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E. Mezzaroma · SciRah

Researcher profile · Semantic Scholar

E. Mezzaroma

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E. Mezzaroma — researcher profile on SciRah

h-index: 40
Works: 150
Citations: 5,216

Most-cited papers

Targeting the NLRP3 Inflammasome in Cardiovascular Diseases
S. Toldo, E. Mezzaroma, L. Buckley, Nicola Potere +4 more
2021Pharmacology and Therapeutics309 citations Open access
Semantic Scholar
A NOVEL PHARMACOLOGIC INHIBITOR OF THE NLRP3 INFLAMMASOME LIMITS MYOCARDIAL INJURY FOLLOWING ISCHEMIA-REPERFUSION IN THE MOUSE
C. Marchetti, Jeremy E. Chojnacki, S. Toldo, E. Mezzaroma +6 more
2014Journal of Cardiovascular Pharmacology251 citations Open access
Semantic Scholar
Inhibition of the NLRP3 inflammasome limits the inflammatory injury following myocardial ischemia-reperfusion in the mouse.
S. Toldo, C. Marchetti, A. Mauro, Jeremy E. Chojnacki +6 more
2016International Journal of Cardiology235 citations
Semantic Scholar
The Inflammasome in Myocardial Injury and Cardiac Remodeling
S. Toldo, E. Mezzaroma, A. Mauro, Fadi N. Salloum +2 more
2015Antioxidants and Redox Signaling157 citations
Semantic Scholar
Interleukin-18 as a Therapeutic Target in Acute Myocardial Infarction and Heart Failure
Laura C. O’Brien, E. Mezzaroma, B. Van Tassell, C. Marchetti +3 more
2014Molecular Medicine155 citations Open access
Semantic Scholar
Pharmacologic inhibition of the NLRP3 inflammasome preserves cardiac function after ischemic and non-ischemic injury in the mouse
C. Marchetti, S. Toldo, Jeremy E. Chojnacki, E. Mezzaroma +12 more
2015Journal of Cardiovascular Pharmacology152 citations Open access
Semantic Scholar
Interleukin-18 mediates interleukin-1-induced cardiac dysfunction.
S. Toldo, E. Mezzaroma, Laura C. O’Brien, C. Marchetti +5 more
2014American Journal of Physiology. Heart and Circulatory Physiology138 citations Open access
Semantic Scholar
The NLRP3 Inflammasome Inhibitor, OLT1177 (Dapansutrile), Reduces Infarct Size and Preserves Contractile Function After Ischemia Reperfusion Injury in the Mouse
S. Toldo, A. Mauro, Zachary S. Cutter, B. Van Tassell +5 more
2019Journal of Cardiovascular Pharmacology130 citations Open access
Semantic Scholar
Induction of MicroRNA-21 with Exogenous Hydrogen Sulfide Attenuates Myocardial Ischemic and Inflammatory Injury in Mice
S. Toldo, Anindita Das, E. Mezzaroma, V. Chau +11 more
2014Circulation: Cardiovascular Genetics108 citations Open access
Semantic Scholar
The Role of NLRP3 Inflammasome in Pericarditis
A. Mauro, A. Bonaventura, A. Vecchié, E. Mezzaroma +11 more
2021JACC: Basic to Translational Science92 citations Open access
Semantic Scholar
Independent roles of the priming and the triggering of the NLRP3 inflammasome in the heart.
S. Toldo, E. Mezzaroma, Matthew D. McGeough, C. Peña +7 more
2015Cardiovascular Research82 citations Open access
Semantic Scholar
Formation of the inflammasome in acute myocarditis.
S. Toldo, Harsha R. Kannan, R. Bussani, M. Anzini +9 more
2014International Journal of Cardiology82 citations
Semantic Scholar
Interleukin-1&bgr; Blockade Improves Left Ventricular Systolic/Diastolic Function and Restores Contractility Reserve in Severe Ischemic Cardiomyopathy in the Mouse
S. Toldo, E. Mezzaroma, E. Bressi, C. Marchetti +4 more
2014Journal of Cardiovascular Pharmacology80 citations Open access
Semantic Scholar
The NLRP3 inflammasome in acute myocardial infarction.
A. Mauro, A. Bonaventura, E. Mezzaroma, M. Quader +1 more
2019Journal of Cardiovascular Pharmacology75 citations
Semantic Scholar
A high-sugar and high-fat diet impairs cardiac systolic and diastolic function in mice.
S. Carbone, A. Mauro, E. Mezzaroma, Donatas Kraskauskas +5 more
2015International Journal of Cardiology74 citations
Semantic Scholar
NLRP3 Inflammasome Inhibitors in Cardiovascular Diseases
E. Mezzaroma, A. Abbate, S. Toldo
2021Molecules71 citations Open access
Semantic Scholar
Dietary Fat, Sugar Consumption, and Cardiorespiratory Fitness in Patients With Heart Failure With Preserved Ejection Fraction
S. Carbone, J. Canada, L. Buckley, C. Trankle +11 more
2017JACC: Basic to Translational Science71 citations Open access
Semantic Scholar
An Overview of Cannabidiol as a Multifunctional Drug: Pharmacokinetics and Cellular Effects
Nadia Martinez Naya, Jazmin Kelly, Giuliana Corna, M. Golino +4 more
2024Molecules62 citations Open access
Semantic Scholar
Preservation of Contractile Reserve and Diastolic Function by Inhibiting the NLRP3 Inflammasome with OLT1177® (Dapansutrile) in a Mouse Model of Severe Ischemic Cardiomyopathy Due to Non-Reperfused Anterior Wall Myocardial Infarction
J. Aliaga, A. Bonaventura, E. Mezzaroma, Y. Dhakal +3 more
2021Molecules42 citations Open access
Semantic Scholar
Low-Density Lipoprotein Receptor–Related Protein-1 Is a Therapeutic Target in Acute Myocardial Infarction
S. Toldo, Dana E Austin, A. Mauro, E. Mezzaroma +6 more
2017JACC: Basic to Translational Science42 citations Open access
Semantic Scholar
Reduction of Myocardial Ischemia–Reperfusion Injury by Inhibiting Interleukin-1 Alpha
A. Mauro, E. Mezzaroma, J. Torrado, Priyanka Kundur +6 more
2017Journal of Cardiovascular Pharmacology42 citations
Semantic Scholar
IPW-5371 Proves Effective as a Radiation Countermeasure by Mitigating Radiation-Induced Late Effects
Christopher S. Rabender, E. Mezzaroma, A. Mauro, R. Mullangi +4 more
2016Radiation Research41 citations Open access
Semantic Scholar
Interleukin-18 mediates cardiac dysfunction induced by western diet independent of obesity and hyperglycemia in the mouse
S. Carbone, P. Lee, AG Mauro, E. Mezzaroma +4 more
2017Nutrition & Diabetes40 citations Open access
Semantic Scholar
Role of Interleukin-1 in Radiation-Induced Cardiomyopathy
E. Mezzaroma, R. Mikkelsen, S. Toldo, A. Mauro +6 more
2015Molecular Medicine40 citations Open access
Semantic Scholar
Targeting the Innate Immune Response to Improve Cardiac Graft Recovery after Heart Transplantation: Implications for the Donation after Cardiac Death
S. Toldo, M. Quader, Fadi N. Salloum, E. Mezzaroma +1 more
2016International Journal of Molecular Sciences35 citations Open access
Semantic Scholar
A mouse model of heart failure with preserved ejection fraction due to chronic infusion of a low subpressor dose of angiotensin II.
Jessica A. Regan, A. Mauro, S. Carbone, C. Marchetti +7 more
2015American Journal of Physiology. Heart and Circulatory Physiology35 citations Open access
Semantic Scholar
NLRP3-mediated inflammation in cardio-oncology: sterile yet harmful
A. Mauro, E. Mezzaroma, S. Toldo, Giselle C. Meléndez +5 more
2022Translational Research: The Journal of Laboratory and Clinical Medicine33 citations Open access
Semantic Scholar
CALL FOR PAPERS Mechanisms of Diastolic Dysfunction in Cardiovascular Disease A mouse model of heart failure with preserved ejection fraction due to chronic infusion of a low subpressor dose of angiotensin II
J. Regan, A. Mauro, S. Carbone, C. Marchetti +7 more
201533 citations
Semantic Scholar
The inflammasome in heart failure
E. Mezzaroma, A. Abbate, S. Toldo
2020Current Opinion in Physiology25 citations Open access
Semantic Scholar
An Orally Available NLRP3 Inflammasome Inhibitor Prevents Western Diet–Induced Cardiac Dysfunction in Mice
S. Carbone, A. Mauro, Andrea Prestamburgo, M. Halquist +6 more
2018Journal of Cardiovascular Pharmacology25 citations Open access
Semantic Scholar
Recombinant Human Alpha-1 Antitrypsin-Fc Fusion Protein Reduces Mouse Myocardial Inflammatory Injury After Ischemia–Reperfusion Independent of Elastase Inhibition
S. Toldo, A. Mauro, C. Marchetti, S. W. Rose +5 more
2016Journal of Cardiovascular Pharmacology25 citations
Semantic Scholar
Determinants of Cardiorespiratory Fitness Following Thoracic Radiotherapy in Lung or Breast Cancer Survivors
J. Canada, C. Trankle, S. Carbone, L. Buckley +14 more
2019American Journal of Cardiology21 citations Open access
Semantic Scholar
BIOMARKERS OF CARDIAC INJURY IN PATIENTS UNDERGOING THORACIC RADIATION THERAPY
N. Serrano, R. Mikkelsen, J. Canada, E. Mezzaroma +2 more
2016International Journal of Cardiology19 citations Open access
Semantic Scholar
Targeting the NLRP3 inflammasome to reduce warm ischemic injury in donation after circulatory death heart
M. Quader, E. Mezzaroma, Kristine L. Kenning, S. Toldo
2020Clinical Transplantation18 citations
Semantic Scholar
A Preclinical Translational Study of the Cardioprotective Effects of Plasma-Derived Alpha-1 Anti-trypsin in Acute Myocardial Infarction
A. Mauro, E. Mezzaroma, C. Marchetti, Pratyush Narayan +7 more
2017Journal of Cardiovascular Pharmacology18 citations
Semantic Scholar
Modulation of Interleukin-1 and -18 mediated Injury in Donation after Circulatory Death Mice Heart
M. Quader, E. Mezzaroma, Kristine L. Kenning, S. Toldo
2020Journal of Surgical Research13 citations Open access
Semantic Scholar
Determination of Optimal Coronary Flow for the Preservation of “Donation after Circulatory Death” in Murine Heart Model
M. Quader, S. Toldo, J. Torrado, Suraj Mishra +6 more
2017ASAIO journal (1992)13 citations
Semantic Scholar
Mitigation of Radiation-Induced Lung and Heart Injuries in Mice by Oral Sepiapterin after Irradiation
Christopher S. Rabender, E. Mezzaroma, V. Yakovlev, A. Mauro +3 more
2021Radiation Research10 citations Open access
Semantic Scholar
The interleukin-1 receptor type I promotes the development of aging-associated cardiomyopathy in mice.
Pratyush Narayan, Elefterios Trikantzopoulos, E. Mezzaroma, A. Mauro +3 more
2022Cytokine8 citations
Semantic Scholar
Orally Delivered Milk-Derived Nanovesicles Loaded with Connexin 43 Peptides for Targeted Cardiac Ischemia-Reperfusion Therapy
Spencer R. Marsh, M. R. Amin, S. Toldo, Claire Beard +10 more
2025bioRxiv7 citations
Semantic Scholar
Refining murine heterotopic heart transplantation: A model to study ischemia and reperfusion injury in donation after circulatory death hearts
M. Quader, R. Cholyway, Niluka Wickramaratne, Oluwatoyin Akande +6 more
2021Animal Models and Experimental Medicine5 citations Open access
Semantic Scholar
Electron Transport Chain Inhibition to Decrease Reperfusion Injury in Transplanted Donation after Circulatory Death Rat Hearts
M. Quader, Qun Chen, Oluwatoyin Akande, Renee Cholyway +3 more
2023Journal of Cardiovascular Pharmacology4 citations Open access
Semantic Scholar
Improving circulatory death donor heart function: A novel approach
M. Quader, E. Mezzaroma, Niluka Wickramaratne, S. Toldo
2021JTCVS Techniques4 citations Open access
Semantic Scholar
Effects of dimethyl sulfoxide on the NLRP3 inflammasome.
C. Marchetti, E. Mezzaroma, S. Toldo
2015Immunobiology3 citations
Semantic Scholar
Disentangling the Mechanisms of Radiation-Induced Heart Disease in the Treatment of Breast Cancer
E. Mezzaroma, E. Weiss, R. Mikkelsen, D. Gewirtz +4 more
20153 citations Open access
Semantic Scholar
Identifying Inflammasome Activation in Human Tissues.
E. Mezzaroma, A. Mauro, S. Toldo
2023Methods in molecular biology2 citations
Semantic Scholar
A Heterotopic Rat Heart Transplantation Model using Circulatory Death Donor Hearts.
M. Quader, Renee Cholyway, Oluwatoyin Akande, J. Bradley +2 more
2022Journal of Visualized Experiments2 citations
Semantic Scholar
Abstract 18896: Plasma Derived Alpha-2 Macroglobulin Limits the Inflammatory Injury in a Mouse Myocardial Ischemia-reperfusion Model
S. Toldo, A. Mauro, Pratyush Narayan, Priyanka Kundur +3 more
20172 citations
Semantic Scholar
Abstract 402: Vitamin C Deficiency Impairs Cardiac Function and Post-infarction Survival in the Mouse
A. Mauro, Donatas Kraskauskas, B. Mohammed, B. Fisher +4 more
20172 citations
Semantic Scholar
IPW-5371 Proves Effective as a Radiation Countermeasure by Mitigating Radiation-Induced Late Effects.
Christopher S. Rabender, E. Mezzaroma, A. Mauro, R. Mullangi +4 more
2016Radiation Research2 citations
Semantic Scholar

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