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L. Kèlland · SciRah

Researcher profile · Semantic Scholar

L. Kèlland

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L. Kèlland — researcher profile on SciRah

h-index: 67
Works: 264
Citations: 20K

Most-cited papers

The resurgence of platinum-based cancer chemotherapy
L. Kèlland
2007Nature Reviews. Cancer4,438 citations
Semantic Scholar
Short tandem repeat profiling provides an international reference standard for human cell lines
J. Masters, J. Thomson, B. Daly-Burns, Y. Reid +12 more
2001Proceedings of the National Academy of Sciences of the United States of America466 citations Open access
Semantic Scholar
Discovery and development of anticancer aptamers
C. Ireson, L. Kèlland
2006Molecular Cancer Therapeutics446 citations Open access
Semantic Scholar
Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases.
F. Raynaud, S. Eccles, P. Clarke, A. Hayes +21 more
2007Cancer Research382 citations Open access
Semantic Scholar
Of mice and men: values and liabilities of the athymic nude mouse model in anticancer drug development.
L. Kèlland
2004European Journal of Cancer336 citations
Semantic Scholar
A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity.
Sharon M. Gowan, J. Harrison, Lisa Patterson, M. Valenti +3 more
2002Molecular Pharmacology278 citations
Semantic Scholar
Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics--current status and future prospects.
L. Kèlland
2005European Journal of Cancer242 citations
Semantic Scholar
Preclinical Perspectives on Platinum Resistance
L. Kèlland
2012Drugs193 citations
Semantic Scholar
Phase II study of the efficacy and tolerability of two dosing regimens of the farnesyl transferase inhibitor, R115777, in advanced breast cancer.
S. Johnston, T. Hickish, P. Ellis, S. Houston +7 more
2003Journal of Clinical Oncology191 citations
Semantic Scholar
Trisubstituted acridine derivatives as potent and selective telomerase inhibitors.
R. Harrison, J. Cuesta, G. Chessari, Martin A. Read +9 more
2003Journal of Medicinal Chemistry175 citations Open access
Semantic Scholar
A novel small molecule inhibitor of protein kinase D blocks pancreatic cancer growth in vitro and in vivo
K. Harikumar, A. Kunnumakkara, N. Ochi, Zhimin Tong +21 more
2010Molecular Cancer Therapeutics163 citations Open access
Semantic Scholar
A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells.
Christopher M Incles, C. Schultes, H. Kempski, H. Koehler +2 more
2004Molecular Cancer Therapeutics156 citations
Semantic Scholar
Targeting the Limitless Replicative Potential of Cancer: The Telomerase/Telomere Pathway
L. Kèlland
2007Clinical Cancer Research145 citations Open access
Semantic Scholar
Pharmacokinetic-Pharmacodynamic Relationships for the Heat Shock Protein 90 Molecular Chaperone Inhibitor 17-Allylamino , 17-Demethoxygeldanamycin in Human Ovarian Cancer
U. Banerji, M. Walton, F. Raynaud, R. Grimshaw +4 more
2005137 citations
Semantic Scholar
In vitro and In vivo Pharmacokinetic-Pharmacodynamic Relationships for the Trisubstituted Aminopurine Cyclin-Dependent Kinase Inhibitors Olomoucine, Bohemine and CYC202
F. Raynaud, S. Whittaker, P. Fischer, S. Mcclue +11 more
2005Clinical Cancer Research135 citations Open access
Semantic Scholar
Synthesis, characterization, and cytotoxicity of a novel highly charged trinuclear platinum compound. Enhancement of cellular uptake with charge.
A. Harris, Xiaohong Yang, Alexander Hegmans, L. Povirk +3 more
2005Inorganic Chemistry119 citations Open access
Semantic Scholar
SJG-136 (NSC 694501), a Novel Rationally Designed DNA Minor Groove Interstrand Cross-Linking Agent with Potent and Broad Spectrum Antitumor Activity
J. Hartley, V. Spanswick, Natalie Brooks, Peter H. Clingen +13 more
2004Cancer Research119 citations Open access
Semantic Scholar
Broadening the clinical use of platinum drug–based chemotherapy with new analogues
L. Kèlland
2007Expert Opinion on Investigational Drugs112 citations
Semantic Scholar
Antitumor polycyclic acridines. 8.(1) Synthesis and telomerase-inhibitory activity of methylated pentacyclic acridinium salts.
R. Heald, Chetna Modi, J. Cookson, I. Hutchinson +4 more
2002Journal of Medicinal Chemistry106 citations Open access
Semantic Scholar
Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding.
R. Harrison, A. Reszka, S. Haider, B. Romagnoli +6 more
2004Bioorganic & Medicinal Chemistry Letters76 citations Open access
Semantic Scholar
Comparative in vitro cytotoxicity of taxol and Taxotere against cisplatin-sensitive and-resistant human ovarian carcinoma cell lines
L. Kèlland, G. Abel
2004Cancer Chemotherapy and Pharmacology75 citations
Semantic Scholar
Mechanisms of tumor vascular shutdown induced by 5,6‐dimethylxanthenone‐4‐acetic acid (DMXAA): Increased tumor vascular permeability
Liang-Li Zhao, Lai-Ming Ching, P. Kestell, L. Kèlland +1 more
2005International Journal of Cancer72 citations
Semantic Scholar
Structure-based design of benzylamino-acridine compounds as G-quadruplex DNA telomere targeting agents.
Cristina Martins, M. Gunaratnam, J. Stuart, Vaidahi Makwana +4 more
2007Bioorganic & Medicinal Chemistry Letters64 citations Open access
Semantic Scholar
Antitumor and cellular pharmacological properties of a novel platinum(IV) complex: trans-[PtCl(2)(OH)(2)(dimethylamine) (isopropylamine)].
J. Pérez, L. Kèlland, Eva I. Montero, F. Boxall +3 more
2003Molecular Pharmacology60 citations
Semantic Scholar
New Developments and Approaches in the Platinum Arena
I. Judson, L. Kèlland
2012Drugs59 citations
Semantic Scholar
ErbB2 overexpression in an ovarian cancer cell line confers sensitivity to the HSP90 inhibitor geldanamycin.
V. Smith, S. Hobbs, W. Court, S. Eccles +2 more
2002Anticancer Research59 citations
Semantic Scholar
A phase I and pharmacology study of an oral platinum complex, JM216: dose-dependent pharmacokinetics with single-dose administration
M. McKeage, P. Mistry, J. Ward, F. Boxall +9 more
2004Cancer Chemotherapy and Pharmacology58 citations
Semantic Scholar
Enhancement of aqueous solubility and stability employing a trans acetate axis in trans planar amine platinum compounds while maintaining the biological profile.
Erin S. F. Ma, W. Bates, A. Edmunds, L. Kèlland +2 more
2005Journal of Medicinal Chemistry50 citations
Semantic Scholar
Retention of activity by the new generation platinum agent AMD0473 in four human tumour cell lines possessing acquired resistance to oxaliplatin.
S. Sharp, C. O'Neill, Paul M. Rogers, F. Boxall +1 more
2002European Journal of Cancer50 citations
Semantic Scholar
Targeting Established Tumor Vasculature: A Novel Approach to Cancer Treatment
L. Kèlland
200548 citations
Semantic Scholar
Characterization of the biological effects of a novel protein kinase D inhibitor in endothelial cells
I. Evans, Azadeh Bagherzadeh, M. Charles, T. Raynham +4 more
2010Biochemical Journal45 citations Open access
Semantic Scholar
Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line.
V. Smith, M. Rowlands, Elaine Barrie, P. Workman +1 more
2002Clinical Cancer Research43 citations
Semantic Scholar
Rat tumor response to the vascular-disrupting agent 5,6-dimethylxanthenone-4-acetic acid as measured by dynamic contrast-enhanced magnetic resonance imaging, plasma 5-hydroxyindoleacetic acid levels, and tumor necrosis.
L. D. McPhail, D. McIntyre, C. Ludwig, P. Kestell +3 more
2006Neoplasia41 citations Open access
Semantic Scholar
cis-Diamminedichloroplatinum(II)-induced cell death through apoptosis in sensitive and resistant human ovarian carcinoma cell lines
M. Ormerod, C. O'Neill, D. Robertson, L. Kèlland +1 more
2009Cancer Chemotherapy and Pharmacology39 citations
Semantic Scholar
Acquired cellular resistance to flavopiridol in a human colon carcinoma cell line involves up-regulation of the telomerase catalytic subunit and telomere elongation. Sensitivity of resistant cells to combination treatment with a telomerase inhibitor.
Christopher M Incles, C. Schultes, L. Kèlland, S. Neidle
2003Molecular Pharmacology39 citations
Semantic Scholar
G-quadruplex compounds and cis-platin act synergistically to inhibit cancer cell growth in vitro and in vivo.
M. Gunaratnam, C. Green, J. B. Moreira, A. Moorhouse +3 more
2009Biochemical Pharmacology38 citations Open access
Semantic Scholar
Discontinued drugs in 2005: oncology drugs
L. Kèlland
2006Expert Opinion on Investigational Drugs34 citations
Semantic Scholar
Tumor Dose Response to the Vascular Disrupting Agent, 5,6-Dimethylxanthenone-4-Acetic Acid, Using In vivo Magnetic Resonance Spectroscopy
L. D. McPhail, Yuen-Li Chung, B. Madhu, S. Clark +3 more
2005Clinical Cancer Research34 citations
Semantic Scholar
Design, synthesis and biological evaluation of 6-pyridylmethylaminopurines as CDK inhibitors.
Stuart C. Wilson, B. Atrash, C. Barlow, S. Eccles +15 more
2011Bioorganic & Medicinal Chemistry33 citations Open access
Semantic Scholar
Variation in RNA expression and genomic DNA content acquired during cell culture
L. Hiorns, Tracey D. Bradshaw, L. Skelton, Qingnan Yu +2 more
2004British Journal of Cancer33 citations Open access
Semantic Scholar
Increased tumour extracellular pH induced by Bafilomycin A1 inhibits tumour growth and mitosis in vivo and alters 5-fluorouracil pharmacokinetics.
P. Mcsheehy, H. Troy, L. Kèlland, Ian R. Judson +2 more
2003European Journal of Cancer32 citations
Semantic Scholar
Amide-based prodrugs of spermidine-bridged dinuclear platinum. Synthesis, DNA binding, and biological activity.
Alexander Hegmans, J. Kašpárková, O. Vrána, L. Kèlland +2 more
2008Journal of Medicinal Chemistry31 citations Open access
Semantic Scholar
Characterization of a human colorectal carcinoma cell line with acquired resistance to flavopiridol.
V. Smith, Florence I. Raynaud, Paul Workman, L. Kèlland
2001Molecular Pharmacology31 citations
Semantic Scholar
Farnesyl transferase inhibitors in the treatment of breast cancer
L. Kèlland
2003Expert Opinion on Investigational Drugs30 citations
Semantic Scholar
Accumulation, platinum-DNA adduct formation and cytotoxicity of cisplatin, oxaliplatin and satraplatin in sensitive and resistant human osteosarcoma cell lines, characterized by p53 wild-type status.
L. Martelli, F. di Mario, P. Botti, E. Ragazzi +2 more
2007Biochemical Pharmacology29 citations
Semantic Scholar
Human ovarian-carcinoma cell lines and companion xenografts: a disease-oriented approach to new platinum anticancer drug discovery
L. Kèlland, Mervyn Jones, G. Abel, M. Valenti +2 more
2004Cancer Chemotherapy and Pharmacology29 citations
Semantic Scholar
5,6-Dimethylxanthenone-4-Acetic Acid (DMXAA)
M. McKeage, L. Kèlland
200627 citations
Semantic Scholar
Pharmacokinetic-Pharmacodynamic Relationships for the Heat Shock Protein 90 Molecular Chaperone Inhibitor 17-Allylamino, 17-Demethoxygeldanamycin in Human Ovarian Cancer Xenograft Models
U. Banerji, Michael I. Walton, Florence I. Raynaud, R. Grimshaw +4 more
2005Clinical Cancer Research27 citations Open access
Semantic Scholar
Sequence-dependent synergism between the new generation platinum agent ZD0473 and paclitaxel in cisplatin-sensitive and -resistant human ovarian carcinoma cell lines.
Paul M. Rogers, Frances E. Boxall, C. Allott, T. Stephens +1 more
2002European Journal of Cancer22 citations
Semantic Scholar
Evidence for the involvement of p38 MAP kinase in the action of the vascular disrupting agent 5,6-dimethylxanthenone-4-acetic acid (DMXAA)
Liang-Li Zhao, E. Marshall, L. Kèlland, B. Baguley
2007Investigational new drugs17 citations
Semantic Scholar

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