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G. Vandecasteele · SciRah

Researcher profile · Semantic Scholar

G. Vandecasteele

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G. Vandecasteele — researcher profile on SciRah

h-index: 38
Works: 127
Citations: 4,585

Most-cited papers

Compartmentation of cyclic nucleotide signaling in the heart: the role of cyclic nucleotide phosphodiesterases.
R. Fischmeister, Liliana R. V. Castro, A. Abi-Gerges, F. Rochais +3 more
2006Circulation Research161 citations Open access
Semantic Scholar
Spatiotemporal Dynamics of β-Adrenergic cAMP Signals and L-Type Ca2+ Channel Regulation in Adult Rat Ventricular Myocytes: Role of Phosphodiesterases
J. Leroy, A. Abi-Gerges, V. Nikolaev, Wito Richter +5 more
2008Circulation Research160 citations Open access
Semantic Scholar
PDEs create local domains of cAMP signaling.
D. Mika, J. Leroy, G. Vandecasteele, R. Fischmeister
2012Journal of Molecular and Cellular Cardiology155 citations Open access
Semantic Scholar
Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.
J. Leroy, Wito Richter, D. Mika, L. Castro +12 more
2011Journal of Clinical Investigation139 citations Open access
Semantic Scholar
Phosphodiesterase-2 is up-regulated in human failing hearts and blunts β-adrenergic responses in cardiomyocytes.
Hind Mehel, J. Emons, C. Vettel, K. Wittköpper +17 more
2013Journal of the American College of Cardiology136 citations Open access
Semantic Scholar
Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on β-adrenergic cAMP signals
A. Abi-Gerges, Wito Richter, F. Lefebvre, P. Mateo +7 more
2009Circulation Research132 citations Open access
Semantic Scholar
Cyclic adenosine monophosphate phosphodiesterase type 4 protects against atrial arrhythmias.
C. Molina, J. Leroy, Wito Richter, Moses Xie +11 more
2012Journal of the American College of Cardiology127 citations Open access
Semantic Scholar
Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation.
Y. Sassi, L. Lipskaia, G. Vandecasteele, V. Nikolaev +8 more
2008Journal of Clinical Investigation127 citations Open access
Semantic Scholar
A cardiac mitochondrial cAMP signaling pathway regulates calcium accumulation, permeability transition and cell death
Z. Wang, D. Liu, A. Varin, V. Nicolas +8 more
2016Cell Death and Disease99 citations Open access
Semantic Scholar
Cyclic nucleotide phosphodiesterases in heart and vessels: A therapeutic perspective.
P. Bobin, M. Belacel-Ouari, Ibrahim Bedioune, Liang Zhang +4 more
2016Archives of Cardiovascular Diseases95 citations Open access
Semantic Scholar
Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiac hypertrophy and heart failure
Rima Kamel, J. Leroy, G. Vandecasteele, R. Fischmeister
2022Nature Reviews Cardiology87 citations Open access
Semantic Scholar
Phosphoinositide 3-Kinase γ Protects Against Catecholamine-Induced Ventricular Arrhythmia Through Protein Kinase A–Mediated Regulation of Distinct Phosphodiesterases
A. Ghigo, A. Perino, Hind Mehel, A. Zahradníková +16 more
2012Circulation77 citations Open access
Semantic Scholar
Phosphodiesterase 11A (PDE11A) gene defects in patients with acth-independent macronodular adrenal hyperplasia (AIMAH): functional variants may contribute to genetic susceptibility of bilateral adrenal tumors.
D. Vezzosi, R. Libé, C. Baudry, M. Rizk-Rabin +7 more
2012Journal of Clinical Endocrinology and Metabolism75 citations Open access
Semantic Scholar
Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure
S. Karam, J. P. Margaria, Aurélia Bourcier, D. Mika +22 more
2020Circulation68 citations Open access
Semantic Scholar
Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction
C. Vettel, Marta Lindner, Matthias Dewenter, K. Lorenz +19 more
2017Circulation Research65 citations Open access
Semantic Scholar
Differential regulation of cardiac excitation-contraction coupling by cAMP phosphodiesterase subtypes.
D. Mika, P. Bobin, M. Pomérance, P. Lechène +5 more
2013Cardiovascular Research58 citations Open access
Semantic Scholar
An SRF/miR-1 axis regulates NCX1 and annexin A5 protein levels in the normal and failing heart.
E. Tritsch, Y. Mallat, F. Lefebvre, N. Diguet +7 more
2013Cardiovascular Research55 citations Open access
Semantic Scholar
Functional localization of cAMP signalling in cardiac myocytes.
G. Vandecasteele, F. Rochais, A. Abi-Gerges, R. Fischmeister
2006Biochemical Society Transactions44 citations Open access
Semantic Scholar
Heterologous desensitization of cardiac &bgr;-adrenergic signal via hormone-induced &bgr;AR/arrestin/PDE4 complexes
Qian Shi, Minghui Li, D. Mika, Qin Fu +5 more
2017Cardiovascular Research41 citations Open access
Semantic Scholar
Interventricular Differences in β‐Adrenergic Responses in the Canine Heart: Role of Phosphodiesterases
C. Molina, Daniel M. Johnson, Hind Mehel, R. L. Spätjens +10 more
2014Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease41 citations Open access
Semantic Scholar
Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes.
Zeineb Haj Slimane, Ibrahim Bedioune, P. Lechène, A. Varin +10 more
2014Cardiovascular Research38 citations Open access
Semantic Scholar
cAMP–PKA inhibition of SK3 channel reduced both Ca2+ entry and cancer cell migration by regulation of SK3–Orai1 complex
Lucie Clarysse, M. Guéguinou, M. Potier-Cartereau, G. Vandecasteele +4 more
2014Pflügers Archiv: European Journal of Physiology38 citations
Semantic Scholar
Cardiac adenylyl cyclase overexpression precipitates and aggravates age-related myocardial dysfunction.
N. Mougenot, D. Mika, G. Czibik, Élisabeth Marcos +14 more
2019Cardiovascular Research34 citations Open access
Semantic Scholar
Calmodulin kinase II inhibition limits the pro-arrhythmic Ca2+ waves induced by cAMP-phosphodiesterase inhibitors.
P. Bobin, A. Varin, F. Lefebvre, R. Fischmeister +2 more
2016Cardiovascular Research34 citations
Semantic Scholar
Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins
A. Tibbo, Delphine Mika, Sara Dobi, J. Ling +12 more
2020bioRxiv24 citations Open access
Semantic Scholar
Cyclic nucleotide signalling compartmentation by PDEs in cultured vascular smooth muscle cells
Liang Zhang, Kaouter Bouadjel, B. Manoury, G. Vandecasteele +2 more
2019British Journal of Pharmacology24 citations Open access
Semantic Scholar
Synergic PDE3 and PDE4 control intracellular cAMP and cardiac excitation-contraction coupling in a porcine model.
D. Mika, P. Bobin, Marta Lindner, Angèle Boet +11 more
2019Journal of Molecular and Cellular Cardiology23 citations Open access
Semantic Scholar
Cardiac phosphodiesterases are differentially increased in diabetic cardiomyopathy.
Rita A. Hanna, W. Nour-Eldine, Y. Saliba, Carole Dagher-Hamalian +9 more
2021Life Science19 citations
Semantic Scholar
PDE4 and mAKAP&bgr; are nodal organizers of &bgr;2-ARs nuclear PKA signalling in cardiac myocytes
Ibrahim Bedioune, F. Lefebvre, P. Lechène, A. Varin +4 more
2018Cardiovascular Research19 citations Open access
Semantic Scholar
Inactivation of the Carney complex gene 1 (PRKAR1A) alters spatiotemporal regulation of cAMP and cAMP-dependent protein kinase: a study using genetically encoded FRET-based reporters.
L. Cazabat, B. Ragazzon, A. Varin, M. Potier-Cartereau +11 more
2014Human Molecular Genetics18 citations Open access
Semantic Scholar
Cyclic AMP signaling in cardiac myocytes
J. Leroy, G. Vandecasteele, R. Fischmeister
201817 citations Open access
Semantic Scholar
PDE2 regulates membrane potential, respiration and permeability transition of rodent subsarcolemmal cardiac mitochondria.
Da-Wei Liu, Zhen-Yu Wang, V. Nicolas, Marta Lindner +4 more
2019Mitochondrion (Amsterdam. Print)14 citations Open access
Semantic Scholar
Standard and Strain Measurements by Echocardiography Detect Early Overloaded Right Ventricular Dysfunction: Validation against Hemodynamic and Myocyte Contractility Changes in a Large Animal Model
A. Hodzic, P. Bobin, D. Mika, M. Ly +10 more
2017Journal of the American Society of Echocardiography9 citations
Semantic Scholar
Imipramine as an alternative to formamide to detubulate rat ventricular cardiomyocytes
Aurélia Bourcier, M. Barthé, Ibrahim Bedioune, P. Lechène +4 more
2019Experimental Physiology8 citations Open access
Semantic Scholar
Selective changes in cytosolic β-adrenergic cAMP signals and L-type Calcium Channel regulation by Phosphodiesterases during cardiac hypertrophy.
A. Abi-Gerges, L. Castro, J. Leroy, V. Domergue +2 more
2020Journal of Molecular and Cellular Cardiology6 citations Open access
Semantic Scholar
Essential role of the RIα subunit of cAMP-dependent protein kinase in regulating cardiac contractility and heart failure development
Ibrahim Bedioune, M. Gandon-Renard, M. Dessillons, Aurélien Barthou +20 more
2024Circulation5 citations Open access
Semantic Scholar
Differential changes in cyclic adenosine 3′‐5′ monophosphate (cAMP) effectors and major Ca2+ handling proteins during diabetic cardiomyopathy
Victoria Chaoul, R. Hanna, Pia Hachem, M. el Hayek +5 more
2023Journal of Cellular and Molecular Medicine4 citations Open access
Semantic Scholar
[Cyclic nucleotide phosphodiesterases: role in the heart and therapeutic perspectives].
Ibrahim Bedioune, P. Bobin, S. Karam, Marta Lindner +5 more
2016Biologie Aujourd hui4 citations Open access
Semantic Scholar
Identification of PDE1 and PDE5 in adult rat left ventricular cardiomyocytes
T. Keravis, G. Vandecasteele, W. Mokni, R. Fischmeister +1 more
20074 citations
Semantic Scholar
Cyclic Nucleotide Phosphodiesterases and Compartmentation in Normal and Diseased Heart
Ibrahim Bedioune, P. Bobin, J. Leroy, R. Fischmeister +1 more
20173 citations Open access
Semantic Scholar
Investigating cardiac β-adrenergic nuclear signaling with FRET-based biosensors.
G. Vandecasteele, Ibrahim Bedioune
2020Annales d'Endocrinologie2 citations Open access
Semantic Scholar
Cardiac Gene Therapy With Phosphodiesterase 2A Limits Remodeling and Arrhythmias in Mouse Models of Heart Failure
Rima Kamel, Aurélia Bourcier, J. P. Margaria, Valentin Jin +11 more
2025Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease1 citations Open access
Semantic Scholar
Role of SERCA3 protein in alpha1-adrenoceptor-mediated calcium signaling in mouse aortic function
Maeliss Toth, B. Manoury, A. Varin, G. Vandecasteele +2 more
2024Archives of Cardiovascular Diseases1 citations Open access
Semantic Scholar
Investigating potential modifier genes of chronic PKA activation in heart failure
M. Dessillons, Aurélien Barthou, A. Varin, Florent Dumont +1 more
2023Archives of Cardiovascular Diseases Supplements1 citations Open access
Semantic Scholar
Type 4 phosphodiesterases control cardiac pacemaker activity
D. Mika, A. Gómez, R. Fischmeister, G. Vandecasteele
20181 citations Open access
Semantic Scholar
Mrp4 Is A Transmembrane Export Pump Acting As An Endogenous Regulator Of Cyclic- Nucleotides Dependent Pathways
Y. Sassi, L. Lipskaia, G. Vandecasteele, V. Nikolaev +8 more
20091 citations Open access
Semantic Scholar
PKA type I controls heart rate by increasing the L-type Ca2+ current
Anne Breidenstein, Walma Pereira de Vasconcelos, P. Mesirca, Eliane Morais-Pinto +6 more
2026Archives of Cardiovascular Diseases0 citations
Semantic Scholar
Differential control of cardiac pacemaker activity by PDE4 subfamily members.
Walma Pereira de Vasconcelos, P. Mesirca, Anne Breidenstein, A. Varin +18 more
2026Cardiovascular Research0 citations Open access
Semantic Scholar
The type I cyclic AMP-dependent protein kinase regulates cardiac automatism
Anne Breidenstein, W. P. de Vasconcelos, Laetitia Bouchard, F. Rochais +2 more
2025Archives of Cardiovascular Diseases0 citations
Semantic Scholar
TNF-alpha inhibits cAMP-mediated phosphorylation of eNOS at serine-633 in endothelial cells
Vinod Aera, Delphine Angole, V. Leblais, G. Vandecasteele +1 more
2025Archives of Cardiovascular Diseases0 citations
Semantic Scholar

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R. Fischmeister×33
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R. Fischmeister — researcher profile on SciRah
J. Leroy×24
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J. Leroy — researcher profile on SciRah
P. Lechène×15
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P. Lechène — researcher profile on SciRah
D. Mika×14
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D. Mika — researcher profile on SciRah

×11

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F. Lefebvre — researcher profile on SciRah

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A. Varin — researcher profile on SciRah

Ibrahim Bedioune×9

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A. Abi-Gerges×8

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Wito Richter×7

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Wito Richter — researcher profile on SciRah

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P. Bobin — researcher profile on SciRah

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V. Nikolaev — researcher profile on SciRah

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M. Conti — researcher profile on SciRah