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J. Brownlees · SciRah

Researcher profile · Semantic Scholar

J. Brownlees

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J. Brownlees — researcher profile on SciRah

h-index: 22
Works: 42
Citations: 2,358

Most-cited papers

Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content
K. D. De Vos, A. L. Chapman, Maria E. Tennant, C. Manser +10 more
2007Human Molecular Genetics421 citations Open access
Semantic Scholar
Charcot-Marie-Tooth disease neurofilament mutations disrupt neurofilament assembly and axonal transport.
J. Brownlees, S. Ackerley, A. Grierson, N. Jacobsen +5 more
2002Human Molecular Genetics224 citations
Semantic Scholar
Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments
S. Ackerley, P. Thornhill, A. Grierson, J. Brownlees +4 more
2003Journal of Cell Biology211 citations Open access
Semantic Scholar
Glutamate Slows Axonal Transport of Neurofilaments in Transfected Neurons
S. Ackerley, A. Grierson, J. Brownlees, P. Thornhill +4 more
2000Journal of Cell Biology183 citations Open access
Semantic Scholar
Phosphorylation of thr668 in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress‐activated protein kinase 1b (Jun N‐terminal kinase‐3)
Claire L. Standen, J. Brownlees, A. Grierson, S. Kesavapany +3 more
2001122 citations
Semantic Scholar
Peptidases, Peptides, and the Mammalian Blood–Brain Barrier
J. Brownlees, C. Williams
1993Journal of Neurochemistry109 citations
Semantic Scholar
Tau phosphorylation in transgenic mice expressing glycogen synthase kinase‐3β transgenes
J. Brownlees, N. Irving, J. Brion, Barry J. M. Gibb +3 more
1997NeuroReport108 citations
Semantic Scholar
p38α stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis
S. Ackerley, A. Grierson, Steven J. Banner, M. Perkinton +12 more
2004103 citations Open access
Semantic Scholar
Axonal transport of neurofilaments in normal and disease states
Christopher C. J. Miller, S. Ackerley, J. Brownlees, A. Grierson +2 more
2002Cellular and Molecular Life Sciences (CMLS)100 citations
Semantic Scholar
Phosphorylation of neurofilament heavy chain side-arms by stress activated protein kinase-1b/Jun N-terminal kinase-3.
J. Brownlees, A. Yates, N. Bajaj, D. R. Davis +4 more
2000Journal of Cell Science100 citations
Semantic Scholar
ALS2/Alsin Regulates Rac-PAK Signaling and Neurite Outgrowth*
E. L. Tudor, M. Perkinton, A. Schmidt, S. Ackerley +9 more
2005Journal of Biological Chemistry96 citations Open access
Semantic Scholar
p35/cdk5 binds and phosphorylates beta-catenin and regulates beta-catenin/presenilin-1 interaction.
S. Kesavapany, K. Lau, D. M. McLoughlin, J. Brownlees +4 more
2001European Journal of Neuroscience90 citations
Semantic Scholar
Mint2/X11‐like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease
D. M. McLoughlin, Nicholas G. Irving, J. Brownlees, J. Brion +2 more
1999European Journal of Neuroscience79 citations
Semantic Scholar
Overexpression of the mouse dishevelled‐1 protein inhibits GSK‐3β‐mediated phosphorylation of tau in transfected mammalian cells
U. Wagner, J. Brownlees, Nicholas G. Irving, Fiona R. Lucas +2 more
1997FEBS Letters58 citations
Semantic Scholar
Neuropathological Abnormalities in Transgenic Mice Harbouring a Phosphorylation Mutant Neurofilament Transgene
Barry J. M. Gibb, J. Brion, J. Brownlees, B. Anderton +1 more
1998Journal of Neurochemistry55 citations
Semantic Scholar
Alzheimer therapy with an antibody against N-terminal Abeta 4-X and pyroglutamate Abeta 3-X
G. Antonios, H. Borgers, B. C. Richard, A. Brauß +10 more
2015Scientific Reports48 citations Open access
Semantic Scholar
p38alpha stress-activated protein kinase phosphorylates neurofilaments and is associated with neurofilament pathology in amyotrophic lateral sclerosis.
S. Ackerley, A. Grierson, Steven J. Banner, M. Perkinton +12 more
2004Molecular and cellular neurosciences39 citations
Semantic Scholar
Phosphorylation of thr(668) in the cytoplasmic domain of the Alzheimer's disease amyloid precursor protein by stress-activated protein kinase 1b (Jun N-terminal kinase-3).
C. Standen, J. Brownlees, A. Grierson, S. Kesavapany +3 more
2001Journal of Neurochemistry36 citations
Semantic Scholar
Development of a characterised tool kit for the interrogation of NLRP3 inflammasome-dependent responses
Elena Redondo‐Castro, Dörte Faust, Simon G. Fox, A. Baldwin +11 more
2018Scientific Reports31 citations Open access
Semantic Scholar
Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF.
T. Chapman, Kevin J. Gillen, Claire Wallace, M. Lee +9 more
2015Bioorganic & Medicinal Chemistry Letters30 citations Open access
Semantic Scholar
Inhibition of IL-34 Unveils Tissue-Selectivity and Is Sufficient to Reduce Microglial Proliferation in a Model of Chronic Neurodegeneration
J. Obst, Emilie Simon, María Martín-Estebané, E. Pipi +14 more
2020Frontiers in Immunology23 citations Open access
Semantic Scholar
N-Hydroxyimides and hydroxypyrimidinones as inhibitors of the DNA repair complex ERCC1-XPF.
T. Chapman, Claire Wallace, Kevin J. Gillen, Preeti Bakrania +7 more
2015Bioorganic & Medicinal Chemistry Letters23 citations Open access
Semantic Scholar
p35/cdk5 binds and phosphorylates β‐catenin and regulates β‐catenin/presenilin‐1 interaction
S. Kesavapany, K. Lau, D. M. McLoughlin, J. Brownlees +4 more
200118 citations
Semantic Scholar
3D models of neurodegeneration: implementation in drug discovery.
Chloe Whitehouse, Nicola J. Corbett, J. Brownlees
2023TIPS - Trends in Pharmacological Sciences16 citations Open access
Semantic Scholar
Gigaxonin is associated with the Golgi and dimerises via its BTB domain
V. Cullen, J. Brownlees, Steven J. Banner, B. Anderton +3 more
2004NeuroReport15 citations
Semantic Scholar
Thioridazine reverts the phenotype in cellular and Drosophila models of amyotrophic lateral sclerosis by enhancing TDP-43 aggregate clearance.
Lucía Cragnaz, Greta Spinelli, L. De Conti, Emilie A. Bureau +8 more
2021Neurobiology of Disease12 citations Open access
Semantic Scholar
Inhibition of IL34 unveils tissue-selectivity and is sufficient to reduce microglial proliferation in chronic neurodegeneration
J. Obst, Emilie Simon, María Martín-Estebané, E. Pipi +14 more
2020bioRxiv4 citations Open access
Semantic Scholar
Transgenic mice harbouring glycogen synthase kinase-3beta transgenes as a route for manipulating tau phosphorylation in vivo.
J. Brownlees, J. Woodgett, J. Brion, B. Anderton +5 more
19952 citations
Semantic Scholar
[P1–131]: PHENOTYPIC HIGH‐CONTENT SCREEN MEASURING CLEARANCE OF TDP ‐ 43 AGGREGATES
Emilie A. Bureau, C. Mpamhanga, L. De Conti, P. Wright +6 more
20171 citations Open access
Semantic Scholar
Identification of potent inhibitors of microtubule affinity regulating kinase for inhibition of tau hyperphosphorylation
Alison Levy, Michelle Newman, J. Brownlees, Denise J. Harding +8 more
2013Molecular Neurodegeneration1 citations Open access
Semantic Scholar
Identification of potent inhibitors of microtubule affinity regulating kinase for inhibition of tau hyperphosphorylation
Alison Levy, Michelle Newman, J. Brownlees, Denise J. Harding +8 more
2013Molecular Neurodegeneration1 citations Open access
Semantic Scholar
Using GFP-tagged neurofilament middle chain to investigate slow transport in cultured cortical neurons
S. Ackerley, A. Grierson, J. Brownlees, P. Leigh +2 more
20001 citations
Semantic Scholar
CHAPTER 9. How to Do Health and Safety Right from the Beginning
M. Ulusoy, J. Presland, J. Brownlees, E. Howley +4 more
20200 citations
Semantic Scholar
Peptidases and Peptides at the Blood-Brain Barrier
J. Brownlees, C. H. Williams
20200 citations
Semantic Scholar
[P1–100]: IL‐34:CSF1R SIGNALLING: IN VITRO TARGET VALIDATION FOR MODULATION OF MICROGLIAL PROLIFERATION AND SCREENING FOR POTENTIAL INHIBITORS
Simon G. Fox, Lisa Hale, Diego Gomez-Nicola, D. McCoull +8 more
20170 citations
Semantic Scholar
[P2–064]: NOVEL NLRP3 INFLAMMASOME INHIBITORS: EVALUATION IN IL‐1β RELEASE AND HIGH‐CONTENT ASC‐SPECK CELLULAR ASSAYS
Dörte Faust, Simon G. Fox, D. Brough, Elena Redondo‐Castro +9 more
20170 citations
Semantic Scholar
A picture is worth a thousand endpoints: high-content imaging in drug discovery
J. Brownlees, Emilie A. Bureau, J. Cook, Debra L. Taylor
20160 citations
Semantic Scholar
Role(s) of Mitogen and Stress-Activated Kinases in Neurodegeneration
Christopher C. J. Miller, S. Ackerley, J. Brownlees, A. Grierson +1 more
20030 citations Open access
Semantic Scholar
ABERRANT CYTOSKELETAL PHOSPHORYLATION AS A PATHOGENIC MECHANISM IN NEURODEGENERATIVE DISEASES - MECHANISMS OF CYTOSKELETAL PHOSPHORYLATION STUDIED IN CULTURED-CELLS AND TRANSGENIC ANIMALS
Miller Ccj., J. Brownlees, Barry J. M. Gibb, S. Guidato +5 more
19950 citations
Semantic Scholar
Amine oxidases of cerebral microvessels
J. Brownlees, C. Williams
19920 citations
Semantic Scholar
Some enzymes of the blood-brain barrier.
J. Brownlees
19910 citations
Semantic Scholar
Edinburgh Research Explorer Catechols and 3-hydroxypyridones as inhibitors of the DNA repair complex ERCC1-XPF
T. Chapman, Kevin J. Gillen, Claire Wallace, M. Lee +9 more
0 citations
Semantic Scholar

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Christopher C. J. Miller×10
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D. M. McLoughlin

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