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G. Pantouris · SciRah

Researcher profile · Semantic Scholar

G. Pantouris

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G. Pantouris — researcher profile on SciRah

h-index: 15
Works: 64
Citations: 754

Most-cited papers

Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1
G. Pantouris, Martynas Serys, H. Yuasa, H. Ball +1 more
2014Amino Acids122 citations
Semantic Scholar
An analysis of MIF structural features that control functional activation of CD74
G. Pantouris, M. Syed, C. Fan, D. Rajasekaran +5 more
2015Chemistry and Biology83 citations Open access
Semantic Scholar
Interaction of MIF Family Proteins in Myocardial Ischemia/Reperfusion Damage and Their Influence on Clinical Outcome of Cardiac Surgery Patients
C. Stoppe, S. Rex, A. Goetzenich, S. Kraemer +15 more
2015Antioxidants and Redox Signaling67 citations Open access
Semantic Scholar
MIF but not MIF-2 recruits inflammatory macrophages in an experimental polymicrobial sepsis model.
P. Tilstam, W. Schulte, T. Holowka, Bong-Sung Kim +9 more
2021Journal of Clinical Investigation60 citations Open access
Semantic Scholar
Antitumour agents as inhibitors of tryptophan 2,3-dioxygenase.
G. Pantouris, C. Mowat
2014Biochemical and Biophysical Research Communications - BBRC55 citations
Semantic Scholar
Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4
M. Lacy, Christos Kontos, Markus Brandhofer, Kathleen Hille +12 more
2018Scientific Reports44 citations Open access
Semantic Scholar
Nanosecond Dynamics Regulate the MIF-Induced Activity of CD74
G. Pantouris, Junming Ho, Dilip Shah, M. Syed +6 more
2018Angewandte Chemie38 citations Open access
Semantic Scholar
A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activity
P. Tilstam, G. Pantouris, M. Corman, M. Andreoli +6 more
2019Journal of Biological Chemistry29 citations Open access
Semantic Scholar
Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel
G. Pantouris, Leepakshi Khurana, Anthony K. Ma, Erin Skeens +4 more
2020Cell Chemical Biology27 citations Open access
Semantic Scholar
Structural Plasticity in the C‑Terminal Region of Macrophage Migration Inhibitory Factor‑2 Is Associated with an Induced Fit Mechanism for a Selective Inhibitor
G. Pantouris, R. Bucala, E. Lolis
2018Biochemistry27 citations Open access
Semantic Scholar
Modeling of both shared and distinct interactions between MIF and its homologue D-DT with their common receptor CD74
R. Meza-Romero, G. Benedek, Kelley R. Jordan, L. Leng +4 more
2016Cytokine27 citations Open access
Semantic Scholar
Insights into the mechanism of inhibition of tryptophan 2,3-dioxygenase by isatin derivatives
G. Pantouris, James Loudon-Griffiths, C. Mowat
2016Journal of Enzyme Inhibition and Medicinal Chemistry26 citations Open access
Semantic Scholar
An allosteric site on MKP5 reveals a strategy for small molecule inhibition
Z.T.K. Gannam, Kisuk Min, Shanelle R. Shillingford, Lei Zhang +13 more
2020Science Signaling19 citations Open access
Semantic Scholar
2,5-Pyridinedicarboxylic acid is a bioactive and highly selective inhibitor of D-dopachrome tautomerase.
A. Parkins, P. Das, Varsha M. Prahaladan, Vanessa M. Rangel +4 more
2023Structure16 citations Open access
Semantic Scholar
Crystallographic and Receptor Binding Characterization of Plasmodium falciparum Macrophage Migration Inhibitory Factor Complexed to Two Potent Inhibitors
G. Pantouris, D. Rajasekaran, Alvaro Baeza Garcia, V. Ruiz +4 more
2014Journal of Medicinal Chemistry16 citations Open access
Semantic Scholar
The N-terminus of MIF Regulates the Dynamic Profile of Residues Involved in CD74 Activation.
A. Parkins, Erin Skeens, C. McCallum, George P. Lisi +1 more
2021Biophysical Journal15 citations Open access
Semantic Scholar
Structural basis for decreased induction of class IB PI3‐kinases expression by MIF inhibitors
A. Singh, G. Pantouris, S. Borosch, Siripong Rojanasthien +1 more
2016Journal of Cellular and Molecular Medicine13 citations Open access
Semantic Scholar
Elucidating the role of an immunomodulatory protein in cancer: From protein expression to functional characterization.
Leepakshi Khurana, M. ElGindi, P. Tilstam, G. Pantouris
2019Methods in Enzymology12 citations
Semantic Scholar
Underrepresented Impurities in 4-Hydroxyphenylpyruvate Affect the Catalytic Activity of Multiple Enzymes.
A. Parkins, S. Sandin, J. Knittel, A. Franz +3 more
2023Analytical Chemistry10 citations
Semantic Scholar
Ligand-induced Conformational Changes Enable Intersubunit Communications in D-Dopachrome Tautomerase.
A. Parkins, EmilyY . Chen, Vanessa M. Rangel, Mandeep Singh +3 more
2023Biophysical Journal9 citations Open access
Semantic Scholar
A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies
Erin Skeens, G. Pantouris, Dilip Shah, R. Manjula +5 more
2022Frontiers in Molecular Biosciences7 citations Open access
Semantic Scholar
A small-molecule allele-selective transcriptional inhibitor of the MIF immune susceptibility locus
Jia Li, L. Leng, G. Pantouris, Ramu Manjula +7 more
2024Journal of Biological Chemistry5 citations Open access
Semantic Scholar
Human indoleamine 2,3-dioxygenase-2 has substrate specificity and inhibition characteristics distinct from those of indoleamine 2,3-dioxygenase-1
G. Pantouris, Martynas Serys, H. Yuasa, H. Ball +1 more
2014Amino Acids5 citations
Semantic Scholar
Protocol for purification and enzymatic characterization of members of the human macrophage migration inhibitory factor superfamily
A. Parkins, G. Pantouris
2023STAR Protocols4 citations Open access
Semantic Scholar
The N-terminal length and side-chain composition of CXCL13 affect crystallization, structure and functional activity
E. Rosenberg, J. Herrington, D. Rajasekaran, J. Murphy +2 more
2020Acta Crystallographica Section D: Structural Biology4 citations Open access
Semantic Scholar
Hands-On Methods to Educate High School Students about Cancer Research
C. Argueta, Jasmine Vargas, A. Parkins, Jian-Hua Ren +1 more
2023Journal of Chemical Education3 citations
Semantic Scholar
A selective small-molecule inhibitor of macrophage migration inhibitory factor-2 (MIF-2), a MIF cytokine superfamily member, inhibits MIF-2 biological activity
Tilstam, G. Pantouris, M. Corman, Monica +7 more
20193 citations
Semantic Scholar
Expression, Purification and Crystallization of the Novel Xenopus tropicalis ALDH16B1, a Homologue of Human ALDH16A1
G. Pantouris, E. Dioletis, Ying Chen, David C. Thompson +2 more
2019Chemico-Biological Interactions3 citations Open access
Semantic Scholar
Inhibition of MIF with an Allosteric Inhibitor Triggers Cell Cycle Arrest in Acute Myeloid Leukemia
G. Pantouris, Leepakshi Khurana, P. Tilstam, Alison Benner +10 more
2025ACS Omega2 citations Open access
Semantic Scholar
Insights into inhibition of heme-dependent dioxygenases
G. Pantouris
20122 citations
Semantic Scholar
A novel enzymatic assay for the identification of 4-hydroxyphenylpyruvate dioxygenase modulators
A. Parkins, G. Pantouris
2023STAR Protocols1 citations Open access
Semantic Scholar
Selective Recruitment of Lethal Pro-inflammatory Macrophages in Sepsis by MIF but not D-DT (MIF-2)
P. Tilstam, W. Schulte, T. Holowka, Bong-Sung Kim +6 more
2019Journal of Immunology1 citations
Semantic Scholar
The N-terminus of MIF controls the flexibility of specific β-sheet residues resulting in dynamic regulation of CD74 activation
A. Parkins, Erin Skeens, C. McCallum, George P. Lisi +1 more
2022Biophysical Journal0 citations Open access
Semantic Scholar
Crystal structure of Y99G mutant of human macrophage migration inhibitory factor
G. Pantouris, E. Lolis
20200 citations
Semantic Scholar
Crystal structure of H62F mutant of human macrophage migration inhibitory factor
G. Pantouris, E. Lolis
20200 citations
Semantic Scholar
Crystal structure of Y99F mutant of human macrophage migration inhibitory factor
G. Pantouris, E. Lolis
20200 citations
Semantic Scholar
Crystal structure of H62G mutant of human macrophage migration inhibitory factor
G. Pantouris, E. Lolis
20200 citations
Semantic Scholar
Crystal structure of S111A mutant of human macrophage migration inhibitory factor
G. Pantouris, E. Lolis
20180 citations
Semantic Scholar
Crystal structure of N110A mutant of human macrophage migration inhibitory factor
G. Pantouris, E. Lolis
20180 citations
Semantic Scholar
Crystal structure of N97A mutant of human macrophage migration inhibitory factor
G. Pantouris, E. Lolis
20180 citations
Semantic Scholar
Crystal structure of H62A mutant of human macrophage migration inhibitory factor
G. Pantouris, E. Lolis
20180 citations
Semantic Scholar
Identification of an Arg-Leu-Arg tripeptide that contributes to the binding interface between the cytokine MIF and the chemokine receptor CXCR4
M. Lacy, Christos Kontos, Markus Brandhofer, Kathleen Hille +12 more
2018Scientific Reports0 citations Open access
Semantic Scholar
Human D-Dopachrome tautomerase (D-DT)/ macrophage migration inhibitory factor 2 (MIF2) complexed with the selective inhibitor 4-CPPC
G. Pantouris, E. Lolis
20180 citations
Semantic Scholar
Crystal structure of G107A mutant of human macrophage migration inhibitory factor
G. Pantouris, E. Lolis
20180 citations
Semantic Scholar
Crystal structure of N102A mutant of human macrophage migration inhibitory factor
G. Pantouris, E. Lolis
20180 citations
Semantic Scholar
Crystal structure of H62Y mutant of human macrophage migration inhibitory factor
G. Pantouris, E. Lolis
20180 citations
Semantic Scholar
Crystal structure of S63A mutant of human macrophage migration inhibitory factor
G. Pantouris, E. Lolis
20160 citations
Semantic Scholar
Crystal structure of Macrophage Migration inhibitory factor in complex with furan-2-ylmethyl)imino methanethiol
G. Pantouris, E. Lolis
20160 citations
Semantic Scholar
Crystal structure of Pro1 deletion and M2A double mutant of Macrophage Migration Inhibitory Factor
G. Pantouris, E. Lolis
20160 citations
Semantic Scholar
Crystal structure of K66A mutant of human macrophage migration inhibitory factor
G. Pantouris, E. Lolis
20150 citations
Semantic Scholar

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Erin Skeens — researcher profile on SciRah

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