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W. Borcherds · SciRah

Researcher profile · Semantic Scholar

W. Borcherds

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W. Borcherds — researcher profile on SciRah

h-index: 17
Works: 56
Citations: 2,093

Most-cited papers

Deciphering how naturally occurring sequence features impact the phase behaviors of disordered prion-like domains
Anne Bremer, M. Farag, W. Borcherds, I. Peran +3 more
2021bioRxiv423 citations Open access
Semantic Scholar
How do intrinsically disordered protein regions encode a driving force for liquid-liquid phase separation?
W. Borcherds, Anne Bremer, Madeleine B. Borgia, T. Mittag
2020Current Opinion in Structural Biology330 citations Open access
Semantic Scholar
Condensates formed by prion-like low-complexity domains have small-world network structures and interfaces defined by expanded conformations
M. Farag, Samuel R. Cohen, W. Borcherds, Anne Bremer +2 more
2022Nature Communications213 citations Open access
Semantic Scholar
Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells.
W. Borcherds, François-Xavier Theillet, A. Katzer, A. Finzel +8 more
2014Nature Chemical Biology178 citations
Semantic Scholar
Sequence-specific interactions determine viscoelasticity and aging dynamics of protein condensates
Ibraheem Alshareedah, W. Borcherds, Samuel R. Cohen, Anurag Singh +8 more
2024Nature Physics158 citations Open access
Semantic Scholar
Phase separation of protein mixtures is driven by the interplay of homotypic and heterotypic interactions
M. Farag, W. Borcherds, Anne Bremer, T. Mittag +1 more
2023Nature Communications135 citations Open access
Semantic Scholar
Conformational buffering underlies functional selection in intrinsically disordered protein regions
Nicolás S. González-Foutel, Juliana Glavina, W. Borcherds, Matías Safranchik +15 more
2021Nature Structural & Molecular Biology119 citations Open access
Semantic Scholar
Interaction between p53 N terminus and core domain regulates specific and nonspecific DNA binding
F. He, W. Borcherds, T. Song, Xi Wei +4 more
2019Proceedings of the National Academy of Sciences of the United States of America83 citations Open access
Semantic Scholar
α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53–MDM2/MDMX Protein–Protein Interactions
P. Sang, Yan Shi, Jun-Hao Lu, Li-Hong Chen +7 more
2020Journal of Medicinal Chemistry55 citations Open access
Semantic Scholar
Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound Complex
Michael D. Crabtree, W. Borcherds, Anusha Poosapati, Sarah L. Shammas +2 more
2017Biochemistry50 citations Open access
Semantic Scholar
Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding
Xi Wei, Shaofang Wu, T. Song, Li-Hong Chen +4 more
2016Proceedings of the National Academy of Sciences of the United States of America45 citations Open access
Semantic Scholar
Autoinhibition of MDMX by intramolecular p53 mimicry
Li-Hong Chen, W. Borcherds, Shaofang Wu, A. Becker +3 more
2015Proceedings of the National Academy of Sciences of the United States of America43 citations Open access
Semantic Scholar
Optimal Affinity Enhancement by a Conserved Flexible Linker Controls p53 Mimicry in MdmX.
W. Borcherds, A. Becker, Li-Hong Chen, Jian-Dong Chen +2 more
2017Biophysical Journal30 citations Open access
Semantic Scholar
Conserved Glycines Control Disorder and Function in the Cold-Regulated Protein, COR15A
Oluwakemi T. Sowemimo, Patrick Knox-Brown, W. Borcherds, Tobias Rindfleisch +2 more
2019Biomolecules22 citations Open access
Semantic Scholar
Uncoupling the folding and binding of an intrinsically disordered protein
Anusha Poosapati, E. Gregory, W. Borcherds, L. Chemes +1 more
2018Journal of Molecular Biology22 citations Open access
Semantic Scholar
Quantifying Coexistence Concentrations in Multi-Component Phase-Separating Systems Using Analytical HPLC
Anne Bremer, Ammon E. Posey, Madeleine B. Borgia, W. Borcherds +3 more
2022bioRxiv19 citations Open access
Semantic Scholar
Using NMR Chemical Shifts to Determine Residue-Specific Secondary Structure Populations for Intrinsically Disordered Proteins
W. Borcherds, G. Daughdrill
2018Methods in Enzymology19 citations Open access
Semantic Scholar
Structural divergence is more extensive than sequence divergence for a family of intrinsically disordered proteins
W. Borcherds, S. Kashtanov, Hong-Wei Wu, G. Daughdrill
2013Proteins: Structure, Function, and Bioinformatics17 citations
Semantic Scholar
Sequence-encoded grammars determine material properties and physical aging of protein condensates
Ibraheem Alshareedah, W. Borcherds, Samuel R. Cohen, M. Farag +6 more
202316 citations
Semantic Scholar
Condensates of disordered proteins have small-world network structures and interfaces defined by expanded conformations
M. Farag, Samuel R. Cohen, W. Borcherds, Anne Bremer +2 more
2022bioRxiv15 citations Open access
Semantic Scholar
Disorder Predictors Also Predict Backbone Dynamics for a Family of Disordered Proteins
G. Daughdrill, W. Borcherds, Hong-Wei Wu
2011PLoS ONE15 citations Open access
Semantic Scholar
Optical characterization of molecular interaction strength in protein condensates
Timon Beck, Lize Van der Linden, W. Borcherds, Kyoohyun Kim +9 more
2024bioRxiv14 citations Open access
Semantic Scholar
Using chemical shifts to assess transient secondary structure and generate ensemble structures of intrinsically disordered proteins.
S. Kashtanov, W. Borcherds, Hong-Wei Wu, G. Daughdrill +1 more
2012Methods in molecular biology14 citations
Semantic Scholar
Relationship between gene duplicability and diversifiability in the topology of biochemical networks
Zhanyong Guo, Wen Jiang, Nuno F. Lages, W. Borcherds +1 more
2014BMC Genomics13 citations Open access
Semantic Scholar
The MDMX Acidic Domain Uses Allovalency to Bind Both p53 and MDMX
M. Fenton, W. Borcherds, Li-Hong Chen, A. Anbanandam +3 more
2022Journal of Molecular Biology9 citations Open access
Semantic Scholar
Using chemical shifts to generate structural ensembles for intrinsically disordered proteins with converged distributions of secondary structure
F. M. Ytreberg, W. Borcherds, Hong-Wei Wu, G. Daughdrill
2015Intrinsically Disordered Proteins9 citations Open access
Semantic Scholar
Phase Separation in Mixtures of Prion-Like Low Complexity Domains is Driven by the Interplay of Homotypic and Heterotypic Interactions
M. Farag, W. Borcherds, Anne Bremer, T. Mittag +1 more
2023bioRxiv7 citations Open access
Semantic Scholar
A stickers-and-spacers framework explains the viscoelastic and aging properties of biomolecular condensates.
W. Borcherds, Ibraheem Alshareedah, Anurag Singh, T. Das +4 more
2023Biophysical Journal7 citations
Semantic Scholar
p53 Phosphomimetics Preserve Transient Secondary Structure but Reduce Binding to Mdm2 and MdmX
Robin Levy, E. Gregory, W. Borcherds, G. Daughdrill
2019Biomolecules6 citations Open access
Semantic Scholar
Sequence-specific interactions determine viscoelasticity and aging dynamics of protein condensates
Ibraheem Alshareedah, W. Borcherds, Samuel R. Cohen, Anurag Singh +8 more
2023bioRxiv5 citations Open access
Semantic Scholar
Phase Separation in Mixtures of Prion-Like Low Complexity Domains is Driven by the Interplay of Homotypic and Heterotypic Interactions
R. Pappu, M. Farag, W. Borcherds, Anne Bremer +1 more
2023Research Square3 citations Open access
Semantic Scholar
Modified Rouse-Zimm theory for computing sequence-specific viscoelastic properties of biomolecular condensates.
Samuel R. Cohen, Ibraheem Alshareedah, W. Borcherds, M. Farag +3 more
2023Biophysical Journal2 citations
Semantic Scholar
Evolution of Transient Helicity and Disorder in Late Embryogenesis Abundant Protein COR15A
Oluwakemi T. Sowemimo, W. Borcherds, Patrick Knox-Brown, Tobias Rindfleisch +2 more
2019Biophysical Journal1 citations Open access
Semantic Scholar
Conserved helix-flanking prolines modulate IDP:target affinity by altering the lifetime of the bound complex
Michael D. Crabtree, W. Borcherds, A. Poospati, Sarah L. Shammas +2 more
20171 citations
Semantic Scholar
Structural Divergence Exceeds Sequence Divergence for a Family of Intrinsically Disordered Proteins
W. Borcherds, S. Kashtanov, G. Daughdrill
20131 citations Open access
Semantic Scholar
BPS2025 - Aging transitions in metastable biomolecular condensates characterized using active and passive nanoscale rheology
Anurag Singh, Ibraheem Alshareedah, W. Borcherds, Ruoyao Zhang +4 more
2025Biophysical Journal0 citations Open access
Semantic Scholar
Complex coacervation contributes to the joint phase behaviors of mixtures of charge-deficient prion-like low-complexity domains.
M. Farag, Anne Bremer, W. Borcherds, T. Mittag +1 more
2023Biophysical Journal0 citations Open access
Semantic Scholar
Uncovering the distinct roles of enthalpy and entropy that give rise to viscoelasticity in biomolecular condensates.
Ibraheem Alshareedah, W. Borcherds, Anurag Singh, Samuel R. Cohen +4 more
2023Biophysical Journal0 citations Open access
Semantic Scholar
Molecular Gymnastics Required for Mdmx Inhibition of P53 DNA Binding Activity
M. Fenton, W. Borcherds, Li-Hong Chen, A. Anbanandam +2 more
2022Social Science Research Network0 citations Open access
Semantic Scholar
Exploring the Effects of Increased Charge Content on the Phase Behavior of a Protein Low Complexity Domain
W. Borcherds, Anne Bremer, M. Farag, I. Peran +3 more
20210 citations Open access
Semantic Scholar
How do Evolutionarily Encoded Compositional Biases Influence the Phase Behaviors of Intrinsically Disordered Low Complexity Domains of Proteins?
M. Farag, Anne Bremer, W. Borcherds, T. Mittag +1 more
20210 citations Open access
Semantic Scholar
Hidden Complexities in the Phase Behavior of Low-Complexity Disordered Proteins
Anne Bremer, M. Farag, W. Borcherds, R. Pappu +1 more
20210 citations Open access
Semantic Scholar
Protein Disorder Regulates the DNA Binding Specificity of p53
Robin Levy, W. Borcherds, F. He, G. Daughdrill +1 more
20200 citations Open access
Semantic Scholar
Conformational Flexibility of p53 Transactivation Domain Controls DNA Binding Specificity and Promoter Selectivity
Emily R. Gregory-Lott, W. Borcherds, F. He, Mi Zhou +1 more
20200 citations Open access
Semantic Scholar
Correction to α-Helix-Mimicking Sulfono-γ-AApeptide Inhibitors for p53–MDM2/MDMX Protein–Protein Interactions
P. Sang, Yan Shi, Jun-Hao Lu, Li-Hong Chen +7 more
2020Journal of Medicinal Chemistry0 citations Open access
Semantic Scholar
MDMX Acidic Domain Requires the WF Motif for the Initiation of the Secondary Interaction with the P53DBD
M. Fenton, W. Borcherds, G. Daughdrill, Li-Hong Chen +1 more
20200 citations Open access
Semantic Scholar
Effect of Transient Helicity of cMyb TAD on its Binding Affinity to the Kix Domain of CBP/p300
Anusha Poosapati, W. Borcherds, Michael D. Carbtree, Sarah L. Shammas +2 more
2017The FASEB Journal0 citations Open access
Semantic Scholar
PNAS Plus Significance Statements
Wei-Zhang Xi, W. Borcherds, G. Daughdrill, N. Brown +7 more
2016Proceedings of the National Academy of Sciences of the United States of America0 citations Open access
Semantic Scholar
Relationship between gene duplicability and diversifiability in the topology of biochemical networks
Zhanyong Guo, Wen Jiang, Nuno F. Lages, W. Borcherds +1 more
2014BMC Genomics0 citations Open access
Semantic Scholar
De Novo Generation of Bound Structures for an Intrinsically Disordered Protein using Only Alpha Carbon Chemical Shifts
F. M. Ytreberg, S. Kashtanov, W. Borcherds, Hong-Wei Wu +1 more
20130 citations Open access
Semantic Scholar

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