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C. Gaucher · SciRah

Researcher profile · Semantic Scholar

C. Gaucher

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C. Gaucher — researcher profile on SciRah

h-index: 23
Works: 66
Citations: 2,112

Most-cited papers

Factor VIII gene inversions in severe hemophilia A: results of an international consortium study.
S. Antonarakis, J. Rossiter, M. Young, J. Horst +62 more
1995Blood368 citations Open access
Semantic Scholar
Direct PCR from whole blood, without DNA extraction.
B. Mercier, C. Gaucher, O. Feugeas, C. Mazurier
1990Nucleic Acids Research207 citations Open access
Semantic Scholar
Gene Defects in 150 Unrelated French Cases with Type 2 von Willebrand Disease: from the Patient to the Gene
D. Meyer, É. Fressinaud, C. Gaucher, J. Lavergne +4 more
1997Thrombosis and Haemostasis125 citations
Semantic Scholar
Chronic lymphocytic leukaemia cells are efficiently killed by an anti‐CD20 monoclonal antibody selected for improved engagement of FcγRIIIA/CD16
C. de Romeuf, C. Dutertre, M. Le Garff-Tavernier, N. Fournier +12 more
2008British Journal of Haematology115 citations
Semantic Scholar
Selection of a human anti-RhD monoclonal antibody for therapeutic use: impact of IgG glycosylation on activating and inhibitory Fc gamma R functions.
S. Sibéril, C. de Romeuf, N. Bihoreau, Nadine Fernandez +12 more
2006Clinical Immunology98 citations
Semantic Scholar
Biological effect of desmopressin in eight patients with type 2n (‘Normandy’) von Willebrand disease
C. Mazurier, C. Gaucher, S. Jorieux, M. Goudemand
1994British Journal of Haematology94 citations
Semantic Scholar
Identification of two mutations (Arg611Cys and Arg611His) in the A1 loop of von Willebrand factor (vWF) responsible for type 2 von Willebrand disease with decreased platelet-dependent function of vWF.
L. Hilbert, C. Gaucher, C. Mazurier
1995Blood77 citations
Semantic Scholar
Expression of von Willebrand factor "Normandy": an autosomal mutation that mimics hemophilia A.
E. Tuley, C. Gaucher, S. Jorieux, N. Worrall +2 more
1991Proceedings of the National Academy of Sciences of the United States of America77 citations Open access
Semantic Scholar
Molecular cloning, characterization, genomic organization and promoter analysis of the α1,6-fucosyltransferase gene (fut8) expressed in the rat hybridoma cell line YB2/0
Béatrice Teylaert, E. Meurice, Marie Bobowski, A. Harduin-lepers +4 more
2011BMC Biotechnology74 citations Open access
Semantic Scholar
Evidence for a von Willebrand factor defect in factor VIII binding in three members of a family previously misdiagnosed mild haemophilia A and haemophilia A carriers: consequences for therapy and genetic counselling
C. Mazurier, C. Gaucher, S. Jorieux, A. Parquet‐Gernez +1 more
1990British Journal of Haematology74 citations
Semantic Scholar
The "Normandy" variant of von Willebrand disease: characterization of a point mutation in the von Willebrand factor gene.
C. Gaucher, S. Jorieux, B. Mercier, D. Oufkir +1 more
1991Blood68 citations Open access
Semantic Scholar
Leu 697-->Val mutation in mature von Willebrand factor is responsible for type IIB von Willebrand disease.
L. Hilbert, C. Gaucher, C. de Romeuf, M. Horellou +2 more
1994Blood62 citations
Semantic Scholar
Conformational changes in the D' domain of von Willebrand factor induced by CYS 25 and CYS 95 mutations lead to factor VIII binding defect and multimeric impairment.
S. Jorieux, É. Fressinaud, Jenny Goudemand, C. Gaucher +2 more
2000Blood61 citations
Semantic Scholar
Identification of two point mutations in the von Willebrand factor gene of three families with the ‘Normandy’variant of von Willebrand disease
C. Gaucher, B. Mercier, S. Jorieux, D. Oufkir +1 more
1991British Journal of Haematology54 citations
Semantic Scholar
Association between high von Willebrand factor levels and the Thr789Ala vWF gene polymorphism but not with nephropathy in type I diabetes
C. Lacquemant, C. Gaucher, C. Delorme, G. Chatellier +7 more
200048 citations Open access
Semantic Scholar
Characterization of von Willebrand factor gene defects in two unrelated patients with type IIC von Willebrand disease.
C. Gaucher, Jocelyne Dieval, C. Mazurier
1994Blood47 citations Open access
Semantic Scholar
A novel mutation in the D3 domain of von Willebrand factor markedly decreases its ability to bind factor VIII and affects its multimerization.
S. Jorieux, C. Gaucher, J. Goudemand, C. Mazurier
1998Blood43 citations
Semantic Scholar
MUTATIONS IN THE FVIII GENE IN SEVEN FAMILIES WITH MILD HAEMOPHILIA A
C. Mazurier, C. Gaucher, S. Jorieux, A. Parquet‐Gernez
1997British Journal of Haematology41 citations Open access
Semantic Scholar
The mutation Arg (53)----Trp causes von Willebrand disease Normandy by abolishing binding to factor VIII. Studies with recombinant von Willebrand factor.
S. Jorieux, E. Tuley, C. Gaucher, C. Mazurier +1 more
1992Blood41 citations Open access
Semantic Scholar
Characterization of von Willebrand factor gene defects in two unrelated patients with type IIC von Willebrand disease
C. Gaucher, J. Dieval, C. Mazurier
199435 citations Open access
Semantic Scholar
Fine epitope mapping of monoclonal antibodies to the NH2‐terminal part of von Willebrand factor (vWF) by using recombinant and synthetic peptides: interest for the localization of the factor VIII binding domain
S. Jorieux, C. Gaucher, Geneviégve Piéatu, Ghislaine Chéarel +2 more
1994British Journal of Haematology28 citations
Semantic Scholar
Type 2M vWD Resulting from a Lysine Deletion within a Four Lysine Residue Repeat in the A1 Loop of von Willebrand Factor
L. Hilbert, P. Jenkins, C. Gaucher, E. Meriane +3 more
2000Thrombosis and Haemostasis26 citations
Semantic Scholar
Association between high von willebrand factor levels and the Thr789Ala vWF gene polymorphism but not with nephropathy in type I diabetes. The GENEDIAB Study Group and the DESIR Study Group.
C. Lacquemant, C. Gaucher, C. Delorme, G. Chatellier +7 more
2000Kidney International26 citations
Semantic Scholar
Effects of different amino‐acid substitutions in the leucine 694‐proline 708 segment of recombinant von Willebrand factor
L. Hubert, C. Gaucher, C. Mazurier
1995British Journal of Haematology22 citations
Semantic Scholar
A Novel Mutation in the D3 Domain of von Willebrand Factor Markedly Decreases Its Ability to Bind Factor VIII and Affects Its Multimerization
S. Jorieux, C. Gaucher, J. Goudemand, C. Mazurier
199820 citations
Semantic Scholar
Type 2N von Willebrand Disease: Rapid Genetic Diagnosis of G2811A (R854Q), C2696T (R816W), T2701A (H817Q) and G2823T (C858F) – Detection of a Novel Candidate Type 2N Mutation: C2810T (R854W)
D. J. Bowen, Graham R. Standen, C. Mazurier, C. Gaucher +3 more
1998Thrombosis and Haemostasis20 citations
Semantic Scholar
Characterisation of 98 alleles in 105 unrelated individuals in the F8VWF gene.
B. Mercier, C. Gaucher, C. Mazurier
1991Nucleic Acids Research20 citations Open access
Semantic Scholar
The anti-tumor efficacy of 3C23K, a glyco-engineered humanized anti-MISRII antibody, in an ovarian cancer model is mainly mediated by engagement of immune effector cells
Pauline Estupina, A. Fontayne, J. Barret, N. Kersual +18 more
2017OncoTarget17 citations Open access
Semantic Scholar
Molecular genetics of von Willebrand disease.
C. Mazurier, A. Ribba, C. Gaucher, D. Meyer
1998Annales de Genetique17 citations
Semantic Scholar
Diagnosis of Subtype 2B von Willebrand Disease in a Patient with 2A Phenotype of Plasma von Willebrand Factor
C. Gaucher, C. de Romeuf, M. Rauïs-Morret, F. Corazza +2 more
1995Thrombosis and Haemostasis14 citations
Semantic Scholar
Identification of new type 2B von Willebrand disease mutations: Arg543Gln, Arg545Pro and Arg578Leu
L. Hilbert, C. Gaucher, J. Abgrall, Armelle Parquet +2 more
1998British Journal of Haematology12 citations
Semantic Scholar
A new candidate mutation (N528S) within the von Willebrand factor propeptide identified in a Japanese patient with phenotype IIC of von Willebrand disease
C. Gaucher, H. Uno, T. Yamazaki, H. Mashiba +1 more
1998European Journal of Haematology12 citations
Semantic Scholar
Guidelines for the Management of von Willebrand Disease 2021
Willebrand, V. Willebrand, Fviii Vwf, W. Nichols +496 more
2021Japanese Journal of Thrombosis and Hemostasis10 citations Open access
Semantic Scholar
Substitution of cysteine for phenylalanine 751 in mature von Willebrand factor is a novel candidate mutation in a family with type IIA von Willebrand disease
C. Gaucher, M. Hanss, M. Dechavanne, C. Mazurier
1993British Journal of Haematology10 citations
Semantic Scholar
Von Willebrand disease family studies: comparison of three methods of analysis of the von Willebrand factor gene polymorphism related to a variable number tandem repeat sequence in intron 40
C. Gaucher, B. Mercier, C. Mazurier
1992British Journal of Haematology10 citations
Semantic Scholar
Factor VIII deficiency not induced by FVIII gene mutation in a female first cousin of two brothers with haemophilia A
C. Mazurier, A. Parquet‐Gernez, C. Gaucher, J. Lavergne +1 more
2002British Journal of Haematology9 citations Open access
Semantic Scholar
Rapid mutation screening in type 2A von Willebrand's disease using universal heteroduplex generators
Doris Culpan, G. Standen, N. Wood, C. Mazurier +2 more
1997British Journal of Haematology8 citations Open access
Semantic Scholar
An MspI polymorphism in the von Willebrand factor gene.
B. Mercier, C. Gaucher, C. Mazurier
1990Nucleic Acids Research6 citations Open access
Semantic Scholar
Combined Hereditary Disorders of Haemophilia B Leyden (-6 G → A) and Type 1 von Willebrand Disease
G. Pernod, C. Vinciguerra, C. Gaucher, C. Mazurier +2 more
1996Thrombosis and Haemostasis5 citations
Semantic Scholar
New variant of type II von willebrand's disease with structural abnormality of plasma von willebrand factor in a patient with very mild bleeding history
P. Baillod, C. Gaucher, B. Affolter, C. Mazurier +1 more
1995American journal of hematology/oncology5 citations
Semantic Scholar
Expression of Human Anti-Rh (D) Monoclonal Antibodies into Different Cell Lines: Influence on their Functional Properties
C. de Romeuf, C. Gaucher, A. Glacet, S. Jorieux +2 more
20042 citations Open access
Semantic Scholar
Characterization of factor VIII gene inversions using a non-radioactive detection method: a survey of 102 unrelated haemophilia A families from northern France.
C. Gaucher, C. Mazurier
1995Nouvelle revue francaise d'hematologie2 citations
Semantic Scholar
Expression in Escherichia coli of a recombinant fragment (Ile 914‐Leu 1364) of human von Willebrand factor containing a collagen binding domain
S. JorieuΛ, G. Piétu, C. Gaucher, F. Mischler +3 more
1990Blood Coagulation and Fibrinolysis2 citations
Semantic Scholar
A novel treatment for ovarian cancer (OC): Anti-Müllerian inhibiting substance type II receptor (MISRII) humanized monoclonal antibody (mAb) 3C23K—Preclinical validation.
C. Gaucher, A. Jacquet, N. Kersual, V. Garambois +10 more
20121 citations
Semantic Scholar
Abstract 2528: 3C23K: an anti-human Müllerian inhibiting substance type II receptor humanized monoclonal antibody for ovarian cancer targeted therapy
A. Jacquet, N. Kersual, V. Garambois, A. Fontayne +10 more
20121 citations
Semantic Scholar
Molecular cloning , characterization , genomic organization and promoter analysis of the a 1 , 6-fucosyltransferase gene ( fut 8 ) expressed in the rat hybridoma cell line YB 2 / 0
Béatrice Teylaert, E. Meurice, Marie Bobowski, A. Harduin-lepers +4 more
20111 citations
Semantic Scholar
Improvement in the analysis of the Bcl I polymorphism of the factor VIII gene by PCR: introduction of a constant Bcl I site in one of the primers as a digestion control.
B. Mercier, C. Gaucher, C. Mazurier
1991Thrombosis Research1 citations
Semantic Scholar
Abstract 4574: Towards a new targeted therapy for ovarian cancer : Development of an anti-human müllerian inhibiting substance type II receptor humanized antibody
A. Jacquet, N. Kersual, V. Garambois, P. Colombo +9 more
20110 citations
Semantic Scholar
Novel pharmaceutical compositions comprising an antibody binding the human receptor of the type of anti-Mullerian hormone ii
C. Gaucher, I. Navarro-Teulon
20110 citations
Semantic Scholar
Willebrand factor by abolishing binding to factor VIII. Studies with recombinant von The mutation Arg (53)----Trp causes von Willebrand disease Normandy
S. Jorieux, EA Tuley, C. Gaucher, C. Mazurier +1 more
20110 citations
Semantic Scholar

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B. Mercier×7
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