Trieu D. Nguyen

Most-cited papers

1. Atheroprotective roles of smooth muscle cell phenotypic modulation and the TCF21 disease gene as revealed by single-cell analysis

   Robert C. Wirka, Dhananjay Wagh, David T. Paik, M. Pjanić +17 more

   2019Nature Medicine785 citations Open access

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2. Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements

   Maxwell R. Mumbach, Ansuman T. Satpathy, E. Boyle, Chao Dai +23 more

   2017Nature Genetics445 citations Open access

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3. Isolation of single-base genome-edited human iPS cells without antibiotic selection

   Y. Miyaoka, Amanda H. Chan, Luke M. Judge, Jennie C. Yoo +5 more

   2014Nature Methods304 citations Open access

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4. Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales

   Nathaniel Huebsch, Peter Loskill, M. Mandegar, Natalie C. Marks +12 more

   2015Tissue Engineering. Part C, Methods287 citations Open access

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5. Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci

   Clint L. Miller, M. Pjanić, Ting Wang, Trieu D. Nguyen +16 more

   2016Nature Communications148 citations Open access

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6. Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass

   Edward C. Hsiao, B. Boudignon, Wei-Chen Chang, M. Bencsik +6 more

   2008Proceedings of the National Academy of Sciences of the United States of America111 citations Open access

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7. Induced pluripotent stem cells from patients with human fibrodysplasia ossificans progressiva show increased mineralization and cartilage formation

   Y. Matsumoto, Y. Hayashi, C. Schlieve, M. Ikeya +12 more

   2013Orphanet Journal of Rare Diseases107 citations Open access

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8. Deciphering the impact of genomic variation on function

   Jesse M. Heather A. Harinder Lea M. Gary C. Hannah Nidhi Engreitz Lawson Singh Starita Hon Carter Sahni Red, Jesse M. Heather A. Harinder Lea M. Gary C. Hannah Nidhi Engreitz Lawson Singh Starita Hon Carter Sahni Red, Jesse M. Engreitz, Heather A. Lawson +496 more

   2024Nature94 citations Open access

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9. BMP-SMAD-ID promotes reprogramming to pluripotency by inhibiting p16/INK4A-dependent senescence

   Y. Hayashi, Edward C. Hsiao, Salma Sami, M. Lancero +14 more

   2016Proceedings of the National Academy of Sciences of the United States of America94 citations Open access

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10. Genetic regulatory mechanisms of smooth muscle cells map to coronary artery disease risk loci

    Boxiang Liu, M. Pjanić, Ting Wang, Trieu D. Nguyen +10 more

    2018bioRxiv92 citations Open access

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11. Coronary Disease Associated Gene TCF21 Inhibits Smooth Muscle Cell Differentiation by Blocking the Myocardin-Serum Response Factor Pathway

    M. Nagao, Qing R. Lyu, Quan-Yi Zhao, Robert C. Wirka +7 more

    2019Circulation Research88 citations Open access

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12. Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation

    W. Tingley, Ludmila Pawlikowska, J. Zaroff, Taeryn Kim +6 more

    2007Proceedings of the National Academy of Sciences of the United States of America72 citations Open access

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13. Marking Embryonic Stem Cells with a 2A Self-Cleaving Peptide: A NKX2-5 Emerald GFP BAC Reporter

    Edward C. Hsiao, Y. Yoshinaga, Trieu D. Nguyen, Stacy L. Musone +6 more

    2008PLoS ONE67 citations Open access

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14. TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells

    J. Kim, M. Pjanić, Trieu D. Nguyen, Clint L. Miller +9 more

    2017PLoS Genetics62 citations Open access

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15. Gain-of-function cardiomyopathic mutations in RBM20 rewire splicing regulation and re-distribute ribonucleoprotein granules within processing bodies

    Aidan M. Fenix, Y. Miyaoka, A. Bertero, Steven M. Blue +18 more

    2021Nature Communications58 citations Open access

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16. ZEB2 Shapes the Epigenetic Landscape of Atherosclerosis

    Paul P. Cheng, Robert C. Wirka, Lee Shoa Clarke, Quan-Yi Zhao +10 more

    2022Circulation56 citations Open access

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17. Coronary artery disease genes SMAD3 and TCF21 promote opposing interactive genetic programs that regulate smooth muscle cell differentiation and disease risk

    D. Iyer, Quan-Yi Zhao, RC Wirka, Ameay V. Naravane +8 more

    2018PLoS Genetics54 citations Open access

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18. Smad3 regulates smooth muscle cell fate and mediates adverse remodeling and calcification of the atherosclerotic plaque

    Paul P. Cheng, RC Wirka, J. Kim, Hyun-jung Kim +9 more

    2022Nature Cardiovascular Research53 citations Open access

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19. Genomic profiling of human vascular cells identifies TWIST1 as a causal gene for common vascular diseases

    S. Nürnberg, M. Guerraty, Robert C. Wirka, H. Rao +18 more

    2020PLoS Genetics52 citations Open access

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20. TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression

    Quan-Yi Zhao, Robert C. Wirka, Trieu D. Nguyen, M. Nagao +5 more

    2019Genome Medicine46 citations Open access

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21. The environment-sensing aryl-hydrocarbon receptor inhibits the chondrogenic fate of modulated smooth muscle cells in atherosclerotic lesions

    J. Kim, Quan-Yi Zhao, Trieu D. Nguyen, M. Pjanić +5 more

    2020bioRxiv44 citations Open access

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22. The environment-sensing aryl-hydrocarbon receptor inhibits the chondrogenic fate of modulated smooth muscle cells in atherosclerotic lesions

    J. Kim, Quan-Yi Zhao, Trieu D. Nguyen, M. Pjanić +6 more

    2020Circulation44 citations Open access

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23. Functional regulatory mechanism of smooth muscle cell-restricted LMOD1 coronary artery disease locus

    Vivek Nanda, Ting Wang, M. Pjanić, Boxiang Liu +14 more

    2018PLoS Genetics41 citations Open access

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24. Molecular mechanisms of coronary artery disease risk at the PDGFD locus

    Hyun-jung Kim, Paul P. Cheng, S. Travisano, Chad S. Weldy +10 more

    2023bioRxiv30 citations Open access

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25. Molecular mechanisms of coronary disease revealed using quantitative trait loci for TCF21 binding, chromatin accessibility, and chromosomal looping

    Quan-Yi Zhao, Michael Dacre, Trieu D. Nguyen, M. Pjanić +7 more

    2020Genome Biology29 citations Open access

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26. Constitutive Gs activation using a single-construct tetracycline-inducible expression system in embryonic stem cells and mice

    Edward C. Hsiao, Trieu D. Nguyen, J. K. Ng, Mark J. Scott +3 more

    2011Stem cell research & therapeutics17 citations Open access

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27. A cell and transcriptome atlas of human arterial vasculature

    Quan-Yi Zhao, Albert J. Pedroza, Disha Sharma, Wen-Duo Gu +21 more

    2024bioRxiv15 citations

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28. A cell and transcriptome atlas of human arterial vasculature

    Quan-Yi Zhao, Albert J. Pedroza, Disha Sharma, Wen-Duo Gu +21 more

    2025Cell Genomics11 citations Open access

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29. Vascular smooth muscle cell state trajectories mediate molecular mechanisms of coronary disease risk

    D. Li, Soumya Kundu, P. Cheng, Wen-Duo Gu +15 more

    2026Nature Communications7 citations Open access

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30. Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of the RNA sensor MDA5 in atherosclerosis

    Chad S. Weldy, Qin Li, J. Monteiro, Tim S. Peters +18 more

    2025Nature Cardiovascular Research7 citations Open access

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31. Epigenomic landscape of single vascular cells reflects developmental origin and disease risk loci

    Chad S. Weldy, Soumya Kundu, J. Monteiro, Wen-Duo Gu +14 more

    2025Molecular Systems Biology7 citations Open access

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32. Enhancer connectome in primary human cells reveals target genes of disease-associated DNA elements

    Maxwell R. Mumbach, Ansuman T. Satpathy, E. Boyle, Chao Dai +23 more

    2017bioRxiv6 citations Open access

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33. Discovery of trans-acting long non-coding RNAs that regulate smooth muscle cell phenotype

    Huitong Shi, Trieu D. Nguyen, Quan-Yi Zhao, Paul P. Cheng +7 more

    2023Circulation Research5 citations Open access

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34. Abstract 222: The Molecular Mechanisms Of Coronary Artery Disease Risk At The Pdgfd Locus

    Hyun-jung Kim, Paul P. Cheng, R. Kundu, Trieu D. Nguyen +5 more

    2022Arteriosclerosis, Thrombosis and Vascular Biology5 citations

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35. Vascular smooth muscle cell atherosclerosis trajectories characterized at single cell resolution identify causal transcriptomic and epigenomic mechanisms of disease risk

    D. Li, Soumya Kundu, Paul Cheng, Wen-Duo Gu +13 more

    2025bioRxiv4 citations Open access

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36. Smooth muscle expression of RNA editing enzyme ADAR1 controls activation of RNA sensor MDA5 in atherosclerosis

    Chad S. Weldy, Qin Li, J. Monteiro, Tim S. Peters +18 more

    2024bioRxiv4 citations Open access

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37. Enhancer-targeting CRISPR screens at coronary artery disease loci suggest shared mechanisms of disease risk

    M. Ramste, Chad S. Weldy, Soumya Kundu, Quan-Yi Zhao +20 more

    2025medRxiv2 citations Open access

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38. Aryl-hydrocarbon receptor in smooth muscle cells protect against dioxin induced adverse remodeling of atherosclerosis

    G. Qin, Quan-Yi Zhao, Ayaka Fujita, Isabella Damiani +14 more

    2024bioRxiv2 citations

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39. Abstract 220: Smad3 Regulates Smooth Muscle Cell Fate And Governs Adverse Remodeling And Calcification Of Atherosclerotic Plaque

    Paul P. Cheng, Robert C. Wirka, J. Kim, Trieu D. Nguyen +8 more

    2022Arteriosclerosis, Thrombosis and Vascular Biology2 citations

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40. Abstract 21021: Functional Regulatory Mechanism of Smooth Muscle Cell-Restricted LMOD1 Coronary Artery Disease Locus

    Vivek Nanda, Ting Wang, D. Iyer, M. Pjanić +6 more

    2017Circulation2 citations

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41. Abstract 4358524: The epigenomic landscape of single vascular cells reflects developmental origin and identifies disease risk loci

    Chad S. Weldy, Soumya Kundu, J. Monteiro, Wen-Duo Gu +14 more

    2025Circulation1 citations

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42. Abstract 129: The Epigenomic Landscape Of Single Vascular Cells Reflects Developmental Origin And Identifies Disease Risk Loci

    Chad S. Weldy, Paul P. Cheng, Albert J. Pedroza, Alex R. Dalal +7 more

    2022Arteriosclerosis, Thrombosis and Vascular Biology1 citations

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43. Quantitative trait loci mapped for TCF21 binding, chromatin accessibility and chromosomal looping in coronary artery smooth muscle cells reveal molecular mechanisms of coronary disease loci

    Quan-Yi Zhao, Michael Dacre, Trieu D. Nguyen, M. Pjanić +7 more

    2020bioRxiv1 citations Open access

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44. PS 07-09 EFFECT OF RESVERATROL AS AN ARGINASE INHIBITOR ON VASCULAR SMOOTH MUSCLE CELL PROLIFERATION INDUCED BY NATIVE LOW-DENSITY LIPOPROTEIN

    Trieu D. Nguyen, Sungwoo Ryoo, H. Choi

    20161 citations

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45. Chronic Electronic Cigarette Exposure Promotes Atherosclerosis and Chondrogenic Modulation of Smooth Muscle Cells

    Isabella Damiani, Chad S. Weldy, Quan-Yi Zhao, Elena Hurtado Solberg +14 more

    2026bioRxiv0 citations

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46. An in vitro System for Studying Osteochondrogenic Differentiation of Smooth Muscle Cells and Modeling Intimal Vascular Calcification

    J. Monteiro, Matthew D. Worssam, Wen-Duo Gu, D. Li +13 more

    2026bioRxiv0 citations Open access

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47. Aryl-hydrocarbon receptor in smooth muscle cells protects against dioxin-induced atherosclerosis

    G. Qin, Quan-Yi Zhao, Ayaka Fujita, Isabella Damiani +16 more

    2026Communications Medicine0 citations Open access

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48. Abstract Or137: Systematic Mapping of Smooth Muscle Cell Gene Programs That Drive Genetic Risk for Coronary Artery Disease

    D. Li, Quan-Yi Zhao, J. Monteiro, Helen Kang +7 more

    2026Arteriosclerosis, Thrombosis and Vascular Biology0 citations

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49. Abstract Tu0087: Uncovering Sex-Specific Mechanisms in Vascular Disease through a Multi-Omics Approach

    Meghana Iyer, D. Li, Wen-Duo Gu, William R Jackson +6 more

    2025Arteriosclerosis, Thrombosis and Vascular Biology0 citations

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50. The epigenomic landscape of single vascular cells reflects developmental origin and identifies disease risk loci

    Chad S. Weldy, Soumya Kundu, J. Monteiro, Wen-Duo Gu +14 more

    2025bioRxiv0 citations Open access

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