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Takeshi Hirota · SciRah

Researcher profile · Semantic Scholar

Takeshi Hirota

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Takeshi Hirota — researcher profile on SciRah

h-index: 25
Works: 82
Citations: 2,644

Most-cited papers

Polymorphisms of OATP‐C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics
Yohei Nishizato, I. Ieiri, Hiroshi Suzuki, M. Kimura +10 more
2003Clinical pharmacology and therapy518 citations
Semantic Scholar
FUNCTIONAL ASSESSMENT OF ABCG2 (BCRP) GENE POLYMORPHISMS TO PROTEIN EXPRESSION IN HUMAN PLACENTA
Daisuke Kobayashi, I. Ieiri, Takeshi Hirota, H. Takane +9 more
2005Drug Metabolism And Disposition280 citations
Semantic Scholar
An updated review of pharmacokinetic drug interactions and pharmacogenetics of statins
Takeshi Hirota, Yuito Fujita, I. Ieiri
2020Expert Opinion on Drug Metabolism & Toxicology157 citations
Semantic Scholar
Population Pharmacokinetic and Pharmacodynamic Analysis of Linezolid and a Hematologic Side Effect, Thrombocytopenia, in Japanese Patients
Tomohiro Sasaki, H. Takane, K. Ogawa, S. Isagawa +5 more
2011Antimicrobial Agents and Chemotherapy127 citations Open access
Semantic Scholar
Impact of genetic polymorphisms in CYP2C9 and CYP2C19 on the pharmacokinetics of clinically used drugs.
Takeshi Hirota, Shunsuke Eguchi, I. Ieiri
2013Drug Metabolism and Pharmacokinetics115 citations
Semantic Scholar
Microdosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1), and Interaction (Grapefruit Juice) Profiles of Celiprolol Following the Oral Microdose and Therapeutic Dose
I. Ieiri, Y. Doi, K. Maeda, Tomohiro Sasaki +7 more
2012Journal of clinical pharmacology109 citations
Semantic Scholar
Sequence variability and candidate gene analysis in two cancer patients with complex clinical outcomes during morphine therapy.
Takeshi Hirota, I. Ieiri, H. Takane, H. Sano +8 more
2003Drug Metabolism And Disposition94 citations
Semantic Scholar
Haplotype-Oriented Genetic Analysis and Functional Assessment of Promoter Variants in the MDR1 (ABCB1) Gene
H. Takane, Daisuke Kobayashi, Takeshi Hirota, J. Kigawa +3 more
2004Journal of Pharmacology and Experimental Therapeutics88 citations
Semantic Scholar
Drug–drug interactions that interfere with statin metabolism
Takeshi Hirota, I. Ieiri
2015Expert Opinion on Drug Metabolism & Toxicology82 citations
Semantic Scholar
Dihydropyrimidine dehydrogenase (DPD) expression is negatively regulated by certain microRNAs in human lung tissues.
Takeshi Hirota, Y. Date, Yu Nishibatake, H. Takane +7 more
2012Lung Cancer64 citations
Semantic Scholar
Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers.
D. Mori, Yushi Kashihara, Takashi Yoshikado, M. Kimura +7 more
2019Drug Metabolism and Pharmacokinetics63 citations
Semantic Scholar
Genetic polymorphisms of drug transporters: pharmacokinetic and pharmacodynamic consequences in pharmacotherapy
I. Ieiri, H. Takane, Takeshi Hirota, K. Otsubo +1 more
2006Expert Opinion on Drug Metabolism & Toxicology60 citations
Semantic Scholar
MicroRNA-433 negatively regulates the expression of thymidylate synthase (TYMS) responsible for 5-fluorouracil sensitivity in HeLa cells
Keisuke Gotanda, Takeshi Hirota, Nozomi Matsumoto, I. Ieiri
2013BMC Cancer56 citations Open access
Semantic Scholar
Allelic expression imbalance of the human CYP3A4 gene and individual phenotypic status.
Takeshi Hirota, I. Ieiri, H. Takane, S. Maegawa +8 more
2004Human Molecular Genetics56 citations Open access
Semantic Scholar
Identification of drug transporters contributing to oxaliplatin‐induced peripheral neuropathy
Shunsuke Fujita, Takeshi Hirota, R. Sakiyama, Misaki Baba +1 more
2018Journal of Neurochemistry51 citations Open access
Semantic Scholar
Small-Dosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1 and ABCG2), and Interaction (Atorvastatin and Grapefruit Juice) Profiles of 5 Probes for OATP2B1 and BCRP.
Yushi Kashihara, I. Ieiri, Takashi Yoshikado, K. Maeda +8 more
2017Journal of Pharmacy and Science51 citations
Semantic Scholar
Clinical Pharmacokinetics of Anaplastic Lymphoma Kinase Inhibitors in Non-Small-Cell Lung Cancer
Takeshi Hirota, Shota Muraki, I. Ieiri
2018Clinical Pharmacokinetics41 citations
Semantic Scholar
Pharmacokinetic interaction between pravastatin and olmesartan in relation to SLCO1B1 polymorphism
S. Suwannakul, I. Ieiri, M. Kimura, K. Kawabata +5 more
2008Journal of Human Genetics38 citations Open access
Semantic Scholar
Mechanisms of Pharmacokinetic Enhancement Between Ritonavir and Saquinavir; Micro/Small Dosing Tests Using Midazolam (CYP3A4), Fexofenadine (p‐Glycoprotein), and Pravastatin (OATP1B1) as Probe Drugs
I. Ieiri, S. Tsunemitsu, K. Maeda, Yukie Ando +14 more
2013Journal of clinical pharmacology35 citations
Semantic Scholar
Epigenetic regulation of genes encoding drug-metabolizing enzymes and transporters; DNA methylation and other mechanisms.
I. Ieiri, Takeshi Hirota, H. Takane, S. Higuchi
2008Current drug metabolism30 citations
Semantic Scholar
Circulating intestine-derived exosomal miR-328 in plasma, a possible biomarker for estimating BCRP function in the human intestines
Keisuke Gotanda, Takeshi Hirota, Jumpei Saito, Masato Fukae +7 more
2016Scientific Reports29 citations Open access
Semantic Scholar
Clinical Pharmacokinetics and Pharmacodynamics of Fostamatinib and Its Active Moiety R406
R. Matsukane, K. Suetsugu, Takeshi Hirota, I. Ieiri
2022Clinical Pharmacokinetics28 citations Open access
Semantic Scholar
Interindividual differences in placental expression of the SLC22A2 (OCT2) gene: relationship to epigenetic variations in the 5'-upstream regulatory region.
Jumpei Saito, Takeshi Hirota, Naomi Kikunaga, K. Otsubo +1 more
2011Journal of Pharmacy and Science27 citations Open access
Semantic Scholar
Efficacy of DPP‐4 inhibitors, GLP‐1 analogues, and SGLT2 inhibitors as add‐ons to metformin monotherapy in T2DM patients: a model‐based meta‐analysis
H. Inoue, Yoko Tamaki, Yushi Kashihara, Shota Muraki +3 more
2018British Journal of Clinical Pharmacology25 citations Open access
Semantic Scholar
Sulfasalazine disposition in a subject with 376C>T (nonsense mutation) and 421C>A variants in the ABCG2 gene
Keisuke Gotanda, Tomoko Tokumoto, Takeshi Hirota, Masato Fukae +1 more
2015British Journal of Clinical Pharmacology25 citations Open access
Semantic Scholar
Role of methotrexate polyglutamation and reduced folate carrier 1 (RFC1) gene polymorphisms in clinical assessment indexes.
Yukie Ando, H. Shimada, Nozomi Matsumoto, Takeshi Hirota +6 more
2013Drug Metabolism and Pharmacokinetics25 citations
Semantic Scholar
Association between DNA Methylation in the miR-328 5’-Flanking Region and Inter-individual Differences in miR-328 and BCRP Expression in Human Placenta
Jumpei Saito, Takeshi Hirota, S. Furuta, Daisuke Kobayashi +2 more
2013PLoS ONE24 citations Open access
Semantic Scholar
Pharmacogenomic/pharmacokinetic assessment of a four-probe cocktail for CYPs and OATPs following oral microdosing.
I. Ieiri, Masato Fukae, K. Maeda, Yukie Ando +10 more
2012International journal of clinical pharmacology and therapeutics24 citations
Semantic Scholar
Epigenetic regulation of drug transporter expression in human tissues
Takeshi Hirota, Toshihiro Tanaka, Hiroaki Takesue, I. Ieiri
2017Expert Opinion on Drug Metabolism & Toxicology23 citations
Semantic Scholar
Systematic screening of human ABCC3 polymorphisms and their effects on MRP3 expression and function.
Tomohiro Sasaki, Takeshi Hirota, Yuriko Ryokai, Daisuke Kobayashi +4 more
2011Drug Metabolism and Pharmacokinetics22 citations
Semantic Scholar
Korean, Japanese, and Chinese populations featured similar genes encoding drug-metabolizing enzymes and transporters: a DMET Plus microarray assessment
S. Yi, H. An, Howard Lee, Sangin Lee +15 more
2014Pharmacogenetics & Genomics21 citations
Semantic Scholar
Nucleosome Positioning and Gene Regulation of the SGLT2 Gene in the Renal Proximal Tubular Epithelial Cells
Hiroaki Takesue, Takeshi Hirota, Mami Tachimura, Ayane Tokashiki +1 more
2018Molecular Pharmacology20 citations Open access
Semantic Scholar
Interindividual Differences in the Expression of ATP-Binding Cassette and Solute Carrier Family Transporters in Human Skin: DNA Methylation Regulates Transcriptional Activity of the Human ABCC3 Gene
T. Takechi, Takeshi Hirota, Tatsuya Sakai, N. Maeda +2 more
2018Drug Metabolism And Disposition19 citations Open access
Semantic Scholar
Systematic surveillance of immune-related adverse events in clinical practice and impact of subsequent steroid medication on survival outcomes
R. Matsukane, K. Suetsugu, K. Hata, Keisuke Matsuda +6 more
2023International Journal of Clinical Oncology18 citations
Semantic Scholar
Population pharmacokinetic–pharmacodynamic modeling and model-based prediction of docetaxel-induced neutropenia in Japanese patients with non-small cell lung cancer
Masato Fukae, Y. Shiraishi, Takeshi Hirota, Y. Sasaki +4 more
2016Cancer Chemotherapy and Pharmacology16 citations
Semantic Scholar
Population pharmacodynamic analysis of LDL-cholesterol lowering effects by statins and co-medications based on electronic medical records.
Makoto Kakara, Hiroko Nomura, Masato Fukae, Keisuke Gotanda +5 more
2014British Journal of Clinical Pharmacology16 citations Open access
Semantic Scholar
Population pharmacokinetic model and dosing optimization of vancomycin in hematologic malignancies with neutropenia and augmented renal clearance.
Tassadit Belabbas, T. Yamada, N. Egashira, Takeshi Hirota +5 more
2023Journal of Infection and Chemotherapy13 citations Open access
Semantic Scholar
Novel large-scale deletion (whole exon 7) in the ABCC2 gene in a patient with the Dubin-Johnson syndrome.
D. Kanda, H. Takagi, Yasutsugu Kawahara, Y. Yata +10 more
2009Drug Metabolism and Pharmacokinetics13 citations
Semantic Scholar
Neonatal Dubin–Johnson syndrome: Novel compound heterozygous mutation in the ABCC2 gene
H. Okada, T. Kusaka, Noriko Fuke, Jun Kunikata +6 more
2014Pediatrics International12 citations
Semantic Scholar
Regulation of Organic Anion Transporting Polypeptide 2B1 Expression by MicroRNA in the Human Liver.
A. Tajiri, Takeshi Hirota, S. Kawano, Akira Yonamine +1 more
2020Molecular Pharmaceutics10 citations
Semantic Scholar
Relationship between DNA Methylation in the 5′ CpG Island of the SLC47A1 (Multidrug and Toxin Extrusion Protein MATE1) Gene and Interindividual Variability in MATE1 Expression in the Human Liver
Toshihiro Tanaka, Takeshi Hirota, I. Ieiri
2018Molecular Pharmacology10 citations Open access
Semantic Scholar
Identification and Functional Characterization of Novel Nonsynonymous Variants in the Human Multidrug and Toxin Extrusion 2-K
K. Nishimura, Ryosuke Ide, Takeshi Hirota, Kana Kawazu +3 more
2014Drug Metabolism And Disposition10 citations Open access
Semantic Scholar
Population Pharmacokinetic Analysis of Drug-Drug Interactions Between Perampanel and Carbamazepine Using Enzyme Induction Model in Epileptic Patients.
Yuito Fujita, Mariko Murai, Shota Muraki, K. Suetsugu +4 more
2023Therapeutic Drug Monitoring8 citations
Semantic Scholar
Effects of Letermovir and/or Methylprednisolone Coadministration on Voriconazole Pharmacokinetics in Hematopoietic Stem Cell Transplantation: A Population Pharmacokinetic Study
K. Suetsugu, Shota Muraki, Junshiro Fukumoto, R. Matsukane +6 more
2021Drugs in R&D8 citations Open access
Semantic Scholar
Effects of magnesium oxide on pharmacokinetics of L-dopa/carbidopa and assessment of pharmacodynamic changes by a model-based simulation
Yushi Kashihara, Y. Terao, Kensaku Yoda, Takeshi Hirota +6 more
2018European Journal of Clinical Pharmacology8 citations
Semantic Scholar
Interindividual variability in statin pharmacokinetics and effects of drug transporters
Takeshi Hirota, I. Ieiri
2024Expert Opinion on Drug Metabolism & Toxicology7 citations
Semantic Scholar
Neuroprotective effects of ibudilast against tacrolimus induced neurotoxicity.
Wei Zhang, R. Matsukane, N. Egashira, Yuichi Tsuchiya +4 more
2022Toxicology and Applied Pharmacology7 citations Open access
Semantic Scholar
Genetic Polymorphisms of Hepatic ABC-Transporter in Patients with Hepatocellular Carcinoma
M. Fukuda, Yasutsugu Kawahara, Takeshi Hirota, Setsuko Akizuki +4 more
20107 citations Open access
Semantic Scholar
Effect of Curcumin on Sulfasalazine Pharmacokinetics in Healthy Volunteers
Tomoko Tokumoto, Takeshi Hirota, Keisuke Got, M. Kimura +3 more
20166 citations
Semantic Scholar
MicroRNA-433 negatively regulates the expression of thymidylate synthase (TYMS) responsible for 5-fluorouracil sensitivity in HeLa cells
Keisuke Gotanda, Takeshi Hirota, Nozomi Matsumoto, I. Ieiri
2013BMC Cancer5 citations Open access
Semantic Scholar

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I. Ieiri×50
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I. Ieiri — researcher profile on SciRah
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M. Kimura — researcher profile on SciRah
S. Irie×12
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S. Irie — researcher profile on SciRah
H. Takane×10
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S. Higuchi — researcher profile on SciRah

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K. Otsubo — researcher profile on SciRah

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Daisuke Kobayashi — researcher profile on SciRah

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