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B. Mannervik · SciRah

Researcher profile · Semantic Scholar

B. Mannervik

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B. Mannervik — researcher profile on SciRah

h-index: 55
Works: 528
Citations: 24K

Most-cited papers

Synthesis and characterization of a series of highly fluorogenic substrates for glutathione transferases, a general strategy.
Jie Zhang, Aya Shibata, Mika Ito, S. Shuto +4 more
2011Journal of the American Chemical Society114 citations
Semantic Scholar
MOLECULAR ENZYMOLOGY OF THE GLYOXALASE SYSTEM
B. Mannervik
2008Drug Metabolism and Drug Interactions70 citations
Semantic Scholar
Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction
Sandro Huenchuguala, Patricia Muñoz, P. Zavala, Mónica Villa +8 more
2014Autophagy68 citations Open access
Semantic Scholar
Glutathione transferase: new model for glutathione activation.
Daniel F. A. R. Dourado, P. Fernandes, B. Mannervik, M. Ramos
2008Chemistry65 citations
Semantic Scholar
Glutathione Transferase-M2-2 Secreted from Glioblastoma Cell Protects SH-SY5Y Cells from Aminochrome Neurotoxicity
C. Cuevas, Sandro Huenchuguala, Patricia Muñoz, Mónica Villa +3 more
2015Neurotoxicity research48 citations Open access
Semantic Scholar
Structural basis for featuring of steroid isomerase activity in alpha class glutathione transferases.
K. Ta̅rs, B. Olin, B. Mannervik
2010Journal of Molecular Biology47 citations
Semantic Scholar
Enzymatic Detoxication, Conformational Selection, and the Role of Molten Globule Active Sites*
Matthew T. Honaker, M. Acchione, Wei Zhang, B. Mannervik +1 more
2013Journal of Biological Chemistry46 citations Open access
Semantic Scholar
Five Decades with Glutathione and the GSTome
B. Mannervik
2012Journal of Biological Chemistry46 citations Open access
Semantic Scholar
Substrate Specificity Combined with Stereopromiscuity in Glutathione Transferase A4-4-dependent Metabolism of 4-Hydroxynonenal
L. Balogh, I. Le Trong, K. Kripps, L. Shireman +4 more
2010Biochemistry46 citations Open access
Semantic Scholar
FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1.
Yaman Muşdal, Usama M. Hegazy, Y. Aksoy, B. Mannervik
2013Chemico-Biological Interactions45 citations
Semantic Scholar
Mapping of amino acid substitutions conferring herbicide resistance in wheat glutathione transferase.
S. Govindarajan, B. Mannervik, J. Silverman, Kath Wright +6 more
2015ACS Synthetic Biology37 citations Open access
Semantic Scholar
Multidimensional epistasis and fitness landscapes in enzyme evolution.
Wei Zhang, Daniel F. A. R. Dourado, P. Fernandes, M. Ramos +1 more
2012Biochemical Journal36 citations
Semantic Scholar
Astrocytes protect dopaminergic neurons against aminochrome neurotoxicity
J. Segura-Aguilar, B. Mannervik, J. Inzunza, M. Varshney +2 more
2022Neural Regeneration Research35 citations Open access
Semantic Scholar
Mechanism of glutathione transferase P1-1-catalyzed activation of the prodrug canfosfamide (TLK286, TELCYTA).
Daniel F. A. R. Dourado, P. Fernandes, M. Ramos, B. Mannervik
2013Biochemistry35 citations
Semantic Scholar
Identification of emerging quasi-species in directed enzyme evolution.
S. Kurtovic, B. Mannervik
2009Biochemistry33 citations
Semantic Scholar
Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine.
Wei Zhang, Olof Modén, B. Mannervik
2010Chemico-Biological Interactions32 citations
Semantic Scholar
Neuroprotection against Aminochrome Neurotoxicity: Glutathione Transferase M2-2 and DT-Diaphorase
J. Segura-Aguilar, Patricia Muñoz, J. Inzunza, M. Varshney +2 more
2022Antioxidants30 citations Open access
Semantic Scholar
Targeting human glutathione transferase A3-3 attenuates progesterone production in human steroidogenic cells.
F. Raffalli-Mathieu, Carolina Orre, M. Stridsberg, Maryam Hansson Edalat +1 more
2008Biochemical Journal28 citations Open access
Semantic Scholar
On the biosynthesis of 15-HETE and eoxin C4 by human airway epithelial cells.
Åsa Brunnström, Y. Tryselius, Stina Feltenmark, Erik Andersson +5 more
2015Prostaglandins & other lipid mediators27 citations
Semantic Scholar
Structural determinants of glutathione transferases with azathioprine activity identified by DNA shuffling of alpha class members.
S. Kurtovic, Olof Modén, A. Shokeer, B. Mannervik
2008Journal of Molecular Biology27 citations
Semantic Scholar
A Preclinical Model for Parkinson’s Disease Based on Transcriptional Gene Activation via KEAP1/NRF2 to Develop New Antioxidant Therapies
J. Segura-Aguilar, B. Mannervik
2023Antioxidants26 citations Open access
Semantic Scholar
Interactions between Odorants and Glutathione Transferases in the Human Olfactory Cleft.
Mathieu Schwartz, F. Ménétrier, J. Heydel, Evelyne Chavanne +7 more
2020Chemical Sensors26 citations
Semantic Scholar
Glutathione transferases in the bioactivation of azathioprine.
Olof Modén, B. Mannervik
2014Advances in Cancer Research26 citations
Semantic Scholar
Structural Analysis of a Glutathione Transferase A1-1 Mutant Tailored for High Catalytic Efficiency with Toxic Alkenals
L. Balogh, I. Le Trong, K. Kripps, K. Ta̅rs +3 more
2009Biochemistry26 citations Open access
Semantic Scholar
Evolution of Negative Cooperativity in Glutathione Transferase Enabled Preservation of Enzyme Function*
A. Bocedi, R. Fabrini, M. Lo Bello, A. Caccuri +4 more
2016Journal of Biological Chemistry23 citations Open access
Semantic Scholar
Expression of a Drosophila glutathione transferase in Arabidopsis confers the ability to detoxify the environmental pollutant, and explosive, 2,4,6-trinitrotoluene.
Kyriakos Tzafestas, M. Razalan, Ivan S Gyulev, Aslam M. A. Mazari +3 more
2017New Phytologist22 citations Open access
Semantic Scholar
Glutathione Transferases as Efficient Ketosteroid Isomerases
B. Mannervik, A. Ismail, H. Lindström, Birgitta Sjödin +1 more
2021Frontiers in Molecular Biosciences21 citations Open access
Semantic Scholar
Engineering GST M2-2 for high activity with indene 1,2-oxide and indication of an H-site residue sustaining catalytic promiscuity.
Malena A. Norrgård, B. Mannervik
2011Journal of Molecular Biology20 citations
Semantic Scholar
Hidden allostery in human glutathione transferase p1-1 unveiled by unnatural amino acid substitutions and inhibition studies.
Usama M. Hegazy, Yaman Muşdal, B. Mannervik
2013Journal of Molecular Biology19 citations
Semantic Scholar
A novel quasi-species of glutathione transferase with high activity towards naturally occurring isothiocyanates evolves from promiscuous low-activity variants.
Arna Rúnarsdóttir, B. Mannervik
2010Journal of Molecular Biology19 citations
Semantic Scholar
Cellular Trafficking of Glutathione Transferase M2-2 Between U373MG and SHSY-S7 Cells is Mediated by Exosomes
Raúl Valdes, A. Armijo, Patricia Muñoz, K. Hultenby +6 more
2021Neurotoxicity research18 citations
Semantic Scholar
Characterization of equine GST A3-3 as a steroid isomerase.
H. Lindström, S. M. Peer, N. Ing, B. Mannervik
2017Journal of Steroid Biochemistry and Molecular Biology18 citations
Semantic Scholar
Comparison of epsilon- and delta-class glutathione S-transferases: the crystal structures of the glutathione S-transferases DmGSTE6 and DmGSTE7 from Drosophila melanogaster.
M. Scian, I. Le Trong, Aslam M. A. Mazari, B. Mannervik +2 more
2015Acta Crystallographica Section D: Biological Crystallography18 citations Open access
Semantic Scholar
Structure-based redesign of GST A2-2 for enhanced catalytic efficiency with azathioprine.
Wei Zhang, Olof Modén, K. Ta̅rs, B. Mannervik
2012Chemistry and Biology18 citations Open access
Semantic Scholar
Porcine glutathione transferase Alpha 2-2 is a human GST A3-3 analogue that catalyses steroid double-bond isomerization.
N. Fedulova, F. Raffalli-Mathieu, B. Mannervik
2010Biochemical Journal18 citations Open access
Semantic Scholar
Multi-substrate-activity space and quasi-species in enzyme evolution: Ohno's dilemma, promiscuity and functional orthogonality.
B. Mannervik, Arna Rúnarsdóttir, S. Kurtovic
2009Biochemical Society Transactions18 citations
Semantic Scholar
Emergence of a novel highly specific and catalytically efficient enzyme from a naturally promiscuous glutathione transferase.
Cecilia Blikstad, A. Shokeer, S. Kurtovic, B. Mannervik
2008Biochimica et Biophysica Acta18 citations
Semantic Scholar
Exploring sequence-function space of a poplar glutathione transferase using designed information-rich gene variants
Yaman Muşdal, S. Govindarajan, B. Mannervik
2017Protein engineering, design & selection : PEDS17 citations Open access
Semantic Scholar
Identification of new inhibitors for human hematopoietic prostaglandin D2 synthase among FDA-approved drugs and other compounds.
Aslam M. A. Mazari, Usama M. Hegazy, B. Mannervik
2015Chemico-Biological Interactions17 citations
Semantic Scholar
Glutathione transferase A1-1: catalytic importance of arginine 15.
Daniel F. A. R. Dourado, P. Fernandes, B. Mannervik, M. Ramos
2010Journal of Physical Chemistry B17 citations
Semantic Scholar
Structure and steroid isomerase activity of Drosophila glutathione transferase E14 essential for ecdysteroid biosynthesis
J. Škerlová, H. Lindström, E. Gonis, Birgitta Sjödin +3 more
2019FEBS Letters16 citations Open access
Semantic Scholar
Isomerization of Δ5-androstene-3,17-dione into Δ4-androstene-3,17-dione catalyzed by human glutathione transferase A3-3: a computational study identifies a dual role for glutathione.
Daniel F. A. R. Dourado, P. Fernandes, B. Mannervik, M. Ramos
2014Journal of Physical Chemistry A16 citations
Semantic Scholar
Evolution of Broad Spectrum β-Lactam Resistance in an Engineered Metallo-β-lactamase*
Song Sun, Wei Zhang, B. Mannervik, D. Andersson
2012Journal of Biological Chemistry16 citations Open access
Semantic Scholar
Biosynthesis of 14,15-Hepoxilins in Human L1236 Hodgkin Lymphoma Cells and Eosinophils
Åsa Brunnström, M. Hamberg, W. Griffiths, B. Mannervik +1 more
2010Lipids16 citations
Semantic Scholar
Novel Alpha-Synuclein Oligomers Formed with the Aminochrome-Glutathione Conjugate Are Not Neurotoxic
Sandro Huenchuguala, Birgitta Sjödin, B. Mannervik, J. Segura-Aguilar
2018Neurotoxicity research15 citations Open access
Semantic Scholar
Substrate specificities of two tau class glutathione transferases inducible by 2,4,6-trinitrotoluene in poplar.
Yaman Muşdal, B. Mannervik
2015Biochimica et Biophysica Acta15 citations
Semantic Scholar
Fluorogenic probes using 4-substituted-2-nitrobenzenesulfonyl derivatives as caging groups for the analysis of human glutathione transferase catalyzed reactions.
Aya Shibata, Yukiko Nakano, Mika Ito, Mika Araki +7 more
2013In Analysis15 citations Open access
Semantic Scholar
Single-nucleotide polymorphic variants of human glutathione transferase T1-1 differ in stability and functional properties.
P. Josephy, Meredith Kent, B. Mannervik
2009Archives of Biochemistry and Biophysics15 citations
Semantic Scholar
Universal Caging Group for the in‐Cell Detection of Glutathione Transferase Applied to 19F NMR and Bioluminogenic Probes
Mika Ito, Aya Shibata, Jie Zhang, M. Hiroshima +8 more
2012ChemBioChem14 citations
Semantic Scholar
Modulating catalytic activity by unnatural amino acid residues in a GSH-binding loop of GST P1-1.
Usama M. Hegazy, K. Ta̅rs, U. Hellman, B. Mannervik
2008Journal of Molecular Biology14 citations
Semantic Scholar

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