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P. Spégel · SciRah

Researcher profile · Semantic Scholar

P. Spégel

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P. Spégel — researcher profile on SciRah

h-index: 38
Works: 107
Citations: 5,946

Most-cited papers

Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables.
E. Ahlqvist, P. Storm, A. Käräjämäki, M. Martinell +20 more
2018The Lancet Diabetes and Endocrinology1,972 citations
Semantic Scholar
A common variant in the melatonin receptor gene (MTNR1B) is associated with increased risk of future type 2 diabetes and impaired early insulin secretion
V. Lyssenko, C. Nagorny, M. Erdos, N. Wierup +21 more
2008Nature Genetics782 citations Open access
Semantic Scholar
The mosaic oat genome gives insights into a uniquely healthy cereal crop
N. Kamal, Nikos Tsardakas Renhuldt, J. Bentzer, H. Gundlach +25 more
2022Nature185 citations Open access
Semantic Scholar
Selectivity toward multiple predetermined targets in nanoparticle capillary electrochromatography.
P. Spégel, L. Schweitz, S. Nilsson
2003Analytical Chemistry96 citations
Semantic Scholar
Time-resolved metabolomics analysis of β-cells implicates the pentose phosphate pathway in the control of insulin release.
P. Spégel, V. Sharoyko, I. Goehring, Anders P. H. Danielsson +8 more
2013Biochemical Journal95 citations Open access
Semantic Scholar
Molecularly imprinted polymer formats for capillary electrochromatography.
J. Nilsson, P. Spégel, S. Nilsson
2004Journal of chromatography. B, Analytical technologies in the biomedical and life sciences94 citations
Semantic Scholar
Altered serotonin (5-HT) 1D and 2A receptor expression may contribute to defective insulin and glucagon secretion in human type 2 diabetes.
H. Bennet, A. Balhuizen, A. Medina, M. Nitert +7 more
2015Peptides93 citations
Semantic Scholar
Molecularly imprinted polymers in capillary electrochromatography: Recent developments and future trends
P. Spégel, L. Schweitz, S. Nilsson
2003Electrophoresis82 citations
Semantic Scholar
Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production
J. G. Knudsen, A. Hamilton, R. Ramracheya, A. Tarasov +9 more
2019Cell Metabolism78 citations Open access
Semantic Scholar
The pathogenetic role of β-cell mitochondria in type 2 diabetes.
M. Fex, L. Nicholas, N. Vishnu, A. Medina +4 more
2018Journal of Endocrinology77 citations Open access
Semantic Scholar
Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line
Lotta E. Andersson, B. Valtat, A. Bagge, V. Sharoyko +5 more
2015PLoS ONE77 citations Open access
Semantic Scholar
Development and optimization of a metabolomic method for analysis of adherent cell cultures.
Anders P. H. Danielsson, T. Moritz, H. Mulder, P. Spégel
2010Analytical Biochemistry75 citations
Semantic Scholar
Nanoparticles as pseudostationary phase in capillary electrochromatography/ESI-MS.
P. Viberg, M. Jornten-Karlsson, P. Petersson, P. Spégel +1 more
2002Analytical Chemistry71 citations
Semantic Scholar
Gastric Bypass Improves β-Cell Function and Increases β-Cell Mass in a Porcine Model
A. Lindqvist, P. Spégel, M. Ekelund, Eliana Garcia Vaz +6 more
2014Diabetes70 citations Open access
Semantic Scholar
Genotype-based treatment of type 2 diabetes with an α2A-adrenergic receptor antagonist
Yun-Zhao Tang, A. Axelsson, P. Spégel, Lotta E. Andersson +4 more
2014Science Translational Medicine67 citations
Semantic Scholar
Coordinate Changes in Histone Modifications, mRNA Levels, and Metabolite Profiles in Clonal INS-1 832/13 β-Cells Accompany Functional Adaptations to Lipotoxicity*
Siri Malmgren, P. Spégel, Anders P. H. Danielsson, C. Nagorny +5 more
2013Journal of Biological Chemistry67 citations Open access
Semantic Scholar
NFATc3 regulates trypsinogen activation, neutrophil recruitment, and tissue damage in acute pancreatitis in mice.
D. Awla, A. Zetterqvist, A. Abdulla, C. Camello +7 more
2012Gastroenterology67 citations Open access
Semantic Scholar
Fumarate Hydratase Deletion in Pancreatic β Cells Leads to Progressive Diabetes
Julie Adam, R. Ramracheya, M. Chibalina, N. Ternette +24 more
2017Cell Reports65 citations Open access
Semantic Scholar
Nanoparticle-based continuous full filling capillary electrochromatography/electrospray ionization-mass spectrometry for separation of neutral compounds.
Christian Nilsson, P. Viberg, P. Spégel, M. Jornten-Karlsson +2 more
2006Analytical Chemistry60 citations
Semantic Scholar
Loss of TFB1M results in mitochondrial dysfunction that leads to impaired insulin secretion and diabetes.
V. Sharoyko, M. Abels, Jiang-Ming Sun, L. Nicholas +12 more
2014Human Molecular Genetics59 citations
Semantic Scholar
Identification of lignin oligomers in Kraft lignin using ultra-high-performance liquid chromatography/high-resolution multiple-stage tandem mass spectrometry (UHPLC/HRMSn)
Jens Prothmann, P. Spégel, M. Sandahl, C. Turner
2018Analytical and Bioanalytical Chemistry52 citations Open access
Semantic Scholar
Metabolomic analysis of a human oral glucose tolerance test reveals fatty acids as reliable indicators of regulated metabolism
P. Spégel, Anders P. H. Danielsson, K. Bacos, C. Nagorny +3 more
2010Metabolomics52 citations
Semantic Scholar
Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal β-cell lines.
P. Spégel, Siri Malmgren, V. Sharoyko, P. Newsholme +2 more
2011Biochemical Journal51 citations Open access
Semantic Scholar
Ultrasonic-trap-enhanced selectivity in capillary electrophoresis.
M. Wiklund, P. Spégel, S. Nilsson, H. Hertz
2003Ultrasonics51 citations
Semantic Scholar
Metabolomic and proteomic analysis of a clonal insulin-producing beta-cell line (INS-1 832/13).
C. Fernandez, Ulrika Fransson, Elna Hallgard, P. Spégel +5 more
2008Journal of Proteome Research49 citations
Semantic Scholar
NNT reverse mode of operation mediates glucose control of mitochondrial NADPH and glutathione redox state in mouse pancreatic β-cells
Laila R. B. Santos, Carole Muller, A. D. de Souza, H. Takahashi +5 more
2017Molecular Metabolism47 citations Open access
Semantic Scholar
Metabolite Profiling Reveals Normal Metabolic Control in Carriers of Mutations in the Glucokinase Gene (MODY2)
P. Spégel, Ella Ekholm, T. Tuomi, L. Groop +2 more
2013Diabetes47 citations Open access
Semantic Scholar
Cognitive Impairment and Metabolite Profile Alterations in the Hippocampus and Cortex of Male and Female Mice Exposed to a Fat and Sugar-Rich Diet are Normalized by Diet Reversal
A. Garcia-Serrano, Adélaïde A. Mohr, Juliette Philippe, Cecilia Skoug +2 more
2021bioRxiv46 citations Open access
Semantic Scholar
Ultra-high-performance supercritical fluid chromatography with quadrupole-time-of-flight mass spectrometry (UHPSFC/QTOF-MS) for analysis of lignin-derived monomeric compounds in processed lignin samples
Jens Prothmann, Mingzhe Sun, P. Spégel, M. Sandahl +1 more
2017Analytical and Bioanalytical Chemistry46 citations Open access
Semantic Scholar
Chronic High Glucose and Pyruvate Levels Differentially Affect Mitochondrial Bioenergetics and Fuel-stimulated Insulin Secretion from Clonal INS-1 832/13 Cells
I. Gohring, V. Sharoyko, Siri Malmgren, Lotta E. Andersson +3 more
2013Journal of Biological Chemistry43 citations Open access
Semantic Scholar
Metabolite profile deviations in an oral glucose tolerance test—a comparison between lean and obese individuals
Nina Geidenstam, P. Spégel, H. Mulder, K. Filipsson +2 more
2014Obesity42 citations Open access
Semantic Scholar
Metabolite profiling of obese individuals before and after a one year weight loss program
N. Geidenstam, M. Al-Majdoub, M. J. Ekman, P. Spégel +1 more
2017International Journal of Obesity41 citations
Semantic Scholar
Sox5 regulates beta-cell phenotype and is reduced in type 2 diabetes
A. Axelsson, T. Mahdi, H. Nenonen, T. Singh +25 more
2017Nature Communications38 citations Open access
Semantic Scholar
Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans.
A. Lindqvist, P. Spégel, M. Ekelund, H. Mulder +3 more
2013Journal of Clinical Endocrinology and Metabolism38 citations Open access
Semantic Scholar
Inhibition of Nuclear Factor of Activated T-Cells (NFAT) Suppresses Accelerated Atherosclerosis in Diabetic Mice
A. Zetterqvist, L. Berglund, F. Blanco, E. Garcia-Vaz +8 more
2013PLoS ONE37 citations Open access
Semantic Scholar
Metabolic Effects of Gastric Bypass Surgery: Is It All About Calories?
Ada Admin, Katharina Herzog, Johan Berggren, Mahmoud Al Majdoub +6 more
2020Diabetes31 citations Open access
Semantic Scholar
Pressurized carbon dioxide as a potential tool for decellularization of pulmonary arteries for transplant purposes
Alicia Gil-Ramírez, O. Rosmark, P. Spégel, K. Swärd +3 more
2020Scientific Reports31 citations Open access
Semantic Scholar
Development of a gas chromatography/mass spectrometry based metabolomics protocol by means of statistical experimental design
Anders P. H. Danielsson, T. Moritz, H. Mulder, P. Spégel
2011Metabolomics30 citations
Semantic Scholar
Effect of metformin on plasma metabolite profile in the Copenhagen Insulin and Metformin Therapy (CIMT) trial
N. Safai, T. Suvitaival, A. Ali, P. Spégel +4 more
2018Diabetic Medicine28 citations
Semantic Scholar
Screening of stationary phase selectivities for global lipid profiling by ultrahigh performance supercritical fluid chromatography.
Said Al Hamimi, M. Sandahl, M. Armeni, C. Turner +1 more
2018Journal of Chromatography A27 citations
Semantic Scholar
Pyruvate dehydrogenase kinase 1 controls mitochondrial metabolism and insulin secretion in INS-1 832/13 clonal beta-cells.
U. Krus, O. Kotova, P. Spégel, Elna Hallgard +6 more
2010Biochemical Journal27 citations Open access
Semantic Scholar
Glutamine-Elicited Secretion of Glucagon-Like Peptide 1 Is Governed by an Activated Glutamate Dehydrogenase
Lotta E. Andersson, L. Shcherbina, M. Al-Majdoub, N. Vishnu +7 more
2017Diabetes26 citations Open access
Semantic Scholar
Unique and Shared Metabolic Regulation in Clonal β-Cells and Primary Islets Derived From Rat Revealed by Metabolomics Analysis.
P. Spégel, Lotta E. Andersson, P. Storm, V. Sharoyko +3 more
2015Endocrinology25 citations Open access
Semantic Scholar
A comparative study of the fatty acid profile of common fruits and fruits claimed to confer health benefits
Azemina Bajramova, P. Spégel
2022Journal of Food Composition and Analysis23 citations Open access
Semantic Scholar
Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion
N. Vishnu, A. Hamilton, A. Bagge, A. Wernersson +10 more
2021Molecular Metabolism22 citations Open access
Semantic Scholar
Metabolomics Analysis of Nutrient Metabolism in β-Cells.
P. Spégel, H. Mulder
2020Journal of Molecular Biology22 citations
Semantic Scholar
Probiotic fruit beverages with different polyphenol profiles attenuated early insulin response
Jie Xu, Tommy Jönsson, M. Plaza, Å. Håkansson +5 more
2018Nutrix Journal22 citations Open access
Semantic Scholar
Treatment of Swedish Patients with Graves' Hyperthyroidism Is Associated with Changes in Acylcarnitine Levels
M. Al-Majdoub, M. Lantz, P. Spégel
2017Thyroid22 citations
Semantic Scholar
Cryo-EM structure supports a role of AQP7 as a junction protein
Peng Huang, R. Venskutonytė, R. Prasad, H. Ardalani +8 more
2023Nature Communications21 citations Open access
Semantic Scholar
Metabolite Profiling of LADA Challenges the View of a Metabolically Distinct Subtype
M. Al-Majdoub, Arslan Ali, P. Storm, A. Rosengren +2 more
2016Diabetes21 citations Open access
Semantic Scholar

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