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L. Lynch · SciRah

Researcher profile · Semantic Scholar

L. Lynch

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L. Lynch — researcher profile on SciRah

h-index: 44
Works: 97
Citations: 7,859

Most-cited papers

Metabolic reprogramming of natural killer cells in obesity limits antitumor responses
X. Michelet, Lydia Dyck, A. Hogan, R. Loftus +16 more
2018Nature Immunology554 citations
Semantic Scholar
Adipose Tissue Invariant NKT Cells Protect Against Diet-Induced Obesity and Metabolic Disorder Through Regulatory Cytokine Production
L. Lynch, Michael D. Nowak, B. Varghese, Justice Clark +6 more
2012Immunity498 citations Open access
Semantic Scholar
Glucose-regulated phosphorylation of TET2 by AMPK reveals a pathway linking diabetes to cancer
Di Wu, Di Hu, Hao Chen, G. Shi +32 more
2018Nature437 citations Open access
Semantic Scholar
Srebp-controlled glucose metabolism is essential for NK cell functional responses
Nadine Assmann, Katie O'Brien, R. Donnelly, Lydia Dyck +8 more
2017Nature Immunology342 citations Open access
Semantic Scholar
Lactate-Mediated Acidification of Tumor Microenvironment Induces Apoptosis of Liver-Resident NK Cells in Colorectal Liver Metastasis
C. Harmon, M. Robinson, F. Hand, Dalal Almuaili +6 more
2018Cancer immunology research307 citations Open access
Semantic Scholar
Clinical anxiety, cortisol and interleukin-6: Evidence for specificity in emotion–biology relationships
A. O'Donovan, Brian M. Hughes, George M. Slavich, L. Lynch +3 more
2010Brain, behavior, and immunity305 citations Open access
Semantic Scholar
γδ T cells producing interleukin-17A regulate adipose regulatory T cell homeostasis and thermogenesis
A. Kohlgruber, S. Gal-Oz, Nelson M LaMarche, Moto Shimazaki +13 more
2018Nature Immunology303 citations Open access
Semantic Scholar
Regulatory iNKT cells lack expression of the transcription factor PLZF and control the homeostasis of Treg cells and macrophages in adipose tissue
L. Lynch, X. Michelet, Sai Zhang, P. Brennan +11 more
2014Nature Immunology300 citations Open access
Semantic Scholar
Invariant NKT cells and CD1d+ cells amass in human omentum and are depleted in patients with cancer and obesity
L. Lynch, D. O'Shea, D. Winter, J. Geoghegan +2 more
2009European Journal of Immunology262 citations Open access
Semantic Scholar
Are Natural Killer Cells Protecting the Metabolically Healthy Obese Patient?
L. Lynch, J. O'Connell, Anna Kwasnik, T. Cawood +2 more
2009Obesity227 citations Open access
Semantic Scholar
Interplay between the immune system and adipose tissue in obesity.
M. Exley, Laura E. Hand, D. O'Shea, L. Lynch
2014Journal of Endocrinology219 citations Open access
Semantic Scholar
Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus
A. Hogan, Gadintshware Gaoatswe, L. Lynch, M. Corrigan +3 more
2014Diabetologia216 citations Open access
Semantic Scholar
The Relationship of Omental and Subcutaneous Adipocyte Size to Metabolic Disease in Severe Obesity
J. O'Connell, L. Lynch, T. Cawood, Anna Kwasnik +5 more
2010PLoS ONE201 citations Open access
Semantic Scholar
Adipose Type One Innate Lymphoid Cells Regulate Macrophage Homeostasis through Targeted Cytotoxicity
S. Boulenouar, X. Michelet, D. Duquette, David Alvarez +11 more
2017Immunity182 citations Open access
Semantic Scholar
Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis
A. Hogan, A. Tobin, T. Ahern, M. Corrigan +9 more
2011Diabetologia181 citations Open access
Semantic Scholar
UCP1 governs liver extracellular succinate and inflammatory pathogenesis
E. Mills, C. Harmon, Mark P. Jedrychowski, Hao-Peng Xiao +11 more
2021Nature Metabolism175 citations Open access
Semantic Scholar
iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy
L. Lynch, A. Hogan, D. Duquette, Chantel Lester +11 more
2016Cell Metabolism174 citations Open access
Semantic Scholar
Distinct metabolic programs established in the thymus control effector functions of γδ T cell subsets in tumor microenvironments
Noëlla Lopes, C. McIntyre, Stefani M. Martin, Mathilde Raverdeau +18 more
2021Nature Immunology172 citations Open access
Semantic Scholar
Altered Distribution and Increased IL-17 Production by Mucosal-Associated Invariant T Cells in Adult and Childhood Obesity
E. Carolan, L. Tobin, B. Mangan, M. Corrigan +10 more
2015Journal of Immunology167 citations Open access
Semantic Scholar
Natural Killer Cells in Obesity: Impaired Function and Increased Susceptibility to the Effects of Cigarette Smoke
D. O'Shea, T. Cawood, C. O'Farrelly, L. Lynch
2010PLoS ONE165 citations Open access
Semantic Scholar
Adipose Tissue Inflammation in the Pathogenesis of Type 2 Diabetes
A. Kohlgruber, L. Lynch
2015Current Diabetes Reports156 citations
Semantic Scholar
Spinal cord injury-induced immunodeficiency is mediated by a sympathetic-neuroendocrine adrenal reflex
H. Prüss, Andrea Tedeschi, Aude Thiriot, L. Lynch +16 more
2017Nature Neuroscience153 citations
Semantic Scholar
Innate Immune Control of Adipose Tissue Homeostasis.
Harry Kane, L. Lynch
2019Trends in immunology149 citations
Semantic Scholar
Regulatory iNKT cells lack PLZF expression and control Treg cell and macrophage homeostasis in adipose tissue
L. Lynch, X. Michelet, Sai Zhang, P. Brennan +11 more
2014Nature Immunology149 citations Open access
Semantic Scholar
Immune and non-immune functions of adipose tissue leukocytes
W. Trim, L. Lynch
2021Nature reviews. Immunology127 citations
Semantic Scholar
Diet, lipids, and antitumor immunity
Hannah Prendeville, L. Lynch
2022Cellular & Molecular Immunology108 citations Open access
Semantic Scholar
Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function
Lydia Dyck, Hannah Prendeville, Mathilde Raverdeau, Mieszko M. Wilk +15 more
2022Journal of Experimental Medicine97 citations Open access
Semantic Scholar
Distinct iNKT cell populations use IFNγ or ER stress-induced IL-10 to control adipose tissue homeostasis
Nelson M LaMarche, Harry Kane, A. Kohlgruber, Han Dong +2 more
2020Cell Metabolism88 citations Open access
Semantic Scholar
The A2aR adenosine receptor controls cytokine production in iNKT cells
Michael D. Nowak, L. Lynch, Simon C. Yue, A. Ohta +3 more
2010European Journal of Immunology88 citations Open access
Semantic Scholar
γδ T cells in cancer: a small population of lymphocytes with big implications
Mathilde Raverdeau, S. Cunningham, C. Harmon, L. Lynch
2019Clinical & Translational Immunology77 citations Open access
Semantic Scholar
Preadipocyte factor-1 is associated with metabolic profile in severe obesity.
J. O'Connell, L. Lynch, A. Hogan, T. Cawood +1 more
2011Journal of Clinical Endocrinology and Metabolism71 citations Open access
Semantic Scholar
γδ T cell dichotomy with opposing cytotoxic and wound healing functions in human solid tumors
C. Harmon, A. Zaborowski, H. Moore, Pamela St Louis +13 more
2023Nature Cancer70 citations
Semantic Scholar
The transcriptional programs of iNKT cells
E. Kim, L. Lynch, P. Brennan, Nadia R. Cohen +1 more
2015Seminars in Immunology70 citations Open access
Semantic Scholar
Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses
Aisling O'Brien, R. Loftus, M. Pisarska, L. Tobin +15 more
2019Journal of Immunology67 citations Open access
Semantic Scholar
Phosphorylation of Beta-3 adrenergic receptor at serine 247 by ERK MAP kinase drives lipolysis in obese adipocytes
Shang-Yu Hong, Wei Song, Peter-James H. Zushin, Bing-Yang Liu +13 more
2018Molecular Metabolism66 citations Open access
Semantic Scholar
ImmGen at 15
Stephanie Vargas Aguilar, O. Aguilar, R. Allan, E. Amir +218 more
2020Nature Immunology63 citations Open access
Semantic Scholar
Adipose invariant natural killer T cells
L. Lynch
2014Immunology60 citations Open access
Semantic Scholar
Adipose tissue at the nexus of systemic and cellular immunometabolism.
A. Kohlgruber, Nelson M LaMarche, L. Lynch
2016Seminars in Immunology57 citations
Semantic Scholar
Cysteine 253 of UCP1 regulates energy expenditure and sex-dependent adipose tissue inflammation
E. Mills, C. Harmon, Mark P. Jedrychowski, Hao-Peng Xiao +12 more
2021Cell Metabolism55 citations Open access
Semantic Scholar
Human Granzyme K Is a Feature of Innate T Cells in Blood, Tissues, and Tumors, Responding to Cytokines Rather than TCR Stimulation.
D. Duquette, C. Harmon, A. Zaborowski, X. Michelet +4 more
2023Journal of Immunology53 citations
Semantic Scholar
Developing Understanding of the Roles of CD1d-restricted T cell Subsets in Cancer: Reversing Tumor-induced Defects
M. Exley, L. Lynch, B. Varghese, Michael D. Nowak +2 more
2011Clinical Immunology51 citations Open access
Semantic Scholar
Stromal cell cadherin-11 regulates adipose tissue inflammation and diabetes.
S. Chang, A. Kohlgruber, F. Mizoguchi, X. Michelet +8 more
2017Journal of Clinical Investigation48 citations Open access
Semantic Scholar
Interleukin-17 as a key player in neuroimmunometabolism
A. Douglas, Brenneth Stevens, L. Lynch
2023Nature Metabolism46 citations
Semantic Scholar
Cancer, obesity and immunometabolism - Connecting the dots.
Lydia Dyck, L. Lynch
2018Cancer Letters46 citations
Semantic Scholar
KLF10 Deficiency in CD4+ T Cells Triggers Obesity, Insulin Resistance, and Fatty Liver
A. Wara, Shi-Jia Wang, Chun Wu, F. Fang +14 more
2020Cell Reports45 citations Open access
Semantic Scholar
Endogenous Oils Derived From Human Adipocytes Are Potent Adjuvants That Promote IL-1α–Dependent Inflammation
G. A. Tynan, Claire H A Hearnden, E. Oleszycka, C. Lyons +13 more
2014Diabetes44 citations Open access
Semantic Scholar
Diet, nutrient supply, and tumor immune responses.
C. McIntyre, Ayantu Temesgen, L. Lynch
2023Trends in Cancer36 citations
Semantic Scholar
Correction: Suppressive effects of the obese tumor microenvironment on CD8 T cell infiltration and effector function
Lydia Dyck, Hannah Prendeville, Mathilde Raverdeau, Mieszko M. Wilk +15 more
2022Journal of Experimental Medicine34 citations Open access
Semantic Scholar
The therapeutic and prognostic implications of immunobiology in colorectal cancer: a review
A. Zaborowski, D. Winter, L. Lynch
2021British Journal of Cancer34 citations Open access
Semantic Scholar
Cigarette smoke alters the invariant natural killer T cell function and may inhibit anti-tumor responses.
A. Hogan, M. Corrigan, V. O'Reilly, Gadintshware Gaoatswe +4 more
2011Clinical Immunology33 citations
Semantic Scholar

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D. O'Shea×14
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D. O'Shea — researcher profile on SciRah
A. Hogan×12
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A. Hogan — researcher profile on SciRah
C. O'Farrelly×10
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C. O'Farrelly — researcher profile on SciRah
M. Brenner×10
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D. Duquette — researcher profile on SciRah

J. O'Connell×8

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J. O'Connell — researcher profile on SciRah

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X. Michelet — researcher profile on SciRah

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Lydia Dyck — researcher profile on SciRah

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R. Loftus — researcher profile on SciRah

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C. Harmon — researcher profile on SciRah

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A. Kohlgruber — researcher profile on SciRah

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M. Corrigan — researcher profile on SciRah