omega8 citations Open access
Semantic Scholar
Mechanism of CK2 Inhibition by a Ruthenium-Based Polyoxometalate
Simone Fabbian, G. Giachin, M. Bellanda, C. Borgo +7 more
2022Frontiers in Molecular Biosciences7 citations Open access
Semantic Scholar
Recognition Mechanisms between a Nanobody and Disordered Epitopes of the Human Prion Protein: An Integrative Molecular Dynamics Study
L. Mollica, G. Giachin
2022Journal of Chemical Information and Modeling5 citations Open access
Semantic Scholar
Structural and dynamical determinants of a β-sheet-enriched intermediate involved in amyloid fibrillar assembly of human prion protein
L. Russo, G. Salzano, Andrea Corvino, E. Bistaffa +9 more
2022Chemical Science4 citations Open access
Semantic Scholar
Postal code for a plant MAPK.
A. Teich, O. Arancio, B. Ellis, I. J. Frame +33 more
2012Biochemical Journal4 citations
Semantic Scholar
Evidence of Orientation-Dependent Early States of Prion Protein Misfolded Structures from Single Molecule Force Spectroscopy
A. Raspadori, Valentina Vignali, Anna Murello, G. Giachin +5 more
2022Biology3 citations Open access
Semantic Scholar
Comparative Molecular Dynamics Investigation of the Electromotile Hearing Protein Prestin
Gianfranco Abrusci, Thomas Tarenzi, M. Sturlese, G. Giachin +2 more
2021International Journal of Molecular Sciences3 citations Open access
Semantic Scholar
A novel conformational state for SARS-CoV-2 main protease
Emanuele Fornasier, M. L. Macchia, G. Giachin, A. Sosic +7 more
2021bioRxiv3 citations Open access
Semantic Scholar
The N-terminus of the Prion Protein Mediates Functional Interactions with NCAM Fibronectin Domain
G. Salzano, Ladan Amin, R. Abskharon, G. Ilc +4 more
20163 citations
Semantic Scholar
The acidic intrinsically disordered region of the inflammatory mediator HMGB1 mediates fuzzy interactions with chemokine CXCL12
M. Mantonico, F. De Leo, G. Quilici, L. Colley +9 more
2023bioRxiv1 citations Open access
Semantic Scholar
Nanobody-stabilize the crystal structure of full-length human PrP
R. Abskharon, S. Soror, G. Giachin, E. Pardon +5 more
20121 citations
Semantic Scholar
Structural characterization of the PTG and PTG/PP1 complex
M. Semrau, G. Lolli, P. Storici, G. Giachin +1 more
2021Acta Crystallographica Section A: Foundations and Advances0 citations Open access
Semantic Scholar
Deciphering copper coordination in the animal prion protein amyloidogenic domain
G. Salzano, M. Brennich, G. Mancini, Thanh Hoa Tran +3 more
20180 citations Open access
Semantic Scholar
Structural features of human prion protein variants revealed by NMR
I. Biljan, G. Ilc, G. Giachin, G. Legname +1 more
20170 citations
Semantic Scholar
NMR solution structure of human FNIII domain 2 of NCAM
U. Slapsak, G. Salzano, L. Amin, R. Abskharon +6 more
20160 citations
Semantic Scholar
The Prion Switch Unravelled
G. Salzano, Thanh Hoa Tran, G. Giachin, F. Benetti +2 more
20150 citations
Semantic Scholar

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