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J. Hazeldine · SciRah

Researcher profile · Semantic Scholar

J. Hazeldine

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J. Hazeldine — researcher profile on SciRah

h-index: 26
Works: 66
Citations: 2,681

Most-cited papers

The impact of ageing on natural killer cell function and potential consequences for health in older adults
J. Hazeldine, J. Lord
2013Ageing Research Reviews310 citations Open access
Semantic Scholar
Reduced release and binding of perforin at the immunological synapse underlies the age‐related decline in natural killer cell cytotoxicity
J. Hazeldine, P. Hampson, J. M. Lord
2012Aging Cell201 citations Open access
Semantic Scholar
University of Birmingham Impaired neutrophil extracellular trap formation : a novel defect in the innate immune system of aged individuals
J. Hazeldine, P. Harris, I. Chapple, Melissa +6 more
2014193 citations
Semantic Scholar
Neutrophil Dysfunction, Immature Granulocytes, and Cell-free DNA are Early Biomarkers of Sepsis in Burn-injured Patients: A Prospective Observational Cohort Study
P. Hampson, R. Dinsdale, C. Wearn, A. Bamford +5 more
2017Annals of Surgery184 citations Open access
Semantic Scholar
Dehydroepiandrosterone as a regulator of immune cell function.
J. Hazeldine, W. Arlt, J. Lord
2010Journal of Steroid Biochemistry and Molecular Biology171 citations
Semantic Scholar
Traumatic Brain Injury and Peripheral Immune Suppression: Primer and Prospectus
J. Hazeldine, J. Lord, A. Belli
2015Frontiers in Neurology146 citations Open access
Semantic Scholar
Prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury: A prospective cohort study
J. Hazeldine, D. Naumann, E. Toman, D. Davies +9 more
2017PLoS Medicine138 citations Open access
Semantic Scholar
The impact of trauma on neutrophil function.
J. Hazeldine, P. Hampson, J. Lord
2014Injury122 citations Open access
Semantic Scholar
Endotheliopathy of Trauma is an on-Scene Phenomenon, and is Associated with Multiple Organ Dysfunction Syndrome: A Prospective Observational Study
D. Naumann, J. Hazeldine, D. Davies, J. Bishop +4 more
2017Shock106 citations Open access
Semantic Scholar
Primary adrenal insufficiency is associated with impaired natural killer cell function: a potential link to increased mortality
I. Bancos, J. Hazeldine, V. Chortis, P. Hampson +3 more
2017European Journal of Endocrinology103 citations Open access
Semantic Scholar
Innate immunesenescence: underlying mechanisms and clinical relevance
J. Hazeldine, J. Lord
2015Biogerontology (Dordrecht)101 citations
Semantic Scholar
Impaired neutrophil extracellular trap formation: a novel defect in the innate immune system of aged individuals
J. Hazeldine, Phillipa Harris, I. Chapple, Melissa Grant +4 more
2014Aging Cell99 citations Open access
Semantic Scholar
N-Formyl peptides drive mitochondrial damage associated molecular pattern induced neutrophil activation through ERK1/2 and P38 MAP kinase signalling pathways.
J. Hazeldine, P. Hampson, F. Opoku, M. Foster +1 more
2015Injury84 citations Open access
Semantic Scholar
Neutrophils and COVID-19: Active Participants and Rational Therapeutic Targets
J. Hazeldine, J. Lord
2021Frontiers in Immunology74 citations Open access
Semantic Scholar
Immunesenescence: A Predisposing Risk Factor for the Development of COVID-19?
J. Hazeldine, J. Lord
2020Frontiers in Immunology49 citations Open access
Semantic Scholar
Changes in the pattern of plasma extracellular vesicles after severe trauma
S. Kuravi, Clara M. Yates, M. Foster, P. Harrison +6 more
2017PLoS ONE46 citations Open access
Semantic Scholar
Cyclin-Dependent Kinase 9 Activity Regulates Neutrophil Spontaneous Apoptosis
Ke-Qing Wang, P. Hampson, J. Hazeldine, V. Kryštof +3 more
2012PLoS ONE46 citations Open access
Semantic Scholar
Endotheliopathy is associated with higher levels of cell-free DNA following major trauma: A prospective observational study
D. Naumann, J. Hazeldine, R. Dinsdale, J. Bishop +4 more
2017PLoS ONE45 citations Open access
Semantic Scholar
Immunesenescence and inflammaging: A contributory factor in the poor outcome of the geriatric trauma patient.
J. Hazeldine, J. Lord, P. Hampson
2015Ageing Research Reviews39 citations Open access
Semantic Scholar
Traumatic Injury and Exposure to Mitochondrial-Derived Damage Associated Molecular Patterns Suppresses Neutrophil Extracellular Trap Formation
J. Hazeldine, R. Dinsdale, P. Harrison, J. Lord
2019Frontiers in Immunology38 citations Open access
Semantic Scholar
Traumatic injury is associated with reduced deoxyribonuclease activity and dysregulation of the actin scavenging system
J. Hazeldine, R. Dinsdale, D. Naumann, A. Acharjee +3 more
2021Burns & Trauma34 citations Open access
Semantic Scholar
The diagnostic and prognostic value of systems biology research in major traumatic and thermal injury: a review
J. Hazeldine, P. Hampson, J. Lord
2016Burns & Trauma33 citations Open access
Semantic Scholar
A combination nutritional supplement reduces DNA methylation age only in older adults with a raised epigenetic age
Kirsty C. Mcgee, Jack Sullivan, J. Hazeldine, Lisa J. Schmunk +3 more
2024GeroScience31 citations Open access
Semantic Scholar
The immune suppressive properties of damage associated molecular patterns in the setting of sterile traumatic injury
E. Horner, J. Lord, J. Hazeldine
2023Frontiers in Immunology29 citations Open access
Semantic Scholar
Dehydroepiandrosterone: a potential therapeutic agent in the treatment and rehabilitation of the traumatically injured patient
Conor Bentley, J. Hazeldine, C. Greig, J. Lord +1 more
2019Burns & Trauma27 citations Open access
Semantic Scholar
Machine learning for the detection of early immunological markers as predictors of multi-organ dysfunction
Laura Bravo-Merodio, A. Acharjee, J. Hazeldine, Conor Bentley +3 more
2019Scientific Data27 citations Open access
Semantic Scholar
Investigating the potential of a prematurely aged immune phenotype in severely injured patients as predictor of risk of sepsis
M. Foster, Conor Bentley, J. Hazeldine, A. Acharjee +4 more
2022Immunity & Ageing22 citations Open access
Semantic Scholar
Senescent cell-derived extracellular vesicles as potential mediators of innate immunosenescence and inflammaging.
S. Hanley, Yung-Yi Chen, J. Hazeldine, J. M. Lord
2024Experimental Gerontology21 citations Open access
Semantic Scholar
Neutrophil apoptosis and its induction as a potential treatment for chronic inflammatory disease
P. Hampson, J. Hazeldine, J. Lord
2013Current opinion in hematology21 citations Open access
Semantic Scholar
IL-8 Induces Neutrophil Extracellular Trap Formation in Severe Thermal Injury
Ali Asiri, J. Hazeldine, N. Moiemen, P. Harrison
2024International Journal of Molecular Sciences18 citations Open access
Semantic Scholar
Severe thermal and major traumatic injury results in elevated plasma concentrations of total heme that are associated with poor clinical outcomes and systemic immune suppression
S. Tullie, T. Nicholson, Jonathan R. B. Bishop, Kirsty C. Mcgee +9 more
2024Frontiers in Immunology16 citations Open access
Semantic Scholar
Physical Activity Modifies the Metabolic Profile of CD4 + and CD8 + T‐Cell Subtypes at Rest and Upon Activation in Older Adults
J. Hazeldine, Edward Withnall, A. Llibre, Niharika A. Duggal +2 more
2024bioRxiv15 citations Open access
Semantic Scholar
Accelerated aging of skeletal muscle and the immune system in patients with chronic liver disease
T. Nicholson, A. Dhaliwal, J. Quinlan, S. Allen +10 more
2024Experimental and Molecular Medicine14 citations Open access
Semantic Scholar
Differential benefits of steroid therapies in adults following major burn injury.
K. Altarrah, Poh Tan, A. Acharjee, J. Hazeldine +5 more
2022Journal of Plastic, Reconstructive & Aesthetic Surgery13 citations Open access
Semantic Scholar
Integration of Metabolomic and Clinical Data Improves the Prediction of Intensive Care Unit Length of Stay Following Major Traumatic Injury
A. Acharjee, J. Hazeldine, A. Bazarova, Lavanya Deenadayalu +7 more
2021Metabolites13 citations Open access
Semantic Scholar
Impact of Senescent Cell‐Derived Extracellular Vesicles on Innate Immune Cell Function
Yung-Yi Chen, Jack Sullivan, S. Hanley, Joshua Price +7 more
2024Advances in Biology10 citations Open access
Semantic Scholar
Multicentre, longitudinal, observational cohort study to examine the relationship between neutrophil function and sepsis in adults and children with severe thermal injuries: a protocol for the Scientific Investigation of the Biological Pathways Following Thermal Injury-2 (SIFTI-2) study
J. Hazeldine, K. McGee, K. Altarrah, T. Hassouna +9 more
2021BMJ Open9 citations Open access
Semantic Scholar
Heparin resistance in severe thermal injury: a prospective cohort study
L. Cato, B. Bailiff, Joshua Price, Christos Ermogeneous +8 more
2021Burns & Trauma9 citations Open access
Semantic Scholar
The ultra-acute steroid response to traumatic injury: a cohort study.
Conor Bentley, J. Hazeldine, L. Bravo, A. Taylor +7 more
2023European Journal of Endocrinology7 citations Open access
Semantic Scholar
Accelerated epigenetic ageing after burn injury
Jack Sullivan, T. Nicholson, J. Hazeldine, N. Moiemen +1 more
2025GeroScience4 citations Open access
Semantic Scholar
A prospective, phase II, single-centre, cross-sectional, randomised study investigating Dehydroepiandrosterone supplementation and its Profile in Trauma: ADaPT
Conor Bentley, C. Potter, K. Yakoub, K. Brock +18 more
2021BMJ Open4 citations Open access
Semantic Scholar
The impact of trauma relevant concentrations of prostaglandin E2 on the anti-microbial activity of the innate immune system
T. Nicholson, Antonio Belli, Janet M. Lord, J. Hazeldine
2024Frontiers in Immunology3 citations Open access
Semantic Scholar
Major Traumatic Injury and Exposure to Mitochondrial-Derived Damage-Associated Molecular Patterns Promotes Neutrophil Survival Accompanied by Stabilisation of the Anti-Apoptotic Protein Mcl-1
T. Nicholson, Michael Macleod, Antonio Belli, Janet M. Lord +1 more
2025Cells2 citations Open access
Semantic Scholar
Day One Cell-Free DNA Levels as an Objective Prognostic Marker of Mortality in Major Burns Patients
S. Tullie, Ali Asiri, A. Acharjee, N. Moiemen +3 more
2025Cells2 citations Open access
Semantic Scholar
The Impact of Age on Neutrophil Extracellular Trap Formation
J. Hazeldine, J. Lord
2019Handbook of Immunosenescence2 citations
Semantic Scholar
Innate Immunosenescence and Its Impact on Health in Old Age
Mohammad A. Tariq, J. Hazeldine, J. Lord
20172 citations
Semantic Scholar
Neutrophil Dysfunction, Immature Granulocytes, and Cell-free DNA are Early Biomarkers of Sepsis in Burn-injured Patients
P. Hampson, MPharmacol Robert J. Dinsdale, C. Wearn, L. Amy +6 more
20162 citations
Semantic Scholar
Major Traumatic and Severe Thermal Injuries Lead to Immediate and Persistent Elevations in Circulating Concentrations of Resistin That Are Associated with Poor Clinical Outcomes and Impaired Innate Immune Responses
Emily Horner, Kirsty C. Mcgee, S. Tullie, D. N. Naumann +11 more
2026Biomolecules1 citations Open access
Semantic Scholar
Immunesenescence and Compromised Removal of Senescent Cells: Implications for Health in Old Age
J. Hazeldine, J. Lord
2021Healthy Ageing and Longevity1 citations
Semantic Scholar
University of Birmingham Neutrophil dysfunction, immature granulocytes, and cell-free DNA are early biomarkers of sepsis in burn-injured patients
P. Hampson, MPharmacol Robert J. Dinsdale, C. Wearn, L. Amy +6 more
20161 citations
Semantic Scholar

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