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Zhen-Yu Li · SciRah

Researcher profile · Semantic Scholar

Zhen-Yu Li

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Zhen-Yu Li — researcher profile on SciRah

h-index: 38
Works: 87
Citations: 5,276

Most-cited papers

ATVB in Focus Platelets Unplugged: Focus on Platelet Biology
Susan S. Smyth, Zhen-Yu Li, M. Keegan, Delaney +2 more
2010779 citations
Semantic Scholar
LPS stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway
Guoying Zhang, Jing-Yan Han, Emily J. Welch, Richard D. Ye +4 more
2009Journal of Immunology367 citations Open access
Semantic Scholar
Inflammasome activation triggers blood clotting and host death through pyroptosis
Congqing Wu, Wei Lu, Yan Zhang, Guoying Zhang +16 more
2019Immunity363 citations Open access
Semantic Scholar
A stimulatory role for cGMP-dependent protein kinase in platelet activation.
Zhen-Yu Li, X. Xi, M. Gu, R. Feil +4 more
2003Cell300 citations Open access
Semantic Scholar
Two distinct roles of mitogen-activated protein kinases in platelets and a novel Rac1-MAPK-dependent integrin outside-in retractile signaling pathway.
P. Flevaris, Zhen-Yu Li, Guoying Zhang, Yi Zheng +2 more
2009Blood205 citations Open access
Semantic Scholar
Platelets protect from septic shock by inhibiting macrophage-dependent inflammation via the cyclooxygenase 1 signaling pathway
Binggang Xiang, Guoying Zhang, Ling Guo, Xiang-An Li +5 more
2013Nature Communications200 citations Open access
Semantic Scholar
Pyroptosis-induced inflammation and tissue damage
Yi-Nan Wei, Ling Yang, Ankit Pandeya, Jian Cui +2 more
2021Journal of Molecular Biology160 citations Open access
Semantic Scholar
A predominant role for cAMP-dependent protein kinase in the cGMP-induced phosphorylation of vasodilator-stimulated phosphoprotein and platelet inhibition in humans.
Zhen-Yu Li, Jasna Ajdic, M. Eigenthaler, Xiao-Ping Du
2003Blood154 citations
Semantic Scholar
Autophagy is induced upon platelet activation and is essential for hemostasis and thrombosis.
Madhu M Ouseph, Yun-Jie Huang, M. Banerjee, Smita Joshi +12 more
2015Blood146 citations Open access
Semantic Scholar
Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin αIIbβ3
Zhen-Yu Li, Guoying Zhang, R. Feil, Jia-Huai Han +1 more
2006145 citations Open access
Semantic Scholar
Two Waves of Platelet Secretion Induced by Thromboxane A2 Receptor and a Critical Role for Phosphoinositide 3-Kinases*
Zhen-Yu Li, Guoying Zhang, G. L. le Breton, Xiao-Pei Gao +2 more
2003Journal of Biological Chemistry143 citations Open access
Semantic Scholar
A Mitogen-activated Protein Kinase-dependent Signaling Pathway in the Activation of Platelet Integrin αIIbβ3 *
Zhen-Yu Li, X. Xi, Xiao-Ping Du
2001Journal of Biological Chemistry120 citations Open access
Semantic Scholar
Hsp47 promotes cancer metastasis by enhancing collagen-dependent cancer cell-platelet interaction
G. Xiong, Jie Chen, Guoying Zhang, Shike Wang +7 more
2020Proceedings of the National Academy of Sciences of the United States of America117 citations Open access
Semantic Scholar
Src family tyrosine kinase Lyn mediates VWF/GPIb-IX-induced platelet activation via the cGMP signaling pathway.
Hong-Chao Yin, Jun-Ling Liu, Zhen-Yu Li, M. Berndt +2 more
2008Blood116 citations Open access
Semantic Scholar
Regulation of Glycoprotein Ib-IX-von Willebrand Factor Interaction by cAMP-dependent Protein Kinase-mediated Phosphorylation at Ser 166 of Glycoprotein Ibβ*
R. Bodnar, X. Xi, Zhen-Yu Li, M. Berndt +1 more
2002Journal of Biological Chemistry92 citations Open access
Semantic Scholar
Stimulatory Roles of Nitric-oxide Synthase 3 and Guanylyl Cyclase in Platelet Activation*
Jasna A. Marjanovic, Zhen-Yu Li, Aleksandra Stojanovic, Xiao-Ping Du
2005Journal of Biological Chemistry90 citations Open access
Semantic Scholar
Sequential activation of p38 and ERK pathways by cGMP-dependent protein kinase leading to activation of the platelet integrin alphaIIb beta3.
Zhen-Yu Li, Guoying Zhang, R. Feil, Jia-Huai Han +1 more
2006Blood86 citations
Semantic Scholar
Biphasic roles for soluble guanylyl cyclase (sGC) in platelet activation.
Guoying Zhang, Binggang Xiang, An-Ping Dong, R. Skoda +4 more
2011Blood82 citations Open access
Semantic Scholar
A Platelet Secretion Pathway Mediated by cGMP-dependent Protein Kinase*
Zhen-Yu Li, Guoying Zhang, Jasna A. Marjanovic, C. Ruan +1 more
2004Journal of Biological Chemistry82 citations Open access
Semantic Scholar
Regulation of von Willebrand Factor Binding to the Platelet Glycoprotein Ib-IX by a Membrane Skeleton-dependent Inside-out Signal*
G. D. Englund, R. Bodnar, Zhen-Yu Li, Z. Ruggeri +1 more
2001Journal of Biological Chemistry82 citations Open access
Semantic Scholar
Human Cancer and Platelet Interaction, a Potential Therapeutic Target
Shike Wang, Zhen-Yu Li, Ren Xu
2018International Journal of Molecular Sciences81 citations Open access
Semantic Scholar
The Cytoplasmic Domain of the Platelet Glycoprotein Ibα Is Phosphorylated at Serine 609*
R. Bodnar, M. Gu, Zhen-Yu Li, G. D. Englund +1 more
1999Journal of Biological Chemistry80 citations Open access
Semantic Scholar
Sirt1 Deletion Leads to Enhanced Inflammation and Aggravates Endotoxin-Induced Acute Kidney Injury
Rong Gao, Jiao Chen, Yu-Xin Hu, Zhen-Yu Li +3 more
2014PLoS ONE78 citations Open access
Semantic Scholar
Aspirin-triggered resolvin D1 down-regulates inflammatory responses and protects against endotoxin-induced acute kidney injury
Jiao Chen, S. Shetty, Ping Zhang, Rong Gao +4 more
2014Toxicology and Applied Pharmacology76 citations Open access
Semantic Scholar
Clopidogrel treatment on the incidence and severity of community acquired pneumonia in a cohort study and meta-analysis of antiplatelet therapy in pneumonia and critical illness
A. K. Gross, Steven P. Dunn, David J. Feola, Craig A. Martin +4 more
2013Journal of Thrombosis and Thrombolysis69 citations Open access
Semantic Scholar
A critical role for Lyn kinase in strengthening endothelial integrity and barrier function.
Jing-Yan Han, Guoying Zhang, Emily J. Welch, Ying-Jian Liang +7 more
2013Blood65 citations Open access
Semantic Scholar
Critical roles for the COOH-terminal NITY and RGT sequences of the integrin β3 cytoplasmic domain in inside-out and outside-in signaling
X. Xi, R. Bodnar, Zhen-Yu Li, S. Lam +1 more
2003Journal of Cell Biology64 citations Open access
Semantic Scholar
Distinct Roles for Rap1b Protein in Platelet Secretion and Integrin αIIbβ3 Outside-in Signaling*
Guoying Zhang, Binggang Xiang, S. Ye, M. Chrzanowska-Wodnicka +6 more
2011Journal of Biological Chemistry63 citations Open access
Semantic Scholar
Arf6 controls platelet spreading and clot retraction via integrin αIIbβ3 trafficking.
Yun-Jie Huang, Smita Joshi, Binggang Xiang, Y. Kanaho +4 more
2016Blood62 citations Open access
Semantic Scholar
Platelet secretion and hemostasis require syntaxin-binding protein STXBP5.
S. Ye, Yun-Jie Huang, Smita Joshi, Jinchao Zhang +6 more
2014Journal of Clinical Investigation61 citations Open access
Semantic Scholar
Inflammasome activation promotes venous thrombosis through pyroptosis.
Yan Zhang, Jian Cui, Guoying Zhang, Congqing Wu +7 more
2021Blood Advances58 citations Open access
Semantic Scholar
Caveolin-1 Protects against Sepsis by Modulating Inflammatory Response, Alleviating Bacterial Burden, and Suppressing Thymocyte Apoptosis*
H. Feng, Ling Guo, Zhi-Qing Song, Hai-Qing Gao +6 more
2010Journal of Biological Chemistry57 citations Open access
Semantic Scholar
Gasdermin D (GSDMD) as a new target for the treatment of infection.
Ankit Pandeya, Lan Li, Zhen-Yu Li, Yi-Nan Wei
2019MedChemComm51 citations Open access
Semantic Scholar
An Important Role of the Src Family Kinase Lyn in Stimulating Platelet Granule Secretion*
Zhen-Yu Li, Guoying Zhang, Jun-Ling Liu, Aleksandra Stojanovic +3 more
2010Journal of Biological Chemistry47 citations Open access
Semantic Scholar
Receptor-interacting protein kinase 3 promotes platelet activation and thrombosis
Yi-Wen Zhang, Jian Zhang, R. Yan, Jing-Luan Tian +11 more
2017Proceedings of the National Academy of Sciences of the United States of America44 citations Open access
Semantic Scholar
The Src Family Kinases and Protein Kinase C Synergize to Mediate Gq-dependent Platelet Activation*
Binggang Xiang, Guoying Zhang, L. Stefanini, W. Bergmeier +3 more
2012Journal of Biological Chemistry42 citations Open access
Semantic Scholar
Opposing Effects of Platelet-activating Factor and Lyso-Platelet-activating Factor on Neutrophil and Platelet Activation
Emily J. Welch, R. Naikawadi, Zhen-Yu Li, Phoebe Lin +6 more
2008Molecular Pharmacology41 citations Open access
Semantic Scholar
Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKII&dgr; expression in the aged atrium
Xian-Long Gao, Xiaomin Wu, Jia-Jie Yan, Jing-qun Zhang +9 more
2018Cardiovascular Research38 citations Open access
Semantic Scholar
Characterization of a Novel Integrin Binding Protein, VPS33B, Which is Important for Platelet Activation and in vivo Thrombosis and Hemostasis
Binggang Xiang, Guoying Zhang, S. Ye, Rui Zhang +7 more
2015Circulation37 citations Open access
Semantic Scholar
Lysophosphatidic Acid Signaling Protects Pulmonary Vasculature from Hypoxia-induced Remodeling
Hsin‐Yuan Cheng, An-Ping Dong, M. Panchatcharam, P. Mueller +6 more
2011Arteriosclerosis, Thrombosis and Vascular Biology37 citations Open access
Semantic Scholar
A Gi-independent mechanism mediating Akt phosphorylation in platelets
Binggang Xiang, Guoying Zhang, Jun-Ling Liu, Andrew J. Morris +3 more
2010Journal of Thrombosis and Haemostasis36 citations Open access
Semantic Scholar
Inflammasome activation and pyroptosis mediate coagulopathy and inflammation in Salmonella systemic infection
Ankit Pandeya, Yan Zhang, Jian Cui, Ling Yang +5 more
2023Microbiology Research27 citations Open access
Semantic Scholar
Effects of Renin-Angiotensin Inhibition on ACE2 (Angiotensin-Converting Enzyme 2) and TMPRSS2 (Transmembrane Protease Serine 2) Expression
Congqing Wu, Dien Ye, A. Mullick, Zhen-Yu Li +3 more
2020HYPERTENSION26 citations Open access
Semantic Scholar
Latexin Inactivation Enhances Survival and Long-Term Engraftment of Hematopoietic Stem Cells and Expands the Entire Hematopoietic System in Mice
Yi Liu, Cui-Ping Zhang, Zhen-Yu Li, Chi Wang +12 more
2017Stem Cell Reports25 citations Open access
Semantic Scholar
Dasatinib-loaded albumin nanoparticles possess diminished endothelial cell barrier disruption and retain potent anti-leukemia cell activity
Chun-Ling Dong, Bo Li, Zhen-Yu Li, S. Shetty +1 more
2016OncoTarget25 citations Open access
Semantic Scholar
Platelet IKKβ Deficiency Increases Mouse Arterial Neointima Formation via Delayed Glycoprotein Ibα Shedding
Shu-Jian Wei, Huan Wang, Guoying Zhang, Ying Lu +10 more
2012Arteriosclerosis, Thrombosis and Vascular Biology24 citations Open access
Semantic Scholar
The P2Y12 Antagonists, 2MeSAMP and Cangrelor, Inhibit Platelet Activation through P2Y12/Gi-Dependent Mechanism
Binggang Xiang, Guoying Zhang, Hong-Mei Ren, Manjula Sunkara +4 more
2012PLoS ONE21 citations Open access
Semantic Scholar
Effects of Renin-Angiotensin Inhibition on ACE2 and TMPRSS2 Expression: Insights into COVID-19
Congqing Wu, Dien Ye, A. Mullick, Zhen-Yu Li +3 more
2020bioRxiv14 citations Open access
Semantic Scholar
Calcium ion chelation preserves platelet function during cold storage
Binggang Xiang, Guoying Zhang, Yan Zhang, Congqing Wu +6 more
2020bioRxiv14 citations Open access
Semantic Scholar
Extracellular Histones Trigger Disseminated Intravascular Coagulation by Lytic Cell Death
Yan Zhang, Congqing Wu, Lan Li, Ankit Pandeya +7 more
2020bioRxiv12 citations Open access
Semantic Scholar

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