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S. Mahrhold · SciRah

Researcher profile · Semantic Scholar

S. Mahrhold

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S. Mahrhold — researcher profile on SciRah

h-index: 19
Works: 39
Citations: 1,744

Most-cited papers

The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves
S. Mahrhold, A. Rummel, H. Bigalke, B. Davletov +1 more
2006FEBS Letters318 citations
Semantic Scholar
The HCC‐domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction
A. Rummel, S. Mahrhold, H. Bigalke, T. Binz
2003Molecular Microbiology231 citations Open access
Semantic Scholar
Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept
A. Rummel, T. Eichner, T. Weil, Tino Karnath +7 more
2007Proceedings of the National Academy of Sciences of the United States of America178 citations Open access
Semantic Scholar
Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation‐dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor
A. Rummel, Kirstin Häfner, S. Mahrhold, N. Darashchonak +6 more
2009Journal of Neurochemistry165 citations Open access
Semantic Scholar
Clint: a novel clathrin-binding ENTH-domain protein at the Golgi.
Christoph Kalthoff, S. Groos, R. Kohl, S. Mahrhold +1 more
2002Molecular Biology of the Cell130 citations Open access
Semantic Scholar
N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A
G. Yao, Si-Cai Zhang, S. Mahrhold, K. Lam +7 more
2016Nature Structural &Molecular Biology115 citations Open access
Semantic Scholar
Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.
J. Strotmeier, Kwangkook Lee, Anne K. Völker, S. Mahrhold +8 more
2010Biochemical Journal73 citations
Semantic Scholar
The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites
J. Strotmeier, S. Gu, S. Jutzi, S. Mahrhold +7 more
2011Molecular Microbiology69 citations
Semantic Scholar
Clostridial Neurotoxins: Mechanism of SNARE Cleavage and Outlook on Potential Substrate Specificity Reengineering
T. Binz, S. Sikorra, S. Mahrhold
2010Toxins68 citations Open access
Semantic Scholar
Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E.
S. Mahrhold, J. Strotmeier, Consuelo Garcia-Rodriguez, Jianlong Lou +3 more
2013Biochemical Journal49 citations
Semantic Scholar
Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A
J. Strotmeier, S. Mahrhold, N. Krez, Constantin Janzen +4 more
2014FEBS Letters45 citations Open access
Semantic Scholar
Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology
Laura von Berg, D. Stern, D. Pauly, S. Mahrhold +8 more
2019Scientific Reports41 citations Open access
Semantic Scholar
Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain
M. Pirazzini, Tina Henke, O. Rossetto, S. Mahrhold +4 more
2013FEBS Letters38 citations Open access
Semantic Scholar
Exchange of the HCC domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin
A. Rummel, S. Mahrhold, H. Bigalke, T. Binz
2011The FEBS Journal38 citations
Semantic Scholar
Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin
J. Weisemann, D. Stern, S. Mahrhold, B. Dorner +1 more
2016Toxins36 citations Open access
Semantic Scholar
A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency
D. Stern, J. Weisemann, A. L. Le Blanc, Laura von Berg +7 more
2018PLoS Pathogens35 citations Open access
Semantic Scholar
Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1.
S. Mahrhold, T. Bergström, D. Stern, B. Dorner +2 more
2016Biochemical Journal31 citations Open access
Semantic Scholar
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG‐Syt1‐SV2 plasma membrane nanocluster for synaptic vesicle entry
Merja Joensuu, Parnayan Syed, S. H. Saber, Vanessa Lanoue +17 more
2023EMBO Journal27 citations Open access
Semantic Scholar
Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity.
G. Willjes, S. Mahrhold, J. Strotmeier, T. Eichner +2 more
2013Biochemistry24 citations
Semantic Scholar
Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics
Kwangkook Lee, K. Lam, A. Kruel, S. Mahrhold +4 more
2015Toxicon12 citations Open access
Semantic Scholar
Innovative and Highly Sensitive Detection of Clostridium perfringens Enterotoxin Based on Receptor Interaction and Monoclonal Antibodies
T. Neumann, Maren Krüger, J. Weisemann, S. Mahrhold +12 more
2021Toxins11 citations Open access
Semantic Scholar
Exchanging the minimal cell binding fragments of tetanus neurotoxin in botulinum neurotoxin A and B impacts their toxicity at the neuromuscular junction and central neurons.
M. Höltje, S. Schulze, J. Strotmeier, S. Mahrhold +5 more
2013Toxicon9 citations
Semantic Scholar
The 25 kDa HCN Domain of Clostridial Neurotoxins Is Indispensable for Their Neurotoxicity
J. Deppe, J. Weisemann, S. Mahrhold, A. Rummel
2020Toxins4 citations Open access
Semantic Scholar
Design of Novel Fusion Receptor Proteins to Enable Specific Binding of Botulinum Neurotoxins in a Native-like Membrane Environment
Urs von der Kammer, L. Wilk, Adina Przykopanski, S. Mahrhold +2 more
2026Toxicon0 citations
Semantic Scholar
Design of a Soluble, Full-Length SV2A Using the QTY Code for Binding of BoNTs-A and -E
Urs von der Kammer, S. Mahrhold, A. Rummel
2024Toxicon0 citations Open access
Semantic Scholar
Synaptotagmin 1 mediates toxicity of botulinum neurotoxin type A
Merja Joensuu, Vanessa Lanoue, Parnayan Syed, T. Wallis +16 more
2022bioRxiv0 citations Open access
Semantic Scholar
Anthelmintic and anticonvulsive drugs do not alter the biological activity of BoNT in neurons
S. Mahrhold, N. Krez, A. Rummel
2018Toxicon0 citations
Semantic Scholar
Super-resolving botulinum neurotoxin type A molecules: from surface landing to internalization in synaptic vesicles
Merja Joensuu, Ailisa Blum, Mahdie Mollazade, Vanessa Lanoue +6 more
2018Toxicon0 citations
Semantic Scholar
N-linked glycosylation of SV 2 sweetens the uptake of 1 botulinum neurotoxin A 1 2 3
G. Yao, Si-Cai Zhang, S. Mahrhold, K. Lam +8 more
20170 citations
Semantic Scholar
Receptor binding domain of Botulinum neurotoxin A in complex with human glycosylated SV2C
G. Yao, Si-Cai Zhang, S. Mahrhold, K. Lam +7 more
20160 citations
Semantic Scholar
Binding of botulinum neurotoxin (BoNT) to glycosylated SV2
S. Mahrhold, D. Stern, J. Weisemann, T. Bergström +4 more
20160 citations
Semantic Scholar
205. Characterizing the interaction of botulinum neurotoxin type A with rat and human SV2C
J. Weisemann, S. Mahrhold, A. Rummel
20150 citations
Semantic Scholar
132. Insights into the glycosylation-status dependent interaction of SV2C with botulinum neurotoxin type A
S. Mahrhold, J. Weisemann, T. Binz, A. Rummel
20150 citations
Semantic Scholar
Molecular dissection of the botulinum neurotoxin type G synaptotagmin binding site
G. Willjes, S. Mahrhold, H. Bigalke, A. Rummel +1 more
20130 citations
Semantic Scholar
The function of the HCN-domain of clostridial neurotoxins
J. Strotmeier, J. Deppe, S. Mahrhold, T. Binz +2 more
20130 citations
Semantic Scholar
Identification of the SV2-binding site of botulinum neurotoxin type E
S. Mahrhold, A. Rummel, H. Bigalke, T. Binz
20130 citations
Semantic Scholar
Binding receptors of botulinum neurotoxins
A. Rummel, J. Strotmeier, H. Bigalke, S. Mahrhold +1 more
20130 citations
Semantic Scholar
Cell entry of botulinum neurotoxin type C is dependent upon interaction with two ganglioside molecules
J. Strotmeier, S. Gu, S. Jutzi, S. Mahrhold +6 more
20110 citations
Semantic Scholar
The botulinum neurotoxin A receptor protein and its applications
A. Rummel, S. Mahrhold, T. Binz, Johannes Wilhelm Bigalke
20050 citations
Semantic Scholar

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