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J. Lecka · SciRah

Researcher profile · Semantic Scholar

J. Lecka

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J. Lecka — researcher profile on SciRah

h-index: 26
Works: 124
Citations: 2,279

Most-cited papers

Specificity of the ecto‐ATPase inhibitor ARL 67156 on human and mouse ectonucleotidases
SA Lévesque, ÉG Lavoie, J. Lecka, F. Bigonnesse +1 more
2007British Journal of Pharmacology218 citations Open access
Semantic Scholar
Polyoxometalates--potent and selective ecto-nucleotidase inhibitors.
Sang-Yong Lee, Amelie Fiene, Wenjin Li, T. Hanck +10 more
2015Biochemical Pharmacology103 citations
Semantic Scholar
Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8.
Michel Fausther, J. Lecka, F. Kukulski, S. Lévesque +4 more
2007American Journal of Physiology - Gastrointestinal and Liver Physiology88 citations Open access
Semantic Scholar
Extracellular ATP and P2 receptors are required for IL-8 to induce neutrophil migration.
F. Kukulski, Fethia Ben Yebdri, J. Lecka, G. Kauffenstein +3 more
2009Cytokine77 citations Open access
Semantic Scholar
Ciprofloxacin-metal complexes -stability and toxicity tests in the presence of humic substances.
Agnieszka Cuprys, Rama Pulicharla, J. Lecka, S. Brar +2 more
2018Chemosphere71 citations
Semantic Scholar
NTPDase1 Controls IL-8 Production by Human Neutrophils
F. Kukulski, F. Bahrami, Fethia Ben Yebdri, J. Lecka +3 more
2011Journal of Immunology63 citations Open access
Semantic Scholar
Inhibition of human and mouse plasma membrane bound NTPDases by P2 receptor antagonists.
M. Munkonda, G. Kauffenstein, F. Kukulski, S. Lévesque +5 more
2007Biochemical Pharmacology58 citations
Semantic Scholar
Coexpression of ecto-5′-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liver
Michel Fausther, J. Lecka, Elwy M. Soliman, G. Kauffenstein +4 more
201248 citations Open access
Semantic Scholar
Inhibition of vascular ectonucleotidase activities by the pro‐drugs ticlopidine and clopidogrel favours platelet aggregation
J. Lecka, Manjit Singh Rana, J. Sévigny
2010British Journal of Pharmacology46 citations Open access
Semantic Scholar
Highly Potent and Selective Ectonucleotide Pyrophosphatase/Phosphodiesterase I Inhibitors Based on an Adenosine 5′-(α or γ)- Thio-(α,β- or β,γ)-methylenetriphosphate Scaffold
Y. Nadel, J. Lecka, Yocheved Gilad, G. Ben-David +8 more
2014Journal of Medicinal Chemistry45 citations Open access
Semantic Scholar
Diadenosine 5',5''-(boranated)polyphosphonate analogues as selective nucleotide pyrophosphatase/phosphodiesterase inhibitors.
S. Eliahu, J. Lecka, G. Reiser, Michael S. Haas +5 more
2010Journal of Medicinal Chemistry41 citations Open access
Semantic Scholar
Exploration of carboxy pyrazole derivatives: Synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile.
P. Channar, S. Afzal, S. Ejaz, A. Saeed +6 more
2018European journal of medicinal chemistry39 citations Open access
Semantic Scholar
NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD
M. Salem, J. Lecka, J. Pelletier, Danielle Gomes Marconato +6 more
2021Gut38 citations
Semantic Scholar
Identification of novel chromone based sulfonamides as highly potent and selective inhibitors of alkaline phosphatases.
Mariya al-Rashida, R. Raza, G. Abbas, M. Shah +6 more
2013European journal of medicinal chemistry38 citations Open access
Semantic Scholar
Nonhydrolyzable ATP analogues as selective inhibitors of human NPP1: a combined computational/experimental study.
J. Lecka, G. Ben-David, L. Simhaev, S. Eliahu +6 more
2013Journal of Medicinal Chemistry38 citations Open access
Semantic Scholar
Microplastic pollution and associated health hazards: Impact of COVID-19 pandemic
B. R. Tiwari, J. Lecka, Rama Pulicharla, S. Brar
2023Current Opinion in Environmental Science & Health37 citations Open access
Semantic Scholar
Identification of sulfonic acids as efficient ecto-5'-nucleotidase inhibitors.
J. Iqbal, A. Saeed, R. Raza, A. Matin +5 more
2013European journal of medicinal chemistry37 citations Open access
Semantic Scholar
New one-pot synthesis of N-fused isoquinoline derivatives by palladium-catalyzed C-H arylation: potent inhibitors of nucleotide pyrophosphatase-1 and -3.
E. Ausekle, S. Ejaz, S. Khan, Peter Ehlers +5 more
2016Organic and biomolecular chemistry36 citations
Semantic Scholar
High expression and activity of ecto-5′-nucleotidase/CD73 in the male murine reproductive tract
M. Martín-Satué, É. Lavoie, Michel Fausther, J. Lecka +3 more
2010Histochemistry and Cell Biology35 citations
Semantic Scholar
Isonicotinohydrazones as inhibitors of alkaline phosphatase and ecto‐5′‐nucleotidase
P. Channar, S. J. A. Shah, S. Hassan, Z. Nisa +5 more
2017Chemical Biology and Drug Design32 citations Open access
Semantic Scholar
Novel BTEX-degrading strains from subsurface soil: Isolation, identification and growth evaluation.
Gurpreet Kaur, J. Lecka, Magdalena M. Krol, S. Brar
2023Environmental Pollution31 citations
Semantic Scholar
Synthesis, characterization and biological evaluation of novel chalcone sulfonamide hybrids as potent intestinal alkaline phosphatase inhibitors.
S. Ejaz, A. Saeed, Muhammad Siddique, Z. Nisa +4 more
2017Bioorganic chemistry (Print)30 citations Open access
Semantic Scholar
8‐BuS‐ATP derivatives as specific NTPDase1 inhibitors
J. Lecka, Irina Gillerman, Michel Fausther, M. Salem +10 more
2013British Journal of Pharmacology29 citations Open access
Semantic Scholar
Coexpression of ecto-5'-nucleotidase/CD73 with specific NTPDases differentially regulates adenosine formation in the rat liver.
Michel Fausther, J. Lecka, Elwy M. Soliman, G. Kauffenstein +4 more
2012American Journal of Physiology - Gastrointestinal and Liver Physiology29 citations
Semantic Scholar
Design, synthesis and biological evaluation of trinary benzocoumarin-thiazoles-azomethines derivatives as effective and selective inhibitors of alkaline phosphatase.
P. Channar, Hina Irum, A. Mahmood, G. Shabir +7 more
2019Bioorganic chemistry (Print)26 citations
Semantic Scholar
Investigation of quinoline-4-carboxylic acid as a highly potent scaffold for the development of alkaline phosphatase inhibitors: synthesis, SAR analysis and molecular modelling studies
I. Khan, S. J. A. Shah, S. Ejaz, Aliya Ibrar +5 more
201526 citations
Semantic Scholar
Schiff bases of tryptamine as potent inhibitors of nucleoside triphosphate diphosphohydrolases (NTPDases): Structure-activity relationship.
Kanwal, Khalid Mohammed Khan, U. Salar, S. Afzal +7 more
2019Bioorganic chemistry (Print)25 citations
Semantic Scholar
Domino Reactions of Chromone‐3‐carboxylic Acids with Aminoheterocycles: Synthesis of Heteroannulated Pyrido[2,3‐c]coumarins and their Optical and Biological Activity
M. Miliutina, J. Janke, E. Chirkina, S. Hassan +10 more
201724 citations
Semantic Scholar
2-Alkoxy-3-(sulfonylarylaminomethylene)-chroman-4-ones as potent and selective inhibitors of ectonucleotidases.
Mariya al-Rashida, Gazala Batool, A. Sattar, S. Ejaz +5 more
2016European journal of medicinal chemistry24 citations Open access
Semantic Scholar
4-Aminopyridine based amide derivatives as dual inhibitors of tissue non-specific alkaline phosphatase and ecto-5'-nucleotidase with potential anticancer activity.
S. Hassan, S. Ejaz, A. Saeed, M. Shehzad +5 more
2018Bioorganic chemistry (Print)23 citations
Semantic Scholar
Synthesis of 2-arylated thiadiazolopyrimidones by Suzuki–Miyaura cross-coupling: a new class of nucleotide pyrophosphatase (NPPs) inhibitors
B. Jafari, N. Yelibayeva, M. Ospanov, S. Ejaz +12 more
201623 citations
Semantic Scholar
Ecto-5’-Nucleotidase Overexpression Reduces Tumor Growth in a Xenograph Medulloblastoma Model
A. R. Cappellari, M. Pillat, H. D. N. Souza, F. Dietrich +8 more
2015PLoS ONE23 citations Open access
Semantic Scholar
A domino reaction of 3-chlorochromones with aminoheterocycles. Synthesis of pyrazolopyridines and benzofuropyridines and their optical and ecto-5'-nucleotidase inhibitory effects.
M. Miliutina, J. Janke, S. Hassan, Sumera Zaib +7 more
2018Organic and biomolecular chemistry22 citations Open access
Semantic Scholar
Hybrid compounds from chalcone and 1,2-benzothiazine pharmacophores as selective inhibitors of alkaline phosphatase isozymes.
A. Ashraf, S. Ejaz, S. Rahman, W. Siddiqui +8 more
2018European journal of medicinal chemistry21 citations Open access
Semantic Scholar
Enzymatic reactions in the production of biomethane from organic waste.
T. M. Mwene-Mbeja, A. Dufour, J. Lecka, B. Kaur +1 more
2020Enzyme and Microbial Technology20 citations
Semantic Scholar
Investigation of new quinoline derivatives as promising inhibitors of NTPDases: Synthesis, SAR analysis and molecular docking studies.
Komal Hayat, S. Afzal, Altaf Saeed, Amna Murtaza +8 more
2019Bioorganic chemistry (Print)20 citations
Semantic Scholar
Efficient one-pot synthesis of 5-perfluoroalkylpyrazoles by cyclization of hydrazone dianions.
Thang Ngoc Ngo, S. Ejaz, H. Tran, T. Dang +4 more
2015Organic and biomolecular chemistry20 citations
Semantic Scholar
Influence of the diversified structural variations at the imine functionality of 4-bromophenylacetic acid derived hydrazones on alkaline phosphatase inhibition: synthesis and molecular modelling studies
I. Khan, Aliya Ibrar, S. Ejaz, S. Khan +6 more
201520 citations
Semantic Scholar
Identification of hydrolytically stable and selective P2Y1 receptor agonists
S. Eliahu, J. Camden, J. Lecka, G. Weisman +3 more
2008European journal of medicinal chemistry20 citations Open access
Semantic Scholar
Identification of small molecule sulfonic acids as ecto-5'-Nucleotidase inhibitors.
R. Raza, A. Saeed, J. Lecka, J. Sévigny +1 more
2012Medicinal chemistry19 citations
Semantic Scholar
Extracellular Purine Metabolism in Blood Vessels (Part II): Activity of Ecto-Enzymes in Blood Vessels of Patients With Abdominal Aortic Aneurysm
J. Lecka, E. Bloch-boguslawska, S. Molski, M. Komoszyński
2010Clinical and applied thrombosis/hemostasis19 citations
Semantic Scholar
Synthesis, biological evaluation, and molecular docking study of sulfonate derivatives as nucleotide pyrophosphatase/phosphodiesterase (NPP) inhibitors.
M. Semreen, M. El-Gamal, Saif Ullah, Saquib Jalil +5 more
2019Bioorganic & Medicinal Chemistry17 citations Open access
Semantic Scholar
3-(5-(Benzylideneamino)thiazol-3-yl)-2H-chromen-2-ones: a new class of alkaline phosphatase and ecto-5′-nucleotidase inhibitors
A. Saeed, S. Ejaz, M. Shehzad, S. Hassan +4 more
201617 citations
Semantic Scholar
Synthesis and structure-activity relationship of uracil nucleotide derivatives towards the identification of human P2Y6 receptor antagonists.
Diana Meltzer, O. Ethan, G. Arguin, Y. Nadel +5 more
2015Bioorganic & Medicinal Chemistry17 citations Open access
Semantic Scholar
Generation and Characterization of Specific Antibodies to the Murine and Human Ectonucleotidase NTPDase8
J. Pelletier, M. Salem, J. Lecka, Michel Fausther +2 more
2017Frontiers in Pharmacology16 citations Open access
Semantic Scholar
Tricyclic coumarin sulphonate derivatives with alkaline phosphatase inhibitory effects: in vitro and docking studies
J. Iqbal, M. El-Gamal, S. Ejaz, J. Lecka +2 more
2018Journal of Enzyme Inhibition and Medicinal Chemistry15 citations Open access
Semantic Scholar
Fluorescence polarization immunoassays for monitoring nucleoside triphosphate diphosphohydrolase (NTPDase) activity.
Amelie Fiene, Younis Baqi, J. Lecka, J. Sévigny +1 more
2015In Analysis15 citations
Semantic Scholar
Purine-Metabolizing Ectoenzymes Control IL-8 Production in Human Colon HT-29 Cells
F. Bahrami, F. Kukulski, J. Lecka, A. Tremblay +3 more
2014Mediators of Inflammation15 citations Open access
Semantic Scholar
2-MeS-β,γ-CCl2-ATP is a Potent Agent for Reducing Intraocular Pressure
S. Eliahu, Alba Martín-Gil, M. P. D. de Lara, J. Pintor +5 more
2010Journal of Medicinal Chemistry15 citations Open access
Semantic Scholar
Deazapurine Analogues Bearing a 1H‐Pyrazolo[3,4‐b]pyridin‐3(2H)‐one Core: Synthesis and Biological Activity
Linda Supe, S. Afzal, A. Mahmood, S. Ejaz +7 more
201812 citations
Semantic Scholar

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