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F. Hiepe · SciRah

Researcher profile · Semantic Scholar

F. Hiepe

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F. Hiepe — researcher profile on SciRah

h-index: 67
Works: 333
Citations: 21K

Most-cited papers

2019 EULAR/ACR Classification Criteria for Systemic Lupus Erythematosus
M. Aringer, K. Costenbader, D. Daikh, R. Brinks +60 more
2019Annals of the Rheumatic Diseases3,119 citations Open access
Semantic Scholar
Guidelines for the use of flow cytometry and cell sorting in immunological studies
A. Cossarizza, Hyun-Dong Chang, Andreas Radbruch, M. Akdiş +232 more
2017European Journal of Immunology1,153 citations Open access
Semantic Scholar
Type I interferon inhibitor anifrolumab in active systemic lupus erythematosus (TULIP-1): a randomised, controlled, phase 3 trial.
R. Furie, E. Morand, I. Bruce, S. Manzi +9 more
2019The Lancet Rheumatology398 citations Open access
Semantic Scholar
The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus
T. Alexander, R. Sarfert, J. Klotsche, A. Kühl +13 more
2015Annals of the Rheumatic Diseases343 citations Open access
Semantic Scholar
Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus
C. von Spee-Mayer, E. Siegert, D. Abdirama, A. Rose +9 more
2015Annals of the Rheumatic Diseases335 citations
Semantic Scholar
Targeting CD38 with Daratumumab in Refractory Systemic Lupus Erythematosus.
L. Ostendorf, M. Burns, P. Durek, G. Heinz +13 more
2020New England Journal of Medicine262 citations
Semantic Scholar
Plasma cells as an innovative target in autoimmune disease with renal manifestations
F. Hiepe, Andreas Radbruch
2016Nature Reviews Nephrology196 citations
Semantic Scholar
The Maintenance of Memory Plasma Cells
L. Khodadadi, Q. Cheng, Andreas Radbruch, F. Hiepe
2019Frontiers in Immunology184 citations Open access
Semantic Scholar
Rapid induction of clinical remission by low-dose interleukin-2 in a patient with refractory SLE
J. Humrich, C. von Spee-Mayer, E. Siegert, T. Alexander +4 more
2015Annals of the Rheumatic Diseases166 citations
Semantic Scholar
Bortezomib for treatment of therapy-refractory anti-NMDA receptor encephalitis
Franziska Scheibe, H. Prüss, A. Mengel, S. Kohler +6 more
2017Neurology165 citations
Semantic Scholar
Integrative Analysis Reveals a Molecular Stratification of Systemic Autoimmune Diseases
G. Barturen, S. Babaei, F. Català-Moll, M. Martínez-Bueno +128 more
2020Arthritis & Rheumatology161 citations Open access
Semantic Scholar
Repeated administration of dapirolizumab pegol in a randomised phase I study is well tolerated and accompanied by improvements in several composite measures of systemic lupus erythematosus disease activity and changes in whole blood transcriptomic profiles
C. Chamberlain, P. Colman, A. Ranger, L. Burkly +7 more
2017Annals of the Rheumatic Diseases100 citations
Semantic Scholar
Low-dose interleukin-2 therapy in refractory systemic lupus erythematosus: an investigator-initiated, single-centre phase 1 and 2a clinical trial.
J. Humrich, C. von Spee-Mayer, E. Siegert, Martina Bertolo +12 more
2019The Lancet Rheumatology77 citations
Semantic Scholar
Brief Report: A Randomized, Double‐Blind, Parallel‐Group, Placebo‐Controlled, Multiple‐Dose Study to Evaluate AMG 557 in Patients With Systemic Lupus Erythematosus and Active Lupus Arthritis
Laurence E. Cheng, Z. Amoura, B. Cheah, F. Hiepe +6 more
2018Arthritis & Rheumatology75 citations Open access
Semantic Scholar
Serological profiling of the EBV immune response in Chronic Fatigue Syndrome using a peptide microarray
M. Loebel, M. Eckey, F. Sotzny, E. Hahn +15 more
2017PLoS ONE70 citations Open access
Semantic Scholar
European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) SLE classification criteria item performance
M. Aringer, R. Brinks, Thomas Dörner, D. Daikh +60 more
2021Annals of the Rheumatic Diseases65 citations Open access
Semantic Scholar
Proteasome inhibition with bortezomib induces a therapeutically relevant depletion of plasma cells in SLE but does not target their precursors
T. Alexander, Q. Cheng, J. Klotsche, L. Khodadadi +6 more
2018European Journal of Immunology64 citations Open access
Semantic Scholar
CXCR4–CXCL12 interaction is important for plasma cell homing and survival in NZB/W mice
Q. Cheng, L. Khodadadi, A. Taddeo, J. Klotsche +3 more
2018European Journal of Immunology60 citations Open access
Semantic Scholar
Bortezomib Plus Continuous B Cell Depletion Results in Sustained Plasma Cell Depletion and Amelioration of Lupus Nephritis in NZB/W F1 Mice
L. Khodadadi, Q. Cheng, T. Alexander, Özen Sercan-Alp +5 more
2015PLoS ONE55 citations Open access
Semantic Scholar
Antibodies against chemokine receptors CXCR3 and CXCR4 predict progressive deterioration of lung function in patients with systemic sclerosis
Florian Weigold, J. Günther, M. Pfeiffenberger, O. Cabral-Marques +13 more
2018Arthritis Research & Therapy54 citations Open access
Semantic Scholar
Are interferon-related biomarkers advantageous for monitoring disease activity in systemic lupus erythematosus? A longitudinal benchmark study
T. Rose, A. Grützkau, J. Klotsche, P. Enghard +8 more
2017Rheumatology54 citations
Semantic Scholar
Performance of the 2019 EULAR/ACR classification criteria for systemic lupus erythematosus in early disease, across sexes and ethnicities
S. Johnson, R. Brinks, K. Costenbader, D. Daikh +60 more
2020Annals of the Rheumatic Diseases52 citations Open access
Semantic Scholar
SIGLEC1 is a biomarker of disease activity and indicates extraglandular manifestation in primary Sjögren's syndrome
T. Rose, F. Szelinski, A. Lisney, K. Reiter +7 more
2016RMD Open51 citations Open access
Semantic Scholar
Stromal Cell-Contact Dependent PI3K and APRIL Induced NF-κB Signaling Prevent Mitochondrial- and ER Stress Induced Death of Memory Plasma Cells
Rebecca Cornelis, Stefanie Hahne, A. Taddeo, Georg Petkau +15 more
2020Cell Reports50 citations Open access
Semantic Scholar
Use of Consensus Methodology to Determine Candidate Items for Systemic Lupus Erythematosus Classification Criteria
S. Johnson, D. Khanna, D. Daikh, R. Cervera +16 more
2018Journal of Rheumatology50 citations
Semantic Scholar
Resetting the immune system with immunoablation and autologous haematopoietic stem cell transplantation in autoimmune diseases.
T. Alexander, R. Arnold, F. Hiepe, Andreas Radbruch
2016Clinical and Experimental Rheumatology46 citations
Semantic Scholar
Salmonella SiiE prevents an efficient humoral immune memory by interfering with IgG+ plasma cell persistence in the bone marrow
Christian Männe, A. Takaya, Yuzuru Yamasaki, M. Mursell +13 more
2019Proceedings of the National Academy of Sciences of the United States of America45 citations Open access
Semantic Scholar
SIGLEC1 enables straightforward assessment of type I interferon activity in idiopathic inflammatory myopathies
M. Graf, S. V. von Stuckrad, A. Uruha, J. Klotsche +12 more
2022RMD Open41 citations Open access
Semantic Scholar
Bortezomib in antibody-mediated autoimmune diseases (TAVAB): study protocol for a unicentric, non-randomised, non-placebo controlled trial
S. Kohler, S. Märschenz, U. Grittner, T. Alexander +2 more
2019BMJ Open41 citations Open access
Semantic Scholar
Nuclear antigen-reactive CD4+ T cells expand in active systemic lupus erythematosus, produce effector cytokines, and invade the kidneys.
D. Abdirama, S. Tesch, Anna-Sophie Grießbach, C. von Spee-Mayer +14 more
2020Kidney International40 citations Open access
Semantic Scholar
Standardization procedure for flow cytometry data harmonization in prospective multicenter studies
L. Le Lann, Pierre-Emmanuel Jouve, M. Alarcón-Riquelme, C. Jamin +80 more
2020Scientific Reports40 citations Open access
Semantic Scholar
Terminal complement activation is increased and associated with disease severity in CIDP
Isaak Quast, C. Keller, F. Hiepe, B. Tackenberg +1 more
2016Annals of Clinical and Translational Neurology40 citations Open access
Semantic Scholar
Dysregulated CD38 Expression on Peripheral Blood Immune Cell Subsets in SLE
M. Burns, Lennard Ostendorf, R. Biesen, A. Grützkau +3 more
2021International Journal of Molecular Sciences39 citations Open access
Semantic Scholar
Immunological memory in rheumatic inflammation — a roadblock to tolerance induction
P. Maschmeyer, Hyun-Dong Chang, Q. Cheng, M. Mashreghi +3 more
2021Nature Reviews Rheumatology38 citations
Semantic Scholar
Pathogenic memory plasma cells in autoimmunity
Hyun-Dong Chang, K. Tokoyoda, B. Hoyer, T. Alexander +6 more
2019Current Opinion in Immunology37 citations Open access
Semantic Scholar
Integrative epigenomics in Sjögren´s syndrome reveals novel pathways and a strong interaction between the HLA, autoantibodies and the interferon signature
M. Teruel, G. Barturen, M. Martínez-Bueno, O. Castellini-Pérez +94 more
2021Scientific Reports33 citations Open access
Semantic Scholar
Bortezomib at therapeutic doses poorly passes the blood–brain barrier and does not impair cognition
Petra Huehnchen, Andreas Springer, Johannes Kern, U. Kopp +6 more
2020Brain Communications32 citations Open access
Semantic Scholar
Selective depletion of plasma cells in vivo based on the specificity of their secreted antibodies
Q. Cheng, A. Pelz, A. Taddeo, L. Khodadadi +7 more
2019European Journal of Immunology32 citations Open access
Semantic Scholar
Enhanced Programmed Death 1 and Diminished Programmed Death Ligand 1 Up‐Regulation Capacity of Post‐Activated Lupus B Cells
A. Stefanski, A. Wiedemann, K. Reiter, F. Hiepe +2 more
2019Arthritis & Rheumatology32 citations Open access
Semantic Scholar
Selective targeting of pro-inflammatory Th1 cells by microRNA-148a-specific antagomirs in vivo
P. Maschmeyer, Georg Petkau, Francesco Siracusa, J. Zimmermann +19 more
2017Journal of Autoimmunity32 citations Open access
Semantic Scholar
What is the clinical significance of anti-Sm antibodies in systemic lupus erythematosus? A comparison with anti-dsDNA antibodies and C3.
Alexandra Flechsig, T. Rose, Fidan Barkhudarova, Romy Strauß +7 more
2017Clinical and Experimental Rheumatology31 citations
Semantic Scholar
Selection and depletion of plasma cells based on the specificity of the secreted antibody
A. Taddeo, V. Gerl, B. Hoyer, Hyun-Dong Chang +5 more
2015European Journal of Immunology28 citations
Semantic Scholar
Reference standards for the detection of anti-mitochondrial and anti-rods/rings autoantibodies
S. Calise, Bing Zheng, T. Hasegawa, M. Satoh +13 more
2018Clinical Chemistry and Laboratory Medicine26 citations Open access
Semantic Scholar
Sustained responses after anti-CD38 treatment with daratumumab in two patients with refractory systemic lupus erythematosus
T. Alexander, Lennard Ostendorf, R. Biesen, U. Schneider +2 more
2023Annals of the Rheumatic Diseases24 citations
Semantic Scholar
Type I interferon as a biomarker in autoimmunity and viral infection: a leukocyte subset-specific analysis unveils hidden diagnostic options
Romy Strauß, T. Rose, S. Flint, J. Klotsche +14 more
2017Journal of molecular medicine22 citations
Semantic Scholar
BTLA Expression and Function Are Impaired on SLE B Cells
A. Wiedemann, M. Lettau, S. Weißenberg, A. Stefanski +7 more
2021Frontiers in Immunology21 citations Open access
Semantic Scholar
A new molecular classi ﬁ cation to drive precision treatment strategies in primary Sjögren ’ s syndrome
B. Vigone, J. Pers, A. Saraux, V. Devauchelle-Pensec +85 more
202119 citations
Semantic Scholar
Establishment of an international autoantibody reference standard for human anti-DFS70 antibodies: proof-of-concept study for a novel Megapool strategy by pooling individual specific sera
A. Dellavance, D. Baldo, Bing Zheng, Rodrigo A. Mora +8 more
2019Clinical Chemistry and Laboratory Medicine18 citations
Semantic Scholar
Observational study and brief analysis of diagnostic criteria in relapsing polychondritis
T. Rose, U. Schneider, Martina Bertolo, J. Klotsche +4 more
2018Rheumatology International17 citations
Semantic Scholar
Autoantibodies, complement and type I interferon as biomarkers for personalized medicine in SLE
R. Biesen, T. Rose, B. Hoyer, T. Alexander +1 more
2016Lupus17 citations
Semantic Scholar

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