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E. Freed · SciRah

Researcher profile · Semantic Scholar

E. Freed

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E. Freed — researcher profile on SciRah

h-index: 75
Works: 244
Citations: 21K

Most-cited papers

HIV-1 assembly, release and maturation
E. Freed
2015Nature Reviews Microbiology588 citations Open access
Semantic Scholar
Distribution of ESCRT machinery at HIV assembly sites reveals virus scaffolding of ESCRT subunits
S. V. van Engelenburg, G. Shtengel, Prabuddha Sengupta, Kayoko Waki +5 more
2014Science191 citations Open access
Semantic Scholar
Multifunctional RNA Nanoparticles
K. Afonin, Mathias Viard, Alexey Y. Koyfman, Angelica N. Martins +11 more
2014Nano letters (Print)190 citations Open access
Semantic Scholar
IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein
Jing-You Yu, Ming-Hua Li, J. Wilkins, Shi-Lei Ding +7 more
2015Cell Reports166 citations Open access
Semantic Scholar
Activation of different split functionalities upon re-association of RNA-DNA hybrids
K. Afonin, Mathias Viard, Angelica N. Martins, S. Lockett +6 more
2013Nature Nanotechnology114 citations Open access
Semantic Scholar
TIM-family proteins inhibit HIV-1 release
Ming-Hua Li, Sherimay D. Ablan, Chunhui Miao, Yi-Min Zheng +6 more
2014Proceedings of the National Academy of Sciences of the United States of America92 citations Open access
Semantic Scholar
Multiple Roles of HIV-1 Capsid during the Virus Replication Cycle
Mariia Novikova, Yu-Lan Zhang, E. Freed, Ke Peng
2019Virologica Sinica83 citations Open access
Semantic Scholar
Structural and Molecular Determinants of Membrane Binding by the HIV-1 Matrix Protein
Peter Y. Mercredi, Nadine Bucca, Burk W. Loeliger, Christy R Gaines +11 more
2016Journal of Molecular Biology82 citations Open access
Semantic Scholar
Global Rescue of Defects in HIV-1 Envelope Glycoprotein Incorporation: Implications for Matrix Structure
P. Tedbury, Sherimay D. Ablan, E. Freed
2013PLoS Pathogens82 citations Open access
Semantic Scholar
HIV-1 Maturation: Lessons Learned from Inhibitors
A. Kleinpeter, E. Freed
2020Viruses81 citations Open access
Semantic Scholar
MicroRNA binding to the HIV-1 Gag protein inhibits Gag assembly and virus production
Antony K. Chen, Prabuddha Sengupta, Kayoko Waki, S. V. van Engelenburg +4 more
2014Proceedings of the National Academy of Sciences of the United States of America76 citations Open access
Semantic Scholar
Rab27a controls HIV-1 assembly by regulating plasma membrane levels of phosphatidylinositol 4,5-bisphosphate
P. Gerber, M. Cabrini, C. Jancic, Luciana Paoletti +13 more
2015Journal of Cell Biology74 citations Open access
Semantic Scholar
The role of matrix in HIV-1 envelope glycoprotein incorporation
P. Tedbury, E. Freed
2014Trends in Microbiology73 citations Open access
Semantic Scholar
Biochemical evidence of a role for matrix trimerization in HIV-1 envelope glycoprotein incorporation
P. Tedbury, Mariia Novikova, Sherimay D. Ablan, E. Freed
2015Proceedings of the National Academy of Sciences of the United States of America71 citations Open access
Semantic Scholar
A Two-Pronged Structural Analysis of Retroviral Maturation Indicates that Core Formation Proceeds by a Disassembly-Reassembly Pathway Rather than a Displacive Transition
P. Keller, Rick K. Huang, M. England, Kayoko Waki +5 more
2013Journal of Virology71 citations Open access
Semantic Scholar
A stable immature lattice packages IP6 for HIV capsid maturation
D. Mallery, A. Kleinpeter, Nadine Renner, K. M. Rifat Faysal +10 more
2021Science Advances64 citations Open access
Semantic Scholar
PSGL-1 restricts HIV-1 infectivity by blocking virus particle attachment to target cells
Yajing Fu, Sijia He, A. Waheed, Deemah Dabbagh +10 more
2020Proceedings of the National Academy of Sciences of the United States of America59 citations Open access
Semantic Scholar
Quenching protein dynamics interferes with HIV capsid maturation
Ming-Zhang Wang, Caitlin M. Quinn, J. Perilla, Huilan Zhang +13 more
2017Nature Communications58 citations Open access
Semantic Scholar
HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly
Nadine Renner, A. Kleinpeter, D. Mallery, A. Albecka +5 more
2023Nature Structural & Molecular Biology56 citations Open access
Semantic Scholar
S-acylation of SARS-CoV-2 spike protein: Mechanistic dissection, in vitro reconstitution and role in viral infectivity
Robbins Puthenveetil, Man-Lun Cheng, R. E. Murphy, L. Healy +4 more
2021Journal of Biological Chemistry56 citations Open access
Semantic Scholar
Mutations in the HIV-1 envelope glycoprotein can broadly rescue blocks at multiple steps in the virus replication cycle
Rachel Van Duyne, Lillian S. Kuo, P. Pham, K. Fujii +1 more
2019Proceedings of the National Academy of Sciences of the United States of America53 citations Open access
Semantic Scholar
CryoET structures of immature HIV Gag reveal six-helix bundle
L. Mendonça, Dapeng Sun, J. Ning, Ji-Wei Liu +10 more
2021Communications Biology52 citations Open access
Semantic Scholar
Mechanism of Viral Glycoprotein Targeting by Membrane-Associated RING-CH Proteins
Man-Lun Cheng, A. Waheed, Ahlam Majadly, Nicole Powell +1 more
2021mBio48 citations Open access
Semantic Scholar
Alkyl Amine Bevirimat Derivatives Are Potent and Broadly Active HIV-1 Maturation Inhibitors
E. Urano, Sherimay D. Ablan, Rebecca E. K. Mandt, Gary T. Pauly +6 more
2015Antimicrobial Agents and Chemotherapy48 citations Open access
Semantic Scholar
Single molecule fate of HIV-1 envelope reveals late-stage viral lattice incorporation
Carmen A. Buttler, Nairi Pezeshkian, Melissa V. Fernandez, J. Aaron +3 more
2018Nature Communications46 citations Open access
Semantic Scholar
Myosin-X is essential to the intercellular spread of HIV-1 Nef through tunneling nanotubes
Jaime Uhl, S. Gujarathi, A. Waheed, A. Gordon +2 more
2018Journal of cell communication and signaling46 citations Open access
Semantic Scholar
Dual-acting stapled peptides target both HIV-1 entry and assembly
Hong-Tao Zhang, F. Curreli, A. Waheed, Peter Y. Mercredi +9 more
2013Retrovirology46 citations Open access
Semantic Scholar
Analysis of HIV-1 Matrix-Envelope Cytoplasmic Tail Interactions
Ayna Alfadhli, August Staubus, P. Tedbury, Mariia Novikova +2 more
2019Journal of Virology38 citations Open access
Semantic Scholar
HIV-1 Vpu Accessory Protein Induces Caspase-mediated Cleavage of IRF3 Transcription Factor*
S. Park, A. Waheed, Zai-Rong Zhang, E. Freed +1 more
2014Journal of Biological Chemistry38 citations Open access
Semantic Scholar
Mechanistic Analysis of the Broad Antiretroviral Resistance Conferred by HIV-1 Envelope Glycoprotein Mutations
Y. Hikichi, Rachel Van Duyne, P. Pham, J. Groebner +4 more
2020mBio37 citations Open access
Semantic Scholar
A Consensus View of ESCRT-Mediated Human Immunodeficiency Virus Type 1 Abscission
J. Lippincott-Schwartz, E. Freed, S. V. van Engelenburg
2017Annual Review of Virology36 citations Open access
Semantic Scholar
Elucidation of the Molecular Mechanism Driving Duplication of the HIV-1 PTAP Late Domain
Angelica N. Martins, A. Waheed, Sherimay D. Ablan, Wei Huang +4 more
2015Journal of Virology36 citations Open access
Semantic Scholar
The Use of Minimal RNA Toeholds to Trigger the Activation of Multiple Functionalities
K. Afonin, Mathias Viard, P. Tedbury, Eckart Bindewald +7 more
2016Nano letters (Print)34 citations Open access
Semantic Scholar
Reevaluation of the Requirement for TIP47 in Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Incorporation
M. Checkley, B. Luttge, Peter Y. Mercredi, S. Kyere +5 more
2013Journal of Virology34 citations Open access
Semantic Scholar
Enhanced Transmissibility and Decreased Virulence of HIV-1 CRF07_BC May Explain Its Rapid Expansion in China
Zetao Cheng, Huanchang Yan, Qingmei Li, Sherimay D. Ablan +8 more
2022Microbiology spectrum33 citations Open access
Semantic Scholar
Identification of an HIV-1 Mutation in Spacer Peptide 1 That Stabilizes the Immature CA-SP1 Lattice
J. Fontana, P. Keller, E. Urano, Sherimay D. Ablan +2 more
2015Journal of Virology33 citations Open access
Semantic Scholar
TIM-mediated inhibition of HIV-1 release is antagonized by Nef but potentiated by SERINC proteins
Ming-Hua Li, A. Waheed, Jing-You Yu, Cong Zeng +8 more
2019Proceedings of the National Academy of Sciences of the United States of America32 citations Open access
Semantic Scholar
HIV-1 Gag: An Emerging Target for Antiretroviral Therapy
P. Tedbury, E. Freed
2015Current Topics in Microbiology and Immunology27 citations Open access
Semantic Scholar
Structural basis of HIV-1 maturation inhibitor binding and activity
Sucharita Sarkar, K. Zadrozny, Roman Zadorozhnyi, Ryan W. Russell +10 more
2022bioRxiv26 citations Open access
Semantic Scholar
HIV-1 Matrix Trimerization-Impaired Mutants Are Rescued by Matrix Substitutions That Enhance Envelope Glycoprotein Incorporation
P. Tedbury, Mariia Novikova, Ayna Alfadhli, Y. Hikichi +4 more
2019Journal of Virology26 citations Open access
Semantic Scholar
The Cytoplasmic Tail of Retroviral Envelope Glycoproteins
P. Tedbury, E. Freed
2014Progress in Molecular Biology and Translational Science26 citations Open access
Semantic Scholar
PSGL-1 Inhibits the Incorporation of SARS-CoV and SARS-CoV-2 Spike Glycoproteins into Pseudovirions and Impairs Pseudovirus Attachment and Infectivity
Sijia He, A. Waheed, Brian Hetrick, Deemah Dabbagh +4 more
2020Viruses25 citations Open access
Semantic Scholar
Elucidating the Mechanism by which Compensatory Mutations Rescue an HIV-1 Matrix Mutant Defective for Gag Membrane Targeting and Envelope Glycoprotein Incorporation
P. Tedbury, Peter Y. Mercredi, Christy R Gaines, M. Summers +1 more
2015Journal of Molecular Biology25 citations Open access
Semantic Scholar
Resistance to Second-Generation HIV-1 Maturation Inhibitors
E. Urano, U. Timilsina, Justin A. Kaplan, Sherimay D. Ablan +10 more
2018Journal of Virology24 citations Open access
Semantic Scholar
Genomic tagging of endogenous human ESCRT-I complex preserves ESCRT-mediated membrane-remodeling functions
H. K. Hoffman, Melissa V. Fernandez, N. Groves, E. Freed +1 more
2019Journal of Biological Chemistry23 citations Open access
Semantic Scholar
Plasma Membrane Anchoring and Gag:Gag Multimerization on Viral RNA Are Critical Properties of HIV-1 Gag Required To Mediate Efficient Genome Packaging
Alice Duchon, Steven Santos, Jianbo Chen, Matthew Brown +6 more
2021mBio22 citations Open access
Semantic Scholar
Identification of potent maturation inhibitors against HIV-1 clade C
U. Timilsina, Dibya Ghimire, Bivek Timalsina, T. J. Nitz +3 more
2016Scientific Reports21 citations Open access
Semantic Scholar
NMR Structure of the Myristylated Feline Immunodeficiency Virus Matrix Protein
L. A. Brown, C. Cox, Janae L Baptiste, H. R. Summers +8 more
2015Viruses21 citations Open access
Semantic Scholar
Trimer Enhancement Mutation Effects on HIV-1 Matrix Protein Binding Activities
Ayna Alfadhli, A. Mack, C. Ritchie, Isabel Cylinder +4 more
2016Journal of Virology20 citations Open access
Semantic Scholar
Inhibition of neutral sphingomyelinase 2 impairs HIV-1 envelope formation and substantially delays or eliminates viral rebound
Seung-Wan Yoo, A. Waheed, P. Deme, Sehmus Tohumeken +8 more
2023Proceedings of the National Academy of Sciences of the United States of America19 citations Open access
Semantic Scholar

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