A. P. Larsen

Most-cited papers

1. Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters.

   Zeinab Assaf, A. P. Larsen, R. Venskutonytė, Liwei Han +9 more

   2013Journal of Medicinal Chemistry39 citations Open access

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2. 7-Phenoxy-substituted 3,4-Dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides as Positive Allosteric Modulators of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors with Nanomolar Potency

   E. Goffin, Thomas Drapier, A. P. Larsen, Pierre Geubelle +12 more

   2017Journal of Medicinal Chemistry38 citations Open access

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3. Identification and Structure-Function Study of Positive Allosteric Modulators of Kainate Receptors

   A. P. Larsen, S. Fièvre, K. Frydenvang, P. Francotte +3 more

   2017Molecular Pharmacology30 citations

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4. Synthesis and Pharmacology of Mono-, Di-, and Trialkyl-Substituted 7-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-Dioxides Combined with X-ray Structure Analysis to Understand the Unexpected Structure-Activity Relationship at AMPA Receptors.

   A. P. Larsen, P. Francotte, K. Frydenvang, Daniel Tapken +7 more

   2016ACS Chemical Neuroscience27 citations

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5. Molecular Recognition of Two 2,4‐syn‐Functionalized (S)‐Glutamate Analogues by the Kainate Receptor GluK3 Ligand Binding Domain

   R. Venskutonytė, A. P. Larsen, K. Frydenvang, M. Gajhede +6 more

   2014ChemMedChem10 citations

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6. Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with glutamate and positive allosteric modulator BPAM538

   A. P. Larsen, K. Frydenvang, J. Kastrup

   20180 citations

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7. Crystal structure of the GluK1 ligand-binding domain in complex with kainate and BPAM-344 at 1.90 A resolution

   A. P. Larsen, K. Frydenvang, J. Kastrup

   20170 citations

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8. Crystal structure of the GluK3 ligand-binding domain (S1S2) in complex with the agonist (2S,4R)-4-(3-Methoxy-3-oxopropyl)glutamic acid at 2.01 A resolution.

   A. P. Larsen, R. Venskutonytė, K. Frydenvang, M. Gajhede +1 more

   20140 citations

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9. Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist (2S,4R)-4-(3-Methylamino-3-oxopropyl)glutamic acid at 2.6 A resolution

   R. Venskutonytė, A. P. Larsen, K. Frydenvang, M. Gajhede +1 more

   20140 citations

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10. Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist ZA302

    A. P. Larsen, R. Venskutonytė, M. Gajhede, J. Kastrup +1 more

    20120 citations

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