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N. Horscroft · SciRah

Researcher profile · Semantic Scholar

N. Horscroft

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N. Horscroft — researcher profile on SciRah

h-index: 18
Works: 35
Citations: 1,375

Most-cited papers

An infection-based model of neurodevelopmental damage.
M. Hornig, H. Weissenböck, N. Horscroft, W. Lipkin
1999Proceedings of the National Academy of Sciences of the United States of America285 citations Open access
Semantic Scholar
Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response
D. Edwards, E. Jasny, Heesik Yoon, N. Horscroft +5 more
2017Journal of Translational Medicine167 citations Open access
Semantic Scholar
Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model.
Taihua Yang, Marion Poenisch, Rajendra Khanal, Qing-Luan Hu +21 more
2021Journal of Hepatology156 citations Open access
Semantic Scholar
mRNA mediates passive vaccination against infectious agents, toxins, and tumors
Moritz Thran, J. Mukherjee, M. Pönisch, K. Fiedler +9 more
2017EMBO Molecular Medicine151 citations Open access
Semantic Scholar
Investigating Toll-Like Receptor Agonists for Potential To Treat Hepatitis C Virus Infection
A. Thomas, C. Laxton, J. Rodman, Nisha Myangar +2 more
2007Antimicrobial Agents and Chemotherapy70 citations Open access
Semantic Scholar
The Innate Immune Response, Clinical Outcomes, and Ex Vivo HCV Antiviral Efficacy of a TLR7 Agonist (PF‐4878691)
M. Fidock, B. Souberbielle, C. Laxton, J. Rawal +14 more
2011Clinical pharmacology and therapy62 citations
Semantic Scholar
Mutations in NS5B polymerase of hepatitis C virus: impacts on in vitro enzymatic activity and viral RNA replication in the subgenomic replicon cell culture.
I. W. Cheney, Suhaila Naim, V. Lai, S. Dempsey +6 more
2002Virology61 citations Open access
Semantic Scholar
Antiviral applications of Toll-like receptor agonists.
N. Horscroft, D. Pryde, H. Bright
2012Journal of Antimicrobial Chemotherapy55 citations
Semantic Scholar
Replicon Cell Culture System as a Valuable Tool in Antiviral Drug Discovery against Hepatitis C Virus
N. Horscroft, V. Lai, W. Cheney, N. Yao +3 more
2005Antiviral Chemistry & Chemotherapy49 citations Open access
Semantic Scholar
Establishment of a Subgenomic Replicon for Bovine Viral Diarrhea Virus in Huh-7 Cells and Modulation of Interferon-Regulated Factor 3-Mediated Antiviral Response
N. Horscroft, D. Bellows, I. Ansari, V. Lai +5 more
2005Journal of Virology42 citations Open access
Semantic Scholar
Neuroprotection and Reduced Proliferation of Microglia in Ribavirin-Treated Bornavirus-Infected Rats
M. Solbrig, R. Schlaberg, T. Briese, N. Horscroft +1 more
2002Antimicrobial Agents and Chemotherapy33 citations Open access
Semantic Scholar
NTP binding and phosphohydrolase activity associated with purified bluetongue virus non-structural protein NS2.
N. Horscroft, P. Roy
2000Journal of General Virology31 citations Open access
Semantic Scholar
mRNA as a Novel Treatment Strategy for Hereditary Spastic Paraplegia Type 5
S. Hauser, Marion Poenisch, Yvonne Schelling, Philip Höflinger +10 more
2019Molecular Therapy: Methods & Clinical Development28 citations Open access
Semantic Scholar
Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection.
T. Tran, D. Pryde, Peter G. Jones, F. Adam +20 more
2011Bioorganic & Medicinal Chemistry Letters26 citations Open access
Semantic Scholar
Neurotrophic Factor Expression After CNS Viral Injury Produces Enhanced Sensitivity to Psychostimulants: Potential Mechanism for Addiction Vulnerability
M. Solbrig, G. Koob, L. Parsons, T. Kadota +3 more
2000Journal of Neuroscience26 citations Open access
Semantic Scholar
Phenylalanine hydroxylase mRNA rescues the phenylketonuria phenotype in mice
M. Cacicedo, Christine Weinl-Tenbruck, Daniel Frank, M. Limeres +8 more
2022Frontiers in Bioengineering and Biotechnology25 citations Open access
Semantic Scholar
Therapy with TLR7 Agonists Induces Lymphopenia: Correlating Pharmacology to Mechanism in a Mouse Model
Hannah Perkins, Tansi Khodai, Houria Mechiche, P. Colman +10 more
2012Journal of Clinical Immunology25 citations
Semantic Scholar
Discovery of a highly potent series of TLR7 agonists.
Peter G. Jones, D. Pryde, T. Tran, F. Adam +17 more
2011Bioorganic & Medicinal Chemistry Letters18 citations Open access
Semantic Scholar
The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection
D. Pryde, T. Tran, Peter G. Jones, Gemma C. Parsons +19 more
201114 citations
Semantic Scholar
Thermal denaturation of proteins for SDS-PAGE analysis by microwave irradiation.
N. Horscroft, P. Roy
1997BioTechniques13 citations Open access
Semantic Scholar
Knockdown of USP18 Increases Alpha 2a Interferon Signaling and Induction of Interferon-Stimulating Genes but Does Not Increase Antiviral Activity in Huh7 Cells
E. Murray, Frances Burden, N. Horscroft, C. Smith-Burchnell +1 more
2011Antimicrobial Agents and Chemotherapy12 citations Open access
Semantic Scholar
Co-administration of an effector antibody enhances the half-life and therapeutic potential of RNA-encoded nanobodies
Moritz Thran, M. Pönisch, Hillary Danz, N. Horscroft +3 more
2023Scientific Reports9 citations Open access
Semantic Scholar
A Nine-Strain Bacterial Consortium Improves Portal Hypertension and Insulin Signaling and Delays NAFLD Progression In Vivo
Iris Pinheiro, Aurora Barberá, Imma Raurell, F. Estrella +9 more
2022Biomedicines6 citations Open access
Semantic Scholar
Preclinical Studies of Pf-04849285, An Interferon-α8 Fusion Protein for the Treatment of HCV
M. Flores, T. Hickling, S. Sreckovic, M. Fidock +13 more
2012Antiviral Therapy5 citations Open access
Semantic Scholar
Comparison of Rat and Human Responses to Toll-Like Receptor 7 Activation
S. Clarke, C. Laxton, N. Horscroft, Virgile Richard +2 more
2009Journal of Interferon and Cytokine Research5 citations
Semantic Scholar
Corrigendum to 'Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model' [J Hepatol (2021) 1420-1433].
Taihua Yang, Marion Poenisch, Rajendra Khanal, Qing-Luan Hu +21 more
2022Journal of Hepatology3 citations
Semantic Scholar
Preclinical Studies of Pf-04849285, An Interferon-α8 Fusion Protein for the Treatment of HCV
M. Flores, T. Hickling, S. Sreckovic, M. Fidock +13 more
20121 citations Open access
Semantic Scholar
Orbivirus non-structural protein NS2 : its role in virus replication
N. Horscroft
19971 citations
Semantic Scholar
A nine-strain bacterial consortium improves portal hypertension and insulin signaling and delays non-alcoholic fatty liver disease progression in vivo
Iris Pinheiro, Aurora Barberá, Imma Raurell, F. Estrella +9 more
2022Journal of Hepatology0 citations
Semantic Scholar
Rnas for wound healing
N. Horscroft, M. Pönisch, C. Weinl
20170 citations
Semantic Scholar
Adjuvant effects of a sequence-engineered mRNA vaccine: translational profiling demonstrates similar human and murine innate response
D. Edwards, E. Jasny, Heesik Yoon, N. Horscroft +5 more
2017Journal of Translational Medicine0 citations Open access
Semantic Scholar
Rna for treatment or prophylaxis of a liver disease
N. Horscroft, M. Pönisch, C. Weinl
20170 citations
Semantic Scholar
Therapy with TLR7 Agonists Induces Lymphopenia: Correlating Pharmacology to Mechanism in a Mouse Model
Hannah Perkins, Tansi Khodai, Houria Mechiche, P. Colman +10 more
2012Journal of Clinical Immunology0 citations
Semantic Scholar
Antiviral Response Interferon-Regulated Factor 3-Mediated Cells and Modulation of for Bovine Viral Diarrhea Virus in Huh-7 Establishment of a Subgenomic Replicon
Z. Hong, S. Dempsey, Delin Liang, R. Donis +5 more
20050 citations
Semantic Scholar
Orbivirus non-structural protein NS2
N. Horscroft
19970 citations
Semantic Scholar

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