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A. Atrakchi · SciRah

Researcher profile · Semantic Scholar

A. Atrakchi

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A. Atrakchi — researcher profile on SciRah

h-index: 19
Works: 39
Citations: 786

Most-cited papers

Magnesium deficiency-induced cardiomyopathy: protection by vitamin E.
A. M. Freedman, A. Atrakchi, M. M. Cassidy, W. Weglicki
1990Biochemical and Biophysical Research Communications - BBRC76 citations
Semantic Scholar
A regulatory perspective on issues and approaches in characterizing human metabolites.
K. Davis-Bruno, A. Atrakchi
2006Chemical Research in Toxicology62 citations
Semantic Scholar
Calcium currents recorded from a vertebrate presynaptic nerve terminal are resistant to the dihydropyridine nifedipine.
Elis F. Stanley, A. Atrakchi
1990Proceedings of the National Academy of Sciences of the United States of America62 citations Open access
Semantic Scholar
Antioxidants and the cardiomyopathy of Mg-deficiency.
W. Weglicki, Sherman Bloom, Marie M. Cassidy, A. M. Freedman +2 more
1992The American journal of cardiovascular pathology59 citations
Semantic Scholar
Interpretation and considerations on the safety evaluation of human drug metabolites.
A. Atrakchi
2009Chemical Research in Toxicology57 citations
Semantic Scholar
The US Food and Drug Administration's Perspective on the New Antipsychotic Pimavanserin.
Mitchell V. Mathis, Brendan M Muoio, P. Andreason, Amy M Avila +3 more
2017Journal of Clinical Psychiatry42 citations
Semantic Scholar
Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
Xi-Lin Li, Yuan Le, Ji-Eun Seo, Xiao-Qing Guo +14 more
2023Regulatory toxicology and pharmacology : RTP38 citations
Semantic Scholar
Current and future application of genetic toxicity assays: the role and value of in vitro mammalian assays.
R. Elespuru, R. Agarwal, A. Atrakchi, C. Bigger +9 more
2009Toxicological Sciences38 citations Open access
Semantic Scholar
A decade of drug metabolite safety testing: industry and regulatory shared learning
D. Luffer-Atlas, A. Atrakchi
2017Expert Opinion on Drug Metabolism & Toxicology34 citations Open access
Semantic Scholar
Optimizing the detection of N-nitrosamine mutagenicity in the Ames test
R. Heflich, Michelle E. Bishop, R. Mittelstaedt, Jian Yan +15 more
2024Regulatory toxicology and pharmacology : RTP31 citations
Semantic Scholar
Development of soleus muscles in SHR: relationship of muscle deficits to rise in blood pressure.
A. Atrakchi, S. D. Gray, R. Carlsen
1994American Journal of Physiology30 citations
Semantic Scholar
Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s
Xi-Lin Li, Xiaobo He, Yuan Le, Xiao-Qing Guo +7 more
2022Archives of Toxicology26 citations
Semantic Scholar
Regulatory science: a special update from the United States Food and Drug Administration: Preclinical issues and status of investigation of botanical drug products in the United States.
Kuei‐Meng Wu, Joseph J. DeGeorge, A. Atrakchi, E. Barry +12 more
2000Toxicology Letters26 citations
Semantic Scholar
Genotoxicity assessment of eight nitrosamines using 2D and 3D HepaRG cell models
Ji-Eun Seo, Joshua Z Yu, Hannah Xu, Xi-Lin Li +6 more
2023Archives of Toxicology24 citations Open access
Semantic Scholar
Regulatory toxicology perspectives on the development of botanical drug products in the United States.
Kuei‐Meng Wu, J. Farrelly, D. Birnkrant, Shaw T. Chen +12 more
2004American Journal of Therapeutics24 citations
Semantic Scholar
Increased Na(+)-K+ pump number and decreased pump activity in soleus muscles in SHR.
J. Pickar, Richard C. Carlsen, A. Atrakchi, Sarah D. Gray
1994American Journal of Physiology23 citations
Semantic Scholar
Challenges and lessons learned since implementation of the safety pharmacology guidance ICH S7A.
J. Valentin, A. Bass, A. Atrakchi, K. Olejniczak +1 more
2005Journal of pharmacological and toxicological methods22 citations
Semantic Scholar
Hypomagnesemia and isoproterenol cardiomyopathies: Protection by probucol.
A. Atrakchi, S. Bloom, B. Dickens, Tong I. Mak +1 more
1992Cardiovascular pathology21 citations
Semantic Scholar
Appropriate in vivo follow-up assays to an in vitro bacterial reverse mutation (Ames) test positive investigational drug candidate (active pharmaceutical ingredient), drug-related metabolite, or drug-related impurity.
T. Robison, R. Heflich, M. Manjanatha, R. Elespuru +3 more
2021Mutation research20 citations
Semantic Scholar
Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells
Xi-Lin Li, Yuan Le, Xiao-Qing Guo, Sruthi T. King +7 more
2024Regulatory toxicology and pharmacology : RTP16 citations Open access
Semantic Scholar
Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models
Ji-Eun Seo, Hannah Xu, Xi-Lin Li, A. Atrakchi +6 more
2025Regulatory toxicology and pharmacology : RTP14 citations
Semantic Scholar
HESI GTTC Ring Trial: Concordance between Ames and Rodent Carcinogenicity Outcomes for N-Nitrosamines (NAs) with Rat and Hamster Metabolic Conditions.
J. Bercu, A. Trejo-Martin, Connie L. Chen, Maik Schuler +37 more
2025Regulatory toxicology and pharmacology : RTP14 citations Open access
Semantic Scholar
Apparent upregulation of Na+,K+ pump sites in SHR skeletal muscle with reduced transport capacity.
J. Pickar, A. Atrakchi, S. D. Gray, Richard C. Carlsen
1991Clinical and Experimental Hypertension Part A Theory and Practice7 citations
Semantic Scholar
Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes
Ji-Eun Seo, Xiaobo He, Matthew Bryant, A. Atrakchi +4 more
2025Chemico-Biological Interactions6 citations
Semantic Scholar
Beta-receptor properties in soleus muscles from spontaneously hypertensive rats.
A. Atrakchi, Richard C. Carlsen, Sarah D. Gray, A. Michel +1 more
1989HYPERTENSION4 citations Open access
Semantic Scholar
Nitrosamine Ames Data Review and Method Development: proceedings of a US FDA/HESI workshop
A. Atrakchi, Raechel Puglisi, J. Bercu, Jennifer Cheung +13 more
2026Mutagenesis2 citations Open access
Semantic Scholar
N-Nitroso-ethylisopropylamine mutagenicity in rat liver using the cII transgenic mutation assay and Duplex Sequencing analysis of genomic DNA.
Li Xia, Jian Yan, Ying Chen, Kamela Mitchell +4 more
2025Chemico-Biological Interactions2 citations Open access
Semantic Scholar
Mutagenicity of N-nitroso-fluoxetine and N-nitroso-varenicline in human HepaRG cell models.
Ji-Eun Seo, Hannah Xu, Javier R Revollo, Jaime Miranda-Colon +6 more
2026Mutagenesis1 citations
Semantic Scholar
Mutagenicity of EAT-positive NDSRIs in HepaRG spheroids
Ji-Eun Seo, Hannah Xu, Javier R Revollo, Jaime Miranda-Colon +10 more
2026NAM journal1 citations Open access
Semantic Scholar
Integration of the rat liver micronucleus assay into a 28-day treatment protocol: testing the genotoxicity of 4 small-molecule nitrosamines with different carcinogenic potencies and tumor target specificities
Xiao-Qing Guo, Ji-Eun Seo, Hannah Xu, Jian Yan +6 more
2025Toxicological Sciences1 citations
Semantic Scholar
Free Radical Mechanisms of Cellular Injury Symposium: Introduction
A. Atrakchi, L. Clerch
20011 citations
Semantic Scholar
Interaction of lindane and verapamil in isolated left atria from guinea pigs.
A. Atrakchi, T. C. West, R. Joy
1986Proceedings of the Western Pharmacology Society1 citations
Semantic Scholar
Positive inotropy, calcium dependence and arrhythmogenicity of lindane in atrial tissue from the guinea pig.
A. Atrakchi, T. C. West
1985Proceedings of the Western Pharmacology Society1 citations
Semantic Scholar
Nitrosamines as Impurities in Drugs— Health Risk Assessment and Mitigation Public Workshop
Gerhard Eisenbrand, S. Kyrtopoulos, Mark T. Cronin, Joseph Guttenplan +12 more
1 citations
Semantic Scholar
DNA Damage and Micronucleus Induction by Small-Molecule Nitrosamine Drug Impurities and Nitrosamine Drug Substance-Related Impurities in HepaRG Cells.
Hannah Xu, Ji-Eun Seo, Xi-Lin Li, Nan Mei +8 more
2026Environmental and Molecular Mutagenesis0 citations Open access
Semantic Scholar
Adjusting the Preincubation Conditions to Enhance the Ames Test for Detecting the Mutagenicity of N‐Nitrosamines
Michelle E. Bishop, Audrey M. Sims, Sharon K. Guerrero, Kamela Mitchell +8 more
2026Environmental and Molecular Mutagenesis0 citations Open access
Semantic Scholar
54 / 8-Receptor Properties in Soleus Muscles From Spontaneously Hypertensive Rats
A. Atrakchi, R. Carlsen, S. D. Gray, A. Michel +1 more
20050 citations
Semantic Scholar
Radiation Therapy Symposium: Introduction
A. Atrakchi, W. Blakely
20010 citations
Semantic Scholar
Pharmacology of (-) [3H]D888 (desmethoxyverapamil) binding sites in rat skeletal membranes.
A. Atrakchi, E. Kunysz, A. Michel
1987Proceedings of the Western Pharmacology Society0 citations
Semantic Scholar

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