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L. Tobacman · SciRah

Researcher profile · Semantic Scholar

L. Tobacman

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L. Tobacman — researcher profile on SciRah

h-index: 40
Works: 88
Citations: 4,827

Most-cited papers

Thin filament-mediated regulation of cardiac contraction.
L. Tobacman
1996Annual Review of Physiology516 citations
Semantic Scholar
Tropomyosin and actin isoforms modulate the localization of tropomyosin strands on actin filaments.
W. Lehman, V. Hatch, V. Korman, M. Rosol +6 more
2000Journal of Molecular Biology257 citations Open access
Semantic Scholar
Structural Basis for the Activation of Muscle Contraction by Troponin and Tropomyosin
W. Lehman, A. Galińska-Rakoczy, V. Hatch, L. Tobacman +1 more
2008Journal of Molecular Biology183 citations Open access
Semantic Scholar
A comparison of muscle thin filament models obtained from electron microscopy reconstructions and low-angle X-ray fibre diagrams from non-overlap muscle.
K. Poole, M. Lorenz, G. Evans, G. Rosenbaum +5 more
2006Journal of Structural Biology178 citations
Semantic Scholar
Tropomyosin positions in regulated thin filaments revealed by cryoelectron microscopy.
C. Xu, R. Craig, L. Tobacman, R. Horowitz +1 more
1999Biophysical Journal176 citations Open access
Semantic Scholar
Tropomyosin position on F-actin revealed by EM reconstruction and computational chemistry.
X. Li, L. Tobacman, J. Mun, R. Craig +2 more
2011Biophysical Journal166 citations Open access
Semantic Scholar
Structure of the mid-region of tropomyosin: bending and binding sites for actin.
Jerry H. Brown, Zhao Zhou, L. Reshetnikova, H. Robinson +3 more
2005Proceedings of the National Academy of Sciences of the United States of America161 citations Open access
Semantic Scholar
Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism
Ji-Young Mun, M. Previs, Hope Y. Yu, J. Gulick +5 more
2014Proceedings of the National Academy of Sciences of the United States of America157 citations Open access
Semantic Scholar
An atomic model of the thin filament in the relaxed and Ca2+-activated states.
Alnoor Pirani, M. Vinogradova, P. Curmi, W. King +6 more
2006Journal of Molecular Biology140 citations
Semantic Scholar
Hypertrophic Cardiomyopathy Caused by a Novel &agr;-Tropomyosin Mutation (V95A) Is Associated With Mild Cardiac Phenotype, Abnormal Calcium Binding to Troponin, Abnormal Myosin Cycling, and Poor Prognosis
A. Karibe, L. Tobacman, J. Strand, C. Butters +7 more
2001Circulation136 citations
Semantic Scholar
Calcium regulation of thin filament movement in an in vitro motility assay.
Earl Homsher, Bibiana Kim, A. Bobkova, L. Tobacman
1996Biophysical Journal134 citations Open access
Semantic Scholar
Structural basis for the regulation of muscle contraction by troponin and tropomyosin.
A. Galińska-Rakoczy, Patti L. Engel, Chen Xu, H. Jung +3 more
2008Journal of Molecular Biology130 citations Open access
Semantic Scholar
A new model of cooperative myosin-thin filament binding.
L. Tobacman, C. Butters
2000Journal of Biological Chemistry125 citations Open access
Semantic Scholar
Single particle analysis of relaxed and activated muscle thin filaments.
Alnoor Pirani, Chen Xu, V. Hatch, R. Craig +2 more
2005Journal of Molecular Biology123 citations
Semantic Scholar
Altered cardiac troponin T in vitro function in the presence of a mutation implicated in familial hypertrophic cardiomyopathy.
D. Lin, A. Bobkova, Earl Homsher, L. Tobacman
1996Journal of Clinical Investigation118 citations Open access
Semantic Scholar
The Troponin Tail Domain Promotes a Conformational State of the Thin Filament That Suppresses Myosin Activity*
L. Tobacman, Mahta Nihli, C. Butters, M. Heller +4 more
2002Journal of Biological Chemistry98 citations Open access
Semantic Scholar
The crystal structure of the C-terminal fragment of striated-muscle α-tropomyosin reveals a key troponin T recognition site
Y. Li, S. Mui, Jerry H. Brown, J. Strand +3 more
2002Proceedings of the National Academy of Sciences of the United States of America92 citations Open access
Semantic Scholar
Troponin organization on relaxed and activated thin filaments revealed by electron microscopy and three-dimensional reconstruction.
William Lehman, M. Rosol, L. Tobacman, Roger Craig
2001Journal of Molecular Biology92 citations
Semantic Scholar
Functional Consequences of Troponin T Mutations Found in Hypertrophic Cardiomyopathy*
L. Tobacman, David Lin, C. Butters, Cheryl Landis +3 more
1999Journal of Biological Chemistry89 citations Open access
Semantic Scholar
The regulation of actin polymerization and the inhibition of monomeric actin ATPase activity by Acanthamoeba profilin.
L. Tobacman, E. Korn
1982Journal of Biological Chemistry88 citations Open access
Semantic Scholar
Analysis of troponin-tropomyosin binding to actin. Troponin does not promote interactions between tropomyosin molecules.
Laura E. Hill, J. P. Mehegan, C. Butters, L. Tobacman
1992Journal of Biological Chemistry85 citations Open access
Semantic Scholar
Roles for the Troponin Tail Domain in Thin Filament Assembly and Regulation
Ashley Hinkle, Angela Goranson, C. Butters, L. Tobacman
1999Journal of Biological Chemistry83 citations Open access
Semantic Scholar
Folding and Function of the Troponin Tail Domain
Ashley Hinkle, L. Tobacman
2003Journal of Biological Chemistry82 citations Open access
Semantic Scholar
Cooperative interactions between adjacent troponin-tropomyosin complexes may be transmitted through the actin filament.
C. Butters, Kent A. Willadsen, L. Tobacman
1993Journal of Biological Chemistry77 citations Open access
Semantic Scholar
Effects of Tropomyosin Internal Deletions on Thin Filament Function*
Cheryl Landis, N. Back, E. Homsher, L. Tobacman
1999Journal of Biological Chemistry72 citations Open access
Semantic Scholar
Mechanism of regulation of cardiac actin-myosin subfragment 1 by troponin-tropomyosin.
L. Tobacman, R. Adelstein
1986Biochemistry68 citations
Semantic Scholar
Calcium binds cooperatively to the regulatory sites of the cardiac thin filament.
L. Tobacman, Dawyn Sawyer
1990Journal of Biological Chemistry63 citations Open access
Semantic Scholar
The Active State of the Thin Filament Is Destabilized by an Internal Deletion in Tropomyosin*
Cheryl Landis, A. Bobkova, E. Homsher, L. Tobacman
1997Journal of Biological Chemistry62 citations Open access
Semantic Scholar
Structure-function studies of the amino-terminal region of bovine cardiac troponin T.
L. Tobacman
1988Journal of Biological Chemistry60 citations Open access
Semantic Scholar
TROPONIN REVEALED Uncovering the Structure of the Thin Filament On-Off Switch in Striated Muscle.
L. Tobacman
2020Biophysical Journal59 citations Open access
Semantic Scholar
Cardiomyopathic Tropomyosin Mutations That Increase Thin Filament Ca2+ Sensitivity and Tropomyosin N-domain Flexibility*
M. Heller, M. Nili, E. Homsher, L. Tobacman
2003Journal of Biological Chemistry59 citations Open access
Semantic Scholar
The amino acid sequence of Acanthamoeba profilin.
Christophe Ampe, Joël Vandekerckhove, S. Brenner, L. Tobacman +1 more
1985Journal of Biological Chemistry53 citations
Semantic Scholar
Cooperative binding of tropomyosin to actin.
L. Tobacman
2008Advances in Experimental Medicine and Biology49 citations
Semantic Scholar
Electron microscopy and persistence length analysis of semi-rigid smooth muscle tropomyosin strands.
D. Sousa, A. Cammarato, K. Jang, P. Graceffa +3 more
2010Biophysical Journal46 citations Open access
Semantic Scholar
Contractile effects of the exchange of cardiac troponin for fast skeletal troponin in rabbit psoas single myofibrils
N. Piroddi, C. Tesi, M. Pellegrino, L. Tobacman +2 more
2003Journal of Physiology46 citations Open access
Semantic Scholar
Regulatory proteins alter nucleotide binding to acto-myosin of sliding filaments in motility assays.
Earl Homsher, M. Nili, I. Y. Chen, L. Tobacman
2003Biophysical Journal46 citations Open access
Semantic Scholar
Three-dimensional reconstruction of thin filaments containing mutant tropomyosin.
M. Rosol, W. Lehman, R. Craig, C. Landis +2 more
2000Biophysical Journal46 citations Open access
Semantic Scholar
NH2-terminal Truncation of Skeletal Muscle Troponin T Does Not Alter the Ca2+ Sensitivity of Thin Filament Assembly (*)
D. Fisher, Gang Wang, L. Tobacman
1995Journal of Biological Chemistry45 citations Open access
Semantic Scholar
Opposite Effects of Myosin Subfragment 1 on Binding of Cardiac Troponin and Tropomyosin to the Thin Filament*
M. Cassell, L. Tobacman
1996Journal of Biological Chemistry42 citations Open access
Semantic Scholar
Drosophila muscle regulation characterized by electron microscopy and three-dimensional reconstruction of thin filament mutants.
A. Cammarato, V. Hatch, J. Saide, R. Craig +3 more
2004Biophysical Journal41 citations Open access
Semantic Scholar
Molecular polarity in tropomyosin-troponin T co-crystals.
D. Cabral-Lilly, L. Tobacman, J. P. Mehegan, Carolyn Cohen
1997Biophysical Journal39 citations Open access
Semantic Scholar
Modulation of Contractile Activation in Skeletal Muscle by a Calcium-insensitive Troponin C Mutant*
C. Morris, L. Tobacman, E. Homsher
2001Journal of Biological Chemistry37 citations Open access
Semantic Scholar
Cardiomyopathic troponin mutations predominantly occur at its interface with actin and tropomyosin
L. Tobacman, A. Cammarato
2021The Journal of General Physiology31 citations Open access
Semantic Scholar
Modulation of Myosin Function by Isoform-specific Properties ofSaccharomyces cerevisiae and Muscle Tropomyosins*
J. Strand, M. Nili, E. Homsher, L. Tobacman
2001Journal of Biological Chemistry31 citations Open access
Semantic Scholar
Cooperative Effect of Calcium Binding to Adjacent Troponin Molecules on the Thin Filament-Myosin Subfragment 1 MgATPase Rate*
C. Butters, Jeremy Tobacman, L. Tobacman
1997Journal of Biological Chemistry31 citations Open access
Semantic Scholar
Troponin Regulatory Function and Dynamics Revealed by H/D Exchange-Mass Spectrometry*
D. Kowlessur, L. Tobacman
2009Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Enzymatic comparisons between light chain isozymes of human cardiac myosin subfragment-1.
L. Tobacman, R. Adelstein
1984Journal of Biological Chemistry27 citations
Semantic Scholar
Temperature-dependence of isometric tension and cross-bridge kinetics of cardiac muscle fibers reconstituted with a tropomyosin internal deletion mutant.
Xiaoying Lu, L. Tobacman, M. Kawai
2006Biophysical Journal26 citations Open access
Semantic Scholar
Mutations in Actin Subdomain 3 That Impair Thin Filament Regulation by Troponin and Tropomyosin*
V. Korman, L. Tobacman
1999Journal of Biological Chemistry26 citations Open access
Semantic Scholar
Mini-thin filaments regulated by troponin-tropomyosin.
Hui-Yu Gong, V. Hatch, Laith F. Ali, W. Lehman +2 more
2005Proceedings of the National Academy of Sciences of the United States of America25 citations Open access
Semantic Scholar

Frequent co-authors

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R. Craig×11
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W. Lehman×9
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C. Butters×9
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E. Homsher×8
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William Lehman×4

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Earl Homsher×4

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Alnoor Pirani×3

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