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B. Hirshberg · SciRah

Researcher profile · Semantic Scholar

B. Hirshberg

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B. Hirshberg — researcher profile on SciRah

h-index: 46
Works: 153
Citations: 12K

Most-cited papers

Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus.
B. Scirica, Deepak L. Bhatt, E. Braunwald, P. Steg +14 more
2013New England Journal of Medicine3,266 citations Open access
Semantic Scholar
Heart Failure, Saxagliptin, and Diabetes Mellitus: Observations from the SAVOR-TIMI 53 Randomized Trial.
B. Scirica, E. Braunwald, I. Raz, M. Cavender +14 more
2015Circulation628 citations Open access
Semantic Scholar
Dual Add-on Therapy in Type 2 Diabetes Poorly Controlled With Metformin Monotherapy: A Randomized Double-Blind Trial of Saxagliptin Plus Dapagliflozin Addition Versus Single Addition of Saxagliptin or Dapagliflozin to Metformin
J. Rosenstock, L. Hansen, P. Zee, Yan Li +3 more
2014Diabetes Care281 citations Open access
Semantic Scholar
Effects of Cotadutide on Metabolic and Hepatic Parameters in Adults With Overweight or Obesity and Type 2 Diabetes: A 54-Week Randomized Phase 2b Study
Rajaa Nahra, Tao Wang, K. Gadde, J. Oscarsson +5 more
2021Diabetes Care278 citations Open access
Semantic Scholar
MEDI0382, a GLP-1 and glucagon receptor dual agonist, in obese or overweight patients with type 2 diabetes: a randomised, controlled, double-blind, ascending dose and phase 2a study.
P. Ambery, V. Parker, M. Stumvoll, M. Posch +9 more
2018The Lancet252 citations
Semantic Scholar
Effect of Saxagliptin on Renal Outcomes in the SAVOR-TIMI 53 Trial
Ofri Mosenzon, G. Leibowitz, Deepak L. Bhatt, Avivit Cahn +11 more
2016Diabetes Care247 citations Open access
Semantic Scholar
Saxagliptin and Cardiovascular Outcomes in Patients With Type 2 Diabetes and Moderate or Severe Renal Impairment: Observations From the SAVOR-TIMI 53 Trial
J. Udell, Deepak L. Bhatt, E. Braunwald, M. Cavender +14 more
2014Diabetes Care168 citations
Semantic Scholar
Heart Failure, Saxagliptin, and Diabetes Mellitus: Observations from the SAVOR-TIMI 53 Randomized Trial
B. Scirica, E. Braunwald, Itamar Raz, M. Cavender +14 more
2014Circulation165 citations Open access
Semantic Scholar
Randomized, Double-Blind, Phase 3 Trial of Triple Therapy With Dapagliflozin Add-on to Saxagliptin Plus Metformin in Type 2 Diabetes
C. Mathieu, A. Ranetti, Dan-Shi Li, Ella Ekholm +5 more
2015Diabetes Care138 citations Open access
Semantic Scholar
The design and rationale of the saxagliptin assessment of vascular outcomes recorded in patients with diabetes mellitus-thrombolysis in myocardial infarction (SAVOR-TIMI) 53 study.
B. Scirica, Deepak L. Bhatt, E. Braunwald, P. Steg +7 more
2011American Heart Journal108 citations
Semantic Scholar
Efficacy, safety, and mechanistic insights of cotadutide a dual receptor glucagon-like peptide-1 and glucagon agonist.
V. Parker, D. Robertson, Tao Wang, D. Hornigold +10 more
2019Journal of Clinical Endocrinology and Metabolism107 citations Open access
Semantic Scholar
Effect of High-Dose Intravitreal Aflibercept, 8 mg, in Patients With Neovascular Age-Related Macular Degeneration
C. Wykoff, David M. Brown, Kim Reed, Alyson J. Berliner +11 more
2023JAMA ophthalmology102 citations Open access
Semantic Scholar
Prognostic Implications of Biomarker Assessments in Patients With Type 2 Diabetes at High Cardiovascular Risk: A Secondary Analysis of a Randomized Clinical Trial.
B. Scirica, Deepak L. Bhatt, E. Braunwald, I. Raz +9 more
2016JAMA cardiology90 citations Open access
Semantic Scholar
Efficacy and Safety of Saxagliptin in Older Participants in the SAVOR-TIMI 53 Trial
Lawrence A Leiter, H. Teoh, E. Braunwald, Ofri Mosenzon +10 more
2015Diabetes Care85 citations
Semantic Scholar
Randomized, Double-Blind Trial of Triple Therapy With Saxagliptin Add-on to Dapagliflozin Plus Metformin in Patients With Type 2 Diabetes
S. Matthaei, D. Catrinoiu, Aleksander Celiński, Ella Ekholm +5 more
2015Diabetes Care84 citations
Semantic Scholar
Modulation of 11β-Hydroxysteroid Dehydrogenase (11βHSD) Activity Biomarkers and Pharmacokinetics of PF-00915275, a Selective 11βHSD1 Inhibitor
R. Courtney, P. Stewart, M. Toh, M. Ndongo +2 more
200882 citations
Semantic Scholar
Impact of the U.S. Food and Drug Administration Cardiovascular Assessment Requirements on the Development of Novel Antidiabetes Drugs
B. Hirshberg, I. Raz
2011Diabetes Care74 citations Open access
Semantic Scholar
Incidence of Fractures in Patients With Type 2 Diabetes in the SAVOR-TIMI 53 Trial
Ofri Mosenzon, Cheryl Wei, J. Davidson, B. Scirica +8 more
2015Diabetes Care68 citations
Semantic Scholar
MEDI0382, a GLP‐1/glucagon receptor dual agonist, meets safety and tolerability endpoints in a single‐dose, healthy‐subject, randomized, Phase 1 study
Philip Ambery, S. Klammt, M. Posch, M. Petrone +4 more
2018British Journal of Clinical Pharmacology66 citations Open access
Semantic Scholar
Saxagliptin improves glycaemic control and C‐peptide secretion in latent autoimmune diabetes in adults (LADA)
R. Buzzetti, P. Pozzilli, R. Frederich, N. Iqbal +1 more
2016Diabetes/Metabolism Research Reviews64 citations
Semantic Scholar
Technology-Enabled Clinical Trials: Transforming Medical Evidence Generation.
Guillaume Marquis-Gravel, M. Roe, M. Turakhia, W. Boden +26 more
2019Circulation62 citations Open access
Semantic Scholar
Incidence of Pancreatitis and Pancreatic Cancer in a Randomized Controlled Multicenter Trial (SAVOR-TIMI 53) of the Dipeptidyl Peptidase-4 Inhibitor Saxagliptin
I. Raz, Deepak L. Bhatt, B. Hirshberg, Ofri Mosenzon +8 more
2014Diabetes Care62 citations Open access
Semantic Scholar
Postprandial dynamics of plasma glucose, insulin, and glucagon in patients with type 2 diabetes treated with saxagliptin plus dapagliflozin add-on to metformin therapy.
L. Hansen, N. Iqbal, Ella Ekholm, W. Cook +1 more
2014Endocrine Practice61 citations
Semantic Scholar
Baseline characteristics of the patient population in the Saxagliptin Assessment of Vascular Outcomes Recorded in patients with diabetes mellitus (SAVOR)‐TIMI 53 trial
Ofri Mosenzon, I. Raz, B. Scirica, B. Hirshberg +9 more
2013Diabetes/Metabolism Research Reviews60 citations
Semantic Scholar
Safety of saxagliptin: events of special interest in 9156 patients with type 2 diabetes mellitus
B. Hirshberg, Artist Parker, Helen Edelberg, M. Donovan +1 more
2014Diabetes/Metabolism Research Reviews55 citations
Semantic Scholar
Cardiovascular Outcome Studies With Novel Antidiabetes Agents: Scientific and Operational Considerations
B. Hirshberg, A. Katz
2013Diabetes Care49 citations Open access
Semantic Scholar
Implications of the 2008 update from the collaborative islet transplant registry
B. Hirshberg
2009Current Diabetes Reports48 citations
Semantic Scholar
Prevalence and Outcomes of Polyvascular (Coronary, Peripheral, or Cerebrovascular) Disease in Patients With Diabetes Mellitus (From the SAVOR-TIMI 53 Trial).
J. A. Gutierrez, B. Scirica, Marc P. Bonaca, P. Steg +6 more
2019American Journal of Cardiology47 citations
Semantic Scholar
Response to Letter Regarding Article, "Heart Failure, Saxagliptin and Diabetes Mellitus: Observations From the SAVOR-TIMI 53 Randomized Trial".
B. Scirica, E. Braunwald, I. Raz, M. Cavender +14 more
2015Circulation42 citations Open access
Semantic Scholar
Cardiovascular Outcomes of Patients in SAVOR-TIMI 53 by Baseline Hemoglobin A1c.
M. Cavender, B. Scirica, I. Raz, P. Steg +9 more
2016American Journal of Medicine41 citations
Semantic Scholar
Assessment of the cardiovascular safety of saxagliptin in patients with type 2 diabetes mellitus: pooled analysis of 20 clinical trials
N. Iqbal, A. Parker, R. Frederich, M. Donovan +1 more
2014Cardiovascular Diabetology41 citations Open access
Semantic Scholar
Impact of treatment with saxagliptin on glycaemic stability and β‐cell function in the SAVOR‐TIMI 53 study
G. Leibowitz, Avivit Cahn, Deepak L. Bhatt, B. Hirshberg +9 more
2015Diabetes, obesity and metabolism36 citations
Semantic Scholar
Frequency of cancer events with saxagliptin in the SAVOR‐TIMI 53 trial
Lawrence A Leiter, H. Teoh, Ofri Mosenzon, Avivit Cahn +8 more
2016Diabetes, obesity and metabolism34 citations Open access
Semantic Scholar
Non‐linear increase in GLP‐1 levels in response to DPP‐IV inhibition in healthy adult subjects
Hai-Jun Dai, S. Gustavson, G. M. Preston, J. D. Eskra +2 more
2008Diabetes, obesity and metabolism31 citations
Semantic Scholar
Health-related quality-of-life implications of cardiovascular events in individuals with type 2 diabetes mellitus: A subanalysis from the Saxagliptin Assessment of Vascular Outcomes Recorded in Patients with Diabetes Mellitus (SAVOR)-TIMI 53 trial.
A. Briggs, Deepak L. Bhatt, B. Scirica, I. Raz +6 more
2017Diabetes Research and Clinical Practice30 citations Open access
Semantic Scholar
Adding saxagliptin to extended‐release metformin vs. uptitrating metformin dosage
V. Fonseca, Tong Zhu, C. Karyekar, B. Hirshberg
2012Diabetes, obesity and metabolism28 citations
Semantic Scholar
Insights From Cardiovascular Outcome Trials with Novel Antidiabetes Agents: What Have We Learned? An Industry Perspective
B. Hirshberg, A. Katz
2015Current Diabetes Reports25 citations
Semantic Scholar
Statin and Aspirin Therapy for the Prevention of Cardiovascular Events in Patients With Type 2 Diabetes Mellitus
J. Udell, B. Scirica, E. Braunwald, I. Raz +4 more
2012Clinical Cardiology25 citations Open access
Semantic Scholar
COMBINED TREATMENT WITH SAXAGLIPTIN PLUS DAPAGLIFLOZIN REDUCES INSULIN LEVELS BY INCREASED INSULIN CLEARANCE AND IMPROVES β-CELL FUNCTION.
Ella Ekholm, L. Hansen, E. Johnsson, N. Iqbal +3 more
2017Endocrine Practice24 citations
Semantic Scholar
Pancreatic perfusion of healthy individuals and type 1 diabetic patients as assessed by magnetic resonance perfusion imaging
B. Hirshberg, M. Qiu, A. Calí, R. Sherwin +3 more
2009Diabetologia24 citations Open access
Semantic Scholar
Clinical Development Approaches and Statistical Methodologies to Prospectively Assess the Cardiovascular Risk of New Antidiabetic Therapies for Type 2 Diabetes
M. Geiger, C. Mehta, J. R. Turner, C. Arbet-Engels +9 more
2015Therapeutic Innovation and Regulatory Science23 citations
Semantic Scholar
MEDI6012: Recombinant Human Lecithin Cholesterol Acyltransferase, High‐Density Lipoprotein, and Low‐Density Lipoprotein Receptor–Mediated Reverse Cholesterol Transport
R. George, Liron Abuhatzira, Susan M Stoughton, S. Karathanasis +7 more
2021Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease22 citations Open access
Semantic Scholar
Blocking endothelial lipase with monoclonal antibody MEDI5884 durably increases high density lipoprotein in nonhuman primates and in a phase 1 trial
John E. Le Lay, Qun Du, M. B. Mehta, N. Bhagroo +19 more
2021Science Translational Medicine20 citations
Semantic Scholar
Recombinant human Lecithin-Cholesterol acyltransferase in patients with atherosclerosis: Phase 2a primary results and phase 2b design.
Marc P. Bonaca, R. George, D. Morrow, B. Bergmark +9 more
2021European Heart Journal - Cardiovascular Pharmacotherapy20 citations Open access
Semantic Scholar
Challenges in developing endpoints for type 1 diabetes intervention studies
S. Cernea, I. Raz, K. Herold, B. Hirshberg +9 more
2009Diabetes/Metabolism Research Reviews20 citations
Semantic Scholar
Saxagliptin improves glycemic control by modulating postprandial glucagon and C-peptide levels in Chinese patients with type 2 diabetes.
Mikaela Sjöstrand, N. Iqbal, Jane Lu, B. Hirshberg
2014Diabetes Research and Clinical Practice18 citations
Semantic Scholar
Randomized, Placebo-Controlled Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Lecithin Cholesterol Acyltransferase in Acute ST-Segment–Elevation Myocardial Infarction: Results of REAL-TIMI 63B
Marc P. Bonaca, D. Morrow, B. Bergmark, D. Berg +22 more
2022Circulation16 citations Open access
Semantic Scholar
Achievement of Lipid Targets with the Combination of Rosuvastatin and Fenofibric Acid in Patients with Type 2 Diabetes Mellitus
R. Rosenson, D. Carlson, M. Kelly, C. Setze +3 more
2010Cardiovascular Drugs and Therapy16 citations Open access
Semantic Scholar
Predisposing Factors for Any and Major Hypoglycemia With Saxagliptin Versus Placebo and Overall: Analysis From the SAVOR-TIMI 53 Trial
Avivit Cahn, I. Raz, Ofri Mosenzon, G. Leibowitz +11 more
2016Diabetes Care14 citations
Semantic Scholar
Randomised, phase 1, dose-finding study of MEDI4166, a PCSK9 antibody and GLP-1 analogue fusion molecule, in overweight or obese patients with type 2 diabetes mellitus
Meenakshi Jain, G. Carlson, W. Cook, L. Morrow +7 more
2018Diabetologia13 citations Open access
Semantic Scholar

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I. Raz — researcher profile on SciRah
B. Scirica×19
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B. Scirica — researcher profile on SciRah
Deepak L. Bhatt×18
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Deepak L. Bhatt — researcher profile on SciRah
Ofri Mosenzon×16
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E. Braunwald — researcher profile on SciRah

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N. Iqbal — researcher profile on SciRah

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P. Steg — researcher profile on SciRah

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M. Cavender — researcher profile on SciRah