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V. LeBleu · SciRah

Researcher profile · Semantic Scholar

V. LeBleu

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V. LeBleu — researcher profile on SciRah

h-index: 50
Works: 100
Citations: 35K

Most-cited papers

The biology, function, and biomedical applications of exosomes
R. Kalluri, V. LeBleu
2020Science9,903 citations Open access
Semantic Scholar
Glypican1 identifies cancer exosomes and facilitates early detection of cancer
S. Melo, L. B. Luecke, Christoph Kahlert, A. Fernández +11 more
2015Nature2,564 citations Open access
Semantic Scholar
B cells and tertiary lymphoid structures promote immunotherapy response
Beth A. Helmink, S. Reddy, Jian-Jun Gao, Shao-Jun Zhang +56 more
2020Nature2,405 citations Open access
Semantic Scholar
Exosomes Facilitate Therapeutic Targeting of Oncogenic Kras in Pancreatic Cancer
S. Kamerkar, V. LeBleu, H. Sugimoto, Su-Juan Yang +4 more
2017Nature2,391 citations Open access
Semantic Scholar
EMT Program is Dispensable for Metastasis but Induces Chemoresistance in Pancreatic Cancer
Xiao-Feng Zheng, Julienne L. Carstens, Jiha Kim, Matthew Scheible +5 more
2015Nature1,745 citations Open access
Semantic Scholar
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Diminished Survival
B. Özdemir, Tsvetelina Pentcheva-Hoang, Julienne L. Carstens, Xiao-Feng Zheng +17 more
2014Cancer Cell1,675 citations Open access
Semantic Scholar
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival.
B. Özdemir, Tsvetelina Pentcheva-Hoang, Julienne L. Carstens, Xiao-Feng Zheng +17 more
2015Cancer Cell1,399 citations Open access
Semantic Scholar
Origin and Function of Myofibroblasts in Kidney Fibrosis
V. LeBleu, G. Taduri, Joyce T. O'Connell, Ying-Hock Teng +4 more
2013Nature Medicine1,248 citations Open access
Semantic Scholar
PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation to promote metastasis
V. LeBleu, Joyce T. O'Connell, Karina N. Gonzalez Herrera, Harriet Wikman-Kocher +8 more
2014Nature Cell Biology1,027 citations Open access
Semantic Scholar
Epithelial to Mesenchymal Transition induces cell cycle arrest and parenchymal damage in renal fibrosis
S. Lovisa, V. LeBleu, B. Tampe, H. Sugimoto +10 more
2015Nature Medicine914 citations Open access
Semantic Scholar
Generation and testing of clinical-grade exosomes for pancreatic cancer.
M. Mendt, S. Kamerkar, H. Sugimoto, K. McAndrews +13 more
2018JCI Insight727 citations Open access
Semantic Scholar
Structure and Function of Basement Membranes
V. LeBleu, B. Macdonald, R. Kalluri
2007Experimental biology and medicine594 citations
Semantic Scholar
Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular-fibrosis and tumor progression
Hanane Laklai, Y. Miroshnikova, Michael W. Pickup, E. Collisson +18 more
2016Nature Medicine566 citations Open access
Semantic Scholar
Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer
Julienne L. Carstens, P. Correa de Sampaio, Dalu Yang, Souptik Barua +5 more
2017Nature Communications560 citations Open access
Semantic Scholar
Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway
Vesselina G. Cooke, V. LeBleu, Doruk Keskin, Zainab N. Khan +11 more
2012Cancer Cell522 citations Open access
Semantic Scholar
Type I collagen deletion in αSMA+ myofibroblasts enhances immune suppression and accelerates progression of pancreatic cancer
Yang Chen, Jiha Kim, Su-Juan Yang, Hua-Min Wang +4 more
2021Cancer Cell488 citations Open access
Semantic Scholar
A peek into cancer-associated fibroblasts: origins, functions and translational impact
V. LeBleu, R. Kalluri
2018Disease Models & Mechanisms488 citations Open access
Semantic Scholar
Cell Growth and Size Homeostasis in Proliferating Animal Cells
Amit Tzur, Ran Kafri, V. LeBleu, G. Lahav +1 more
2009Science420 citations Open access
Semantic Scholar
TGF-β1-containing exosomes from injured epithelial cells activate fibroblasts to initiate tissue regenerative responses and fibrosis.
F. Borges, S. Melo, B. Özdemir, Noritoshi Kato +5 more
2013Journal of the American Society of Nephrology401 citations Open access
Semantic Scholar
VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization
Joyce T. O'Connell, H. Sugimoto, Vesselina G. Cooke, B. Macdonald +9 more
2011Proceedings of the National Academy of Sciences of the United States of America333 citations Open access
Semantic Scholar
Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer
Lisa M. Becker, Joyce T. O'Connell, A. P. Vo, Margo P. Cain +13 more
2020Cell Reports271 citations Open access
Semantic Scholar
Exploiting cancer cell vulnerabilities to develop a combination therapy for Ras-driven tumors
T. De Raedt, Z. Walton, J. Yecies, Da-Nan Li +13 more
2011Cancer Cell267 citations Open access
Semantic Scholar
Exosomes as a Multicomponent Biomarker Platform in Cancer.
V. LeBleu, R. Kalluri
2020Trends in Cancer243 citations
Semantic Scholar
Biomolecular Characterization and Protein Sequences of the Campanian Hadrosaur B. canadensis
M. Schweitzer, Wenxia Zheng, C. Organ, R. Avci +12 more
2009Science239 citations
Semantic Scholar
Identification of Human Epididymis Protein-4 as a Novel Fibroblast-Derived Mediator of Fibrosis
V. LeBleu, Ying-Hock Teng, Joyce T. O'Connell, D. Charytan +4 more
2013Nature Medicine236 citations Open access
Semantic Scholar
Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer
Su-Juan Yang, Sara P. Y. Che, Paul Kurywchak, Jena L. Tavormina +9 more
2017Cancer Biology & Therapy226 citations Open access
Semantic Scholar
Identification of Functional Heterogeneity of Carcinoma-Associated Fibroblasts with Distinct IL-6 Mediated Therapy Resistance in Pancreatic Cancer
K. McAndrews, Yang Chen, J. Darpolor, Xiao-Feng Zheng +12 more
2022Cancer Discovery218 citations Open access
Semantic Scholar
Exosome-mediated delivery of CRISPR/Cas9 for targeting of oncogenic KrasG12D in pancreatic cancer
K. McAndrews, F. Xiao, A. Chronopoulos, V. LeBleu +2 more
2021Life Science Alliance202 citations Open access
Semantic Scholar
KRASG12D inhibition reprograms the tumor microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells
K. Mahadevan, K. McAndrews, V. LeBleu, Su-Juan Yang +20 more
2023Cancer Cell191 citations Open access
Semantic Scholar
Origin and functional heterogeneity of fibroblasts
V. LeBleu, E. Neilson
2020The FASEB Journal180 citations Open access
Semantic Scholar
Discovery of Double-Stranded Genomic DNA in Circulating Exosomes.
R. Kalluri, V. LeBleu
2016Cold Spring Harbor Symposia on Quantitative Biology163 citations Open access
Semantic Scholar
Circulating ACE2-expressing extracellular vesicles block broad strains of SARS-CoV-2
Lamiaa El-Shennawy, Andrew D Hoffmann, Nurmaa K. Dashzeveg, K. McAndrews +32 more
2022Nature Communications156 citations Open access
Semantic Scholar
Targeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2
Doruk Keskin, Jiha Kim, Vesselina G. Cooke, Chia-Chin Wu +5 more
2015Cell Reports155 citations Open access
Semantic Scholar
Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus.
K. Kanasaki, Y. Kanda, K. Palmsten, H. Tanjore +4 more
2008Developmental Biology148 citations Open access
Semantic Scholar
Activin–like kinase–3 activity is important for kidney regeneration and reversal of fibrosis
H. Sugimoto, V. LeBleu, Dattatreyamurty Basukonda, P. Keck +11 more
2012Nature Medicine140 citations Open access
Semantic Scholar
Tet3-mediated hydroxymethylation of epigenetically silenced genes contributes to bone morphogenic protein 7-induced reversal of kidney fibrosis.
B. Tampe, D. Tampe, C. Müller, H. Sugimoto +6 more
2014Journal of the American Society of Nephrology136 citations Open access
Semantic Scholar
Heterogeneous antibodies against SARS-CoV-2 spike receptor binding domain and nucleocapsid with implications for COVID-19 immunity
K. McAndrews, Dara P. Dowlatshahi, Jianli Dai, Lisa M. Becker +15 more
2020JCI Insight134 citations Open access
Semantic Scholar
Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis
S. Lovisa, Eliot Fletcher-Sananikone, H. Sugimoto, Janine Hensel +14 more
2020Science Signaling132 citations Open access
Semantic Scholar
BMP‐7 functions as a novel hormone to facilitate liver regeneration
H. Sugimoto, Chang-Qing Yang, V. LeBleu, M. Soubasakos +3 more
2007The FASEB Journal122 citations
Semantic Scholar
MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma
Nathanael H Green, Daniel L. Galvan, Shawn S. Badal, B. Chang +4 more
2019Oncogene106 citations Open access
Semantic Scholar
Effective delivery of STING agonist using exosomes suppresses tumor growth and enhances antitumor immunity
K. McAndrews, Sara P. Y. Che, V. LeBleu, R. Kalluri
2021Journal of Biological Chemistry83 citations Open access
Semantic Scholar
Dermal αSMA+ myofibroblasts orchestrate skin wound repair via β1 integrin and independent of type I collagen production
K. McAndrews, T. Miyake, Ehsan A. Ehsanipour, Patience J. Kelly +6 more
2022EMBO Journal81 citations Open access
Semantic Scholar
Engineered exosomes targeting MYC reverse the proneural-mesenchymal transition and extend survival of glioblastoma
Amanda R. Haltom, Wafa E. Hassen, Janine Hensel, Jiha Kim +13 more
2022Extracellular Vesicle78 citations Open access
Semantic Scholar
Therapeutic targeting of STAT3 employing small interference RNAs and antisense oligonucleotides embedded exosomes in liver fibrosis
Min Tang, Yang Chen, Bing-Rui Li, H. Sugimoto +5 more
2021The FASEB Journal69 citations
Semantic Scholar
Protection against SARS-CoV-2 by BCG vaccination is not supported by epidemiological analyses
Janine Hensel, K. McAndrews, D. McGrail, Dara P. Dowlatshahi +2 more
2020Scientific Reports69 citations Open access
Semantic Scholar
Dual reporter genetic mouse models of pancreatic cancer identify an epithelial‐to‐mesenchymal transition‐independent metastasis program
Yang Chen, V. LeBleu, Julienne L. Carstens, H. Sugimoto +4 more
2018EMBO Molecular Medicine68 citations Open access
Semantic Scholar
Stem cell therapies benefit Alport syndrome.
V. LeBleu, H. Sugimoto, T. Mundel, B. Gerami‐Naini +7 more
2009Journal of the American Society of Nephrology68 citations Open access
Semantic Scholar
Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis
Timothy P. Cleland, Elena R. Schroeter, L. Zamdborg, Wenxia Zheng +10 more
2015Journal of Proteome Research67 citations Open access
Semantic Scholar
Elimination of oncogenic Kras in genetic mouse models eradicates pancreatic cancer by inducing Fas-dependent apoptosis by CD8+ T cells
K. Mahadevan, V. LeBleu, E. V. Ramirez, Yang Chen +13 more
2023Developmental Cell65 citations Open access
Semantic Scholar
Loss of placental growth factor ameliorates maternal hypertension and preeclampsia in mice
JG Parchem, K. Kanasaki, M. Kanasaki, H. Sugimoto +13 more
2018Journal of Clinical Investigation54 citations Open access
Semantic Scholar

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