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A. Corbin · SciRah

Researcher profile · Semantic Scholar

A. Corbin

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A. Corbin — researcher profile on SciRah

h-index: 23
Works: 46
Citations: 4,686

Most-cited papers

AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance.
T. O'Hare, W. Shakespeare, Xiaotian Zhu, C. Eide +24 more
2009Cancer Cell1,235 citations Open access
Semantic Scholar
Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity.
A. Corbin, A. Agarwal, M. Loriaux, J. Cortes +2 more
2011Journal of Clinical Investigation803 citations Open access
Semantic Scholar
Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies.
M. Schittenhelm, Sharon Shiraga, Arin J. Schroeder, A. Corbin +6 more
2006Cancer Research475 citations Open access
Semantic Scholar
Several Bcr-Abl kinase domain mutants associated with imatinib mesylate resistance remain sensitive to imatinib.
A. Corbin, P. La Rosée, Eric P. Stoffregen, B. Druker +1 more
2003Blood338 citations
Semantic Scholar
Activity of the Bcr-Abl kinase inhibitor PD180970 against clinically relevant Bcr-Abl isoforms that cause resistance to imatinib mesylate (Gleevec, STI571).
P. La Rosée, A. Corbin, Eric P. Stoffregen, M. Deininger +1 more
2002Cancer Research224 citations
Semantic Scholar
Characterization of murine JAK2V617F-positive myeloproliferative disease.
T. Bumm, Collin R. Elsea, A. Corbin, M. Loriaux +6 more
2006Cancer Research210 citations Open access
Semantic Scholar
Kinase Domain Mutants of Bcr-Abl Exhibit Altered Transformation Potency, Kinase Activity, and Substrate Utilization, Irrespective of Sensitivity to Imatinib
I. Griswold, Mary MacPartlin, T. Bumm, V. Goss +11 more
2006Molecular and Cellular Biology208 citations
Semantic Scholar
Targeted CML therapy: controlling drug resistance, seeking cure.
T. O'Hare, A. Corbin, B. Druker
2006Current Opinion in Genetics and Development186 citations
Semantic Scholar
Analysis of the Structural Basis of Specificity of Inhibition of the Abl Kinase by STI571*
A. Corbin, E. Buchdunger, Furet Pascal, B. Druker
2002Journal of Biological Chemistry173 citations Open access
Semantic Scholar
In vitro efficacy of combined treatment depends on the underlying mechanism of resistance in imatinib-resistant Bcr-Abl-positive cell lines.
P. La Rosée, Kara Johnson, A. Corbin, Eric P. Stoffregen +6 more
2004Blood107 citations
Semantic Scholar
RNAi screening of the tyrosine kinome identifies therapeutic targets in acute myeloid leukemia.
J. Tyner, D. K. Walters, S. Willis, Mary Luttropp +8 more
2008Blood78 citations Open access
Semantic Scholar
SGX393 inhibits the CML mutant Bcr-AblT315I and preempts in vitro resistance when combined with nilotinib or dasatinib
T. O'Hare, C. Eide, J. Tyner, A. Corbin +9 more
2008Proceedings of the National Academy of Sciences of the United States of America77 citations Open access
Semantic Scholar
Sensitivity of oncogenic KIT mutants to the kinase inhibitors MLN518 and PD180970.
A. Corbin, I. Griswold, P. La Rosée, Kevin W. H. Yee +4 more
2004Blood70 citations
Semantic Scholar
Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease.
A. Agarwal, T. Bumm, A. Corbin, T. O'Hare +7 more
2008Blood64 citations Open access
Semantic Scholar
Zoledronate inhibits proliferation and induces apoptosis of imatinib-resistant chronic myeloid leukaemia cells
C. Chuah, D. J. Barnes, M. Kwok, A. Corbin +3 more
2005Leukemia61 citations Open access
Semantic Scholar
In vitro and in vivo activity of ATP-based kinase inhibitors AP23464 and AP23848 against activation-loop mutants of Kit.
A. Corbin, S. Demehri, I. Griswold, Yi-Han Wang +11 more
2005Blood58 citations Open access
Semantic Scholar
The BCR-ABL35INS insertion/truncation mutant is kinase-inactive and does not contribute to tyrosine kinase inhibitor resistance in chronic myeloid leukemia.
T. O'Hare, M. Zabriskie, C. Eide, A. Agarwal +10 more
2011Blood44 citations Open access
Semantic Scholar
Molecular and chromosomal mechanisms of resistance in CML patients after STI571 (Glivec) therapy
S. Kreil, M. Müller, T. Lahaye, P. La Rosée +9 more
200134 citations
Semantic Scholar
A BCR-ABL Mutant Lacking Direct Binding Sites for the GRB2, CBL and CRKL Adapter Proteins Fails to Induce Leukemia in Mice
Kara Johnson, I. Griswold, T. O'Hare, A. Corbin +3 more
2009PLoS ONE33 citations Open access
Semantic Scholar
An activating KRAS mutation in imatinib-resistant chronic myeloid leukemia
A. Agarwal, C. Eide, A. Harlow, A. Corbin +5 more
2008Leukemia32 citations Open access
Semantic Scholar
Interactions of p62 dok with p210 bcr-abl and Bcr-Abl-associated Proteins*
Arun Bhat, Kara Johnson, Tsukasa Oda, A. Corbin +1 more
1998Journal of Biological Chemistry32 citations Open access
Semantic Scholar
Establishment of a murine model of aggressive systemic mastocytosis/mast cell leukemia.
S. Demehri, A. Corbin, M. Loriaux, B. Druker +1 more
2006Experimental Hematology28 citations Open access
Semantic Scholar
KIT signaling governs differential sensitivity of mature and primitive CML progenitors to tyrosine kinase inhibitors
A. Corbin, T. O'Hare, Z. Gu, I. L. Kraft +9 more
2013Cancer Research27 citations Open access
Semantic Scholar
Synergistic Interactions between DMAG and Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitors in Bcr/abl+ Leukemia Cells Sensitive and Resistant to Imatinib Mesylate
T. Nguyen, M. Rahmani, N. Gao, L. Kramer +4 more
2006Clinical Cancer Research23 citations Open access
Semantic Scholar
Potent Antitumor Activity of AP24534, an Orally Active Inhibitor of Bcr-Abl Variants Including T315I, in In Vitro and In Vivo Models of Chronic Myeloid Leukemia (CML).
V. Rivera, Qihong Xu, Frank Y. Wang, Joseph Snodgrass +12 more
200718 citations
Semantic Scholar
Catalytic domains of tyrosine kinases determine the phosphorylation sites within c‐Cbl
A. Grossmann, K. Kolibaba, S. Willis, A. Corbin +3 more
2004FEBS Letters18 citations Open access
Semantic Scholar
Orally Active Inhibitors of the Imatinib Resistant Bcr-Abl Mutant T315I.
W. Shakespeare, Frank Y. Wang, Qihong Xu, Xiaotian Zhu +26 more
200611 citations
Semantic Scholar
Inhibition of T315I Bcr-Abl and Other Imatinib-Resistant Bcr-Abl Mutants by the Selective Abl Kinase Inhibitor SGX70393.
T. O'Hare, C. Eide, J. Tyner, M. Wong +8 more
200611 citations
Semantic Scholar
SGX70393 Inhibits Bcr-AblT315I In Vitro and In Vivo and Completely Suppresses Resistance When Combined with Nilotinib or Dasatinib.
T. O'Hare, C. Eide, J. Tyner, A. Corbin +9 more
20073 citations
Semantic Scholar
Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease. Running Title: The role of SKP2 for BCR-ABL-induced MPD.
A. Agarwal, A. Corbin, J. Van Dyke, S. Willis +3 more
20082 citations
Semantic Scholar
In Vitro and In Vivo Activity of the Src/Abl Kinase Inhibitor AP23464 and Analogs Against Activation Loop Mutants of KIT.
A. Corbin, S. Demehri, I. Griswold, C. Metcalf +8 more
20042 citations
Semantic Scholar
leukemia not contribute to tyrosine kinase inhibitor resistance in chronic myeloid insertion/truncation mutant is kinase-inactive and does 35INS The BCR-ABL
M. Deininger, B. Druker, A. Corbin, Fei Yang +8 more
20121 citations
Semantic Scholar
Suppression of CML Progenitor but Not CML Stem Cell Growth Requires Dual Inhibition of BCR-ABL and KIT
A. Corbin, T. O'Hare, B. Druker, M. Deininger
20081 citations
Semantic Scholar
SGX70393 inhibits the T315I mutant of Bcr-Abl kinase and pre-empts drug resistance when combined with nilotinib or dasatinib
T. O'Hare, C. Eide, J. Tyner, A. Corbin +9 more
20071 citations
Semantic Scholar
Murine Model of Aggressive Systemic Mastocytosis: A Disease Caused by Oncogenic Kit.
S. Demehri, A. Corbin, M. Loriaux, B. Druker +1 more
20041 citations
Semantic Scholar
acute myeloid leukemia RNAi screening of the tyrosine kinome identifies therapeutic targets in
A. Corbin, T. O'Hare, M. Heinrich, M. Deininger +7 more
20130 citations
Semantic Scholar
Therapeutics , Targets , and Chemical Biology KIT Signaling Governs Differential Sensitivity of Mature and Primitive CML Progenitors to Tyrosine Kinase Inhibitors
A. Corbin, T. O'Hare, Z. Gu, I. L. Kraft +9 more
20130 citations
Semantic Scholar
resistance remain sensitive to imatinib Several Bcr-Abl kinase domain mutants associated with imatinib mesylate
A. Corbin, P. La Rosée, Eric P. Stoffregen, B. Druker +1 more
20130 citations
Semantic Scholar
Suppression of CML Progenitor but Not Stem Cells Requires Simultaneous Inhibition of KIT and BCR-ABL1.
Z. Gu, A. Corbin, T. O'Hare, A. Eiring +3 more
20120 citations
Semantic Scholar
The F-Box Protein Skp2 Regulates Expression of p27 in BCR-ABL Transformed Cell Lines and Is Required for Induction of Myeloproliferative Disease in a Murine Model.
A. Agarwal, T. Bumm, A. Corbin, T. O'Hare +5 more
20060 citations
Semantic Scholar
Brief report
T. O'Hare, M. Zabriskie, C. Eide, A. Agarwal +10 more
20060 citations
Semantic Scholar
Dasatinib (BMS-354825), a Multi-Targeted Kinase Inhibitor, Inhibits the Kinase Activity of Wild-Type, Juxtamembrane and Activation Loop Mutant Kit Isoforms Associated with Human Malignancies.
M. Schittenhelm, Sharon Shiraga, Arin J. Schroeder, A. Corbin +5 more
20050 citations
Semantic Scholar
A gene polymorphism within the kinase domain of BCR-ABL and its effects on sensitivity to tyrosine kinase inhibitors
L. Crossman, T. O'Hare, T. Lange, S. Willis +7 more
20050 citations Open access
Semantic Scholar
A Bcr-Abl Mutant Lacking Direct Binding Sites for the Grb2, Cbl and CrkL Adapter Proteins Fails to Induce Leukemia in Mice.
Kara Johnson, I. Griswold, A. Corbin, M. Deininger +1 more
20040 citations
Semantic Scholar
Mutant of the kinase domain of ABL
C. Barthe, S. Branford, A. Corbin, B. Druker +12 more
20020 citations
Semantic Scholar
Mutants de domaines de la kinase de l'ABL
C. Barthe, S. Branford, A. Corbin, B. Druker +12 more
20020 citations
Semantic Scholar

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