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T. Imamura · SciRah

Researcher profile · Semantic Scholar

T. Imamura

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T. Imamura — researcher profile on SciRah

h-index: 30
Works: 111
Citations: 3,273

Most-cited papers

The role of gingipains in the pathogenesis of periodontal disease.
T. Imamura
2003The Journal of Periodontology350 citations
Semantic Scholar
Gingipains, the major cysteine proteinases and virulence factors of Porphyromonas gingivalis: structure, function and assembly of multidomain protein complexes.
J. Potempa, A. Sroka, T. Imamura, J. Travis
2003Current protein and peptide science301 citations
Semantic Scholar
Proteolysis of Human Monocyte CD14 by Cysteine Proteinases (Gingipains) from Porphyromonas gingivalis Leading to Lipopolysaccharide Hyporesponsiveness1
S. Sugawara, E. Nemoto, H. Tada, K. Miyake +2 more
2000Journal of Immunology145 citations
Semantic Scholar
Activation of Blood Coagulation Factor X by Arginine-specific Cysteine Proteinases (Gingipain-Rs) from Porphyromonas gingivalis *
T. Imamura, J. Potempa, S. Tanase, J. Travis
1997Journal of Biological Chemistry130 citations Open access
Semantic Scholar
Induction of vascular leakage through release of bradykinin and a novel kinin by cysteine proteinases from Staphylococcus aureus
T. Imamura, S. Tanase, G. Szmyd, A. Kozik +2 more
2005Journal of Experimental Medicine123 citations Open access
Semantic Scholar
A Novel Mechanism for Bradykinin Production at Inflammatory Sites
A. Kozik, Robert B. Moore, J. Potempa, T. Imamura +2 more
1998Journal of Biological Chemistry116 citations Open access
Semantic Scholar
The biphasic virulence activities of gingipains: activation and inactivation of host proteins.
T. Imamura, J. Travis, J. Potempa
2003Current protein and peptide science103 citations
Semantic Scholar
Degradation of fibrinogen and collagen by staphopains, cysteine proteases released from Staphylococcus aureus.
T. Ohbayashi, A. Irie, Y. Murakami, Magdalena Nowak +4 more
2011Microbiology96 citations Open access
Semantic Scholar
Enhancement of Human Cancer Cell Motility and Invasiveness by Anaphylatoxin C5a via Aberrantly Expressed C5a Receptor (CD88)
H. Nitta, Y. Wada, Y. Kawano, Y. Murakami +11 more
2013Clinical Cancer Research95 citations
Semantic Scholar
Gingipains from Porphyromonas gingivalis synergistically induce the production of proinflammatory cytokines through protease‐activated receptors with Toll‐like receptor and NOD1/2 ligands in human monocytic cells
A. Uehara, T. Imamura, J. Potempa, J. Travis +1 more
2008Cellular Microbiology86 citations Open access
Semantic Scholar
Activation of Human Prothrombin by Arginine-specific Cysteine Proteinases (Gingipains R) from Porphyromonas gingivalis *
T. Imamura, A. Bańbuła, P. Pereira, J. Travis +1 more
2001Journal of Biological Chemistry79 citations Open access
Semantic Scholar
Augmentation of the Enhanced Permeability and Retention Effect with Nitric Oxide–Generating Agents Improves the Therapeutic Effects of Nanomedicines
Waliul Islam, Jun Fang, T. Imamura, T. Etrych +3 more
2018Molecular Cancer Therapeutics76 citations
Semantic Scholar
Enhanced expression of vascular endothelial growth factor by periodontal pathogens in gingival fibroblasts.
Kanyarat Suthin, K. Matsushita, M. Machigashira, S. Tatsuyama +3 more
2003Journal of Periodontal Research67 citations
Semantic Scholar
Cancer cells release anaphylatoxin C5a from C5 by serine protease to enhance invasiveness.
H. Nitta, Y. Murakami, Y. Wada, M. Eto +2 more
2014Oncology Report60 citations Open access
Semantic Scholar
Proteolysis of CD14 on Human Gingival Fibroblasts by Arginine-Specific Cysteine Proteinases from Porphyromonas gingivalis Leading to Down-Regulation of Lipopolysaccharide-Induced Interleukin-8 Production
H. Tada, S. Sugawara, E. Nemoto, N. Takahashi +5 more
2002Infection and Immunity59 citations Open access
Semantic Scholar
Influence of the C5a–C5a receptor system on breast cancer progression and patient prognosis
T. Imamura, M. Yamamoto-Ibusuki, Aiko Sueta, Tatsuko Kubo +4 more
2016Breast Cancer58 citations
Semantic Scholar
Arginine‐specific gingipains from Porphyromonas gingivalis deprive protective functions of secretory leucocyte protease inhibitor in periodontal tissue
T. Into, M. Inomata, Y. Kanno, Takami Matsuyama +6 more
2006Clinical and Experimental Immunology55 citations Open access
Semantic Scholar
Arginine-Specific Gingipains from Porphyromonas gingivalis Stimulate Production of Hepatocyte Growth Factor (Scatter Factor) through Protease-Activated Receptors in Human Gingival Fibroblasts in Culture1
A. Uehara, K. Muramoto, T. Imamura, K. Nakayama +4 more
2005Journal of Immunology53 citations Open access
Semantic Scholar
C5aR is frequently expressed in metastatic renal cell carcinoma and plays a crucial role in cell invasion via the ERK and PI3 kinase pathways.
Yoshihiro Maeda, Y. Kawano, Y. Wada, Junji Yatsuda +5 more
2015Oncology Report52 citations Open access
Semantic Scholar
Inhibition of Trypsin-Like Cysteine Proteinases (Gingipains) fromPorphyromonas gingivalis by Tetracycline and Its Analogues
T. Imamura, K. Matsushita, J. Travis, J. Potempa
2001Antimicrobial Agents and Chemotherapy51 citations Open access
Semantic Scholar
Neuropeptide Release from Dental Pulp Cells by RgpB via Proteinase-Activated Receptor-2 Signaling
S. Tancharoen, K. Sarker, T. Imamura, K. Biswas +6 more
2005Journal of Immunology47 citations Open access
Semantic Scholar
Lysine-specific gingipain promotes lipopolysaccharide- and active vitamin D3-induced osteoclast differentiation by degrading osteoprotegerin
R. Yasuhara, Y. Miyamoto, M. Takami, T. Imamura +3 more
2009Biochemical Journal44 citations Open access
Semantic Scholar
Dual regulation of interleukin-8 production in human oral epithelial cells upon stimulation with gingipains from Porphyromonas gingivalis.
A. Uehara, M. Naito, T. Imamura, J. Potempa +3 more
2008Journal of Medical Microbiology44 citations Open access
Semantic Scholar
Activation of the kallikrein-kinin system and release of new kinins through alternative cleavage of kininogens by microbial and human cell proteinases
T. Imamura, J. Potempa, J. Travis
2004Biological chemistry42 citations Open access
Semantic Scholar
Expression of tissue factor, the clotting initiator, on macrophages in Plasmodium falciparum-infected placentas.
T. Imamura, T. Sugiyama, L. Cuevas, R. Makunde +1 more
2002Journal of Infectious Diseases42 citations
Semantic Scholar
Porphyromonas gingivalis-derived Lysine Gingipain Enhances Osteoclast Differentiation Induced by Tumor Necrosis Factor-α and Interleukin-1β but Suppresses That by Interleukin-17A
T. Akiyama, Y. Miyamoto, K. Yoshimura, A. Yamada +14 more
2014Journal of Biological Chemistry37 citations Open access
Semantic Scholar
Protective effect of vascular endothelial growth factor/vascular permeability factor 165 and 121 on glomerular endothelial cell injury in the rat
K. Miyamoto, Y. Kitamoto, H. Tokunaga, M. Takeya +3 more
2004Laboratory Investigation36 citations Open access
Semantic Scholar
Release of a new vascular permeability enhancing peptide from kininogens by human neutrophil elastase.
T. Imamura, S. Tanase, I. Hayashi, J. Potempa +2 more
2002Biochemical and Biophysical Research Communications - BBRC34 citations
Semantic Scholar
IL-8/NAP-1 is the major T-cell chemoattractant in synovial tissues of rheumatoid arthritis.
H. Nishiura, Junko Tanaka, Motohiro Takeya, Michishi Tsukano +2 more
1996Clinical Immunology and Immunopathology34 citations
Semantic Scholar
Thrombin generates monocyte chemotactic activity from complement factor H.
H. Ohtsuka, T. Imamura, M. Matsushita, S. Tanase +3 more
1993Immunology32 citations
Semantic Scholar
Polymer-conjugated glucosamine complexed with boric acid shows tumor-selective accumulation and simultaneous inhibition of glycolysis.
Waliul Islam, Y. Matsumoto, Jun Fang, A. Harada +9 more
2020Biomaterials30 citations Open access
Semantic Scholar
Enhancement of active MMP release and invasive activity of lymph node metastatic tongue cancer cells by elevated signaling via the TNF-α-TNFR1-NF-κB pathway and a possible involvement of angiopoietin-like 4 in lung metastasis.
Takuya Tanaka, T. Imamura, M. Yoneda, A. Irie +7 more
2016International Journal of Oncology30 citations Open access
Semantic Scholar
Cleavage of Host Cytokeratin-6 by Lysine-Specific Gingipain Induces Gingival Inflammation in Periodontitis Patients
S. Tancharoen, T. Matsuyama, K. Kawahara, Kenji Tanaka +8 more
2015PLoS ONE27 citations Open access
Semantic Scholar
Degradation of vascular endothelial thrombomodulin by arginine- and lysine-specific cysteine proteases from Porphyromonas gingivalis.
M. Inomata, Y. Ishihara, T. Matsuyama, T. Imamura +3 more
2009The Journal of Periodontology27 citations
Semantic Scholar
Production of C5a by ASP, a Serine Protease Released from Aeromonas sobria1
H. Nitta, T. Imamura, Y. Wada, A. Irie +3 more
2008Journal of Immunology27 citations
Semantic Scholar
Thrombin in synovial fluid as a marker of synovial inflammation: a definite measurement by ELISA and correlation with VEGF.
Y. Kitamoto, E. Nakamura, Satoshi Kudo, H. Tokunaga +3 more
2008Clinica chimica acta; international journal of clinical chemistry27 citations
Semantic Scholar
Augmentation of vascular permeability of VEGF is enhanced by KDR-binding proteins.
Y. Yamazaki, Yuta Nakano, T. Imamura, T. Morita
2007Biochemical and Biophysical Research Communications - BBRC27 citations
Semantic Scholar
Prostate cancer C5a receptor expression and augmentation of cancer cell proliferation, invasion, and PD‐L1 expression by C5a
Ryuji Imamura, Saki Kitagawa, Tatsuko Kubo, A. Irie +4 more
2020The Prostate26 citations Open access
Semantic Scholar
Activation of prothrombin by ASP, a serine protease released from Aeromonas sobria
H. Nitta, H. Kobayashi, A. Irie, H. Baba +2 more
2007FEBS Letters26 citations
Semantic Scholar
Induction of Vascular Leakage and Blood Pressure Lowering through Kinin Release by a Serine Proteinase from Aeromonas sobria1
T. Imamura, H. Kobayashi, R. Khan, H. Nitta +1 more
2006Journal of Immunology26 citations Open access
Semantic Scholar
Assessment of thrombin in the urine of glomerulonephritic patients by enzyme-linked immunosorbent assay
Y. Kitamoto, K. Tomita, T. Imamura
2004Annals of Clinical Biochemistry25 citations
Semantic Scholar
Porphyromonas gingivalis Gingipains-Mediated Degradation of Plasminogen Activator Inhibitor-1 Leads to Delayed Wound Healing Responses in Human Endothelial Cells
Li-Ting Song, H. Tada, T. Nishioka, E. Nemoto +5 more
2021Journal of Innate Immunity24 citations Open access
Semantic Scholar
Expression of enteropeptidase in differentiated enterocytes, goblet cells, and the tumor cells in human duodenum.
T. Imamura, Y. Kitamoto
2003American Journal of Physiology - Gastrointestinal and Liver Physiology24 citations
Semantic Scholar
New Functions of Neutrophils in the Arthus Reaction: Expression of Tissue Factor, the Clotting Initiator, and Fibrinolysis by Elastase
T. Imamura, H. Kaneda, Shin Nakamura
2002Laboratory Investigation24 citations Open access
Semantic Scholar
Excessive fibrinolysis in AL-amyloidosis is induced by urokinae-type plasminogen activator from bone marrow plasma cells
M. Uchiba, T. Imamura, H. Hata, H. Tatetsu +5 more
2009Amyloid: Journal of Protein Folding Disorders23 citations
Semantic Scholar
C5a receptor expression is associated with poor prognosis in urothelial cell carcinoma patients treated with radical cystectomy or nephroureterectomy.
Y. Wada, Yoshihiro Maeda, Tatsuko Kubo, K. Kikuchi +2 more
2016Oncology Letters21 citations Open access
Semantic Scholar
Enhancement of cancer invasion and growth via the C5a-C5a receptor system: Implications for cancer promotion by autoimmune diseases and association with cervical cancer invasion
M. Yoneda, Ryuji Imamura, H. Nitta, K. Taniguchi +7 more
2018Oncology Letters20 citations Open access
Semantic Scholar
Expression of the anaphylatoxin C5a receptor in gastric cancer: implications for vascular invasion and patient outcomes
H. Nitta, T. Shimose, Y. Emi, T. Imamura +12 more
2016Medical Oncology19 citations
Semantic Scholar
Induction of vascular leakage and blood pressure lowering through kinin release by a serine proteinase from Aeromonas sobria
T. Imamura, H. Kobayashi, R. Khan, H. Nitta +1 more
2007Journal of Immunology18 citations
Semantic Scholar
DX-9065a inhibits proinflammatory events induced by gingipains and factor Xa.
K. Matsushita, T. Imamura, M. Tomikawa, S. Tancharoen +2 more
2006Journal of Periodontal Research18 citations
Semantic Scholar

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J. Potempa×19
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J. Potempa — researcher profile on SciRah
J. Travis×14
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J. Travis — researcher profile on SciRah
H. Nitta×8
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H. Nitta — researcher profile on SciRah
A. Irie×7
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A. Irie — researcher profile on SciRah

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K. Matsushita — researcher profile on SciRah

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Y. Wada — researcher profile on SciRah

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H. Takada — researcher profile on SciRah

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K. Kikuchi — researcher profile on SciRah

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H. Baba — researcher profile on SciRah

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S. Sugawara — researcher profile on SciRah

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S. Tanase — researcher profile on SciRah

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Y. Murakami — researcher profile on SciRah